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1. 发明授权

US5251624A Pulse generator for use in an implantable atrial defibrillator 失效
标题翻译：用于可植入心房除颤器的脉冲发生器
公开(公告)号：US5251624A
公开(公告)日：1993-10-12
申请号：US902998
申请日：1992-06-22
申请人： Joseph M. Bocek , Kenneth R. Infinger , Darrell O. Wagner
发明人： Joseph M. Bocek , Kenneth R. Infinger , Darrell O. Wagner
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , A61N1/395
摘要： A pulse generator for use in implantable atrial defibrillator provides cardiovertinq electrical energy to the atria of a heart through at least one lead having a pair of electrodes associated with the atria of the heart. The pulse generator includes a depletable, low voltage, power source such as a battery. A charging circuit coupled to the battery includes a flyback transformer for converting the battery voltage to low duty cycle pulsating high voltage electrical energy to store the high voltage electrical energy in a storage capacitor coupled to the charging circuit. A crosspoint switch selectively couples the storage capacitor to the electrodes for applying a portion of the stored electrical energy to the atria of the heart for cardioverting the atria of the heart.

2. 发明授权

US5350402A Atrial defibrillator and method for providing T wave detection and interval timing prior to cardioversion 失效
标题翻译：心房除颤器和在心脏复律前提供T波检测和间隔时间的方法
公开(公告)号：US5350402A
公开(公告)日：1994-09-27
申请号：US67688
申请日：1993-05-26
申请人： Kenneth R. Infinger , Gregory M. Ayers , Darrell O. Wagner , John M. Adams
发明人： Kenneth R. Infinger , Gregory M. Ayers , Darrell O. Wagner , John M. Adams
IPC分类号： A61N1/365 , A61N1/362 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/3622 , A61N1/395 , A61N1/3987
摘要： An implantable atrial defibrillator and method provides cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for detecting R waves of the heart, a second detector for detecting T waves of the heart, and a third detector for detecting atrial activity of the heart. An atrial fibrillation detector is responsive to the third detector for determining when the atria of the heart are in need of cardioversion. A cardioverting stage applies the cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion, after the second detector detects a T wave, and in timed relation to an R wave detected by the first detector after the detected T wave is completed. The atrial defibrillator includes a timer for timing a predetermined delay time after the T wave is detected, which delay time must be completed before the atria are cardioverted in timed relation to a detected R wave to assure that the detected T wave is completed.
摘要翻译：可植入心房除颤器和方法为需要心脏复律的心脏心房提供心律转复的电能。心房除颤器包括用于检测心脏的R波的第一检测器，用于检测心脏的T波的第二检测器，以及用于检测心脏的心房活动的第三检测器。心房颤动检测器响应于第三检测器，用于确定心脏心房何时需要心脏复律。当心脏的心房需要心脏复律时，在第二检测器检测到T波之后，以及在与第一检测器之后检测到的R波的定时关系中，心脏转换的电能将心脏转换的能量应用于心脏的心房检测到T波完成。心房除颤器包括：定时器，用于在检测到T波之后定时预定的延迟时间，该延迟时间必须在心跳与检测的R波的定时关系转换之前完成，以确保检测到的T波完成。

3. 发明授权

US5464432A Implantable atrial defibrillator having an intermittently activated fibrillation detector 失效
标题翻译：具有间歇激活的原纤颤检测器的可植入心房除颤器
公开(公告)号：US5464432A
公开(公告)日：1995-11-07
申请号：US232767
申请日：1994-04-25
申请人： Kenneth R. Infinger , Joseph M. Bocek
发明人： Kenneth R. Infinger , Joseph M. Bocek
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/395
摘要： An implantable automatic atrial defibrillator powered by a depletable battery power source conserves battery power for extending the predicted life of the defibrillator by intermittently detecting for atrial fibrillation. The atrial defibrillator includes a real time clock which, at spaced apart predetermined times, causes heart activity data to be stored in a memory. Thereafter, a normally deactivated atrial fibrillation detector is activated for processing the stored data to detect for atrial fibrillation.
摘要翻译：由可消耗电池电源供电的植入式自动心房除颤器通过间歇检测心房颤动而节省电池电力，延长除颤器的预期寿命。心房除颤器包括实时时钟，其以间隔开的预定时间将心脏活动数据存储在存储器中。此后，激活正常失活的心房颤动检测器用于处理存储的数据以检测心房颤动。

4. 发明授权

US5207219A Atrial defibrillator and method for providing interval timing prior to cardioversion 失效
标题翻译：心房除颤器和在心脏复律前提供间隔时间的方法
公开(公告)号：US5207219A
公开(公告)日：1993-05-04
申请号：US965195
申请日：1992-10-23
申请人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Joseph M. Bocek
发明人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Joseph M. Bocek
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： An implantable atrial defibrillator provides cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for detecting ventricular activations of the heart, a second detector for detecting atrial activity of the heart, and an atrial fibrillation detector responsive to the second detector for determining when the atria of the heart are in need of cardioversion. The atrial defibrillator also includes a cardioverting stage for applying the cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion and when the time between immediately successive ventricular activations is greater than a preselected minimum time interval.

5. 发明授权

US5269298A Atrial defibrillator and method for providing synchronized delayed cardioversion 失效
标题翻译：心房除颤器和提供同步延迟心脏复律的方法
公开(公告)号：US5269298A
公开(公告)日：1993-12-14
申请号：US965168
申请日：1992-10-23
申请人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Yixuan Jin
发明人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger , Yixuan Jin
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： An implantable atrial defibrillator provides cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for detecting ventricular activations of the heart, a second detector for detecting atrial activity of the heart, and an atrial fibrillation detector responsive to the second detector for determining when the atria of the heart are in need of cardioversion. The atrial defibrillator further includes a cardioverter for applying the cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion, and a timer delay stage responsive to the first detector for causing the cardioverter to apply the cardioverting electrical energy to the atria of the heart a predetermined delay time after the first detector detects one of the ventricular activations and before the T wave of the heart immediately following the one of the ventricular activations.

6. 发明授权

US5265600A Atrial defibrillator and method for providing post-cardioversion pacing 失效
标题翻译：心房除颤器和提供心脏起搏起搏的方法
公开(公告)号：US5265600A
公开(公告)日：1993-11-30
申请号：US965156
申请日：1992-10-23
申请人： John M. Adams , Kenneth R. Infinger
发明人： John M. Adams , Kenneth R. Infinger
IPC分类号： A61N1/39 , A61N1/362
CPC分类号： A61N1/3962 , A61N1/395
摘要： An implantable atrial defibrillator applies cardioverting electrical energy to the atria of a human heart in need of cardioversion and thereafter gradually returns the cardiac rate of the heart to a normal cardiac rate. The atrial defibrillator includes a first detector for detecting atrial activity of the heart, and an atrial fibrillation detector, responsive to said first detector, for determining when the atria of the heart are in need of cardioversion. The atrial defibrillator further includes a cardioverter responsive to the atrial fibrillation detector for applying the cardioverting electrical energy to the atria of the heart when the atria are in need of cardioversion, and a pacing output for pacing the ventricles of the heart at a decreasing cardiac rate from a base rate to a final rate lower than the base rate after the atria of the heart are successfully cardioverted.
摘要翻译：可植入心房除颤器将心脏转移电能施加到需要心脏复律的人心脏心房，然后逐渐将心脏的心率恢复至正常心率。心房除颤器包括用于检测心脏的心房活动的第一检测器和响应于所述第一检测器的心房颤动检测器，用于确定心脏心房何时需要心脏复律。心房除颤器还包括响应于心房颤动检测器的心律转复器，当心房需要心脏复律时，将心脏转移电能施加到心脏的心房，以及起搏输出，用于以降低心率进行心脏起搏从心率上升到心脏心房后的基础速率至最终速率低于基础速率。

7. 发明授权

US5403353A Post-heart surgery cardioverting system and method 失效
标题翻译：心脏手术心脏转复系统及方法
公开(公告)号：US5403353A
公开(公告)日：1995-04-04
申请号：US100492
申请日：1993-07-30
申请人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
发明人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3918 , A61N1/05 , A61N1/0587 , A61N1/362 , A61N1/39 , A61N1/395
摘要： A post-surgical cardioverting system and method applies cardioverting electrical energy to the atria of the heart of a post-surgical heart patient. The system includes a first lead including a first elongated electrode having a proximal end and a distal end, a second lead including a second elongated electrode having a proximal end and a distal end, and sutures for releasably anchoring the distal ends of the first and second electrodes to the pericardium and disposing the first and second electrodes along the pericardium overlying the right and left atria respectively. A non-implantable cardiovertor is coupled to the first and second leads for applying the cardioverting electrical energy to the first and second electrodes. When cardioversion is no longer required, the first and second leads may be pulled out of the patient's chest.
摘要翻译：手术后心脏转复系统和方法将心脏转移电能应用于手术后心脏病人心脏的心房。该系统包括第一引线，其包括具有近端和远端的第一细长电极，第二引线包括具有近端和远端的第二细长电极，以及用于可释放地锚固第一和第二末端的缝合线的缝合线电极到心包，并且分别沿着包围右心房和左心房的心包布置第一和第二电极。非植入式心律转换器耦合到第一和第二引线，用于将心电转换电能施加到第一和第二电极。当不再需要心脏复律时，可以将第一和第二引线从病人的胸部拉出。

8. 发明授权

US5348021A Apparatus and method for reliably detecting a depolarization activation wave of the heart and atrial defibrillator utilizing same 失效
标题翻译：利用其可靠地检测心脏和心房除颤器的去极化激活波的装置和方法
公开(公告)号：US5348021A
公开(公告)日：1994-09-20
申请号：US861184
申请日：1992-03-31
申请人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger
发明人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger
IPC分类号： A61N1/39 , A61B5/046
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： An atrial defibrillator reliably detects a depolarization activation wave of the heart and delivers cardioverting electrical energy to the atria of the heart in synchronism with a detected depolarization activation wave. The atrial defibrillator includes a first sensor for producing a first electrical output having a duration substantially equal to the duration of the depolarization activation wave sensed between a first pair of spaced apart locations of the heart. The atrial defibrillator further includes a second sensor for producing a second electrical output having a duration substantially equal to the duration of the depolarization activation wave sensed between a second pair of spaced apart locations of the heart. The spacing between the second pair of locations is greater than the spacing between the first pair of locations. A microprocessor is responsive to the first and second electrical outputs for providing an indication signal indicating the occurrence of the depolarization activation wave when the second electrical output is longer in duration than the first electrical output. A pulse generator coupled to the microprocessor applies electrical cardioverting energy to the atria of the heart in response to the indication signal.
摘要翻译：心房除颤器可靠地检测心脏的去极化激活波，并且与检测到的去极化激活波同步地将心电转移到心脏的心房。心房除颤器包括用于产生第一电输出的第一传感器，其具有基本上等于在心脏的第一对间隔位置之间感测到的去极化激活波的持续时间的持续时间。心房除颤器还包括第二传感器，用于产生第二电输出，该第二电输出的持续时间基本上等于在心脏的第二对间隔位置之间感测的去极化激活波的持续时间。第二对位置之间的间隔大于第一对位置之间的间隔。当第二电输出的持续时间比第一电输出更长时，微处理器响应于第一和第二电输出，用于提供指示去极化激活波的发生的指示信号。耦合到微处理器的脉冲发生器响应于指示信号将心脏转换能量施加到心脏的心房。

9. 发明授权

US5267559A Atrial defibrillator and method for providing atrial sensing 失效
标题翻译：心房除颤器及提供心房感应的方法
公开(公告)号：US5267559A
公开(公告)日：1993-12-07
申请号：US965166
申请日：1992-10-23
申请人： Yixuan Jin , Kenneth R. Infinger
发明人： Yixuan Jin , Kenneth R. Infinger
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/395
摘要： An implantable atrial defibrillator applies cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for sensing atrial activity of the heart, an atrial fibrillation detector responsive to the first detector for determining when the atria of the heart are in need of cardioversion and a second detector for detecting ventricular activations of the heart. The atrial defibrillator further includes a cardioverter for applying cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion and is responsive to the second detector for applying the cardioverting electrical energy to the atria of the heart in predetermined time relation to a detected ventricular activation. The detection of atrial activity of the heart is interrupted when a ventricular activation of the heart is detected by the second detector.

10. 再颁专利

USRE35779E Post-heart surgery cardioverting system and method 失效
公开(公告)号：USRE35779E
公开(公告)日：1998-04-28
申请号：US608410
申请日：1996-02-28
申请人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
发明人： Clifton A. Alferness , Gregory M. Ayers , Jerry C. Griffin , Kenneth R. Infinger
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3918 , A61N1/05 , A61N1/0587 , A61N1/362 , A61N1/39 , A61N1/395
摘要： A post-surgical cardioverting system and method applies cardioverting electrical energy to the atria of the heart of a post-surgical heart patient. The system includes a first lead including a first elongated electrode having a proximal end and a distal end, a second lead including a second elongated electrode having a proximal end and a distal end, and sutures for releasably anchoring the distal ends of the first and second electrodes to the pericardium and disposing the first and second electrodes along the pericardium overlying the right and left atria respectively. A non-implantable cardiovertor is coupled to the first and second leads for applying the cardioverting electrical energy to the first and second electrodes. When cardioversion is no longer required, the first and second leads may be pulled out of the patient's chest.

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