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1. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

2. 发明授权

US09162067B1 Methods and devices for monitoring myocardial electro-mechanical stability 有权
标题翻译：监测心肌机电稳定性的方法和装置
公开(公告)号：US09162067B1
公开(公告)日：2015-10-20
申请号：US11925273
申请日：2007-10-26
申请人： Taraneh Ghaffari Farazi , Eric Falkenberg , Euljoon Park
发明人： Taraneh Ghaffari Farazi , Eric Falkenberg , Euljoon Park
IPC分类号： A61N1/365 , A61N1/37 , A61B5/0452 , A61N1/362
CPC分类号： A61N1/3702 , A61B5/02028 , A61B5/0452 , A61B5/4836 , A61B5/686 , A61N1/3627 , A61N1/36514
摘要： Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial electro-mechanical stability, and responding to the same. One or more signal indicative of electrical functioning of a patient's heart is obtained, as is one or more signal indicative of mechanical functioning of the patient's heart. The patient's myocardial electrical stability is monitored based on the one or more signal indicative of electrical functioning of the patient's heart, and the patient's myocardial mechanical stability is monitored based on the one or more signal indicative of mechanical functioning of the patient's heart. Based on both the myocardial electrical stability and myocardial mechanical stability, the patient's risk of an adverse cardiac event is monitored. Further, when the patient is at risk of an adverse cardiac event, a response is triggered that is specific to both the myocardial electrical stability and the myocardial mechanical stability. This abstract is not intended to be a complete description of, or limit the scope of, the invention.
摘要翻译：本发明的实施例涉及可植入系统及其使用的方法，用于监测心肌电 - 机械稳定性并对其进行响应。获得指示患者心脏的电功能的一个或多个信号，以及指示患者心脏的机械功能的一个或多个信号。基于指示患者心脏的电功能的一个或多个信号来监测患者的心肌电稳定性，并且基于指示患者心脏的机械功能的一个或多个信号监测患者的心肌机械稳定性。基于心肌电稳定性和心肌机械稳定性，监测患者心脏不良事件的风险。此外，当患者处于不良心脏事件的风险时，触发与心肌电稳定性和心肌机械稳定性特异性的反应。本摘要不是对本发明的完整描述或限制本发明的范围。

3. 发明申请

US20100280348A1 METHOD AND IMPLANTABLE SYSTEM FOR BLOOD-GLUCOSE CONCENTRATION MONITORING USING PARALLEL METHODOLOGIES 有权
标题翻译：使用并行方法对血液葡萄糖浓度监测的方法和可植入系统
公开(公告)号：US20100280348A1
公开(公告)日：2010-11-04
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

4. 发明授权

US07580747B1 Inducing premature atrial contractions for the purpose of monitoring autonomic tone, risk of sudden cardiac death and ischemic events 有权
标题翻译：诱发早产性心房收缩以监测自主神经紧张，心源性猝死和缺血事件的风险
公开(公告)号：US07580747B1
公开(公告)日：2009-08-25
申请号：US11181719
申请日：2005-07-13
申请人： Taraneh Ghaffari Farazi , Eric Falkenberg
发明人： Taraneh Ghaffari Farazi , Eric Falkenberg
IPC分类号： A61N1/362 , A61B5/0452
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/02405 , A61B5/0452 , A61B5/0468 , A61B5/4035 , A61B5/7275 , A61N1/36114 , A61N1/3627 , A61N1/36585 , A61N1/3702 , G06F19/00
摘要： Implantable systems, and methods for use therein, perform at least one of a cardiac assessment and an autonomic assessment. Premature atrial contractions (PACs) are induced to thereby cause corresponding premature contractions in the ventricles. Short-term fluctuations in cardiac intervals, that follow the premature contractions in the ventricles caused by the induced PACs, are monitored. At least one of a cardiac assessment and an autonomic assessment is performed based on the monitored fluctuations in cardiac intervals that follow the premature contractions in the ventricles caused by the induced PACs. This can include assessing a patient's risk of sudden cardiac death (SCD), assessing a patient's autonomic tone and/or detecting myocardial ischemic events based on the monitored fluctuations in cardiac intervals that follow the premature contractions in the ventricles caused by the induced PACs.
摘要翻译：可植入系统及其中使用的方法执行心脏评估和自主评估中的至少一个。引起早产性心房收缩（PAC），从而引起心室相应的过早收缩。监测由诱导的PAC引起的脑室过早收缩的心脏间隔的短期波动。基于受诱导PAC引起的心室过早收缩后心脏间隔的监测波动，进行心脏评估和自主评估中的至少一个。这可以包括评估患者心源性猝死（SCD）的风险，评估患者的自主神经紧张和/或基于由诱导的PAC引起的脑室过早收缩后监测的心脏间隔波动来检测心肌缺血事件。

5. 发明授权

US07236829B1 Implantable leadless cardiac device with flexible flaps for sensing 失效
标题翻译：可植入无铅心脏装置，具有灵活的襟翼进行感应
公开(公告)号：US07236829B1
公开(公告)日：2007-06-26
申请号：US10931784
申请日：2004-08-30
申请人： Taraneh Ghaffari Farazi , Eric Falkenberg
发明人： Taraneh Ghaffari Farazi , Eric Falkenberg
IPC分类号： A61N1/372
CPC分类号： A61N1/375 , A61N1/05 , A61N1/3752 , A61N1/3756
摘要： A technique for performing sensing operations in the body subcutaneously employs, in combination, the housing of an electrical stimulator such as a pacemaker or an implantable cardioverter defibrillator and an integral flap member of flexible insulative sheet material which has at least one arm projecting away therefrom to an extreme tip end. Each arm is rolled about itself from the tip end on a lateral axis transverse of the longitudinal axis of the arm into a compact unit adjacent the housing. An incision is made through the skin and a region beneath the skin enlarged to form a cavity. The compact unit is then inserted into the cavity and unrolled about the lateral axis of each arm so as to be laid flat under the skin. When positioned into a desired orientation, each flap member is sutured to the skin to maintain the desired orientation.
摘要翻译：用于在体内执行感测操作的技术组合地使用诸如起搏器或可植入心律转复除颤器的电刺激器的壳体和柔性绝缘片材的整体折片构件，所述折叠构件具有从其突出的至少一个臂，一个极端的尖端。每个臂在从臂的纵向轴线横向的横向轴线上的尖端自身卷绕成邻近壳体的紧凑单元。通过皮肤进行切口，并且皮肤下方的区域扩大以形成腔。然后将紧凑单元插入空腔中并围绕每个臂的横向轴线展开，以便平铺在皮肤下方。当定位成期望的取向时，每个襟翼构件被缝合到皮肤以保持期望的取向。

6. 发明授权

US08548589B2 Inducing premature atrial contractions for the purpose of monitoring autonomic tone risk of sudden cardiac death and ischemic events 有权
标题翻译：诱发早产性心房收缩以监测心源性猝死和缺血事件的自主神经风险
公开(公告)号：US08548589B2
公开(公告)日：2013-10-01
申请号：US12504506
申请日：2009-07-16
申请人： Taraneh Ghaffari Farazi , Eric Falkenberg
发明人： Taraneh Ghaffari Farazi , Eric Falkenberg
IPC分类号： A61N1/362 , A61B5/0452 , A61N1/365
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/02405 , A61B5/0452 , A61B5/0468 , A61B5/4035 , A61B5/7275 , A61N1/36114 , A61N1/3627 , A61N1/36585 , A61N1/3702 , G06F19/00
摘要： Implantable systems, and methods for use therein, perform at least one of a cardiac assessment and an autonomic assessment. Premature atrial contractions (PACs) are induced to thereby cause corresponding premature contractions in the ventricles. Short-term fluctuations in cardiac intervals, that follow the premature contractions in the ventricles caused by the induced PACs, are monitored. At least one of a cardiac assessment and an autonomic assessment is performed based on the monitored fluctuations in cardiac intervals that follow the premature contractions in the ventricles caused by the induced PACs. This can include assessing a patient's risk of sudden cardiac death (SCD), assessing a patient's autonomic tone and/or detecting myocardial ischemic events based on the monitored fluctuations in cardiac intervals that follow the premature contractions in the ventricles caused by the induced PACs.
摘要翻译：可植入系统及其中使用的方法执行心脏评估和自主评估中的至少一个。引起早产性心房收缩（PAC），从而引起心室相应的过早收缩。监测由诱导的PAC引起的脑室过早收缩的心脏间隔的短期波动。基于受诱导PAC引起的心室过早收缩后心脏间隔的监测波动，进行心脏评估和自主评估中的至少一个。这可以包括评估患者心源性猝死（SCD）的风险，评估患者的自主神经紧张和/或基于由诱导的PAC引起的脑室过早收缩后监测的心脏间隔波动来检测心肌缺血事件。

7. 发明申请

US20090281440A1 INDUCING PREMATURE ATRIAL CONTRACTIONS FOR THE PURPOSE OF MONITORING AUTONOMIC TONE RISK OF SUDDEN CARDIAC DEATH AND ISCHEMIC EVENTS 有权
标题翻译：诱导针对监测自发性风湿病心血管疾病和化疗事件的目的的预防性手术合同
公开(公告)号：US20090281440A1
公开(公告)日：2009-11-12
申请号：US12504506
申请日：2009-07-16
申请人： Taraneh Ghaffari Farazi , Eric Falkenberg
发明人： Taraneh Ghaffari Farazi , Eric Falkenberg
IPC分类号： A61B5/0402
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/02405 , A61B5/0452 , A61B5/0468 , A61B5/4035 , A61B5/7275 , A61N1/36114 , A61N1/3627 , A61N1/36585 , A61N1/3702 , G06F19/00
摘要： Implantable systems, and methods for use therein, perform at least one of a cardiac assessment and an autonomic assessment. Premature atrial contractions (PACs) are induced to thereby cause corresponding premature contractions in the ventricles. Short-term fluctuations in cardiac intervals, that follow the premature contractions in the ventricles caused by the induced PACs, are monitored. At least one of a cardiac assessment and an autonomic assessment is performed based on the monitored fluctuations in cardiac intervals that follow the premature contractions in the ventricles caused by the induced PACs. This can include assessing a patient's risk of sudden cardiac death (SCD), assessing a patient's autonomic tone and/or detecting myocardial ischemic events based on the monitored fluctuations in cardiac intervals that follow the premature contractions in the ventricles caused by the induced PACs.
摘要翻译：可植入系统及其中使用的方法执行心脏评估和自主评估中的至少一个。引起早产性心房收缩（PAC），从而引起心室相应的过早收缩。监测由诱导的PAC引起的脑室过早收缩的心脏间隔的短期波动。基于受诱导PAC引起的心室过早收缩后心脏间隔的监测波动，进行心脏评估和自主评估中的至少一个。这可以包括评估患者心源性猝死（SCD）的风险，评估患者的自主神经紧张和/或基于由诱导的PAC引起的脑室过早收缩后监测的心脏间隔波动来检测心肌缺血事件。

8. 发明授权

US07844333B1 Pacing therapy for transient ischemia treatment 有权
标题翻译：起搏治疗短暂性脑缺血治疗
公开(公告)号：US07844333B1
公开(公告)日：2010-11-30
申请号：US11736155
申请日：2007-04-17
申请人： Steve Koh , Euljoon Park , Eric Falkenberg
发明人： Steve Koh , Euljoon Park , Eric Falkenberg
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0452 , A61N1/365
摘要： Embodiments include methods and devices for detecting ischemia in a patient and treating the ischemia with a pacing therapy that increases cardiac efficiency, output, or both, without substantially increasing myocardial oxygen consumption. Such therapy may also be used to mitigate the adverse effects of decreased blood flow to the ischemic tissue by increasing the blood flow an oxygenation thereto.
摘要翻译：实施方案包括用于检测患者局部缺血的方法和装置，并且通过起搏治疗来治疗缺血，其提高心脏效率，输出或两者，而不显着增加心肌耗氧量。这种治疗也可用于通过增加血流对其的氧合来减轻血液流向缺血组织的不利影响。

9. 发明授权

US06788970B1 System and method for treating vasovagal syncope using cardiac pacing 失效
标题翻译：使用心脏起搏治疗血管迷走性晕厥的系统和方法
公开(公告)号：US06788970B1
公开(公告)日：2004-09-07
申请号：US10132044
申请日：2002-04-24
申请人： Euljoon Park , Alan H. Kadish , Eric Falkenberg
发明人： Euljoon Park , Alan H. Kadish , Eric Falkenberg
IPC分类号： A61B1365
CPC分类号： A61N1/368
摘要： A pacemaker or other cardiac stimulation device is configured to predict the onset of vasovagal syncope and administers pacing therapy to prevent the syncope from occurring. Prediction of the onset of vasovagal syncope is based upon an analysis of the contractility of the heart muscle. In an example described herein, the contractility of the heart muscle is detected and compared with the average contractility. If the current contractility exceeds the average contractility by a predetermined threshold, a high risk of vasovagal syncope is thereby detected and the heart is paced at a vasovagal syncope prevention rate which may be, for example, 20 to 40 beats per minute faster than a previous heart rate. The contractility of the heart is determined, for example, by measuring the impedance of the heart tissue, by measuring the movement of heart tissue in the wall of the heart, by pressure using an accelerometer, or based on an electrogram signal. The contractility is averaged over a period of time to determine the average contractility.
摘要翻译：起搏器或其他心脏刺激装置被配置为预测血管迷走性晕厥的发作并施用起搏治疗以防止发生晕厥。血管迷走性晕厥发作的预测是基于对心肌收缩力的分析。在本文描述的示例中，检测心肌的收缩性并将其与平均收缩性进行比较。如果目前的收缩力超过平均收缩力达到预定阈值，则由此检测到血管迷走性晕厥的高风险，并且心脏以血管迷走性晕厥预防率进行起搏，其速率可以比例如以前的速度快20至40次/分钟心率。通过使用加速计的压力或基于电描记图信号测量心脏的心脏组织的心脏移动，通过测量心脏组织的阻抗来确定心脏的收缩性。收缩性在一段时间内平均以确定平均收缩性。

10. 发明授权

US06741885B1 Implantable cardiac device for managing the progression of heart disease and method 有权
标题翻译：用于管理心脏疾病进展的植入式心脏装置和方法
公开(公告)号：US06741885B1
公开(公告)日：2004-05-25
申请号：US09908179
申请日：2001-07-17
申请人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
发明人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
IPC分类号： A61B504
CPC分类号： A61N1/3627 , A61N1/36514
摘要： An implantable cardiac device detects a progression or regression in heart disease such as congestive heart failure. An activity sensor and a respiration sensor generate raw signals indicative of the patient's activity level and respiration level. Degradation or improvement of the patient's activity and respiration over a predetermined time corresponds to an indication of the progression or regression of the heart disease. A processor coupled to the sensors is programmed to process the raw sensor signals over the predetermined time and stores the processed sensor signals in a memory having a data storage area. A telemetry circuit coupled to the memory is configured to transmit the stored sensor signals to an external monitor for subsequent display. The processor further controls pacing of the heart, adjusts pacing therapy responsive to the process signals, and process the raw respiration signals when the patient is in a number of different active states.
摘要翻译：可植入的心脏装置检测心脏病的进展或消退，例如充血性心力衰竭。活动传感器和呼吸传感器产生指示患者的活动水平和呼吸水平的原始信号。在预定时间内降低或改善患者的活动和呼吸对应于心脏病的进展或消退的指征。耦合到传感器的处理器被编程为在预定时间内处理原始传感器信号，并将经处理的传感器信号存储在具有数据存储区域的存储器中。耦合到存储器的遥测电路被配置为将存储的传感器信号发送到外部监视器用于随后的显示。处理器进一步控制心脏的起搏，响应于过程信号调整起搏治疗，并且当患者处于多个不同的活动状态时处理原始呼吸信号。

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