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1. 发明授权

US07856266B1 Implantable cardiac stimulation device providing reduced defibrillation thresholds and method 有权
标题翻译：植入式心脏刺激装置提供降低的除颤阈值和方法
公开(公告)号：US07856266B1
公开(公告)日：2010-12-21
申请号：US11756283
申请日：2007-05-31
申请人： Gene A. Bornzin , Michael E. Benser , Euljoon Park , Taraneh Ghaffari Farazi
发明人： Gene A. Bornzin , Michael E. Benser , Euljoon Park , Taraneh Ghaffari Farazi
IPC分类号： A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/36521 , A61N1/3943
摘要： An implantable cardiac defibrillation device provides pre-shock stimuli to reduce the defibrillation threshold (DFT). The device includes an arrhythmia detector that detects fibrillation of a fibrillating chamber of a heart and a pulse generator that provides a fibrillation therapy output responsive to the arrhythmia detector detecting fibrillation of the fibrillating chamber of the heart. The therapy output includes a defibrillating shock having an output magnitude exceeding a temporary defibrillation threshold of the fibrillating chamber and at least one pre-defibrillating shock output pulse that reduces an initial defibrillation threshold of the fibrillating chamber to the temporary defibrillation threshold. An electrode system having at least two defibrillation electrodes delivers both the at least one pre-defibrillating shock output pulse to the heart and the defibrillating shock to the fibrillating chamber of the heart.
摘要翻译：植入式心脏除颤装置提供预冲击刺激以减少除颤阈值（DFT）。该装置包括心律失常检测器，其检测心脏的原纤化室的原纤维和脉冲发生器，其提供响应于心律失常检测器检测心脏原纤化室的纤颤的原纤维化治疗输出。治疗输出包括具有超过原纤化室的暂时除颤阈值的输出量值的至少一个除纤颤前冲击输出脉冲，其将原纤化室的初始除颤阈值降低到临时除颤阈值。具有至少两个除颤电极的电极系统将至少一个除颤前的冲击输出脉冲和心脏的去纤维化颤动传递给心脏的原纤维室。

2. 发明申请

US20130041274A1 SYSTEMS AND METHODS FOR USE BY IMPLANTABLE MEDICAL DEVICES FOR DETECTING AND DISCRIMINATING STROKE AND CARDIAC ISCHEMIA USING ELECTROCARDIAC SIGNALS 有权
标题翻译：用于通过电刺激信号检测和鉴别卒中和心脏病的植入式医疗设备使用的系统和方法
公开(公告)号：US20130041274A1
公开(公告)日：2013-02-14
申请号：US13207307
申请日：2011-08-10
申请人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh Ghaffari Farazi , Euljoon Park
发明人： Jong Gill , Rupinder Bharmi , Edward Karst , Ryan Rooke , Riddhi Shah , Fujian Qu , Gene A. Bornzin , Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/0468
CPC分类号： A61B5/0468 , A61B5/0031 , A61B5/0205 , A61B5/02158 , A61B5/02405 , A61B5/0295 , A61B5/0422 , A61B5/4839 , A61N1/3702
摘要： Techniques are provided for detecting and distinguishing stroke and cardiac ischemia based on electrocardiac signals. In one example, the device senses atrial and ventricular signals within the patient along a set of unipolar sensing vectors and identifies certain morphological features within the signals such as PR intervals, ST intervals, QT intervals, T-waves, etc. The device detects changes, if any, within the morphological features such as significant shifts in ST interval elevation or an inversion in T-wave shape, which are indicative of stroke or cardiac ischemia. By selectively comparing changes detected along different unipolar sensing vectors, the device distinguishes or discriminates stroke from cardiac ischemia within the patient. The discrimination may be corroborated using various physiological and hemodynamic parameters. In some examples, the device further identifies the location of the ischemia within the heart. In still other examples, the device detects cardiac ischemia occurring during stroke.
摘要翻译：提供了用于基于心电信号检测和区分中风和心脏缺血的技术。在一个示例中，该装置沿着一组单极感测向量感测患者内的心房和心室信号，并且识别信号内的某些形态特征，例如PR间隔，ST间隔，QT间隔，T波等。该装置检测变化（如果有的话）在形态学特征之中，例如ST间期升高的显着变化或T波形的反转，其指示中风或心脏缺血。通过选择性地比较沿着不同的单极性感测向量检测的变化，该装置区分或区分患者体内的心脏缺血的中风。可以使用各种生理和血液动力学参数来确认辨别。在一些实例中，该装置还识别心脏内局部缺血的位置。在另外的例子中，该装置检测在中风期间发生的心脏缺血。

3. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

4. 发明申请

US20100280348A1 METHOD AND IMPLANTABLE SYSTEM FOR BLOOD-GLUCOSE CONCENTRATION MONITORING USING PARALLEL METHODOLOGIES 有权
标题翻译：使用并行方法对血液葡萄糖浓度监测的方法和可植入系统
公开(公告)号：US20100280348A1
公开(公告)日：2010-11-04
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

5. 发明申请

US20110282226A1 CARDIAC ANALYSIS SYSTEM FOR COMPARING CLINICAL AND INDUCED VENTRICULAR TACHYCARDIA EVENTS 有权
标题翻译：用于比较临床和诱发的心室TACHYCARDIA事件的心脏分析系统
公开(公告)号：US20110282226A1
公开(公告)日：2011-11-17
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

6. 发明授权

US08634902B2 Cardiac analysis system for comparing clinical and induced ventricular tachycardia events 有权
标题翻译：用于比较临床和诱导性室性心动过速事件的心脏分析系统
公开(公告)号：US08634902B2
公开(公告)日：2014-01-21
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

7. 发明申请

US20100042173A1 SYSTEM AND METHOD FOR EVALUATING AND OPTIMIZING THE CONTRIBUTION OF PARTICULAR HEART CHAMBERS TO THE OVERALL EFFICACY OF CARDIAC PACING THERAPY 审中-公开
标题翻译：用于评估和优化特定心脏瓣膜对心脏瓣膜治疗的总体效果的系统和方法
公开(公告)号：US20100042173A1
公开(公告)日：2010-02-18
申请号：US12603829
申请日：2009-10-22
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61N1/368 , A61N1/08 , A61N1/365
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3688
摘要： Techniques are provided for evaluating and optimizing the contribution of particular heart chambers to pacing efficacy. Briefly, a pacemaker temporarily alters the mode with which pacing therapy is delivered so as to selectively alter the heart chambers that are paced. The pacemaker detects any transient changes in pacing efficacy following the alteration in pacing mode. The pacemaker then assesses the contribution of particular heart chambers to pacing efficacy based on the alteration in the pacing mode and on any transient changes in the pacing efficacy. Additionally, techniques are provided herein for automatically adjusting pacing parameters to optimize the contribution of particular chambers to pacing efficacy.
摘要翻译：提供技术来评估和优化特定心室对起搏功效的贡献。简而言之，起搏器暂时改变了起搏治疗的方式，以便选择性地改变起搏的心室。心脏起搏器检测起搏模式改变后起搏功效的任何瞬时变化。起搏器然后根据起搏模式的改变以及起搏功效的任何短暂变化来评估特定心室对起搏功效的贡献。此外，本文提供了用于自动调整起搏参数以优化特定腔室对起搏功效的贡献的技术。

8. 发明授权

US07620448B1 Methods and devices for monitoring myocardial mechanical stability 有权
标题翻译：监测心肌机械稳定性的方法和装置
公开(公告)号：US07620448B1
公开(公告)日：2009-11-17
申请号：US11421915
申请日：2006-06-02
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/7264 , A61B7/023 , A61B2562/0219 , A61N1/3622 , A61N1/36521 , A61N1/37258 , A61N1/3962
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，用于基于指示患者心脏对于多个连续节拍的机械功能的信号来监测心肌机械稳定性。某些实施例使用时域技术，而其他实施例使用频域技术来监测心肌机械稳定性。在某些实施例中，使用重复每N次跳动的图案化起搏序列来对患者的心脏进行起搏。在其他实施例中，患者的心脏不需要起搏。本摘要不是对本发明的完整描述或限制本发明的范围。

9. 发明授权

US08934971B1 Implantable cardiac stimulation device and method that stabilizes ventricular rate during episodes of atrial fibrillation 有权
标题翻译：可植入式心脏刺激装置及其在房颤发作期间稳定心室率的方法
公开(公告)号：US08934971B1
公开(公告)日：2015-01-13
申请号：US11940174
申请日：2007-11-14
申请人： Euljoon Park , You-Ho Kim , Taraneh Ghaffari Farazi
发明人： Euljoon Park , You-Ho Kim , Taraneh Ghaffari Farazi
IPC分类号： A61N1/00
CPC分类号： A61N1/3624 , A61N1/3605 , A61N1/36053 , A61N1/365 , A61N1/368 , A61N1/395
摘要： An implantable cardiac stimulation device and method provide electrical stimulation therapy to stabilize the ventricular rate of a heart during episodes of atrial fibrillation. The stimulation therapy may be a plurality of stimulation pulses delivered to the AV node during the AV node refractory period following the sensing of an atrial event. Alternatively, the stimulation therapy may be a plurality of sub-threshold stimulation pulses delivered to capture AV node vagal innervations following the detection of atrial fibrillation.
摘要翻译：可植入心脏刺激装置和方法提供电刺激治疗以在房颤发作期间稳定心脏心室率。刺激治疗可以是在感觉心房事件之后的AV结节不应期期间传送到AV节点的多个刺激脉冲。或者，刺激治疗可以是递送的多个次阈值刺激脉冲，以在检测心房颤动之后捕获AV节点迷走神经支配。

10. 发明授权

US08606352B2 Methods and devices for monitoring myocardial mechanical stability 有权
公开(公告)号：US08606352B2
公开(公告)日：2013-12-10
申请号：US12576488
申请日：2009-10-09
申请人： Taraneh Ghaffari Farazi , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0215 , A61B5/029 , A61B5/0295 , A61B5/0422 , A61B5/0535 , A61B5/1107 , A61B5/1459 , A61B5/6852 , A61B5/7264 , A61B7/023 , A61B2562/0219 , A61N1/3622 , A61N1/36521 , A61N1/37258 , A61N1/3962
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

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