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1. 发明申请

US20100291619A1 Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于培养样品容器的组合检测仪器和用于鉴定和/或表征样品中的微生物剂的仪器
公开(公告)号：US20100291619A1
公开(公告)日：2010-11-18
申请号：US12800467
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman Thorpe , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman Thorpe , Bradford G. Clay
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
摘要翻译：检测仪器确定样品容器（例如血培养瓶）是否对其中存在微生物剂生长是阳性的。当容器被认为是正的时，它被提供（例如，转移或暴露于）到执行微生物剂的鉴定和/或表征的自动化仪器。识别和/或表征仪器将样品的一部分从样品容器中取出并将其放入一次性分离和浓缩装置中。微生物剂通过选择性裂解可能存在的和非离子的非微生物剂细胞材料而浓缩。阅读模块使用光谱方法读取浓缩的微生物剂，例如固有荧光的测量。当微生物剂保持集中在一次性装置中时，可能发生这种询问。

2. 发明授权

US08911987B2 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US08911987B2
公开(公告)日：2014-12-16
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/00 , C12M3/00 , G01N35/00 , C12Q1/24 , G01N35/10
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

3. 发明申请

US20100291669A1 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US20100291669A1
公开(公告)日：2010-11-18
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/34
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

4. 发明申请

US20100288060A1 Device for sampling a specimen container 有权
标题翻译：用于取样样品容器的装置
公开(公告)号：US20100288060A1
公开(公告)日：2010-11-18
申请号：US12800392
申请日：2010-05-14
申请人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John D. Walsh , Jones M. Hyman
发明人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John D. Walsh , Jones M. Hyman
IPC分类号： G01N1/12
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A sampling device for a specimen container having a closure sealing the interior of the specimen container from the environment includes a needle, a body coupled to the needle and defining a chamber in fluid communication with the needle, the body further comprising a port forming an opening in the body, the port in fluid communication with the chamber. A multitude of the sampling devices may be stored in a cassette. The sampling devices may include a second chamber for separation and concentration of a microbial agent present in a sample. In this configuration second chamber is connected to the first chamber via a valve or the like.
摘要翻译：用于样本容器的采样装置具有将样本容器的内部与环境密封的封闭件，其包括：针头，与所述针头相连并且限定与所述针流体连通的室，所述主体还包括形成开口在身体中，与腔室流体连通的端口。多个采样装置可以存储在盒中。采样装置可以包括用于分离和浓缩样品中存在的微生物剂的第二室。在该构造中，第二室通过阀等连接到第一室。

5. 发明授权

US08841118B2 Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于培养样品容器的组合检测仪器和用于鉴定和/或表征样品中的微生物剂的仪器
公开(公告)号：US08841118B2
公开(公告)日：2014-09-23
申请号：US12800467
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman C. Thorpe , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman C. Thorpe , Bradford G. Clay
IPC分类号： C12M1/00 , C12M3/00 , G01N35/00 , C12M1/34 , C12Q1/04 , G01N35/04
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
摘要翻译：检测仪器确定样品容器（例如血培养瓶）是否对其中存在微生物剂生长是阳性的。当容器被认为是正的时，它被提供（例如，转移或暴露于）到执行微生物剂的鉴定和/或表征的自动化仪器。识别和/或表征仪器将样品的一部分从样品容器中取出并将其放入一次性分离和浓缩装置中。微生物剂通过选择性裂解可能存在的和非离子的非微生物剂细胞材料而浓缩。阅读模块使用光谱方法读取浓缩的微生物剂，例如固有荧光的测量。当微生物剂保持集中在一次性装置中时，可能发生这种询问。

6. 发明申请

US20100291618A1 Methods for rapid identification and/or characterization of a microbial agent in a sample 审中-公开
标题翻译：用于快速鉴定和/或表征样品中微生物剂的方法
公开(公告)号：US20100291618A1
公开(公告)日：2010-11-18
申请号：US12800387
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman
IPC分类号： C12Q1/04 , C12Q1/02 , C12N1/00
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent components of the test sample are lysed, thereby producing a lysed sample. The lysed sample is delivered to a disposable separation device. A microbial agent present in test sample is concentrated within the disposable separation device. The concentrated microbial agent is interrogated, e.g., spectroscopically.
摘要翻译：一种测试包含在密封样品容器内的样品样品的方法。用一次性取样装置将样品从样品容器中取出。裂解试验样品的非微生物剂组分，从而产生裂解的样品。裂解的样品被输送到一次性分离装置。存在于试样中的微生物剂集中在一次性分离装置内。浓缩的微生物剂被询问，例如光谱法。

7. 发明授权

US10774300B2 Methods and kits for isolating microorganisms from culture 有权
公开(公告)号：US10774300B2
公开(公告)日：2020-09-15
申请号：US13554704
申请日：2012-07-20
申请人： Jones M. Hyman , John D. Walsh , Ronnie J. Robinson , Christopher Ronsick
发明人： Jones M. Hyman , John D. Walsh , Ronnie J. Robinson , Christopher Ronsick
IPC分类号： C12Q1/689 , C12Q1/6888 , C12M1/00 , C12Q1/04 , C12N1/02 , C12N1/06 , C12Q1/6895 , C12Q1/24
摘要： The present invention is directed to methods and kits for separating, accumulating, characterizing and/or identifying microorganisms known to be present or that may be present in a test sample. The method of the invention comprises optional lysing non-microorganism cells and/or particulates that may be present in a test sample, followed by a subsequent filtration step for isolation and/or accumulation of microorganisms. The kit of the present invention may comprise at least one filter membrane or an integrated filtration and sample transfer device for isolation and/or accumulation of microorganisms.

8. 发明申请

US20130045532A1 METHODS AND KITS FOR ISOLATING MICROORGANISMS FROM CULTURE 审中-公开
标题翻译：从文化中分离微生物的方法和工具
公开(公告)号：US20130045532A1
公开(公告)日：2013-02-21
申请号：US13554704
申请日：2012-07-20
申请人： Jones M. Hyman , John D. Walsh , Ronnie J. Robinson , Christopher Ronsick
发明人： Jones M. Hyman , John D. Walsh , Ronnie J. Robinson , Christopher Ronsick
IPC分类号： C12M1/26 , C12M1/40
CPC分类号： C12M47/02 , C12N1/02 , C12N1/06 , C12Q1/24
摘要： The present invention is directed to methods and kits for separating, accumulating, characterizing and/or identifying microorganisms known to be present or that may be present in a test sample. The method of the invention comprises optional lysing non-microorganism cells and/or particulates that may be present in a test sample, followed by a subsequent filtration step for isolation and/or accumulation of microorganisms. The kit of the present invention may comprise at least one filter membrane or an integrated filtration and sample transfer device for isolation and/or accumulation of microorganisms.
摘要翻译：本发明涉及用于分离，积累，表征和/或鉴定已知存在或可能存在于测试样品中的微生物的方法和试剂盒。本发明的方法包括任选地裂解可能存在于测试样品中的非微生物细胞和/或颗粒，随后进行用于分离和/或积累微生物的随后的过滤步骤。本发明的试剂盒可以包括用于分离和/或积累微生物的至少一个过滤膜或一体化过滤和样品转移装置。

9. 发明申请

US20140335558A1 Method for the Characterization of Microorganisms on Solid or Semi-Solid Media 有权
标题翻译：固体或半固体培养基上微生物表征的方法
公开(公告)号：US20140335558A1
公开(公告)日：2014-11-13
申请号：US14444708
申请日：2014-07-28
申请人： Jones M. Hyman , John D. Walsh , Thurman C. Thorpe
发明人： Jones M. Hyman , John D. Walsh , Thurman C. Thorpe
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic of said microorganisms.
摘要翻译：本发明涉及使用固有荧光（IF）测量在固体或半固体培养基上扫描，检测和监测微生物的方法和系统。所述方法进一步涉及使用所述微生物特征的固有荧光（IF）测量法在固体或半固体培养基上检测，表征和/或鉴定微生物。

10. 发明授权

US07429464B2 Methods for detecting bacterial pathogens 有权
标题翻译：检测细菌病原体的方法
公开(公告)号：US07429464B2
公开(公告)日：2008-09-30
申请号：US11006025
申请日：2004-12-07
申请人： John D. Walsh , Jones M. Hyman
发明人： John D. Walsh , Jones M. Hyman
IPC分类号： C12Q1/14 , C12Q1/04
CPC分类号： G01N33/56916 , C12Q1/04 , C12Q1/10 , C12Q1/14 , G01N33/56938
摘要： The present invention provides for methods for detecting bacterial pathogens in a sample. A preferred method includes the steps of: suspending a sample comprising a medium and microorganisms, the microorganisms suspected of comprising bacterial pathogens; mixing the sample, an adsorbent and a first solution in a vessel; separating the adsorbent and the microorganisms from the medium and the bulk of the first solution and removing the medium and the bulk of the first solution from the vessel; adding a second solution to the vessel to resuspend the adsorbent and the microorganisms; and detecting agglutination of the adsorbent wherein the agglutination of the adsorbent signifies bacterial pathogens are present in the sample.
摘要翻译：本发明提供了检测样品中细菌病原体的方法。优选的方法包括以下步骤：将包含培养基和微生物的样品悬浮在怀疑包含细菌病原体的微生物中; 将样品，吸附剂和第一溶液混合在容器中; 从介质和大部分第一溶液中分离吸附剂和微生物，并从容器中除去介质和第一溶液的体积; 向容器中加入第二溶液以重新悬浮吸附剂和微生物; 并检测吸附剂的凝集，其中吸附剂的凝集表示细菌病原体存在于样品中。

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