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1. 发明申请

WO2011081737A1 TERMINAL CONNECTOR ASSEMBLY FOR A MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：医用电气接线端子连接器总成
公开(公告)号：WO2011081737A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/057025
申请日：2010-11-17
申请人： CARDIAC PACEMAKERS, INC. , LIM, Lily , KUNKEL, Ronald W. , WALKER, Joseph , HALL, Peter C. , SCHULTZ, Steven E. , ARNHOLT, Devon N. , FRUCI, Angelo
发明人： LIM, Lily , KUNKEL, Ronald W. , WALKER, Joseph , HALL, Peter C. , SCHULTZ, Steven E. , ARNHOLT, Devon N. , FRUCI, Angelo
IPC分类号： A61N1/375
CPC分类号： H01R24/58 , A61N1/3752 , H01R43/00 , Y10T29/49171 , Y10T29/49172 , Y10T29/49208
摘要： An IS-4 terminal connector assembly includes three terminal electrodes positioned over an inner tubular member such that they are radially offset from one another. Each of the terminal ring electrodes are configured such that they can withstand both tensile and cyclical bending loads with minimal compromise in their outer geometry. Additionally, each of the terminal electrodes is configured such that they have both an inner and outer geometry that facilitates adequate insulation between a select terminal electrode and an adjacent conductor. Additionally, each of the terminal ring electrodes is configured such that they facilitate an external approach to staking a cable conductor.
摘要翻译： IS-4端子连接器组件包括位于内部管状构件上方的三个端子电极，使得它们彼此径向偏移。每个端子环电极被构造成使得它们能够承受拉伸和循环弯曲载荷，并且在其外部几何形状中具有最小的损害。此外，每个端子电极被配置成使得它们具有促进选择端子电极和相邻导体之间的充分绝缘的内外几何形状。此外，每个端子环电极被构造成使得它们有助于外部接近来铆接电缆导体。

2. 发明申请

WO2013066505A1 IMPLANTABLE MEDICAL DEVICE LEAD INCLUDING INNER COIL REVERSE-WOUND RELATIVE TO SHOCKING COIL 审中-公开
标题翻译：可植入医疗器械引线，包括内圈绕线圈相对于震动线圈
公开(公告)号：WO2013066505A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/055673
申请日：2012-09-15
申请人： CARDIAC PACEMAKERS, INC. , WALKER, Joseph , WULFMAN, David R. , ARNHOLT, Devon N.
发明人： WALKER, Joseph , WULFMAN, David R. , ARNHOLT, Devon N.
IPC分类号： A61N1/08 , A61N1/05
CPC分类号： A61N1/0563 , A61N1/086
摘要： A medical device lead includes a proximal connector configured to couple the lead to a pulse generator and an insulative lead body extending distally from the proximal connector. The lead also includes an inner conductor and one or more cable conductors coupled to the proximal connector at a proximal end and extending through the lead body. The lead further includes one or more defibrillation coil electrodes coupled to a distal end of the one or more cable conductors. The one or more defibrillation coil electrodes are disposed around and electrically isolated from the inner conductor. The one or more defibrillation coil electrodes have a first winding direction and the inner conductor has a second winding direction opposite the first winding direction.
摘要翻译：医疗器械引线包括被配置为将引线耦合到脉冲发生器的近端连接器和从近端连接器向远侧延伸的绝缘引线体。引线还包括内导体和一个或多个电缆导体，其在近端处连接到近端连接器并且延伸穿过引线体。引线还包括耦合到一个或多个电缆导体的远端的一个或多个除颤线圈电极。一个或多个除颤线圈电极设置在内部导体周围并与内部导体电绝缘。一个或多个除颤线圈电极具有第一卷绕方向，并且内部导体具有与第一卷绕方向相反的第二卷绕方向。

3. 发明申请

WO2013078139A1 FIBROUS MATRIX COATING MATERIALS 审中-公开
标题翻译：纤维基质涂料
公开(公告)号：WO2013078139A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/065896
申请日：2012-11-19
申请人： CARDIAC PACEMAKERS, INC. , POLKINGHORNE, Jeannette C. , ARNHOLT, Devon N. , ROHL, James P. , SCHMIDT, Brian L. , SEPPALA, Jan , TADSEN, Richard L. , WILLOUGHBY, Patrick , ZHANG, Steve , DESAI, Shrojalkumar , DELANEY, JR., Joseph T. , WULFMAN, David R.
发明人： POLKINGHORNE, Jeannette C. , ARNHOLT, Devon N. , ROHL, James P. , SCHMIDT, Brian L. , SEPPALA, Jan , TADSEN, Richard L. , WILLOUGHBY, Patrick , ZHANG, Steve , DESAI, Shrojalkumar , DELANEY, JR., Joseph T. , WULFMAN, David R.
IPC分类号： A61N1/05 , A61L29/08
CPC分类号： A61N1/04 , A61L29/085 , A61L29/14 , A61L2400/12 , A61N1/05 , C08L75/04
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from a polyisobutylene urethane, urea or urethane/urea copolymer.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由聚异丁烯氨基甲酸酯，脲或氨基甲酸酯/脲共聚物形成。

4. 发明申请

WO2013025465A1 METHOD FOR COATING DEVICES USING ELECTROSPINNING AND MELT BLOWING 审中-公开
标题翻译：使用电喷雾和熔融吹制涂覆装置的方法
公开(公告)号：WO2013025465A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/050260
申请日：2012-08-10
申请人： CARDIAC PACEMAKERS, INC. , ARNHOLT, Devon N. , PAGORIA, Douglas D. , POLKINGHORNE, Jeannette C.
发明人： ARNHOLT, Devon N. , PAGORIA, Douglas D. , POLKINGHORNE, Jeannette C.
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , D01D5/0023 , D01D5/0084 , D10B2321/08 , D10B2331/06 , Y10T29/4922 , Y10T29/49224
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from a non-conductive polymer.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由非导电聚合物形成。

5. 发明申请

WO2016138283A1 ADJUSTABLE THROW PERCUTANEOUS NEEDLE 审中-公开
标题翻译：可调节刺痛的针头
公开(公告)号：WO2016138283A1
公开(公告)日：2016-09-01
申请号：PCT/US2016/019595
申请日：2016-02-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ARNHOLT, Devon N. , FETTIG, Jonathan P.
发明人： ARNHOLT, Devon N. , FETTIG, Jonathan P.
IPC分类号： A61B10/02
CPC分类号： A61B10/0266 , A61B10/0275 , A61B2010/0208
摘要： A device for collecting a tissue sample includes an outer needle extending longitudinally from a proximal end to a distal end and including a lumen extending therethrough. The device also includes an inner needle extending longitudinally from a proximal end to a distal end and including an opening extending laterally in and along a length thereof. The inner needle is sized and shaped to be slidably received within the lumen of the outer needle and movable relative thereto between an insertion configuration, in which the opening is covered by the outer needle, to a tissue collecting configuration, in which the opening is exposed. In addition, the device includes a handle assembly for adjusting a throw length of the inner needle relative to the outer needle.
摘要翻译：用于收集组织样本的装置包括从近端到远端纵向延伸的外针，并且包括从其延伸穿过的内腔。该装置还包括从近端到远端纵向延伸的内针，并且包括沿其长度方向横向延伸的开口。内针的尺寸和形状被定形成可滑动地容纳在外针的内腔内，并且可以在其中开口被外针覆盖的插入构型与开口暴露在其间的组织收集构型之间相对移动。另外，该装置还包括用于调节内针相对于外针的投掷长度的手柄组件。

6. 发明申请

WO2013159031A2 IMPLANTABLE MEDICAL DEVICE LEAD INCLUDING A UNIFILAR COILED CABLE 审中-公开
标题翻译：可植入医疗器械引导线，包括一根绞线
公开(公告)号：WO2013159031A2
公开(公告)日：2013-10-24
申请号：PCT/US2013/037432
申请日：2013-04-19
申请人： CARDIAC PACEMAKERS, INC.
发明人： WALKER, Joseph , REDDY, G. Shantanu , ARNHOLT, Devon N. , HAASL, Benjamin J.
IPC分类号： A61N1/05
CPC分类号： A61B18/1492 , A61N1/05 , A61N1/056 , A61N1/086
摘要： A medical device lead includes a flexible body having a proximal region with a proximal end, and a distal region with a distal end. A connector is coupled to the proximal end of the flexible body of the lead to electrically and mechanically connect the lead to an implantable pulse generator. The medical device lead also includes an electrode in the distal region of the flexible body, and a cable conductor having a proximal end electrically coupled to the connector and a distal end electrically coupled to the electrode. The cable conductor consists of a single helically coiled filar including a plurality of co-radial turns and having an outer diameter of less than about 0.020 inch (0.508 mm).
摘要翻译：医疗装置引线包括具有近端区域的柔性主体和具有远端的远侧区域。连接器耦合到引线的柔性体的近端，以电和机械地将引线连接到可植入脉冲发生器。医疗装置引线还包括在柔性体的远端区域中的电极，以及具有电连接到连接器的近端的电缆导体和电耦合到电极的远端。电缆导体由包括多个共同径向匝并具有小于约0.020英寸（0.508mm）的外径的单个螺旋线圈的丝状体组成。

7. 发明申请

WO2014025402A2 REINFORCED COIL CREATED FROM POLYMER COATED WIRE FOR IMPROVED TORQUE TRANSFER 审中-公开
标题翻译：聚合物涂层钢丝增强的卷材改善了转矩传递
公开(公告)号：WO2014025402A2
公开(公告)日：2014-02-13
申请号：PCT/US2013/032045
申请日：2013-03-15
申请人： CARDIAC PACEMAKERS, INC.
发明人： ARNHOLT, Devon N.
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , Y10T29/49071
摘要： An implantable medical device lead includes a lead body including a lumen extending from a proximal end of the lead body to a distal end of the lead body, and a helically coiled conductor including one or more filars extending through the lumen and including a plurality of turns. The implantable medical device lead further includes an insulative coating on at least one of the one or more filars, the insulative coating circumferentially covering the outer surface of the at least one of the one or more filars, and at least one cohesive structure formed between adjacent turns of the helically coiled conductor. The at least one cohesive structure includes portions of the insulative coating on the at least one of the one or more filars and is configured to interconnect adjacent turns of the helically coiled conductor.
摘要翻译：植入式医疗装置引线包括引线主体，该引线主体包括从引线主体的近端延伸到引线主体的远端的管腔以及螺旋卷绕导体，该螺旋卷绕导体包括一个或多个延伸穿过内腔并包括多个匝。所述植入式医疗器件引线进一步包括在所述一个或多个线状体中的至少一个上的绝缘涂层，所述绝缘涂层周向地覆盖所述一个或多个线状体中的所述至少一个的外表面，以及至少一个粘合结构，螺旋线圈导体的转动。所述至少一个粘性结构包括所述一个或多个丝状体中的所述至少一个上的绝缘涂层的部分，并且被配置为互连螺旋状卷绕导体的相邻匝。

8. 发明申请

WO2022204035A1 RECHARGEABLE SYSTEMS FOR DELIVERING ELECTRICAL STIMULATION THERAPY FOR CANCER THERAPY 审中-公开
公开(公告)号：WO2022204035A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/021161
申请日：2022-03-21
申请人： CARDIAC PACEMAKERS, INC.
发明人： SCHMIDT, Brian L. , ARNHOLT, Devon N. , AVILES DELGADO, Emilio A. , COLLAZO RODRIGUEZ, David
IPC分类号： A61N1/36 , A61N1/378 , A61N1/05
摘要： Embodiments herein relate to rechargeable electrical stimulation-based cancer therapy systems and related methods. In a first aspect, an electrical stimulation-based cancer therapy system is included having an implantable electrical field generator unit including a housing, a header coupled to the housing, and electrical field generation circuitry is disposed within the housing. The system can also include an implantable recharge lead, wherein the implantable recharge lead is removably coupled to the header. The system can also include a plurality of therapy leads, the therapy leads including a plurality of electrodes, wherein the plurality of therapy leads area also removably coupled to the header. The system can also include an external recharger unit. Other embodiments are also included herein.

9. 发明申请

WO2014042779A9 CONFORMAL POROUS THIN LAYER COATING AND METHOD OF MAKING 审中-公开
公开(公告)号：WO2014042779A9
公开(公告)日：2014-03-20
申请号：PCT/US2013/053448
申请日：2013-08-02
申请人： CARDIAC PACEMAKERS, INC.
发明人： ARNHOLT, Devon N. , EGGERT, Joel T. , BYRON, Mary M. , WULFMAN, David R. , PERREY, Christopher
IPC分类号： B29C45/14 , B29C37/00
摘要： A method of forming an implantable medical device includes forming a porous layer of a first material on a substrate, extruding or molding a second material over the porous layer and removing the substrate after extruding or molding the second material to form an implantable medical device.

10. 发明申请

WO2014036529A1 MRI COMPATIBLE LEAD COIL 审中-公开
标题翻译： MRI兼容铅线圈
公开(公告)号：WO2014036529A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/057732
申请日：2013-08-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： WALKER, Joseph , REDDY, G. Shantanu , ARNHOLT, Devon N. , AMERI, Masoud
IPC分类号： A61N1/08
CPC分类号： A61N1/056 , A61N1/08 , A61N1/086
摘要： Various embodiments concern leads having low peak MRI heating for improved MRI compatibility. Various leads include a lead body having at least one lumen, a proximal end configured to interface with an implantable medical device, and a distal end. Such leads can further include a conductor extending along at least a portion of the lead body within the at least one lumen and a defibrillation coil extending along an exterior portion of the lead body and in electrical connection with the conductor, wherein at least a section of the defibrillation coil is under longitudinal compression. The longitudinal compression can lower peak MRI heating along the defibrillation coil. The longitudinal compression may maintain circumferential contact between adjacent turns of the section of the defibrillation coil.
摘要翻译：各种实施方案涉及具有低峰值MRI加热以提高MRI兼容性的引线。各种引线包括具有至少一个内腔，配置成与可植入医疗装置接合的近端和远端的引线体。这样的导线还可以包括沿着至少一个内腔内的引线体的至少一部分延伸的导体，以及沿引线主体的外部部分延伸并与导体电连接的除颤线圈，其中至少一部分除颤线圈处于纵向压缩状态。纵向压缩可以降低沿除颤线圈的峰值MRI加热。纵向压缩可以保持除颤线圈的部分的相邻匝之间的圆周接触。

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