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1. 发明申请

WO2011146191A1 ACTIVE FIXATION LEADS AND METHOD OF ASSEMBLY 审中-公开
标题翻译：主动固定引线和组装方法
公开(公告)号：WO2011146191A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/032851
申请日：2011-04-18
申请人： CARDIAC PACEMAKERS, INC. , WULFMAN, David, R. , PAGORIA, Douglas, D. , WALKER, Joseph
发明人： WULFMAN, David, R. , PAGORIA, Douglas, D. , WALKER, Joseph
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/0573 , A61N1/056 , A61N1/057 , A61N1/0575 , A61N1/0587 , A61N1/375 , Y10T29/49002 , Y10T29/49826 , Y10T29/4998
摘要： An active fixation lead may have a lead body formed at least in part from an inner member and an outer sheath. The inner member may include a pace/sense lumen and one or more cable lumens. The inner member may include one or more longitudinally extending crumple zones that are configured to reduce stress within the pace/sense lumen that could otherwise be caused by compressive forces applied to the lead.
摘要翻译：主动固定引线可以具有至少部分地由内部构件和外部护套形成的引线体。内部构件可以包括脚步/感测腔和一个或多个电缆腔。内部构件可以包括一个或多个纵向延伸的折叠区域，其被配置为减少脚步/感觉腔内的应力，否则可能由施加到引线的压缩力引起。

2. 发明申请

WO2009042063A1 IMPLANTABLE LEAD WITH AN ELECTROSTIMULATION CAPACITOR 审中-公开
标题翻译：具有电化学电容器的可植入引线
公开(公告)号：WO2009042063A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/010859
申请日：2008-09-18
申请人： CARDIAC PACEMAKERS, INC. , WULFMAN, David, R.
发明人： WULFMAN, David, R.
IPC分类号： A61N1/05 , A61N1/378
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/37205 , A61N1/375
摘要： One example includes an implantable lead with an elongate lead body including a proximal portion and a distal portion. The lead includes a coupler configured to be coupled to an implantable medical device, a conductor, extending through the coupler, a first electrode, and a first electrostimulation capacitor located at the distal portion of the lead body, the first electrostimulation capacitor including a capacitance value that is large enough to store an electrostimulation charge of an electrostimulation energy that is large enough to perform electrostimulation of tissue. The lead includes a first switch located at the distal portion of the lead body and coupled to the conductor, the first switch configured to selectively couple the first electrostimulation capacitor to the first electrode during a stimulating state and to selectively couple the first electrostimulation capacitor to the conductor during a charging state.
摘要翻译：一个示例包括具有包括近端部分和远端部分的细长引线主体的可植入引线。引线包括被配置为耦合到可植入医疗器件的耦合器，延伸穿过耦合器的导体，第一电极和位于引线本体的远端部分的第一电刺激电容器，所述第一电刺激电容器包括电容值其足够大以存储足够大的电刺激能量的电刺激电荷以进行组织的电刺激。引线包括位于引线主体的远端部分并且耦合到导体的第一开关，第一开关被配置为在刺激状态期间将第一电刺激电容器选择性地耦合到第一电极，并且选择性地将第一电刺激电容器耦合到导体在充电状态。

3. 发明申请

WO2004044171A2 WAVEGUIDE SYSTEM FOR DETECTION OF FLUORESCENTLY LABELED NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：用于检测荧光标记核酸序列的波形检测系统
公开(公告)号：WO2004044171A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/036146
申请日：2003-11-13
申请人： WULFMAN, David, R. , BAAS, Tracey, L.
发明人： WULFMAN, David, R. , BAAS, Tracey, L.
IPC分类号： C12N
CPC分类号： G01N21/6428 , C12Q1/6837 , G01N21/552 , G01N21/645 , G01N21/7703 , G01N33/54373 , C12Q2537/143 , C12Q2563/107
摘要： A system for detecting and identifying fluorescently labeled nucleic acid sequences. An embodiment of the system is comprised of an optical waveguide, an excitation light, a photo detector, filters for select fluorescent emissions, a reaction chamber, a data interpretation algorithm, and an addressable array, which assigns a known nucleic acid sequence at a precise location on the waveguide. An embodiment of the system uses a glass slide based array as an optical waveguide. Nucleic acid sequences are immobilized or hybridized to the surface of the waveguide. This abstract is intended to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope of meaning of the claims.
摘要翻译：用于检测和鉴定荧光标记的核酸序列的系统。该系统的一个实施例由光波导，激发光，光电检测器，用于选择荧光发射的滤光器，反应室，数据解释算法和可寻址阵列组成，其将精确地分配已知核酸序列波导上的位置。系统的一个实施例使用基于玻片的阵列作为光波导。核酸序列被固定化或与波导的表面杂交。该摘要旨在符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交的理由是，它不会用于解释或限制权利要求的含义范围。

4. 发明申请

WO2018031627A1 DURABLE ANTIMICROBIAL LAYER FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：用于植入式医疗器械的耐用抗微生物剂层
公开(公告)号：WO2018031627A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/046050
申请日：2017-08-09
申请人： CARDIAC PACEMAKERS, INC.
发明人： WULFMAN, David, R. , FRANKSON, Danielle , AREMU, Adeniyi, O. , FRUCI, Angelo , SHERWOOD, Gregory, J. , BYRON, Mary, M. , DELANEY, JR., Joseph, T. , MCGRAW, Adam
IPC分类号： A61L31/04 , A61L31/10
摘要： An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.
摘要翻译：可植入医疗装置包括聚合物基底和至少一个纳米纤维。聚合物基底包括从基底的表面延伸到聚合物基底中的表面部分。该至少一个纳米纤维包括第一部分和第二部分。第一部分与衬底的表面部分相互渗透，并机械固定到衬底。第二部分从基板表面突出。

5. 发明公开

EP2211979A1 IMPLANTABLE LEAD WITH AN ELECTROSTIMULATION CAPACITOR 审中-公开
标题翻译： WITH A电刺激电容器植入引线，
公开(公告)号：EP2211979A1
公开(公告)日：2010-08-04
申请号：EP08834304.1
申请日：2008-09-18
申请人： Cardiac Pacemakers, Inc.
发明人： WULFMAN, David, R.
IPC分类号： A61N1/05 , A61N1/378
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/37205 , A61N1/375
摘要： One example includes an implantable lead with an elongate lead body including a proximal portion and a distal portion. The lead includes a coupler configured to be coupled to an implantable medical device, a conductor, extending through the coupler, a first electrode, and a first electrostimulation capacitor located at the distal portion of the lead body, the first electrostimulation capacitor including a capacitance value that is large enough to store an electrostimulation charge of an electrostimulation energy that is large enough to perform electrostimulation of tissue. The lead includes a first switch located at the distal portion of the lead body and coupled to the conductor, the first switch configured to selectively couple the first electrostimulation capacitor to the first electrode during a stimulating state and to selectively couple the first electrostimulation capacitor to the conductor during a charging state.

6. 发明授权

EP2571568B1 ACTIVE FIXATION LEADS AND METHOD OF ASSEMBLY 有权
标题翻译：主动固定电极和组装方法
公开(公告)号：EP2571568B1
公开(公告)日：2015-03-18
申请号：EP11716764.3
申请日：2011-04-18
申请人： Cardiac Pacemakers, Inc.
发明人： WULFMAN, David, R. , PAGORIA, Douglas, D. , WALKER, Joseph
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/0573 , A61N1/056 , A61N1/057 , A61N1/0575 , A61N1/0587 , A61N1/375 , Y10T29/49002 , Y10T29/49826 , Y10T29/4998

7. 发明公开

EP3496775A1 DURABLE ANTIMICROBIAL LAYER FOR IMPLANTABLE MEDICAL DEVICES 有权
公开(公告)号：EP3496775A1
公开(公告)日：2019-06-19
申请号：EP17754943.3
申请日：2017-08-09
申请人： Cardiac Pacemakers, Inc.
发明人： WULFMAN, David, R. , FRANKSON, Danielle , AREMU, Adeniyi, O. , FRUCI, Angelo , SHERWOOD, Gregory, J. , BYRON, Mary, M. , DELANEY, JR., Joseph, T. , MCGRAW, Adam
IPC分类号： A61L31/04 , A61L31/10

8. 发明公开

EP2571568A1 ACTIVE FIXATION LEADS AND METHOD OF ASSEMBLY 有权
标题翻译：主动固定电极和组装方法
公开(公告)号：EP2571568A1
公开(公告)日：2013-03-27
申请号：EP11716764.3
申请日：2011-04-18
申请人： Cardiac Pacemakers, Inc.
发明人： WULFMAN, David, R. , PAGORIA, Douglas, D. , WALKER, Joseph
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/0573 , A61N1/056 , A61N1/057 , A61N1/0575 , A61N1/0587 , A61N1/375 , Y10T29/49002 , Y10T29/49826 , Y10T29/4998
摘要： An active fixation lead may have a lead body formed at least in part from an inner member and an outer sheath. The inner member may include a pace/sense lumen and one or more cable lumens. The inner member may include one or more longitudinally extending crumple zones that are configured to reduce stress within the pace/sense lumen that could otherwise be caused by compressive forces applied to the lead.

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