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1. 发明授权

US06208749B1 Systems and methods for the multispectral imaging and characterization of skin tissue 失效
标题翻译：用于多光谱成像和皮肤组织表征的系统和方法
公开(公告)号：US06208749B1
公开(公告)日：2001-03-27
申请号：US09032450
申请日：1998-02-27
申请人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs
发明人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs
IPC分类号： G06K900
CPC分类号： A61B5/442 , A61B5/445 , G06F19/00
摘要： Systems and methods for the multispectral imaging of skin tissue enables automatic characterization of the condition of a region of interest of the skin, based on direct digital imaging of the region of interest or the digitization of color photographic slides of the region of interest, illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is automatically segmented and that segmented mask is used to segment the other images by a digital processor. Parameters related to the texture, asymmetry, blotchiness and border irregularities are also automatically estimated. The region of interest is automatically characterized by the digital processor, based on those parameters. The region of interest may include a skin lesion, in which case the present invention enables the characterization of the lesion as malignant or benign.
摘要翻译：用于皮肤组织的多光谱成像的系统和方法可以基于感兴趣区域的直接数字成像或感兴趣区域的彩色摄影载玻片的数字化，自动表征皮肤感兴趣区域的状况，由适当过滤光。优选地，在低频谱带处的数字图像被自动分段，并且该分割的掩模用于由数字处理器分割其它图像。还会自动估计与纹理，不对称，斑点和边界不规则相关的参数。基于这些参数，感兴趣的区域由数字处理器自动表征。感兴趣的区域可以包括皮肤损伤，在这种情况下，本发明能够将病变表征为恶性或良性。

2. 发明授权

US06307957B1 Multispectral imaging and characterization of biological tissue 失效
标题翻译：生物组织的多光谱成像和表征
公开(公告)号：US06307957B1
公开(公告)日：2001-10-23
申请号：US09604645
申请日：2000-06-27
申请人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
发明人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
IPC分类号： G06K900
CPC分类号： A61B1/00163 , A61B5/0059 , A61B5/0084 , A61B5/442 , A61B5/445 , A61B5/726 , G06K9/0014 , G06T7/0012
摘要： A light image is conveyed from a biological tissue through a flexible optical system to an image receiver, where it is converted to a form which may be entered into a computer. The computer segments the image by generating a segmentation mask defining the boundary of a region of interest in at least one spectral band, estimates at least one rotationally and translationally invariant statistical measure of coefficient distributions of the multiscale wavelet maxima representations of the digital images in at least one spectral band, characterizes the condition of the tissue based on the estimated values, and outputs the characterization of the condition of the tissue.
摘要翻译：光图像从生物组织通过柔性光学系统传送到图像接收器，在那里它被转换成可以输入计算机的形式。计算机通过在至少一个频谱带中生成定义感兴趣区域的边界的分割掩模来分割图像，估计数字图像的多尺度小波最大值表示中的系数分布的至少一个旋转和平移不变的统计量度至少一个光谱带，基于估计值表征组织的状况，并输出组织条件的表征。

3. 发明授权

US06201880B1 Method and apparatus for electronically imaging a tooth through transillumination by light 失效
标题翻译：通过光透过电子成像牙齿的方法和装置
公开(公告)号：US06201880B1
公开(公告)日：2001-03-13
申请号：US08778001
申请日：1996-12-31
申请人： Marek Elbaum , Michael Greenebaum , Adam Jacobs , Sunguk Keem , Allen H. Schneiderman , Theodore S. Shultz
发明人： Marek Elbaum , Michael Greenebaum , Adam Jacobs , Sunguk Keem , Allen H. Schneiderman , Theodore S. Shultz
IPC分类号： G06K900
CPC分类号： A61B1/24 , A61B5/0013 , A61B5/0088 , A61B5/7203 , A61B5/726 , A61B5/7425 , A61B2562/0238 , A61C19/04
摘要： A method and apparatus for imaging teeth includes illuminating a surface of a tooth and electronically imaging the tooth from a non-illuminated surface of the tooth with an electronic camera. Automatic control of the intensity of illumination is preferably provided to avoid saturation of the camera. The camera may include a charge-coupled-device and the resulting digital images are preferably enhanced by wavelet analysis. If a video camera is used, the images may be digitized and then enhanced. Current images of the tooth may be compared to prior images of the same tooth to monitor changes in the tooth over time. The images can be used to detect dental caries and other dental conditions. A handpiece for illuminating the tooth and receiving the light passing through the tooth for reception by the camera in a reproducible manner, is also described.
摘要翻译：用于成像牙齿的方法和装置包括用电子照相机照射牙齿的表面并用牙齿的未被照射的表面电子地成像牙齿。优选提供对照明强度的自动控制，以避免照相机的饱和。相机可以包括电荷耦合器件，并且所得数字图像优选地通过小波分析增强。如果使用摄像机，则图像可能被数字化，然后被增强。牙齿的当前图像可以与同一牙齿的先前图像进行比较，以监测牙齿随时间的变化。该图像可用于检测龋齿和其他牙齿状况。还描述了用于照亮牙齿并且接收通过牙齿的光以便以可再现的方式被照相机接收的手柄。

4. 发明授权

US6081612A Systems and methods for the multispectral imaging and characterization of skin tissue 失效
标题翻译：用于多光谱成像和皮肤组织表征的系统和方法
公开(公告)号：US6081612A
公开(公告)日：2000-06-27
申请号：US31929
申请日：1998-02-27
申请人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
发明人： Dina Gutkowicz-Krusin , Marek Elbaum , Michael Greenebaum , Adam Jacobs , Alexandru Bogdan
IPC分类号： A61B5/103 , G06T5/00 , G06T7/00 , G06T7/40 , G06K9/00 , G06K9/36 , G01B9/02
CPC分类号： G06T7/408 , A61B5/0071 , A61B5/442 , A61B5/444 , A61B5/445 , A61B5/726 , G06T7/0012 , G06T7/402 , G06T2207/10064 , G06T2207/20064 , G06T2207/20148 , G06T2207/30088 , G06T2207/30096
摘要： Systems and methods for the multispectral imaging of skin tissue enables automatic characterization of the condition of a region of interest of the skin, based on direct digital imaging of the region of interest or the digitization of color photographic slides of the region of interest, illuminated by appropriately filtered light. Preferably, a digital image at a low spectral band is automatically segmented and that segmented mask is used to segment the other images by a digital processor. Parameters are estimated through wavelet maxima representations. Parameters related to the texture, asymmetry, blotchiness and border irregularities are also automatically estimated. The region of interest is automatically characterized by the digital processor, based on those parameters. The region of interest may include a skin lesion, in which case the present invention enables the characterization of the lesion as malignant or benign. The region of interest may also include wounds or burns.
摘要翻译：用于皮肤组织的多光谱成像的系统和方法可以基于感兴趣区域的直接数字成像或感兴趣区域的彩色摄影载玻片的数字化，自动表征皮肤感兴趣区域的状况，由适当过滤光。优选地，在低频谱带处的数字图像被自动分段，并且该分割的掩模用于由数字处理器分割其它图像。通过小波最大值表示来估计参数。还会自动估计与纹理，不对称，斑点和边界不规则相关的参数。基于这些参数，感兴趣的区域由数字处理器自动表征。感兴趣的区域可以包括皮肤损伤，在这种情况下，本发明能够将病变表征为恶性或良性。感兴趣的区域还可能包括伤口或烧伤。

5. 发明授权

US5973784A Common path, interferometric systems and methods using a birefringent material for topographic imaging 失效
标题翻译：通用路径，干涉系统和使用双折射材料进行地形成像的方法
公开(公告)号：US5973784A
公开(公告)日：1999-10-26
申请号：US4560
申请日：1998-01-08
申请人： Piotr Szwaykowski , Michael Greenebaum , Theodore S. Shultz
发明人： Piotr Szwaykowski , Michael Greenebaum , Theodore S. Shultz
IPC分类号： G01B9/02 , G01B11/24
CPC分类号： G01B9/02098 , G01B11/2441 , G01B2290/70
摘要： Common path, two beam interferometers and interferometric measurement systems employ a voltage controlled variable phase retarder enabling rapid stepping of the relative phase between two interfering optical beams by suitable control of the voltage. The beams need not be laterally separated. A compact beam expander with a ball lens is preferably included. The system is compact enough to be contained in a hand-held unit. The system can be used for surface mapping, testing of optical components and detecting the motion of mechanical objects, for example. It is particularly well suited for the mapping of the skin of a live subject. An optimum fringe period and optimum illumination wavelengths for imaging skin are disclosed, enabling the topography of substantial areas of human skin to be rapidly and accurately measured, in times on the order of one-tenth of a second. Methods of conducting interferometric analysis are disclosed, as well.
摘要翻译：公共路径，双光束干涉仪和干涉测量系统采用电压可控相位延迟器，可以通过适当控制电压来快速地步进两个干涉光束之间的相对相位。梁不需要横向分离。优选地包括具有球透镜的小型扩束器。该系统足够紧凑以容纳在手持单元中。该系统可用于例如表面映射，光学部件的测试和检测机械物体的运动。它特别适用于活体对象皮肤的测绘。公开了用于成像皮肤的最佳条纹周期和最佳照明波长，使得能够在十分之一秒的时间内快速且准确地测量人皮肤的实质区域的形貌。还公开了进行干涉测量分析的方法。

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