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1. 发明申请

WO2013066505A1 IMPLANTABLE MEDICAL DEVICE LEAD INCLUDING INNER COIL REVERSE-WOUND RELATIVE TO SHOCKING COIL 审中-公开
标题翻译：可植入医疗器械引线，包括内圈绕线圈相对于震动线圈
公开(公告)号：WO2013066505A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/055673
申请日：2012-09-15
申请人： CARDIAC PACEMAKERS, INC. , WALKER, Joseph , WULFMAN, David R. , ARNHOLT, Devon N.
发明人： WALKER, Joseph , WULFMAN, David R. , ARNHOLT, Devon N.
IPC分类号： A61N1/08 , A61N1/05
CPC分类号： A61N1/0563 , A61N1/086
摘要： A medical device lead includes a proximal connector configured to couple the lead to a pulse generator and an insulative lead body extending distally from the proximal connector. The lead also includes an inner conductor and one or more cable conductors coupled to the proximal connector at a proximal end and extending through the lead body. The lead further includes one or more defibrillation coil electrodes coupled to a distal end of the one or more cable conductors. The one or more defibrillation coil electrodes are disposed around and electrically isolated from the inner conductor. The one or more defibrillation coil electrodes have a first winding direction and the inner conductor has a second winding direction opposite the first winding direction.
摘要翻译：医疗器械引线包括被配置为将引线耦合到脉冲发生器的近端连接器和从近端连接器向远侧延伸的绝缘引线体。引线还包括内导体和一个或多个电缆导体，其在近端处连接到近端连接器并且延伸穿过引线体。引线还包括耦合到一个或多个电缆导体的远端的一个或多个除颤线圈电极。一个或多个除颤线圈电极设置在内部导体周围并与内部导体电绝缘。一个或多个除颤线圈电极具有第一卷绕方向，并且内部导体具有与第一卷绕方向相反的第二卷绕方向。

2. 发明申请

WO2011081737A1 TERMINAL CONNECTOR ASSEMBLY FOR A MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：医用电气接线端子连接器总成
公开(公告)号：WO2011081737A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/057025
申请日：2010-11-17
申请人： CARDIAC PACEMAKERS, INC. , LIM, Lily , KUNKEL, Ronald W. , WALKER, Joseph , HALL, Peter C. , SCHULTZ, Steven E. , ARNHOLT, Devon N. , FRUCI, Angelo
发明人： LIM, Lily , KUNKEL, Ronald W. , WALKER, Joseph , HALL, Peter C. , SCHULTZ, Steven E. , ARNHOLT, Devon N. , FRUCI, Angelo
IPC分类号： A61N1/375
CPC分类号： H01R24/58 , A61N1/3752 , H01R43/00 , Y10T29/49171 , Y10T29/49172 , Y10T29/49208
摘要： An IS-4 terminal connector assembly includes three terminal electrodes positioned over an inner tubular member such that they are radially offset from one another. Each of the terminal ring electrodes are configured such that they can withstand both tensile and cyclical bending loads with minimal compromise in their outer geometry. Additionally, each of the terminal electrodes is configured such that they have both an inner and outer geometry that facilitates adequate insulation between a select terminal electrode and an adjacent conductor. Additionally, each of the terminal ring electrodes is configured such that they facilitate an external approach to staking a cable conductor.
摘要翻译： IS-4端子连接器组件包括位于内部管状构件上方的三个端子电极，使得它们彼此径向偏移。每个端子环电极被构造成使得它们能够承受拉伸和循环弯曲载荷，并且在其外部几何形状中具有最小的损害。此外，每个端子电极被配置成使得它们具有促进选择端子电极和相邻导体之间的充分绝缘的内外几何形状。此外，每个端子环电极被构造成使得它们有助于外部接近来铆接电缆导体。

3. 发明申请

WO2011146191A1 ACTIVE FIXATION LEADS AND METHOD OF ASSEMBLY 审中-公开
标题翻译：主动固定引线和组装方法
公开(公告)号：WO2011146191A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/032851
申请日：2011-04-18
申请人： CARDIAC PACEMAKERS, INC. , WULFMAN, David, R. , PAGORIA, Douglas, D. , WALKER, Joseph
发明人： WULFMAN, David, R. , PAGORIA, Douglas, D. , WALKER, Joseph
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/0573 , A61N1/056 , A61N1/057 , A61N1/0575 , A61N1/0587 , A61N1/375 , Y10T29/49002 , Y10T29/49826 , Y10T29/4998
摘要： An active fixation lead may have a lead body formed at least in part from an inner member and an outer sheath. The inner member may include a pace/sense lumen and one or more cable lumens. The inner member may include one or more longitudinally extending crumple zones that are configured to reduce stress within the pace/sense lumen that could otherwise be caused by compressive forces applied to the lead.
摘要翻译：主动固定引线可以具有至少部分地由内部构件和外部护套形成的引线体。内部构件可以包括脚步/感测腔和一个或多个电缆腔。内部构件可以包括一个或多个纵向延伸的折叠区域，其被配置为减少脚步/感觉腔内的应力，否则可能由施加到引线的压缩力引起。

4. 发明申请

WO2008045265A2 PASSIVE LEFT ATRIAL SUPPORT METHOD AND APPARATUS 审中-公开
标题翻译：被动式左心房支持方法和装置
公开(公告)号：WO2008045265A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/021271
申请日：2007-10-03
申请人： CARDIAC PACEMAKERS, INC. , WALKER, Joseph
发明人： WALKER, Joseph
IPC分类号： A61B5/04
CPC分类号： A61F2/2481 , A61N1/0587
摘要： One embodiment of the present subject matter includes a patch for attachment to a heart having a left atrium which includes a coronary sulcus, a line of reflection between the oblique and transverse pericardial sinuses, and left and right pulmonary veins, the patch sized to have a first edge portion disposed along the coronary sulcus and a second edge portion disposed along the line of reflection between the oblique and transverse pericardial sinuses. In one embodiment, the patch formed by the process including measuring left atrial diameter during over-distension, determining a patch size such that the patch is substantially inelastic when the left atrium is in over-distension, cutting the first edge portion of the patch to fit along the coronary sulcus and cutting the second edge portion of the patch to fit along the line of reflection between the oblique and transverse pericardial sinuses.
摘要翻译：本发明主题的一个实施方案包括用于附着于具有左心房的心脏的贴片，所述左心房包括冠状沟，倾斜心包静脉窦和横向心包窦之间的反射线以及左心室和右心室肺所述贴片的大小被确定为具有沿着冠状沟布置的第一边缘部分和沿着倾斜心包静脉窦和横向心包窦之间的反射线布置的第二边缘部分。在一个实施例中，由过程形成的贴片包括在过度膨胀期间测量左心房直径，确定贴片大小，使得当左心房过度膨胀时贴片基本上无弹性，将贴片的第一边缘部分切割成沿着冠状沟配合并切割贴片的第二边缘部分以沿着斜向和横向心包窦之间的反射线配合。

5. 发明申请

WO2009017722A1 SYSTEM FOR EXTERNAL COUNTERPULSATION THERAPY 审中-公开
标题翻译：外部治疗系统
公开(公告)号：WO2009017722A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/009150
申请日：2008-07-29
申请人： CARDIAC PACEMAKERS, INC. , SHIPLEY, Robert , ALVAREZ, Guy , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , WALKER, Joseph
发明人： SHIPLEY, Robert , ALVAREZ, Guy , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , WALKER, Joseph
IPC分类号： A61N1/36
CPC分类号： A61N1/36003 , A61H9/0078 , A61H2201/165 , A61H2230/06 , A61H2230/20 , A61H2230/30 , A61N1/36017 , A61N1/36114
摘要： An improved system for delivering external counterpulsation therapy is described. The system employs muscle stimulation transducers such as cutaneous electrodes in order to stimulate skeletal muscle and/or vascular smooth muscle in synchronization with the cardiac cycle in a manner that increases the fluid pressure within veins and/or arteries during cardiac diastole.
摘要翻译：描述了用于递送外部反搏疗法的改进系统。该系统采用肌肉刺激换能器，例如皮肤电极，以便以心脏舒张期内增加静脉和/或动脉内的流体压力的方式与心脏周期同步地刺激骨骼肌和/或血管平滑肌。

6. 发明申请

WO2008070020A3 DEVICE FOR CARDIAC VASOACTIVE THERAPY 审中-公开
公开(公告)号：WO2008070020A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/024730
申请日：2007-12-03
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha , WALKER, Joseph
发明人： SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha , WALKER, Joseph
IPC分类号： A61N1/36
摘要： A method and device for treating myocardial ischemia in which an implantable pulse generator delivers electrical stimulation to electrodes disposed near a coronary artery. The stimulation parameters may be adjusted to produce vasodilation and/or vasoconstriction of the artery. The device may be configured to operate in a vasodilation and/or vasoconstriction mode in accordance with specified entry and exit conditions.

7. 发明申请

WO2008121231A3 SYSTEMS AND LEADS FOR THERMAL NEUROINHIBITION 审中-公开
公开(公告)号：WO2008121231A3
公开(公告)日：2008-10-09
申请号：PCT/US2008/003545
申请日：2008-03-18
申请人： CARDIAC PACEMAKERS, INC. , LOVETT, Eric G. , LIBBUS, Imad , WALKER, Joseph
发明人： LOVETT, Eric G. , LIBBUS, Imad , WALKER, Joseph
IPC分类号： A61H39/06
摘要： Disclosed herein, among other things, is system for thermal neuroinhibition. According to an embodiment, the system includes at least one implantable fluid-filled conduit adapted to be placed adjacent to a neural target. The system also includes an implantable housing including a power source, a heat pump deriving power from the source and connected to the conduit, and a controller within the housing. The controller is connected to the heat pump, and is adapted to control the heat pump to effect fluid flow in the conduit to cool the neural target using electromechanical refrigeration to reversibly inhibit neural activity as part of a medical treatment.

8. 发明申请

WO2008100390A1 SYSTEMS FOR ELECTRICAL STIMULATION OF BLOOD VESSELS 审中-公开
标题翻译：血管电刺激系统
公开(公告)号：WO2008100390A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/001467
申请日：2008-02-04
申请人： CARDIAC PACEMAKERS, INC. , WALKER, Joseph , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , MOKELKE, Eric
发明人： WALKER, Joseph , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , MOKELKE, Eric
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a system for electrical stimulation of blood vessels. An embodiment of the system includes at least one electrode having electrical contact with a blood vessel. The embodiment also includes a stimulation circuit electrically connected to the electrode, the circuit adapted to provide stimulation to the vessel. The embodiment further includes a controller connected to the circuit, the controller adapted to select frequency and voltage parameters for the stimulation circuit to selectively affect vascular therapy, including constriction of the vessel and dilation of the vessel. According to various embodiments, the stimulation circuit and controller are contained within an implantable medical device (IMD). The system also includes a sensor connected to the controller, and the controller initiates and adjusts therapy based on a signal received from the sensor, in varying embodiments.
摘要翻译：此处公开的是用于电刺激血管的系统。该系统的一个实施例包括至少一个与血管电接触的电极。该实施例还包括电连接到电极的刺激电路，该电路适于向容器提供刺激。该实施例还包括连接到电路的控制器，所述控制器适于选择用于刺激电路的频率和电压参数，以选择性地影响血管治疗，包括容器收缩和血管扩张。根据各种实施例，刺激电路和控制器被包含在可植入医疗装置（IMD）内。该系统还包括连接到控制器的传感器，并且在不同的实施例中，控制器基于从传感器接收的信号来启动和调整治疗。

9. 发明申请

WO2015123249A1 RF SHIELD FOR AN IMPLANTABLE LEAD 审中-公开
标题翻译：射频屏蔽用于可植入引线
公开(公告)号：WO2015123249A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015336
申请日：2015-02-11
申请人： CARDIAC PACEMAKERS, INC
发明人： TRAN, Binh C. , WALKER, Joseph , CARPENTER, Greg P. , GORDON, Jack
IPC分类号： A61N1/37 , A61N1/05 , A61N1/08
CPC分类号： A61N1/08 , A61N1/056 , A61N1/086 , A61N1/3718
摘要： Various embodiments concern shielding an implantable lead from RF energy associated with MRI scans. The lead can include a distal region, a proximal region, an intermediate region between the distal region and the proximal region, at least one electrode disposed on the distal region, and at least one conductor extending from the proximal region to the at least one electrode. Implanting of the lead can include coiling a portion of the intermediate region to define one or more loops and selectively shielding the one or more loops of the lead with a RF shield. The RF shield can comprise metallic material and can be configured to reduce RF signal coupling to the at least one conductor along the one or more loops.
摘要翻译：各种实施例涉及将可植入导线从与MRI扫描相关的RF能量屏蔽。引线可以包括远端区域，近端区域，远端区域和近端区域之间的中间区域，设置在远端区域上的至少一个电极以及从近端区域延伸到至少一个电极的至少一个导体。引线的植入可以包括卷绕中间区域的一部分以限定一个或多个环并且用RF屏蔽选择性地屏蔽引线的一个或多个环。 RF屏蔽可以包括金属材料，并且可以被配置为减少沿着一个或多个环路的至少一个导体的RF信号耦合。

10. 发明申请

WO2014036529A1 MRI COMPATIBLE LEAD COIL 审中-公开
标题翻译： MRI兼容铅线圈
公开(公告)号：WO2014036529A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/057732
申请日：2013-08-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： WALKER, Joseph , REDDY, G. Shantanu , ARNHOLT, Devon N. , AMERI, Masoud
IPC分类号： A61N1/08
CPC分类号： A61N1/056 , A61N1/08 , A61N1/086
摘要： Various embodiments concern leads having low peak MRI heating for improved MRI compatibility. Various leads include a lead body having at least one lumen, a proximal end configured to interface with an implantable medical device, and a distal end. Such leads can further include a conductor extending along at least a portion of the lead body within the at least one lumen and a defibrillation coil extending along an exterior portion of the lead body and in electrical connection with the conductor, wherein at least a section of the defibrillation coil is under longitudinal compression. The longitudinal compression can lower peak MRI heating along the defibrillation coil. The longitudinal compression may maintain circumferential contact between adjacent turns of the section of the defibrillation coil.
摘要翻译：各种实施方案涉及具有低峰值MRI加热以提高MRI兼容性的引线。各种引线包括具有至少一个内腔，配置成与可植入医疗装置接合的近端和远端的引线体。这样的导线还可以包括沿着至少一个内腔内的引线体的至少一部分延伸的导体，以及沿引线主体的外部部分延伸并与导体电连接的除颤线圈，其中至少一部分除颤线圈处于纵向压缩状态。纵向压缩可以降低沿除颤线圈的峰值MRI加热。纵向压缩可以保持除颤线圈的部分的相邻匝之间的圆周接触。

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