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1. 发明申请

WO2008100390A1 SYSTEMS FOR ELECTRICAL STIMULATION OF BLOOD VESSELS 审中-公开
标题翻译：血管电刺激系统
公开(公告)号：WO2008100390A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/001467
申请日：2008-02-04
申请人： CARDIAC PACEMAKERS, INC. , WALKER, Joseph , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , MOKELKE, Eric
发明人： WALKER, Joseph , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , MOKELKE, Eric
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a system for electrical stimulation of blood vessels. An embodiment of the system includes at least one electrode having electrical contact with a blood vessel. The embodiment also includes a stimulation circuit electrically connected to the electrode, the circuit adapted to provide stimulation to the vessel. The embodiment further includes a controller connected to the circuit, the controller adapted to select frequency and voltage parameters for the stimulation circuit to selectively affect vascular therapy, including constriction of the vessel and dilation of the vessel. According to various embodiments, the stimulation circuit and controller are contained within an implantable medical device (IMD). The system also includes a sensor connected to the controller, and the controller initiates and adjusts therapy based on a signal received from the sensor, in varying embodiments.
摘要翻译：此处公开的是用于电刺激血管的系统。该系统的一个实施例包括至少一个与血管电接触的电极。该实施例还包括电连接到电极的刺激电路，该电路适于向容器提供刺激。该实施例还包括连接到电路的控制器，所述控制器适于选择用于刺激电路的频率和电压参数，以选择性地影响血管治疗，包括容器收缩和血管扩张。根据各种实施例，刺激电路和控制器被包含在可植入医疗装置（IMD）内。该系统还包括连接到控制器的传感器，并且在不同的实施例中，控制器基于从传感器接收的信号来启动和调整治疗。

2. 发明申请

WO2009017722A1 SYSTEM FOR EXTERNAL COUNTERPULSATION THERAPY 审中-公开
标题翻译：外部治疗系统
公开(公告)号：WO2009017722A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/009150
申请日：2008-07-29
申请人： CARDIAC PACEMAKERS, INC. , SHIPLEY, Robert , ALVAREZ, Guy , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , WALKER, Joseph
发明人： SHIPLEY, Robert , ALVAREZ, Guy , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , WALKER, Joseph
IPC分类号： A61N1/36
CPC分类号： A61N1/36003 , A61H9/0078 , A61H2201/165 , A61H2230/06 , A61H2230/20 , A61H2230/30 , A61N1/36017 , A61N1/36114
摘要： An improved system for delivering external counterpulsation therapy is described. The system employs muscle stimulation transducers such as cutaneous electrodes in order to stimulate skeletal muscle and/or vascular smooth muscle in synchronization with the cardiac cycle in a manner that increases the fluid pressure within veins and/or arteries during cardiac diastole.
摘要翻译：描述了用于递送外部反搏疗法的改进系统。该系统采用肌肉刺激换能器，例如皮肤电极，以便以心脏舒张期内增加静脉和/或动脉内的流体压力的方式与心脏周期同步地刺激骨骼肌和/或血管平滑肌。

3. 发明公开

EP2117642A1 SYSTEMS FOR ELECTRICAL STIMULATION OF BLOOD VESSELS 审中-公开
标题翻译： SYSTEMS FOR血管电刺激
公开(公告)号：EP2117642A1
公开(公告)日：2009-11-18
申请号：EP08725142.7
申请日：2008-02-04
申请人： Cardiac Pacemakers, Inc.
发明人： WALKER, Joseph , SALO, Rodney W. , IYER, Anand , PASTORE, Joseph, M. , MOKELKE, Eric
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a system for electrical stimulation of blood vessels. An embodiment of the system includes at least one electrode having electrical contact with a blood vessel. The embodiment also includes a stimulation circuit electrically connected to the electrode, the circuit adapted to provide stimulation to the vessel. The embodiment further includes a controller connected to the circuit, the controller adapted to select frequency and voltage parameters for the stimulation circuit to selectively affect vascular therapy, including constriction of the vessel and dilation of the vessel. According to various embodiments, the stimulation circuit and controller are contained within an implantable medical device (IMD). The system also includes a sensor connected to the controller, and the controller initiates and adjusts therapy based on a signal received from the sensor, in varying embodiments.

4. 发明申请

WO2006042240A2 IMMUNOTHERAPY OF AUTOIMMUNE DISORDERS 审中-公开
标题翻译：自身免疫性疾病的免疫治疗
公开(公告)号：WO2006042240A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036436
申请日：2005-10-11
申请人： WYETH , IYER, Anand , DUNUSSI-JOANNOPOULOS, Kyriaki
发明人： IYER, Anand , DUNUSSI-JOANNOPOULOS, Kyriaki
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A61K47/6849 , A61K2039/505
摘要： Compositions and methods for treating autoimmune diseases are described. In particular, the use of B cell depleting agents and cytotoxic drug/B cell depleting agent conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) in treating autoimmune diseases is described. Combination therapies and compositions for treating autoimmune diseases, including the B cell depleting agents, conjugates and/or anti-cytokine agents, are also described.
摘要翻译：描述了用于治疗自身免疫性疾病的组合物和方法。具体而言，描述了使用B细胞消耗剂和细胞毒性药物/ B细胞消耗剂缀合物，其载药量显着高于先前报道的程序，并且在治疗自身免疫性疾病中具有降低的聚集和低结合分数（LCF）。还描述了用于治疗自身免疫疾病的组合疗法和组合物，包括B细胞耗竭剂，缀合物和/或抗细胞因子剂。

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