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1. 发明授权

US06239159B1 Nucleoside analogues 失效
标题翻译：核苷类似物
公开(公告)号：US06239159B1
公开(公告)日：2001-05-29
申请号：US09101978
申请日：1999-05-03
申请人： Daniel Brown , David Loakes , Alan Hamilton , Adrian Simmonds , Clifford Smith
发明人： Daniel Brown , David Loakes , Alan Hamilton , Adrian Simmonds , Clifford Smith
IPC分类号： A01N4352
CPC分类号： C07H21/00 , C07H19/044 , C07H19/052 , C07H19/056
摘要： Nucleoside analogues in which a group M replaces the natural base where M is (1) or (2) or (3), where each of X1, X2 and X3 are C or N, each of R6 and R7 is the same or different and each is H, NO2, CO, COR8, OR8, CN, O, CON(R8)2, COOR8, SO2R8, SO3R8, SR8, NHCHO, (CH2)n(R8)2, halogen, or a reporter moiety, each of R8 and R9 is H or hydrocarbyl or a reporter moiety, and n is 0-4. The analogues are substrates for polymerase and terminal transferase enzymes.
摘要翻译：其中M代替M为（1）或（2）或（3）的天然碱的核苷类似物，其中X1，X2和X3各自为C或N，R6和R7各自相同或不同，各自为H，NO 2，CO，COR 8，OR 8，CN，O，CON（R 8）2，COOR 8，SO 2 R 8，SO 3 R 8，SR 8，NHCHO，（CH 2）n（R 8）2，卤素或报道分子 R8和R9是H或烃基或报道部分，n是0-4。类似物是聚合酶和末端转移酶的底物。

2. 发明授权

US06313286B1 Nucleoside analogues 失效
标题翻译：核苷类似物
公开(公告)号：US06313286B1
公开(公告)日：2001-11-06
申请号：US09117494
申请日：1999-02-05
申请人： Daniel Brown , Alan Hamilton , David Loakes , Adrian Simmonds , Clifford Smith
发明人： Daniel Brown , Alan Hamilton , David Loakes , Adrian Simmonds , Clifford Smith
IPC分类号： C07H1900
CPC分类号： C07H19/06 , C07H21/00 , C12Q1/686 , C12Q1/6869 , G01N33/5308
摘要： Nucleoside analogues containing the degenerate base analogue P and derivatives thereof are provided with reporter moieties preferably comprising signal moieties. The nucleoside analogues are useful for labeling DNA or RNA or for incorporating in oligonucleotides.
摘要翻译：含有简并碱基类似物P及其衍生物的核苷类似物提供有优选包含信号部分的报道部分。核苷类似物可用于标记DNA或RNA或用于掺入寡核苷酸。

3. 发明授权

US06600028B1 Tricyclic base analogues 失效
标题翻译：三环基类似物
公开(公告)号：US06600028B1
公开(公告)日：2003-07-29
申请号：US09402048
申请日：2000-02-01
申请人： Daniel Brown , David Loakes , David Williams , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall , Alan Hamilton , Clifford Smith , Adrian Christopher Simmonds , William Jonathan Cummins , Patrick Finn
发明人： Daniel Brown , David Loakes , David Williams , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall , Alan Hamilton , Clifford Smith , Adrian Christopher Simmonds , William Jonathan Cummins , Patrick Finn
IPC分类号： C07H2100
CPC分类号： C07D498/16 , C07H19/04 , C07H21/00
摘要： Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R8, X is O or N or NR12 or CR10, X′ is O or S or N, provided that when X′ is O or S, then X is C, Y is CH or N, R6 is NH2 or SMe or SO2Me or NHNH2, each of R7 and R8 is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R12 is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R10 is H or ═O or F or alkyl or aryl or a reporter moiety.
摘要翻译：核苷类似物具有结构（2），其中Q是H或糖部分或糖类似物或修饰的糖或核心或骨架类似物，W是0-5个碳原子的亚烷基或亚烯基链，其中任何一个可携带取代基R8，X为O或N或NR12或CR10，X'为O或S或N，条件是当X'为O或S时，则X为C，Y为CH或N，R6为NH2或SMe或SO2Me 或NHNH 2，R 7和R 8各自独立地为H或F，或烷基或链烯基或芳基或酰基或报道部分，R 12独立地为H或烷基或链烯基或芳基或酰基或报道部分，R 10为H或= O 或F或烷基或芳基或报道部分。

4. 发明授权

US06444682B1 Base analogues 失效
标题翻译：基础类似物
公开(公告)号：US06444682B1
公开(公告)日：2002-09-03
申请号：US09463501
申请日：2000-04-18
申请人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
发明人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
IPC分类号： A61K3170
CPC分类号： G01N33/5308 , C07H21/00
摘要： Nucleotide or base analogues having structure (3) or (4) wherein X═O or NH or S and each R6 is independently H or alkyl or alkenyl or alkoxy or aryl or a reporter moiety.
摘要翻译：具有结构（3）或（4）的核苷酸或碱基类似物，其中X = O或NH或S，每个R6独立地为H或烷基或链烯基，烷氧基或芳基或报道部分。

5. 发明授权

US06605611B2 Base analogues 失效
标题翻译：基础类似物
公开(公告)号：US06605611B2
公开(公告)日：2003-08-12
申请号：US10233993
申请日：2002-09-03
申请人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
发明人： Adrian Christopher Simmonds , Alan Hamilton , Clifford Smith , David Loakes , Daniel Brown , Fergal Hill , Shiv Kumar , Satyam Nampalli , Mark McDougall
IPC分类号： A61K31495
CPC分类号： G01N33/5308 , C07H21/00
摘要： Nucleoside analogues or base analogues having structure (I), where X=O or NH or S, Y=N or CHR6 or CR6, W=N or NR6 or CHR6 or CR6 or S, n=1 or 2; each R6 is independently H or O or alkyl or alkenyl or alkoxy or aryl or a reporter moiety; where necessary (i.e. when Y and/or W is N or CR6 where R6 is not O) a double bond is present between Y and W or W and W, and Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue.
摘要翻译：具有结构（I）的核苷类似物或碱基类似物，其中X = O或NH或S，Y = N或CHR 6或CR 6，W = N或NR 6或CHR 6或CR 6或S，n = 1或2; 每个R 6独立地为H或O或烷基或链烯基或烷氧基或芳基或报道部分; 必要时（即当Y和/或W为N或R6，R6不为O时），Y与W或W和W之间存在双键，Q为H或糖或糖类似物或核酸骨架或骨架类似物。

6. 发明授权

US06458966B1 Dye intermediate and method 失效
标题翻译：染料中间体和方法
公开(公告)号：US06458966B1
公开(公告)日：2002-10-01
申请号：US09485177
申请日：2000-04-24
申请人： John Griffiths , John Mama , Valerie Millar , Mark Briggs , Alan Hamilton
发明人： John Griffiths , John Mama , Valerie Millar , Mark Briggs , Alan Hamilton
IPC分类号： C07D20904
CPC分类号： C09B23/145 , C09B11/24 , C09B23/0091 , C09B23/06 , C09B47/00 , C09B57/007 , C09B57/02
摘要： Various classes of dyes are provided having acid, ester or amide groups for covalent linking to biomolecules. The dyes may be prepared by use of a compound of formula (I) where R1 comprises a linker and a carboxy including acid, salt, ester including N-hydroxysuccinimide, activated ester or amide group; R2, R3, R4 and R5 are H, C1-C10 alkyl or aralkyl or a group to modify solubility or electronic or spectral properties or a functional linking group: or R4-R5 and/or R2-R4 and/or R2-R3 are linked to form an extended ring system; and R6 is H or CHO or NO.
摘要翻译：提供了具有酸，酯或酰胺基团以共价连接生物分子的各种类型的染料。染料可以通过使用式（I）化合物制备，其中R 1包含连接基和羧基，包括酸，盐，酯，包括N-羟基琥珀酰亚胺，活化的酯或酰胺基; R2，R3，R4和R5是H，C1-C10烷基或芳烷基或修饰溶解度或电子或光谱性质或官能连接基团的基团：或R 4 -R 5和/或R 2 -R 4和/或R 2 -R 3为链接形成延伸环系统; R6为H或CHO或NO。

7. 发明申请

US20050028546A1 Silencing equipment for an air-cooling assembly 失效
标题翻译：空冷组件的沉降设备
公开(公告)号：US20050028546A1
公开(公告)日：2005-02-10
申请号：US10888322
申请日：2004-07-09
申请人： Henry Young , Ord Randolph , Alan Hamilton , Alexander Jacobs
发明人： Henry Young , Ord Randolph , Alan Hamilton , Alexander Jacobs
IPC分类号： B60H1/32 , B60K20060101 , B60K7/00 , B60K11/06 , E04F17/04 , F01N1/24 , F01N7/00 , F01P11/12 , F25D19/00
CPC分类号： B60K11/06 , B60K7/0007 , F01P11/12 , F01P2050/00 , Y10S454/906
摘要： Silencing equipment is provided for an air-cooling assembly in a large off-road vehicle having wheels, traction motors for the wheels that operate in a motoring mode to propel the vehicle and a power generating dynamic braking mode, resistor grids for dissipating the dynamic braking power, and a blower for moving cooling air past the grids to cool them. The silencing equipment may include a resistor grid housing 24 and at least one upper inlet 22 for passing cooling air to the interior of the housing. The inlet includes noise-absorbing material. A conduit 28 is provided for directing cooling air from the upper inlet through a transition chamber to reach the blower and at least one resistor grid in the housing. The conduit is lined with noise-absorbing material. A removable cover 30 is provided for the conduit for accessing the air blower in the housing through the transition chamber, whereby servicing of the blower may be performed without removal of the entire upper inlet. In another aspect, the silencing equipment includes at least one outlet 31 for exhausting air from the resistor grid housing. This outlet includes a plurality of exhaust vanes positioned at an angle relative to a stream of exhaust air to impart a deflection to the exhaust air into a desired direction. The plurality of exhaust vanes includes noise-adsorbing material whereby this one outlet combines air deflection and silencing in a single device.
摘要翻译：为具有轮子的大型越野车辆提供了一种空气冷却组件的沉没设备，用于车轮的牵引电动机，以驾驶模式运行，以推动车辆和发电动力制动模式，用于消除动态制动的电阻器网格电源和用于使冷却空气通过电网的鼓风机以使其冷却。消音设备可以包括电阻器栅格壳体24和用于将冷却空气传递到壳体内部的至少一个上部入口22。入口包括吸声材料。导管28用于将来自上部入口的冷却空气引导通过过渡室以到达鼓风机和壳体中的至少一个电阻器格栅。导管内衬有吸音材料。为导管提供可拆卸盖30，用于通过过渡室进入壳体中的鼓风机，从而可以在不去除整个上部入口的情况下执行送风机的维修。在另一方面，消音设备包括至少一个用于从电阻器栅格壳体排出空气的出口31。该出口包括多个排气叶片，该排气叶片相对于废气流成一定角度，以将废气偏转到期望的方向。多个排气叶片包括噪声吸附材料，由此该一个出口将空气偏转和消音结合在一个装置中。

8. 发明申请

US20050003408A1 Libraries of oligomers labeled with different tags 失效
标题翻译：用不同标签标记的低聚物的文库
公开(公告)号：US20050003408A1
公开(公告)日：2005-01-06
申请号：US10843873
申请日：2004-05-11
申请人： Edwin Southern , Mikhail Shchepinov , John Housby , Alan Hamilton , John Elder
发明人： Edwin Southern , Mikhail Shchepinov , John Housby , Alan Hamilton , John Elder
IPC分类号： G01N27/62 , C07B61/00 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B20/04 , C40B30/04 , C40B30/10 , C40B40/06 , C40B40/10 , C40B50/10 , C40B60/10 , C40B70/00 , G01N33/483 , G01N33/50 , C12P19/34
CPC分类号： C12Q1/6872 , C07H21/00 , C40B20/04 , C40B30/04 , C40B30/10 , C40B40/06 , C40B40/10 , C40B50/10 , C40B50/16 , C40B60/10 , C40B70/00
摘要： A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels is and their use in assays and nucleic acid analysis methods.
摘要翻译：通过使用优选颗粒载体制备一组标记化合物的方法包括将载体分成批次，在每批载体上进行不同的化学反应。将化学部分连接到许多支持物，用不同的标签标记每批支持物的一小部分，并且组合所述许多支持物。重复这些步骤数次，优选地构建携带标记物的标签的低聚物分子，其标识低聚物的单体单元的性质和位置，并且其可从载体上释放。优选的标记物，可通过裂解从化合物中释放以提供用于通过质谱分析的带电基团，是三苯甲基（三甲基苯基）家族的组。还要求保护的是这些标记的文库是它们在测定和核酸分析方法中的用途。

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