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1. 发明授权

US09066686B2 Functional optical coherent imaging 有权
标题翻译：功能光学相干成像
公开(公告)号：US09066686B2
公开(公告)日：2015-06-30
申请号：US13057593
申请日：2008-07-10
申请人： Theo Lasser , Dimitri Van De Ville , Erica Martin-Williams , Marcel Leutenegger , Iwan Maerki , Michael Friedrich , Martin Villiger
发明人： Theo Lasser , Dimitri Van De Ville , Erica Martin-Williams , Marcel Leutenegger , Iwan Maerki , Michael Friedrich , Martin Villiger
IPC分类号： H04N5/228 , A61B3/12 , A61B5/00 , H04N9/47 , H04N7/18 , H04N5/253 , A61B3/10
CPC分类号： A61B5/0066 , A61B3/102 , A61B3/1233 , A61B5/0048 , A61B5/0059 , A61B5/02028 , A61B5/413 , A61B5/7203 , A61B5/726 , A61B5/7278 , A61B5/742
摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.
摘要翻译：功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 另外本发明涉及一种用于获取刺激激活的被摄体数据的处理，包括以下步骤：对准对象的身体功能单元并监视预先选择的身体功能;选择刺激或刺激;对身体区域进行成像对所述受试者施加一个或一系列刺激;对与所述刺激和预选身体功能同步的感兴趣体部成像;将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）和执行计算以生成与身体功能相关的结果。

2. 发明申请

US20110090325A1 SYSTEM AND METHOD FOR EXAMINING AN OBJECT 有权
标题翻译：用于检查对象的系统和方法
公开(公告)号：US20110090325A1
公开(公告)日：2011-04-21
申请号：US12757000
申请日：2010-04-08
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： H04N7/18 , G06K9/00
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：在用于检查包含流体液体的物体的系统和方法中，用测量光照射物体，并且临时不久后记录图像。每像素评估图像以确定来自高于1kHz的高频部分的灌注数据，并且从低于100Hz的低频部分确定关于对象的属性的进一步信息，诸如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。由评估确定的信息以与对象的白光图像重叠的图像的形式显示。

3. 发明申请

US20090054788A1 METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY 审中-公开
标题翻译：用于显示用于脑外科手术的患者和导航系统的脑区域的方法和装置
公开(公告)号：US20090054788A1
公开(公告)日：2009-02-26
申请号：US12104919
申请日：2008-04-17
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leuteneger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leuteneger , Erica Martin-Williams , Antonio Lopez
IPC分类号： A61B5/00 , G06K9/00 , A61B18/14
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/0261 , A61B5/4064 , A61B34/20 , A61B90/10 , A61B90/14 , A61B90/36 , A61B2017/00061 , A61B2017/00066 , A61B2034/105 , A61B2034/107 , A61B2034/2055 , A61B2034/2065 , A61B2090/365 , A61B2090/373
摘要： A method and an apparatus for displaying a part of a brain of a patient is described. Laser-Doppler-images are acquired before and after a stimulation. The laser-Doppler-images include information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation.
摘要翻译：描述了用于显示患者的脑的一部分的方法和装置。在刺激之前和之后获取激光多普勒图像。激光多普勒图像包括关于血液运动或所获取部分的灌注的信息。然后，比较刺激之前和之后获取的血液运动图像，以识别与刺激相关的患者脑部区域。

4. 发明申请

US20100130869A1 METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY 审中-公开
标题翻译：用于显示用于脑外科手术的患者和导航系统的脑区域的方法和装置
公开(公告)号：US20100130869A1
公开(公告)日：2010-05-27
申请号：US12579194
申请日：2009-10-14
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0042 , A61B5/0261 , A61B5/4064 , A61B34/20 , A61B90/10 , A61B90/14 , A61B90/36 , A61B2017/00061 , A61B2017/00066 , A61B2034/105 , A61B2034/107 , A61B2034/2055 , A61B2034/2065 , A61B2090/365 , A61B2090/373
摘要： A method and an apparatus for displaying a part of a brain of a patient is provided. Laser Doppler images are acquired before and after a stimulation. The laser Doppler images comprise information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation. The identified areas are displayed in dependence of topography data representing a topography of the brain.
摘要翻译：提供了一种用于显示患者的脑部的方法和装置。在刺激之前和之后获取激光多普勒图像。激光多普勒图像包括关于血液运动或所获取部分的灌注的信息。然后，比较刺激之前和之后获取的血液运动图像，以识别与刺激相关的患者脑部区域。所识别的区域根据表示脑的地形的地形数据显示。

5. 发明授权

US08929974B2 System and method for examining an illuminated object 有权
标题翻译：用于检查被照明物体的系统和方法
公开(公告)号：US08929974B2
公开(公告)日：2015-01-06
申请号：US12757000
申请日：2010-04-08
申请人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
发明人： Christoph Hauger , Werner Nahm , Theo Lasser , Marcel Leutenegger , Erica Martin-Williams , Antonio Lopez
IPC分类号： A61B6/00 , G01N21/64 , A61B5/026 , A61B5/145 , A61B5/1455 , G01N21/47 , G06T7/00 , A61B18/00 , A61B5/00
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：在用于检查包含流体液体的物体的系统和方法中，用测量光照射物体，并且暂时不久后记录图像。每像素评估图像以确定来自高于1kHz的高频部分的灌注数据，并且从低于100Hz的低频部分确定关于对象的属性的进一步信息，诸如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。由评估确定的信息以与对象的白光图像重叠的图像的形式显示。

6. 发明申请

US20110169978A1 FUNCTIONAL OPTICAL COHERENT IMAGING 有权
标题翻译：功能光学相干成像
公开(公告)号：US20110169978A1
公开(公告)日：2011-07-14
申请号：US13057593
申请日：2008-07-10
申请人： Theo Lasser , Dimitri Van De Ville , Erica Martin-Williams , Marcel Leutenegger , Iwan Maerki , Michael Friedrich , Martin Villiger
发明人： Theo Lasser , Dimitri Van De Ville , Erica Martin-Williams , Marcel Leutenegger , Iwan Maerki , Michael Friedrich , Martin Villiger
IPC分类号： H04N5/228
CPC分类号： A61B5/0066 , A61B3/102 , A61B3/1233 , A61B5/0048 , A61B5/0059 , A61B5/02028 , A61B5/413 , A61B5/7203 , A61B5/726 , A61B5/7278 , A61B5/742
摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.
摘要翻译：功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 另外本发明涉及一种用于获取刺激激活的被摄体数据的处理，包括以下步骤：对准对象的身体功能单元并监视预先选择的身体功能;选择刺激或刺激;对身体区域进行成像对所述受试者施加一个或一系列刺激;对与所述刺激和预选身体功能同步的感兴趣体部成像;将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）和执行计算以生成与身体功能相关的结果。

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