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1. 发明授权

US08230866B2 Systems and methods for treating glaucoma and systems and methods for imaging a portion of an eye 有权
标题翻译：用于治疗青光眼的系统和方法以及用于对眼睛的一部分进行成像的系统和方法
公开(公告)号：US08230866B2
公开(公告)日：2012-07-31
申请号：US12000477
申请日：2007-12-13
申请人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
发明人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
IPC分类号： A61B19/00
CPC分类号： A61B3/13 , A61B3/102 , A61B3/14 , A61F9/008 , A61F2009/00868
摘要： Systems and methods are described for imaging an eye portion or for treating glaucoma in an eye of a patient. In a first step an optical microscopic image of a portion of the eye is acquired. In the optical microscopic image a distinguishable anatomical structure is identified to predict a location of a volume portion to be imaged three-dimensionally. Three-dimensional imaging of the located volume portion is performed by acquiring an optical coherence tomography image of the located volume portion. The volume portion is treated by either directing a laser beam to the volume portion or inserting an implant based on the OCT-image.
摘要翻译：描述了用于对眼部进行成像或用于治疗患者眼睛中的青光眼的系统和方法。在第一步骤中，获取眼睛的一部分的光学显微镜图像。在光学显微镜图像中，识别出可区分的解剖结构以预测待三维成像的体积部分的位置。通过获取定位体积部分的光学相干断层摄影图像来执行定位体积部分的三维成像。通过将激光束引导到体积部分或基于OCT图像插入植入物来处理体积部分。

2. 发明申请

US20090157062A1 Systems and methods for treating glaucoma and systems and methods for imaging a portion of an eye 有权
标题翻译：用于治疗青光眼的系统和方法以及用于对眼睛的一部分进行成像的系统和方法
公开(公告)号：US20090157062A1
公开(公告)日：2009-06-18
申请号：US12000477
申请日：2007-12-13
申请人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
发明人： Christoph Hauger , Peter Andrews , Werner Nahm , Ralf Kuschnereit , Martin Hacker , Gabor Scharioth
IPC分类号： A61F9/008 , A61B18/20 , A61M27/00 , A61B3/13 , A61B3/14
CPC分类号： A61B3/13 , A61B3/102 , A61B3/14 , A61F9/008 , A61F2009/00868
摘要： Systems and methods are described for imaging an eye portion or for treating glaucoma in an eye of a patient. In a first step an optical microscopic image of a portion of the eye is acquired. In the optical microscopic image a distinguishable anatomical structure is identified to predict a location of a volume portion to be imaged three-dimensionally. Three-dimensional imaging of the located volume portion is performed by acquiring an optical coherence tomography image of the located volume portion. The volume portion is treated by either directing a laser beam to the volume portion or inserting an implant based on the OCT-image.
摘要翻译：描述了用于对眼部进行成像或用于治疗患者眼睛中的青光眼的系统和方法。在第一步骤中，获取眼睛的一部分的光学显微镜图像。在光学显微镜图像中，识别出可区分的解剖结构以预测待三维成像的体积部分的位置。通过获取定位体积部分的光学相干断层摄影图像来执行定位体积部分的三维成像。通过将激光束引导到体积部分或基于OCT图像插入植入物来处理体积部分。

3. 发明申请

US20100277793A1 Optical System, Use of an Optical System and Object Viewing Method Using an Optical System 审中-公开
标题翻译：光学系统，光学系统的使用和使用光学系统的物体观察方法
公开(公告)号：US20100277793A1
公开(公告)日：2010-11-04
申请号：US12223269
申请日：2007-01-22
申请人： Christoph Hauger , Fritz Straehle , Ralf Kuschnereit
发明人： Christoph Hauger , Fritz Straehle , Ralf Kuschnereit
IPC分类号： G02B21/22
CPC分类号： G02B21/0012 , G02B21/361
摘要： The invention relates to an optical system for observing an object, having a first system part with at least one observation beam path and at least one second system part with at least one other observation beam path, wherein the at least two system parts have a common or separate first imaging stage and a different second imaging stage, wherein the first imaging stage has an objective, wherein the second imaging stage of the first system part is designed as visual or digital and the second imaging stage of the second system part is designed as visual or digital, in which a visual imaging stage has at least one eyepiece and a magnification system with different lenses and in which a digital imaging stage has at least one camera adapter and a magnification system with different lenses, and wherein the second imaging stage of the second system part is designed in such a way that it makes possible a higher optical resolution of the object to be observed than the second imaging stage of the first system part. In addition, the invention relates to the use of such an optical system according to the invention as well as a method for observing an object with an optical system according to the invention.
摘要翻译：本发明涉及一种用于观察物体的光学系统，具有具有至少一个观察光束路径的第一系统部分和具有至少一个其它观察光束路径的至少一个第二系统部分，其中所述至少两个系统部分具有共同的或分离的第一成像级和不同的第二成像级，其中第一成像级具有目标，其中第一系统部分的第二成像级被设计为视觉或数字，并且第二系统部分的第二成像级被设计为视觉或数字，其中视觉成像阶段具有至少一个目镜和具有不同透镜的放大系统，并且其中数字成像台具有至少一个相机适配器和具有不同透镜的放大系统，并且其中第二成像阶段第二系统部分被设计成使得可以比第二成像阶段更高的待观察对象的光学分辨率 e第一系统部分。此外，本发明涉及根据本发明的这种光学系统的使用以及根据本发明的用于观察物体的方法。

4. 发明申请

US20110166420A1 IMAGING METHOD AND APPARATUS 审中-公开
标题翻译：成像方法和装置
公开(公告)号：US20110166420A1
公开(公告)日：2011-07-07
申请号：US12756692
申请日：2010-04-08
申请人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter Maxwell Delaney , John D. Allen
发明人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter Maxwell Delaney , John D. Allen
IPC分类号： A61B1/06
CPC分类号： A61B1/00078 , A61B1/00009 , A61B1/00041 , A61B1/00045 , A61B1/0005 , A61B1/0008 , A61B1/00172 , A61B1/042 , A61B1/06 , A61B1/227 , A61B1/233 , A61B1/267 , A61B1/313 , A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61B5/064 , A61B5/065 , A61B5/6835 , A61B5/6852 , A61B5/6855 , A61B7/02 , A61B8/12 , A61B90/90 , A61B90/92 , A61B90/94 , G02B21/0028 , G02B23/2476
摘要： An imaging apparatus and method are provided. The probe for an imaging apparatus includes a manually manipulable proximal portion; a straight distal portion with a distal tip for locating at a site to define an observational field; and a curved portion between the proximal portion and the distal portion. The imaging method includes the steps of locating a distal tip of an imaging probe at a site to define an observational field; irradiating the observational field from the distal tip; and collecting a return signal at the distal tip; wherein the probe comprises a manually manipulable proximal portion. The apparatus and method provided herein are useful for various applications including but not limited to endomicroscopy and other microsurgical procedures performed under optical stereoscopic magnified visualization, such as neurosurgery, ENT/facial surgery and spinal surgery.
摘要翻译：提供了一种成像装置和方法。用于成像装置的探针包括手动可操纵的近端部分; 具有远端的直的远端部分，用于定位在现场以限定观察场; 以及在近端部分和远端部分之间的弯曲部分。该成像方法包括以下步骤：将成像探针的远侧末端定位在位置以限定观察场; 从远端照射观察场; 并在远端收集返回信号; 其中所述探针包括可手动操作的近端部分。本文提供的装置和方法可用于各种应用，包括但不限于在光学立体放大显微镜（例如神经外科手术，ENT /面部手术和脊柱手术）下执行的内窥镜和其他显微外科手术。

5. 发明授权

US08929974B2 System and method for examining an illuminated object 有权
标题翻译：用于检查被照明物体的系统和方法
公开(公告)号：US08929974B2
公开(公告)日：2015-01-06
申请号：US12757000
申请日：2010-04-08
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： A61B6/00 , G01N21/64 , A61B5/026 , A61B5/145 , A61B5/1455 , G01N21/47 , G06T7/00 , A61B18/00 , A61B5/00
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：在用于检查包含流体液体的物体的系统和方法中，用测量光照射物体，并且暂时不久后记录图像。每像素评估图像以确定来自高于1kHz的高频部分的灌注数据，并且从低于100Hz的低频部分确定关于对象的属性的进一步信息，诸如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。由评估确定的信息以与对象的白光图像重叠的图像的形式显示。

6. 发明申请

US20110178395A1 IMAGING METHOD AND SYSTEM 审中-公开
标题翻译：成像方法与系统
公开(公告)号：US20110178395A1
公开(公告)日：2011-07-21
申请号：US12756765
申请日：2010-04-08
申请人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
发明人： Hans-Joachim Miesner , Christoph Hauger , Werner Nahm , Frank Rudolph , Guido Hattendorf , Peter M. Delaney , John D. Allen
IPC分类号： A61B6/00
CPC分类号： A61B5/064 , A61B1/00041 , A61B1/0005 , A61B1/0008 , A61B1/00096 , A61B1/00149 , A61B1/00172 , A61B1/042 , A61B1/313 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/065 , A61B5/445 , A61B5/6835 , A61B5/6852 , A61B5/6855 , A61B8/12 , A61B8/4245 , A61B8/5238 , A61B34/20 , A61B90/20 , A61B90/36 , A61B2090/364 , A61B2562/0242 , G02B21/0012 , G02B21/0024
摘要： Imaging systems and methods are provided herein. An imaging system for imaging a surgical site, may include a macroscopic visualization system; and an imaging apparatus with a probe, the imaging apparatus being adapted to image the observational field and generate second image data; wherein the system is operable to control the macroscopic visualization system and the imaging apparatus to image the site and the observational field respectively at substantially the same time, and to associate the first image data and the second image data. Imaging methods provided herein may include the steps of: imaging the site with a macroscopic visualization system and generating first image data; imaging at substantially the same time an observational field with an imaging apparatus and generating second image data; and associating the first image data and the second image data.
摘要翻译：本文提供成像系统和方法。用于成像外科手术部位的成像系统可以包括宏观可视化系统; 以及具有探针的成像装置，所述成像装置适于对所述观察场进行成像并生成第二图像数据; 其中所述系统可操作以控制所述宏观可视化系统和所述成像装置，以在基本相同的时间分别对所述场地和所述观测场进行成像，并且将所述第一图像数据和所述第二图像数据相关联。本文提供的成像方法可以包括以下步骤：用宏观可视化系统对站点进行成像并产生第一图像数据; 在大体上相同的时间成像具有成像装置的观察场并产生第二图像数据; 以及将所述第一图像数据和所述第二图像数据相关联。

7. 发明申请

US20110090325A1 SYSTEM AND METHOD FOR EXAMINING AN OBJECT 有权
标题翻译：用于检查对象的系统和方法
公开(公告)号：US20110090325A1
公开(公告)日：2011-04-21
申请号：US12757000
申请日：2010-04-08
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：在用于检查包含流体液体的物体的系统和方法中，用测量光照射物体，并且临时不久后记录图像。每像素评估图像以确定来自高于1kHz的高频部分的灌注数据，并且从低于100Hz的低频部分确定关于对象的属性的进一步信息，诸如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。由评估确定的信息以与对象的白光图像重叠的图像的形式显示。

8. 发明申请

US20090054788A1 METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY 审中-公开
标题翻译：用于显示用于脑外科手术的患者和导航系统的脑区域的方法和装置
公开(公告)号：US20090054788A1
公开(公告)日：2009-02-26
申请号：US12104919
申请日：2008-04-17
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leuteneger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leuteneger , Erica Martin-Williams , Antonio Lopez
IPC分类号： A61B5/00 , G06K9/00 , A61B18/14
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/0261 , A61B5/4064 , A61B34/20 , A61B90/10 , A61B90/14 , A61B90/36 , A61B2017/00061 , A61B2017/00066 , A61B2034/105 , A61B2034/107 , A61B2034/2055 , A61B2034/2065 , A61B2090/365 , A61B2090/373
摘要： A method and an apparatus for displaying a part of a brain of a patient is described. Laser-Doppler-images are acquired before and after a stimulation. The laser-Doppler-images include information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation.
摘要翻译：描述了用于显示患者的脑的一部分的方法和装置。在刺激之前和之后获取激光多普勒图像。激光多普勒图像包括关于血液运动或所获取部分的灌注的信息。然后，比较刺激之前和之后获取的血液运动图像，以识别与刺激相关的患者脑部区域。

9. 发明申请

US20100130869A1 METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY 审中-公开
标题翻译：用于显示用于脑外科手术的患者和导航系统的脑区域的方法和装置
公开(公告)号：US20100130869A1
公开(公告)日：2010-05-27
申请号：US12579194
申请日：2009-10-14
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/0261 , A61B5/4064 , A61B34/20 , A61B90/10 , A61B90/14 , A61B90/36 , A61B2017/00061 , A61B2017/00066 , A61B2034/105 , A61B2034/107 , A61B2034/2055 , A61B2034/2065 , A61B2090/365 , A61B2090/373
摘要： A method and an apparatus for displaying a part of a brain of a patient is provided. Laser Doppler images are acquired before and after a stimulation. The laser Doppler images comprise information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation. The identified areas are displayed in dependence of topography data representing a topography of the brain.
摘要翻译：提供了一种用于显示患者的脑部的方法和装置。在刺激之前和之后获取激光多普勒图像。激光多普勒图像包括关于血液运动或所获取部分的灌注的信息。然后，比较刺激之前和之后获取的血液运动图像，以识别与刺激相关的患者脑部区域。所识别的区域根据表示脑的地形的地形数据显示。

10. 发明申请

US20110181702A1 METHOD AND SYSTEM FOR GENERATING A REPRESENTATION OF AN OCT DATA SET 审中-公开
标题翻译：用于产生OCT数据集的表示的方法和系统
公开(公告)号：US20110181702A1
公开(公告)日：2011-07-28
申请号：US12844696
申请日：2010-07-27
申请人： Christoph Hauger , Martin Hacker
发明人： Christoph Hauger , Martin Hacker
IPC分类号： H04N13/02 , G06K9/00 , H04N15/00
CPC分类号： G01B9/02087 , A61B3/102 , A61B3/1225 , G01B9/0203 , G01B9/02091
摘要： A method of generating a representation of an OCT data set includes obtaining the OCT data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a value of a scattering intensity, obtaining a color image data set representing a plurality of tuples, each of which comprises values of two spatial coordinates and a color value, and generating an image data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a color value. Generating the image data set is performed depending on an analysis of the OCT data set and an analysis of the color image data set.
摘要翻译：一种产生OCT数据集的表示的方法包括获得表示多个元组的OCT数据集，每个元组包括三个空间坐标值和散射强度的值，获得表示多个的彩色图像数据集每个元组包括两个空间坐标和颜色值的值，并且生成表示多个元组的图像数据集，每个元组包括三个空间坐标和颜色值的值。根据OCT数据集的分析和彩色图像数据集的分析来执行图像数据集的生成。

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