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1. 发明授权

US09031792B2 Method of using a lead to regulate protein expression 有权
标题翻译：使用铅调节蛋白质表达的方法
公开(公告)号：US09031792B2
公开(公告)日：2015-05-12
申请号：US11277552
申请日：2006-03-27
申请人： Darrell O. Wagner , Haris J. Sih , Jihong Qu , Jeffrey Ross , Steven D. Girouard , Ronald W. Heil, Jr.
发明人： Darrell O. Wagner , Haris J. Sih , Jihong Qu , Jeffrey Ross , Steven D. Girouard , Ronald W. Heil, Jr.
IPC分类号： G01N33/48 , A61K48/00 , A61N1/05
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

2. 发明申请

US20080058881A1 METHOD AND SYSTEM FOR TREATING POST-MI PATIENTS 审中-公开
标题翻译：治疗后MI患者的方法和系统
公开(公告)号：US20080058881A1
公开(公告)日：2008-03-06
申请号：US11469767
申请日：2006-09-01
申请人： Darrell O. Wagner , Haris J. Sih , Tamara Colette Baynham , Steven D. Girouard , Joseph M. Pastore , Mark Schwartz
发明人： Darrell O. Wagner , Haris J. Sih , Tamara Colette Baynham , Steven D. Girouard , Joseph M. Pastore , Mark Schwartz
IPC分类号： A61N1/05
CPC分类号： A61N5/0601 , A61N1/3627 , A61N1/36585 , A61N1/3962 , A61N5/062 , A61N2005/063
摘要： An implantable device for delivering phototherapy is described that enables the phototherapy to be delivered to internal locations in either a clinical or ambulatory setting for treatment of post-MI patients. Telemetry circuitry enables the device to deliver the phototherapy upon command or be programmed to delivery the phototherapy according to a specified schedule. The device may also incorporate one or more sensing modalities that can be used to trigger delivery of phototherapy upon occurrence of a sensed event or condition. In one particular embodiment, the phototherapy device is incorporated into a cardiac rhythm management device that also delivers pacing and/or defibrillation therapy.
摘要翻译：描述了用于递送光疗法的可植入装置，其使得光疗能够在临床或动态设置中被输送到内部位置以用于治疗MI后患者。遥测电路使得设备能够根据命令传送光疗，或者被编程为根据指定的时间表传送光疗。该装置还可以包括一个或多个感测模式，其可以用于在感测的事件或状况发生时触发光疗的传送。在一个特定实施例中，光疗装置被并入还可以进行起搏和/或除颤疗法的心律管理装置中。

3. 发明申请

US20110077701A1 METHOD AND APPARATUS FOR TISSUE PROTECTION AGAINST ISCHEMIA USING REMOTE CONDITIONING 有权
标题翻译：使用远程调节对组织织物组织防护的方法和装置
公开(公告)号：US20110077701A1
公开(公告)日：2011-03-31
申请号：US12963224
申请日：2010-12-08
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

4. 发明授权

US08874207B2 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US08874207B2
公开(公告)日：2014-10-28
申请号：US12963224
申请日：2010-12-08
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

5. 发明申请

US20110137385A1 METHOD AND APPARATUS FOR RELIEVING ANGINA SYMPTOMS USING LIGHT 审中-公开
标题翻译：使用光来消除神经症状的方法和装置
公开(公告)号：US20110137385A1
公开(公告)日：2011-06-09
申请号：US13024975
申请日：2011-02-10
申请人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
发明人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
IPC分类号： A61N5/06
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61F2250/0002 , A61N1/3787 , A61N5/0601 , A61N2005/0602 , A61N2005/0652 , A61N2005/0653
摘要： An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.
摘要翻译：可植入医疗装置包括并入血管内支架中的发光电路。发光电路将光发射到缺血区域。该光具有适合于重现与缺血相关的心绞痛症状的特征。

6. 发明授权

US07885710B2 Method and apparatus for tissue protection against ischemia using remote conditioning 有权
标题翻译：使用远程调理的组织保护针对缺血的方法和装置
公开(公告)号：US07885710B2
公开(公告)日：2011-02-08
申请号：US11318263
申请日：2005-12-23
申请人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
发明人： Haris J. Sih , Tamara Colette Baynham , Darrell O. Wagner
IPC分类号： A61N1/372
CPC分类号： A61N1/3627
摘要： A stimulation system delivers stimulation to protect an ischemic region of a body from tissue damage caused by ischemia. The stimulation is delivered to one or more stimulation sites remote from the ischemic region to elicit a physiological effect that protects the ischemic region from the tissue damage caused by ischemia. In one embodiment, the stimulation system delivers cardioprotective stimulation to one or more stimulation sites remote from the heart to protect the heart from injuries associated with cardiac ischemic events. In another embodiment, the stimulation system delivers remote conditioning stimulation to one or more stimulation sites in or on the heart to protect a non-cardiac region from injuries associated with non-cardiac ischemic events.
摘要翻译：刺激系统提供刺激以保护身体的缺血区域免于由局部缺血引起的组织损伤。刺激被递送到远离缺血区域的一个或多个刺激部位，以产生保护缺血区域免受缺血引起的组织损伤的生理作用。在一个实施例中，刺激系统将心脏保护刺激递送到远离心脏的一个或多个刺激部位，以保护心脏免于与心脏缺血事件相关的损伤。在另一个实施例中，刺激系统将远程调节刺激递送到心脏中或心脏上的一个或多个刺激部位，以保护非心脏区域免于与非心脏缺血事件相关的损伤。

7. 发明授权

US08568286B2 Methods to position therapeutic agents using a magnetic field 有权
标题翻译：使用磁场定位治疗剂的方法
公开(公告)号：US08568286B2
公开(公告)日：2013-10-29
申请号：US11424107
申请日：2006-06-14
申请人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
发明人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
IPC分类号： A61N2/00
CPC分类号： A61N1/3956 , A61M37/00 , A61N2/002
摘要： A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided.
摘要翻译：提供了一种用于控制给予哺乳动物的治疗剂的位置的系统。该系统使用能够产生磁场的装置和用磁响应部分标记的治疗剂。还提供了使用该装置和治疗剂的方法。

8. 发明申请

US20080281305A1 METHOD AND APPARATUS FOR RELIEVING ANGINA SYMPTOMS USING LIGHT 审中-公开
标题翻译：使用光来消除神经症状的方法和装置
公开(公告)号：US20080281305A1
公开(公告)日：2008-11-13
申请号：US11746829
申请日：2007-05-10
申请人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
发明人： Tamara Colette Baynham , Darrell O. Wagner , Haris J. Sih
IPC分类号： A61B18/18 , A61F2/06 , A61F7/12 , A61N5/06
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61F2250/0002 , A61N1/3787 , A61N5/0601 , A61N2005/0602 , A61N2005/0652 , A61N2005/0653
摘要： An implantable medical device includes a light emitting circuit incorporated into an intravascular stent. The light emitting circuit emits a light to an ischemic region. The light has characteristics suitable for reliving the angina symptoms associated with ischemia.
摘要翻译：可植入医疗装置包括并入血管内支架中的发光电路。发光电路将光发射到缺血区域。该光具有适合于重现与缺血相关的心绞痛症状的特征。

9. 发明申请

US20080006281A1 METHODS TO POSITION THERAPEUTIC AGENTS USING A MAGNETIC FIELD 有权
标题翻译：使用磁场的位置治疗药物的方法
公开(公告)号：US20080006281A1
公开(公告)日：2008-01-10
申请号：US11424107
申请日：2006-06-14
申请人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
发明人： Haris J. Sih , Craig Stolen , Jihong Ou , Darrell O. Wagner
IPC分类号： A61B19/00
CPC分类号： A61N1/3956 , A61M37/00 , A61N2/002
摘要： A system for controlling the location of a therapeutic agent administered to a mammal is provided. The system employs a device that is capable of generating a magnetic field and a therapeutic agent labeled with a magnetically responsive moiety. Methods which employ the device and the therapeutic agent are also provided.
摘要翻译：提供了一种用于控制给予哺乳动物的治疗剂的位置的系统。该系统使用能够产生磁场的装置和用磁响应部分标记的治疗剂。还提供了使用该装置和治疗剂的方法。

10. 发明授权

US5251624A Pulse generator for use in an implantable atrial defibrillator 失效
标题翻译：用于可植入心房除颤器的脉冲发生器
公开(公告)号：US5251624A
公开(公告)日：1993-10-12
申请号：US902998
申请日：1992-06-22
申请人： Joseph M. Bocek , Kenneth R. Infinger , Darrell O. Wagner
发明人： Joseph M. Bocek , Kenneth R. Infinger , Darrell O. Wagner
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , A61N1/395
摘要： A pulse generator for use in implantable atrial defibrillator provides cardiovertinq electrical energy to the atria of a heart through at least one lead having a pair of electrodes associated with the atria of the heart. The pulse generator includes a depletable, low voltage, power source such as a battery. A charging circuit coupled to the battery includes a flyback transformer for converting the battery voltage to low duty cycle pulsating high voltage electrical energy to store the high voltage electrical energy in a storage capacitor coupled to the charging circuit. A crosspoint switch selectively couples the storage capacitor to the electrodes for applying a portion of the stored electrical energy to the atria of the heart for cardioverting the atria of the heart.

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