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1. 发明申请

WO2005010532A1 MULTIPLEXED BINDING ASSAYS FOR RECEPTOR ARRAYS 审中-公开
标题翻译：用于受体阵列的多重绑定测定
公开(公告)号：WO2005010532A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/019750
申请日：2004-06-21
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , PENG, Jinlin , WEBB, Brian L
发明人： FANG, Ye , FERRIE, Ann M , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , PENG, Jinlin , WEBB, Brian L
IPC分类号： G01N33/566
CPC分类号： C40B30/04 , G01N33/74 , G01N2333/726
摘要： A thematic microarray and methods for multiplexed binding assays using a cocktail solution of labeled ligands in the presence or absence of a target compound is provided. The methods enables researchers to screening compounds against multiple targets using a microarray format.
摘要翻译：提供了一种专题微阵列和在存在或不存在目标化合物的情况下使用标记配体的混合溶液进行多重结合测定的方法。这些方法使研究人员可以使用微阵列格式来筛选多个靶点的化合物。

2. 发明申请

WO2009067174A1 NORMALIZATION METHODS FOR G-PROTEIN COUPLED RECEPTOR MEMBRANE ARRAY 审中-公开
标题翻译： G蛋白偶联受体膜阵列的正常化方法
公开(公告)号：WO2009067174A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/012805
申请日：2008-11-14
申请人： CORNING INCORPORATED , DONG, Longying , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , LIU, Li , LYNN, Jeffrey G
发明人： DONG, Longying , HONG, Yulong , LAHIRI, Joydeep , LAI, Fang , LIU, Li , LYNN, Jeffrey G
IPC分类号： G01N33/50
CPC分类号： G01N33/554 , G01N2333/726 , G01N2500/10
摘要： Reference membrane components are either pre-labeled or labeled during assays for purposes of normalizing signals associated with binding or functional assays employing G-protein coupled receptor microarrays. A reference component may be included in a membrane in which the target GPCR is embedded or may be present in another membrane printed in conjunction with the target membrane on a microspot. Or, a GPCR microarray may be pre-labeled by incorporating a label on an exposed substrate in a defect in the printed microspot.
摘要翻译：参考膜组分在测定期间被预标记或标记，目的是使与G-蛋白偶联受体微阵列的结合或功能测定相关的信号归一化。参考组分可以包含在其中嵌入目标GPCR的膜中，或者可以存在于与微孔上的靶膜结合印刷的另一膜中。或者，GPCR微阵列可以通过在印刷的微点的缺陷中的暴露的基底上并入标签来进行预标记。

3. 发明申请

WO2006071696A2 POROUS SUBSTRATES AND ARRAYS COMPRISING THE SAME 审中-公开
标题翻译：多孔基材和包含该材料的阵列
公开(公告)号：WO2006071696A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/046450
申请日：2005-12-21
申请人： CORNING INCORPORATED , TEPESCH, Patrick, D. , WIGHT, John, F. Jr., , YUEN, Po, Ki , MOZDY, Eric, J. , COONAN, Everett, W. , FANG, Ye , FERRIE, Ann, M. , FU, Xiadong , HONG, Yulong , LESLIE, Thomas, M. , LI, Xinghua , MONAHAN, Beth, C. , MUELLER, Dirk , TANNER, Cameron, W.
发明人： TEPESCH, Patrick, D. , WIGHT, John, F. Jr., , YUEN, Po, Ki , MOZDY, Eric, J. , COONAN, Everett, W. , FANG, Ye , FERRIE, Ann, M. , FU, Xiadong , HONG, Yulong , LESLIE, Thomas, M. , LI, Xinghua , MONAHAN, Beth, C. , MUELLER, Dirk , TANNER, Cameron, W.
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/5085 , B01J2219/00315 , B01J2219/00317 , B01J2219/00423 , B01J2219/00639 , B01J2219/00644 , B01J2219/00722 , B01L2300/0819
摘要： The present invention relates to arrays comprising porous substrates for attachment of nucleic acids, polypeptides, membranes, or other biological or organic materials. In many embodiments, the arrays of the present invention have a flow-through configuration such that washing buffers or samples can access to the porous substrates from at least two sides of the arrays. The present invention also features arrays comprising UV-compatible porous substrates, arrays comprising three-dimensional membranes in sol-gels, and arrays comprising silica-based porous substrates prepared using a low-temperature fusion process.
摘要翻译：本发明涉及包含用于连接核酸，多肽，膜或其他生物或有机材料的多孔底物的阵列。在许多实施方案中，本发明的阵列具有流通构型，使得洗涤缓冲液或样品可以从阵列的至少两侧接近多孔基材。本发明的特征还在于包含UV-可兼容的多孔基材的阵列，包含溶胶 - 凝胶中的三维膜的阵列以及包含使用低温熔融工艺制备的基于二氧化硅的多孔基材的阵列。

4. 发明申请

WO2005115622A1 POROUS SUBSTRATE PLATES AND THE USE THEREOF 审中-公开
标题翻译：多孔基板及其使用
公开(公告)号：WO2005115622A1
公开(公告)日：2005-12-08
申请号：PCT/US2005/012040
申请日：2005-04-12
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann, M. , HONG, Yulong , WEBB, Brian, Lynn
发明人： FANG, Ye , FERRIE, Ann, M. , HONG, Yulong , WEBB, Brian, Lynn
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized a as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.
摘要翻译：公开了适用于生物或化学测定的底物板或装置。该装置可以采用具有三维多孔层的多孔板的形式，作为每个孔内的支撑表面的一部分，用于固定探针物质。多孔层的特征在于具有由连续的固体材料的基体限定的多个相互连接的空隙。还描述了一种方法及其变体。

5. 发明申请

WO2005066633A2 FLUORESCENT LIGANDS FOR GPCR ARRAYS 审中-公开
标题翻译：用于GPCR阵列的荧光配体
公开(公告)号：WO2005066633A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/041935
申请日：2004-12-13
申请人： CORNING INCORPORATED , FANG, Ye , HONG, Yulong , PENG, Jinlin
发明人： FANG, Ye , HONG, Yulong , PENG, Jinlin
IPC分类号： G01N33/543
CPC分类号： G01N33/582 , C07K7/083 , C07K14/63 , G01N33/6845 , G01N33/74 , G01N2333/63 , G01N2333/726
摘要： A fluorescent ligand includes a material having a binding affinity in the range of about 0.01 to about 25 nM, or about 0.1 to about 10 nM; a specificity to its cognate receptor in the range of about 50 to about 99%, or about 65 to about 99%; a cross-activity to other receptors of 0 to about 20%, or 0 to about 10%; a net charge per ligand of about -3 to about +5, or more preferably, about -2 to about +2 or most preferably for small compound ligands about -1 to about +2. The ligand may also have a hydrophobicity in the range of about 3 to about 55 minutes eluting time (as measured under specified eluting conditions) . In some embodiments, the ligand including fluorescently labeled motilin 1-16 labeled with Bodipy-TMR, rhodamine or Cy5-. Other embodiments include fluorescently labeled Cy5-naltrexone, Cy5-neurotensin 2-13, N-terminal labeled neurotensin 2-13 or lys-labeled labeled neurotensin 2-13.
摘要翻译：荧光配体包括具有约0.01至约25nM，或约0.1至约10nM范围内的结合亲和力的材料; 在约50至约99％，或约65至约99％的范围内对其同源受体的特异性; 与其他受体的交叉活性为0至约20％，或0至约10％; 每个配体的净电荷为约-3至约+5，或更优选约-2至约+2，或最优选约为-1至约+2的小化合物配体。配体还可以具有约3至约55分钟洗脱时间（在规定的洗脱条件下测量）的疏水性。在一些实施方案中，配体包括用Bodipy-TMR，罗丹明或Cy5-标记的荧光标记的胃动素1-16。其他实施方案包括荧光标记的Cy5-纳曲酮，Cy5-神经丝氨酸2-13，N-末端标记的神经丝氨酸蛋白酶2-13或lys-标记的标记的神经丝氨酸素2-13。

6. 发明申请

WO2014085308A1 CELL CULTURE MEDIUM FOR ENHANCED HEPATOCYTE FUNCTION 审中-公开
标题翻译：细胞培养基用于增强肝细胞功能
公开(公告)号：WO2014085308A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/071636
申请日：2013-11-25
申请人： CORNING INCORPORATED , FARIS, Ronald Allen , HONG, Yulong , LAHIRI, Joydeep , LIU, Jin , WEEKS, Olivia Grace
发明人： FARIS, Ronald Allen , HONG, Yulong , LAHIRI, Joydeep , LIU, Jin , WEEKS, Olivia Grace
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , C12N2501/727 , C12N2501/999 , C12N2503/02 , C12N2506/02 , C12N2533/54 , C12Q1/6876 , C12Q2600/158 , G01N33/5067 , G01N2333/90245
摘要： Cell culture compositions containing LFM-A13 or a structurally related compound can enhance global hepatic function. For example, LFM-A13 is shown to enhance levels of a broad variety of drug metabolism enzymes, including CYP enzymes, and other hepatic enzymes. LFM-A13 is also shown to promote differentiation of stem cells into hepatocytes. LFM-A13 and structurally related compounds can be used in cell culture to enhance global drug metabolism of liver cells for enhanced in vitro study the effects of drug metabolism on other candidate drug compounds.
摘要翻译：含有LFM-A13或结构相关化合物的细胞培养组合物可以增强全身肝功能。例如，LFM-A13被证明可以增强多种药物代谢酶的水平，包括CYP酶和其他肝酶。还显示LFM-A13促进干细胞分化成肝细胞。 LFM-A13和结构相关的化合物可用于细胞培养，以增强肝细胞的全球药物代谢，增强体外研究药物代谢对其他候选药物化合物的作用。

7. 发明申请

WO2012162042A1 METHODS OF MAKING AND USING POLYMERS AND COMPOSITIONS 审中-公开
标题翻译：制备和使用聚合物和组合物的方法
公开(公告)号：WO2012162042A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/038031
申请日：2012-05-16
申请人： CORNING INCORPORATED , HONG, Yulong , LESLIE, Thomas, Mark , SU, Hui , TAN, Jian
发明人： HONG, Yulong , LESLIE, Thomas, Mark , SU, Hui , TAN, Jian
IPC分类号： C12N5/00
CPC分类号： C08F220/20 , C08F2230/085
摘要： Disclosed are methods of making and using polymers compositions. The polymer compositions may have monomer/oligomer mixtures that may have at least one silicone monomer or oligomer and at least one non-silicone monomer or oligomer, at least one cross-linker, and/or at least one polymerization initiator. The polymer compositions are cured, after which they may be useful in bio-applications, such as for use as freestanding films or coatings on a substrate, such as a mold, for cell culture.
摘要翻译：公开了制备和使用聚合物组合物的方法。聚合物组合物可以具有可以具有至少一个硅氧烷单体或低聚物和至少一种非硅氧烷单体或低聚物，至少一个交联剂和/或至少一种聚合引发剂的单体/低聚物混合物。聚合物组合物固化，之后它们可用于生物应用，例如用作基底上的独立膜或涂层，例如用于细胞培养的模具。

8. 发明申请

WO2013015939A1 COMPOSITE SUBSTRATE FOR 3D CELL CULTURE 审中-公开
标题翻译：用于3D细胞培养的复合基材
公开(公告)号：WO2013015939A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/044591
申请日：2012-06-28
申请人： CORNING INCORPORATED , GORAL, Vasiliy Nikolaevich , HONG, Yulong , SU, Hui , TAN, Jian
发明人： GORAL, Vasiliy Nikolaevich , HONG, Yulong , SU, Hui , TAN, Jian
IPC分类号： C12M1/00 , C12N5/00
CPC分类号： C12N5/0068 , C12M23/12 , C12M23/20 , C12M25/06 , C12N2533/30
摘要： A cell culture article comprises a substrate having a micro-structured surface and a thin hydrophobic elastomeric coating disposed on the substrate. The coating forms a micro-structured cell culture surface and is sufficiently thin to reduce absorption of hydrophobic molecules from an aqueous medium in contact with the coating, relative to articles fabricated entirely from the hydrophobic elastomer.
摘要翻译：细胞培养物品包括具有微结构化表面的基底和设置在基底上的薄疏水弹性体涂层。相对于完全由疏水弹性体制造的制品，涂层形成微结构的细胞培养表面，并且足够薄以减少与涂层接触的水性介质中的疏水性分子的吸收。

9. 发明申请

WO2016138338A1 FITTED LID FOR MULTI-WELL PLATE 审中-公开
标题翻译：适用于多层板的盖子
公开(公告)号：WO2016138338A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019684
申请日：2016-02-26
申请人： CORNING INCORPORATED
发明人： HONG, Yulong , TRAN, Elizabeth
IPC分类号： B01L3/00 , C12M1/32 , C12M1/12
CPC分类号： B01L3/50853 , B01L2200/025 , B01L2200/0684 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2300/046 , B01L2300/048 , B01L2300/0809 , B01L2300/0829 , B01L2300/0848 , B01L2300/12 , C12M23/12 , C12M23/38
摘要： A lid for a multi-well plate having apertures, each aperture having a gas permeable membrane, and fittings extending from the bottom surface of the lid to fit with a multi-well plate to reduce evaporation of liquid contents from within the wells of the multi-well plate, protect the contents of a multi-well plate from spilling or from mingling with the contents of a neighboring well in a multi-well plate is disclosed. The gas permeable membrane comprises one or more of (i) a continuous or discontinuous thin film associated with each aperture, (ii) a locally-thinned portion of the main body, and (iii) a quantity of material at least partially filling each aperture.
摘要翻译：用于具有孔的多孔板的盖，每个孔具有透气膜，以及从盖的底表面延伸的配件，以配合多孔板，以减少来自多孔的孔内的液体内含物的蒸发公开了一种保护多孔板的内容物免受溢出或与多孔板中相邻孔的内容物混合的影响。透气膜包括以下一种或多种：（i）与每个孔相关联的连续或不连续薄膜，（ii）主体的局部变薄的部分，和（iii）至少部分地填充每个孔的一定量的材料。

10. 发明公开

EP1742740A1 POROUS SUBSTRATE PLATES AND THE USE THEREOF 审中-公开
标题翻译：多孔基材小组及其用途
公开(公告)号：EP1742740A1
公开(公告)日：2007-01-17
申请号：EP05780019.5
申请日：2005-04-12
申请人： Corning Incorporated
发明人： FANG, Ye , FERRIE, Ann, M. , HONG, Yulong , WEBB, Brian, Lynn
IPC分类号： B01L3/00
CPC分类号： B01L3/5085 , B01L2200/12 , B01L2300/069 , B01L2300/0829 , Y10S435/81 , Y10S436/809 , Y10T29/49885
摘要： A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The porous layer is characterized a as having a plurality of interconnected voids defined by a matrix of contiguous solid material. A method and its variants are also described.

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