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1. 发明申请

US20100291619A1 Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于培养样品容器的组合检测仪器和用于鉴定和/或表征样品中的微生物剂的仪器
公开(公告)号：US20100291619A1
公开(公告)日：2010-11-18
申请号：US12800467
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman Thorpe , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman Thorpe , Bradford G. Clay
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.
摘要翻译：检测仪器确定样品容器（例如血培养瓶）是否对其中存在微生物剂生长是阳性的。当容器被认为是正的时，它被提供（例如，转移或暴露于）到执行微生物剂的鉴定和/或表征的自动化仪器。识别和/或表征仪器将样品的一部分从样品容器中取出并将其放入一次性分离和浓缩装置中。微生物剂通过选择性裂解可能存在的和非离子的非微生物剂细胞材料而浓缩。阅读模块使用光谱方法读取浓缩的微生物剂，例如固有荧光的测量。当微生物剂保持集中在一次性装置中时，可能发生这种询问。

2. 发明授权

US5991700A EMI stability indicator for tympanic thermometer 失效
标题翻译：鼓膜温度计的EMI稳定指标
公开(公告)号：US5991700A
公开(公告)日：1999-11-23
申请号：US950711
申请日：1997-10-15
申请人： Bradford G. Clay , John J. Korff
发明人： Bradford G. Clay , John J. Korff
IPC分类号： G01J5/04 , G01K13/00 , G01K7/00
CPC分类号： G01J5/04 , G01J5/02 , G01J5/025 , G01J5/026 , G01J5/049 , G01J5/16
摘要： The present invention is directed to an electronic device for sensing and indicating the presence of electromagnetic interference in the vicinity of a electronic thermometer and preventing the display of a core body temperature reading when the electromagnetic interference exceeds a predetermined threshold. Disclosed is a tympanic thermometer comprising circuitry and a microprocessor that takes a a plurality of voltage readings from the null input of an operational amplifier in the circuitry. After taking into account ambient temperature conditions into the temperature calculations, the microprocessor compares the average value of the voltage readings taken from the null input against a predetermined threshold in the memory of the microprocessor. If the value exceeds the predetermined threshold, then the microprocessor prevents the display of the core body temperature and directs a display to write an error message. However, if the value does not exceed the predetermined threshold, the microprocessor directs the displays the core body temperature taken by the tympanic thermometer.
摘要翻译：本发明涉及一种用于在电子温度计附近感测和指示电磁干扰的存在并防止当电磁干扰超过预定阈值时显示核心体温读数的电子设备。公开了一种鼓膜温度计，其包括电路和微处理器，其从电路中的运算放大器的零输入获取多个电压读数。在考虑到温度计算中的环境温度条件之后，微处理器将从空输入获得的电压读数的平均值与微处理器的存储器中的预定阈值进行比较。如果该值超过预定阈值，则微处理器防止显示核心体温并引导显示器写入错误消息。然而，如果该值不超过预定阈值，则微处理器指示显示器由鼓膜温度计摄取的核心体温。

3. 发明申请

US20120021455A1 Detector Arrangement for Blood Culture Bottles With Colorimetric Sensors 有权
标题翻译：带有比色传感器的血液培养瓶的检测器布置
公开(公告)号：US20120021455A1
公开(公告)日：2012-01-26
申请号：US13185898
申请日：2011-07-19
申请人： Bradford G. Clay
发明人： Bradford G. Clay
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： G01N33/84 , C12M41/26 , C12M41/34 , C12M41/36 , G01N21/3151 , G01N21/78 , G01N21/783 , G01N21/80 , G01N2021/3181 , G01N2201/127
摘要： A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
摘要翻译：一种用于血液培养瓶的检测器装置，其包含由于血培养瓶内的样品介质的pH或CO 2的变化而使颜色变化的比色传感器。检测器装置包括照亮比色传感器的传感器LED，照亮比色传感器的参考LED，用于选择性地和交替地激活传感器LED和参考LED的控制电路和光电检测器。光电检测器在比色传感器与传感器LED和参考LED的选择性和交替照明期间测量来自比色传感器的反射率，并产生强度信号。参考LED被选择为具有照明的峰值波长，使得来自参考LED的照明的光电检测器的强度信号基本上不受比色传感器的颜色的变化的影响。

4. 发明授权

US08911987B2 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US08911987B2
公开(公告)日：2014-12-16
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/00 , C12M3/00 , G01N35/00 , C12Q1/24 , G01N35/10
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

5. 发明授权

US08512975B2 Method for detection and characterization of a microorganism in a sample using time dependent spectroscopic measurements 有权
标题翻译：使用时间依赖光谱测量法检测和表征样品中微生物的方法
公开(公告)号：US08512975B2
公开(公告)日：2013-08-20
申请号：US12460607
申请日：2009-07-22
申请人： John D. Walsh , Jones M. Hyman , Bradford G. Clay , Thurman C. Thorpe
发明人： John D. Walsh , Jones M. Hyman , Bradford G. Clay , Thurman C. Thorpe
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/10 , G01N21/31 , G01N21/47 , G01N21/64 , G01N21/6486 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides a method for detecting, and characterizing a microorganism present in a blood culture medium whereby the method may be accomplished utilizing a time-dependent spectroscopic technique to obtain at least two measurements directly of a blood culture medium and correlating said measurements for the detection and characterization of a microorganism, that may be present in the blood culture.
摘要翻译：本发明提供了一种用于检测和表征存在于血液培养基中的微生物的方法，由此可以使用时间依赖性光谱技术来完成该方法，以直接获得血液培养基的至少两次测量，并将所述测量结果与可能存在于血液培养物中的微生物的检测和表征。

6. 发明申请

US20100291669A1 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US20100291669A1
公开(公告)日：2010-11-18
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/34
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

7. 发明授权

US09447372B2 Detector arrangement for blood culture bottles with colorimetric sensors 有权
标题翻译：带有比色传感器的血培养瓶的检测器装置
公开(公告)号：US09447372B2
公开(公告)日：2016-09-20
申请号：US13352428
申请日：2012-01-18
申请人： Bradford G. Clay
发明人： Bradford G. Clay
IPC分类号： G01N21/00 , C12M1/34 , G01N21/78 , G01N21/80 , G01N21/31
CPC分类号： G01N33/84 , C12M41/26 , C12M41/34 , C12M41/36 , G01N21/3151 , G01N21/78 , G01N21/783 , G01N21/80 , G01N2021/3181 , G01N2201/127
摘要： A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
摘要翻译：公开了一种用于含有比色传感器的血培养瓶的检测器装置，该比色传感器由于血培养瓶内样品介质的pH或CO2的变化而经受颜色变化。检测器装置包括照亮比色传感器的传感器LED，照亮比色传感器的参考LED，用于选择性地和交替地激活传感器LED和参考LED的控制电路和光电检测器。光电检测器在比色传感器与传感器LED和参考LED的选择性和交替照明期间测量来自比色传感器的反射率，并产生强度信号。参考LED被选择为具有照明的峰值波长，使得来自参考LED的照明的光电检测器的强度信号基本上不受比色传感器的颜色的变化的影响。

8. 发明授权

US06863658B2 Automated system for the radiation treatment of a desired area within the body of a patient 有权
标题翻译：用于辐射治疗患者体内所需区域的自动化系统
公开(公告)号：US06863658B2
公开(公告)日：2005-03-08
申请号：US10385107
申请日：2003-03-10
申请人： James David Hughett , Bradford G. Clay , Bryan Dale Knodel
发明人： James David Hughett , Bradford G. Clay , Bryan Dale Knodel
IPC分类号： G21K5/00 , A61M36/04 , A61N5/10 , G21K5/02 , A61M31/00
CPC分类号： A61N5/1007 , A61N5/1002 , A61N2005/1008
摘要： A system comprising a microprocessor-controlled transfer device and a separate catheter for intraluminal treatment of a selected site in a body of a patient by at least one treating element advanced from a removable treating element cartridge received in the transfer device into a lumen of the separate catheter by means of pressurized fluid controlled by a fluid control switch moveable between send and return positions, and a safety interlock for use with the system.
摘要翻译：一种系统，包括微处理器控制的转移装置和单独的导管，用于通过至少一个处理元件进行管腔内处理患者体内的选定部位，所述至少一个处理元件从容纳在所述转移装置中的可移除处理元件筒进入到分离的内腔中通过由可在发送和返回位置之间移动的流体控制开关控制的加压流体以及用于该系统的安全联锁来进行导管。

9. 发明授权

US06585684B1 Automated system for the radiation treatment of a desired area within the body of a patient 有权
公开(公告)号：US06585684B1
公开(公告)日：2003-07-01
申请号：US09522759
申请日：2000-03-10
申请人： James David Hughett , Bradford G. Clay , Bryan Dale Knodel
发明人： James David Hughett , Bradford G. Clay , Bryan Dale Knodel
IPC分类号： A61M3100
CPC分类号： A61N5/1007 , A61N5/1002 , A61N2005/1008
摘要： A system comprising a microprocessor-controlled transfer device and a separate catheter for intraluminal treatment of a selected site in a body of a patient by at least one treating element advanced from a removable treating element cartridge received in the transfer device into a lumen of the separate catheter by means of pressurized fluid controlled by a fluid control switch moveable between send and return positions. A safety interlock is provided for preventing both (1) the disassembly of the system unless the treating element resides in the treating element cartridge and (2) the actuation of the fluid control switch unless the system is assembled. The safety interlock comprises a first lock moveable from a first position to a second position only if both the catheter and the treating element cartridge are secured to the transfer device. The first lock blocks the movement of the fluid control switch to the send position when in its first position and prevents disassembly of either the catheter or the treating element cartridge from the transfer device when in its second position. The fluid control switch further locks the first lock into its second position when the fluid control switch is in the send position. A system is also provided for detecting whether the treating element resides at a targeted location along the lumen of the transfer device. The detection system comprises a pressure transducer that is in fluid communication with the lumen of the transfer device so as to be capable of measuring the fluid pressure at the targeted location of the lumen. Circuitry is provided for comparing the measured presssure to a reference pressure corresponding to the pressure at the targeted location when the treating elements are stored at the targeted location under fluid pressure. A signal generator provides a signal when the measured pressure differs from the reference pressure by more than a predetermined amount. The signal may activate an optical signal and/or a mechanical interlock, the latter preventing separation of the catheter from the transfer device and preventing closure of the gate when activated by a signal from the signal generator corresponding to the pressure encountered when the treating element does not reside at the targeted location.

10. 发明授权

US09739788B2 Detector arrangement for blood culture bottles with colorimetric sensors 有权
公开(公告)号：US09739788B2
公开(公告)日：2017-08-22
申请号：US13185898
申请日：2011-07-19
申请人： Bradford G. Clay
发明人： Bradford G. Clay
IPC分类号： G01N21/00 , G01N33/84 , G01N21/78 , G01N21/80 , C12M1/34 , G01N21/31
CPC分类号： G01N33/84 , C12M41/26 , C12M41/34 , C12M41/36 , G01N21/3151 , G01N21/78 , G01N21/783 , G01N21/80 , G01N2021/3181 , G01N2201/127
摘要： A detector arrangement for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.

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