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1. 发明授权

US5447529A Method of using endocardial impedance for determining electrode-tissue contact, appropriate sites for arrhythmia ablation and tissue heating during ablation 失效
标题翻译：使用心内膜阻抗来确定电极组织接触的方法，适当的心律失常消融部位和消融期间的组织加热
公开(公告)号：US5447529A
公开(公告)日：1995-09-05
申请号：US188514
申请日：1994-01-28
申请人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottleb , Isaac Chang
发明人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottleb , Isaac Chang
IPC分类号： A61B18/14 , A61N1/05 , A61N1/40 , A61B17/39
CPC分类号： A61N1/025 , A61B18/1492 , A61N1/05 , A61N1/056 , A61N1/40 , A61B18/1402 , A61B2018/00702 , A61B2018/00875 , A61B2018/126 , A61B2034/2051 , A61B2090/065
摘要： A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.
摘要翻译：在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗心跳的房间。将测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。也将测量结果与梗塞边界区域的范围进行比较。根据本发明，可以设置梗塞边界区域。梗死边界区是心律失常的重要来源，特别是室性心动过速。此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。

2. 发明授权

US5673704A Method of using endocardial impedance for determining electrode-tissue contact 失效
标题翻译：使用心内膜阻抗来确定电极组织接触的方法
公开(公告)号：US5673704A
公开(公告)日：1997-10-07
申请号：US654197
申请日：1996-05-28
申请人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottlieb , Isaac Chang
发明人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottlieb , Isaac Chang
IPC分类号： A61B18/14 , A61N1/05 , A61N1/40 , A61B17/39
CPC分类号： A61N1/025 , A61B18/1492 , A61N1/05 , A61N1/056 , A61N1/40 , A61B18/1402 , A61B2018/00702 , A61B2018/00875 , A61B2018/126 , A61B2034/2051 , A61B2090/065
摘要： A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.
摘要翻译：在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗心跳的房间。将测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。也将测量结果与梗塞边界区域的范围进行比较。根据本发明，可以设置梗塞边界区域。梗死边界区是心律失常的重要来源，特别是室性心动过速。此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。

3. 发明授权

US5562721A Method of using endocardial impedance for assessing tissue heating during ablation 失效
标题翻译：使用心内膜阻抗来评估消融期间组织加热的方法
公开(公告)号：US5562721A
公开(公告)日：1996-10-08
申请号：US438326
申请日：1995-05-10
申请人： Francis E. Marchlinski , David S Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottlieb , Isaac Chang
发明人： Francis E. Marchlinski , David S Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottlieb , Isaac Chang
IPC分类号： A61B18/14 , A61N1/05 , A61N1/40 , A61B17/39
CPC分类号： A61N1/025 , A61B18/1492 , A61N1/05 , A61N1/056 , A61N1/40 , A61B18/1402 , A61B2018/00702 , A61B2018/00875 , A61B2018/126 , A61B2034/2051 , A61B2090/065
摘要： A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.
摘要翻译：在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗心跳的房间。将所测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。也将测量结果与梗塞边界区域的范围进行比较。根据本发明，可以设置梗塞边界区域。梗死边界区是心律失常的重要来源，特别是室性心动过速。此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。

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