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1. 发明授权

US6081612A Systems and methods for the multispectral imaging and characterization of skin tissue 失效
标题翻译：用于多光谱成像和皮肤组织表征的系统和方法
公开(公告)号：US6081612A
公开(公告)日：2000-06-27
申请号：US31929
申请日：1998-02-27
申请人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
发明人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
IPC分类号： A61B5/103 , G06T5/00 , G06T7/00 , G06T7/40 , G06K9/00 , G06K9/36 , G01B9/02
CPC分类号： G06T7/408 , A61B5/0071 , A61B5/442 , A61B5/444 , A61B5/445 , A61B5/726 , G06T7/0012 , G06T7/402 , G06T2207/10064 , G06T2207/20064 , G06T2207/20148 , G06T2207/30088 , G06T2207/30096
摘要： Systems and methods for the multispectral imaging of skin tissue enables automatic characterization of the condition of a region of interest of the skin, based on direct digital imaging of the region of interest or the digitization of color photographic slides of the region of interest, illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is automatically segmented and that segmented mask is used to segment the other images by a digital processor. Parameters are estimated through wavelet maxima representations. Parameters related to the texture, asymmetry, blotchiness and border irregularities are also automatically estimated. The region of interest is automatically characterized by the digital processor, based on those parameters. The region of interest may include a skin lesion, in which case the present invention enables the characterization of the lesion as malignant or benign. The region of interest may also include wounds or burns.
摘要翻译：用于皮肤组织的多光谱成像的系统和方法可以基于感兴趣区域的直接数字成像或感兴趣区域的彩色摄影载玻片的数字化，自动表征皮肤感兴趣区域的状况，由适当过滤光。优选地，在低频谱带处的数字图像被自动分段，并且该分割的掩模用于由数字处理器分割其它图像。通过小波最大值表示来估计参数。还会自动估计与纹理，不对称，斑点和边界不规则相关的参数。基于这些参数，感兴趣的区域由数字处理器自动表征。感兴趣的区域可以包括皮肤损伤，在这种情况下，本发明能够将病变表征为恶性或良性。感兴趣的区域还可能包括伤口或烧伤。

2. 发明授权

US06307957B1 Multispectral imaging and characterization of biological tissue 失效
标题翻译：生物组织的多光谱成像和表征
公开(公告)号：US06307957B1
公开(公告)日：2001-10-23
申请号：US09604645
申请日：2000-06-27
申请人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
发明人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
IPC分类号： G06K900
CPC分类号： A61B1/00163 , A61B5/0059 , A61B5/0084 , A61B5/442 , A61B5/445 , A61B5/726 , G06K9/0014 , G06T7/0012
摘要： A light image is conveyed from a biological tissue through a flexible optical system to an image receiver, where it is converted to a form which may be entered into a computer. The computer segments the image by generating a segmentation mask defining the boundary of a region of interest in at least one spectral band, estimates at least one rotationally and translationally invariant statistical measure of coefficient distributions of the multiscale wavelet maxima representations of the digital images in at least one spectral band, characterizes the condition of the tissue based on the estimated values, and outputs the characterization of the condition of the tissue.
摘要翻译：光图像从生物组织通过柔性光学系统传送到图像接收器，在那里它被转换成可以输入计算机的形式。计算机通过在至少一个频谱带中生成定义感兴趣区域的边界的分割掩模来分割图像，估计数字图像的多尺度小波最大值表示中的系数分布的至少一个旋转和平移不变的统计量度至少一个光谱带，基于估计值表征组织的状况，并输出组织条件的表征。

3. 发明授权

US06208749B1 Systems and methods for the multispectral imaging and characterization of skin tissue 失效
标题翻译：用于多光谱成像和皮肤组织表征的系统和方法
公开(公告)号：US06208749B1
公开(公告)日：2001-03-27
申请号：US09032450
申请日：1998-02-27
申请人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs
发明人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs
IPC分类号： G06K900
CPC分类号： A61B5/442 , A61B5/445 , G06F19/00
摘要： Systems and methods for the multispectral imaging of skin tissue enables automatic characterization of the condition of a region of interest of the skin, based on direct digital imaging of the region of interest or the digitization of color photographic slides of the region of interest, illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is automatically segmented and that segmented mask is used to segment the other images by a digital processor. Parameters related to the texture, asymmetry, blotchiness and border irregularities are also automatically estimated. The region of interest is automatically characterized by the digital processor, based on those parameters. The region of interest may include a skin lesion, in which case the present invention enables the characterization of the lesion as malignant or benign.
摘要翻译：用于皮肤组织的多光谱成像的系统和方法可以基于感兴趣区域的直接数字成像或感兴趣区域的彩色摄影载玻片的数字化，自动表征皮肤感兴趣区域的状况，由适当过滤光。优选地，在低频谱带处的数字图像被自动分段，并且该分割的掩模用于由数字处理器分割其它图像。还会自动估计与纹理，不对称，斑点和边界不规则相关的参数。基于这些参数，感兴趣的区域由数字处理器自动表征。感兴趣的区域可以包括皮肤损伤，在这种情况下，本发明能够将病变表征为恶性或良性。

4. 发明授权

US06201880B1 Method and apparatus for electronically imaging a tooth through transillumination by light 失效
标题翻译：通过光透过电子成像牙齿的方法和装置
公开(公告)号：US06201880B1
公开(公告)日：2001-03-13
申请号：US08778001
申请日：1996-12-31
申请人： Marek Elbaum , Michael Greenebaum , Adam Jacobs , Sunguk Keem , Allen H. Schneiderman , Theodore S. Shultz
发明人： Marek Elbaum , Michael Greenebaum , Adam Jacobs , Sunguk Keem , Allen H. Schneiderman , Theodore S. Shultz
IPC分类号： G06K900
CPC分类号： A61B1/24 , A61B5/0013 , A61B5/0088 , A61B5/7203 , A61B5/726 , A61B5/7425 , A61B2562/0238 , A61C19/04
摘要： A method and apparatus for imaging teeth includes illuminating a surface of a tooth and electronically imaging the tooth from a non-illuminated surface of the tooth with an electronic camera. Automatic control of the intensity of illumination is preferably provided to avoid saturation of the camera. The camera may include a charge-coupled-device and the resulting digital images are preferably enhanced by wavelet analysis. If a video camera is used, the images may be digitized and then enhanced. Current images of the tooth may be compared to prior images of the same tooth to monitor changes in the tooth over time. The images can be used to detect dental caries and other dental conditions. A handpiece for illuminating the tooth and receiving the light passing through the tooth for reception by the camera in a reproducible manner, is also described.
摘要翻译：用于成像牙齿的方法和装置包括用电子照相机照射牙齿的表面并用牙齿的未被照射的表面电子地成像牙齿。优选提供对照明强度的自动控制，以避免照相机的饱和。相机可以包括电荷耦合器件，并且所得数字图像优选地通过小波分析增强。如果使用摄像机，则图像可能被数字化，然后被增强。牙齿的当前图像可以与同一牙齿的先前图像进行比较，以监测牙齿随时间的变化。该图像可用于检测龋齿和其他牙齿状况。还描述了用于照亮牙齿并且接收通过牙齿的光以便以可再现的方式被照相机接收的手柄。

5. 发明授权

US07127094B1 Method of controlling data gathered at remote locations 失效
标题翻译：控制在偏远地区收集的数据的方法
公开(公告)号：US07127094B1
公开(公告)日：2006-10-24
申请号：US10336025
申请日：2003-01-02
申请人： Marek Elbaum , Adam Jacobs , Nikolai Kabelev , Sunguk Keem
发明人： Marek Elbaum , Adam Jacobs , Nikolai Kabelev , Sunguk Keem
IPC分类号： G06K9/00
CPC分类号： G06F19/321 , G06F19/00
摘要： Data corresponding to biological tissue or lesions imaged in a remote location are communicated automatically to a central location, where the data are analyzed using data and algorithms stored securely at the central location. A result of the analysis is communicated from the central location to the remote location. Payment to an entity associated with the central location is made for each image or set of images.
摘要翻译：对应于在远程位置成像的生物组织或病变的数据被自动传送到中心位置，其中使用安全地存储在中心位置的数据和算法对数据进行分析。分析结果从中心位置传递到远程位置。对于每个图像或一组图像，对与中心位置相关联的实体的支付。

6. 发明申请

US20060035195A1 Method of transillumination of teeth 审中-公开
标题翻译：牙齿透照的方法
公开(公告)号：US20060035195A1
公开(公告)日：2006-02-16
申请号：US11199568
申请日：2005-08-08
申请人： Adam Jacobs
发明人： Adam Jacobs
IPC分类号： A61C1/00 , A61C5/00
CPC分类号： A61B1/24 , A61B1/06 , A61B1/247 , A61B5/0088 , A61B2562/0238 , A61C1/088
摘要： A face of a tooth is illuminated with light obtained from an injection laser with a defined coherence, wherein the illuminating light impinging on the face of the tooth has less than the defined coherence. Light propagating from the illuminated face and scattered until it exits from another face of the tooth is captured to form an image of the other face of the tooth.
摘要翻译：用具有确定的相干性的注射激光器获得的光照射牙齿的表面，其中照射在牙齿表面上的照明光小于限定的相干性。从被照射的面散射并从其另一面离开的光被捕获以形成牙齿另一面的图像。

7. 发明授权

US06714657B1 Apparatus for holding optical instruments in a reproducible position with respect to teeth 失效
标题翻译：用于将光学仪器保持在相对于牙齿可再现的位置的装置
公开(公告)号：US06714657B1
公开(公告)日：2004-03-30
申请号：US09467345
申请日：1999-12-20
申请人： Adam Jacobs , Tomasz Momot
发明人： Adam Jacobs , Tomasz Momot
IPC分类号： G06K900
CPC分类号： A61B1/247 , A61B5/0002 , A61B5/0088 , A61B2562/0238 , A61C19/04 , G02B6/0001
摘要： An apparatus for holding an optical system in a reproducible position with respect to a tooth in a mouth is presented. The apparatus has a body with a light source attached to a prong by a spring, and the prong contacts the proximal surface of the tooth.
摘要翻译：提出了一种用于将光学系统保持在相对于口中的牙齿的可重现位置的装置。该装置具有通过弹簧将光源附着到插脚的主体，并且插脚与牙齿的近侧表面接触。

8. 发明授权

US06626558B2 Apparatus for uniform illumination of an object 失效
公开(公告)号：US06626558B2
公开(公告)日：2003-09-30
申请号：US09944248
申请日：2001-08-31
申请人： Tomasz Momot , Adam Jacobs
发明人： Tomasz Momot , Adam Jacobs
IPC分类号： F21Y10102
CPC分类号： A61B1/247 , A61B1/0676 , A61B1/0684 , A61B5/0059 , A61B5/445 , A61B2562/0238 , Y10S362/80
摘要： A method, apparatus, and system for uniform illumination of an object is presented. A plurality of light sources is adjusted relative to a base in order to give a defined illumination pattern with respect to the base. Then, the light sources are rigidly affixed to the base.

9. 发明授权

US06341957B1 Method of transillumination imaging of teeth 有权
标题翻译：牙齿透照成像方法
公开(公告)号：US06341957B1
公开(公告)日：2002-01-29
申请号：US09722248
申请日：2000-11-24
申请人： Tomasz Momot , Adam Jacobs
发明人： Tomasz Momot , Adam Jacobs
IPC分类号： A61C500
CPC分类号： A61B1/06 , A61B1/247 , A61B5/0088 , A61B2562/0238
摘要： An elastomeric locator held against a proximal surface of the tooth and against the gum holds a light source and imaging optics in a reproducible position for imaging a tooth in vivo.
摘要翻译：弹性体定位器抵靠牙齿的近端表面并抵靠牙龈固定，可将光源和成像光学元件保持在可重现的位置，用于在体内成像牙齿。

10. 发明授权

US06710947B1 Method for assembling lens elements 失效
标题翻译：透镜元件组装方法
公开(公告)号：US06710947B1
公开(公告)日：2004-03-23
申请号：US10361299
申请日：2003-02-10
申请人： Tomasz Momot , Adam Jacobs
发明人： Tomasz Momot , Adam Jacobs
IPC分类号： G02B702
CPC分类号： G02B7/02 , G02B27/62
摘要： A set of lens elements is assembled to form a lens by adjusting a first and a second lens element in a spaced apart optical relationship with respect to each other, then affixing the two elements in the spaced apart optical relationship by affixing a lens element holder to at least the second lens element. Further lens elements are assembled in turn and affixed in spaced apart optical relationship to the preceding lens elements to form a finished lens.
摘要翻译：一组透镜元件通过相对于彼此间隔开的光学关系调节第一和第二透镜元件而被组装以形成透镜，然后通过将透镜元件固定器固定到间隔开的光学关系中来固定两个元件至少第二透镜元件。另外的透镜元件依次组装并且以与前述透镜元件间隔开的光学关系固定以形成成品透镜。

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