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1. 发明授权

US07819810B2 Multiplanar ultrasonic vascular sensor assembly, system and methods employing same, apparatus for movably affixing a sensor assembly to a body and associated methods 有权
标题翻译：多平面超声波血管传感器组件，使用其的系统和方法，用于将传感器组件可移动地附接到身体的装置和相关方法
公开(公告)号：US07819810B2
公开(公告)日：2010-10-26
申请号：US10911860
申请日：2004-08-03
申请人： Bradley J. Stringer , Gary A. Simmons , Douglas A. Christensen , Shayne Messerly , Cameron P. Ford , Robert W. Evensen
发明人： Bradley J. Stringer , Gary A. Simmons , Douglas A. Christensen , Shayne Messerly , Cameron P. Ford , Robert W. Evensen
IPC分类号： A61B8/00
CPC分类号： A61B8/0841 , A61B5/489 , A61B8/06 , A61B8/0833 , A61B8/13 , A61B8/145 , A61B8/42 , A61B8/4227 , A61B8/4455
摘要： An apparatus, method and system for cannulation of blood vessels. The apparatus comprises a sensor assembly including two linear transducer arrays oriented perpendicular to each other to form a “T” shape to provide ultrasound images of at least one blood vessel in a portion of a patient's body in two perpendicular planes. The sensor assembly may have graphic markings on an exterior surface thereof to facilitate orientation of the sensor assembly on the patient and guidance of a needle toward a desired target vessel during the cannulation procedure. The sensor assembly may also include an associated structure to cooperate with a reference location element to place, align and secure the sensor assembly to the patient's skin at a desired location.
摘要翻译：用于插管血管的装置，方法和系统。该装置包括传感器组件，其包括彼此垂直定向以形成“T”形状的两个线性换能器阵列，以在两个垂直平面中的患者身体的一部分中提供至少一个血管的超声图像。传感器组件可以在其外表面上具有图形标记，以便于在插管过程期间传感器组件在患者身上的取向和针朝向期望的目标血管的引导。传感器组件还可以包括相关联的结构，以与参考位置元件协作以将传感器组件放置，对准并将其固定到患者的皮肤上的所需位置。

2. 发明授权

US07214191B2 Multiplanar ultrasonic vascular imaging device, system incorporating same, method of use and protective sheath 有权
标题翻译：多平面超声波血管成像装置，系统结合，使用方法和护套
公开(公告)号：US07214191B2
公开(公告)日：2007-05-08
申请号：US10872699
申请日：2004-06-21
申请人： Bradley J. Stringer , Gary A. Simmons , Douglas A. Christensen , Shayne Messerly , Cameron P. Ford , Robert W. Evensen
发明人： Bradley J. Stringer , Gary A. Simmons , Douglas A. Christensen , Shayne Messerly , Cameron P. Ford , Robert W. Evensen
IPC分类号： A61B8/14
CPC分类号： A61B8/0841 , A61B5/489 , A61B8/06 , A61B8/0833 , A61B8/13 , A61B8/145 , A61B8/42 , A61B8/4227 , A61B8/4455
摘要： An apparatus, method, system, component kit and protective sheath for cannulation of blood vessels are disclosed. The apparatus comprises a sensor assembly to provide ultrasound images of at least one blood vessel in a portion of a patient's body in two perpendicular planes. The sensor assembly may have graphic markings on an exterior surface thereof to facilitate orientation of the sensor assembly on the patient and guidance of a needle towards a desired target vessel during the cannulation procedure. The sensor assembly may also include associated structure to cooperate with a reference location element to place, align and secure the sensor assembly to the patient's skin at a desired location.
摘要翻译：公开了一种用于血管插管的装置，方法，系统，部件套件和护套。该装置包括传感器组件，以在两个垂直平面中的患者身体的一部分中提供至少一个血管的超声图像。传感器组件可以在其外表面上具有图形标记，以便于在插管过程期间传感器组件在患者身上的取向和针朝向期望的目标血管的引导。传感器组件还可以包括相关联的结构，以与参考位置元件配合，以将传感器组件放置，对准并将其固定到患者的皮肤上的所需位置。

3. 发明授权

US06755789B2 Ultrasonic vascular imaging system and method of blood vessel cannulation 有权
标题翻译：超声血管成像系统及血管插管方法
公开(公告)号：US06755789B2
公开(公告)日：2004-06-29
申请号：US10072662
申请日：2002-02-05
申请人： Bradley J. Stringer , Gary A. Simmons , Douglas A. Christensen , Shayne Messerly , Cameron P. Ford , Robert W. Evensen
发明人： Bradley J. Stringer , Gary A. Simmons , Douglas A. Christensen , Shayne Messerly , Cameron P. Ford , Robert W. Evensen
IPC分类号： A61B814
CPC分类号： A61B8/0841 , A61B5/489 , A61B8/06 , A61B8/0833 , A61B8/13 , A61B8/145 , A61B8/42 , A61B8/4227 , A61B8/4455
摘要： An apparatus, method and system for cannulation of blood vessels. The apparatus comprises a sensor assembly including two linear transducer arrays oriented perpendicularly to each other to form a “T” shape to provide substantially simultaneous ultrasound images of at least one blood vessel in a portion of a patient's body in two perpendicular planes. The apparatus may also include one or more Doppler transducer elements to transmit and receive one or more Doppler beams at an incident angle beneath one of the transducer arrays and in alignment therewith to determine blood flow direction and velocity within the at least one blood vessel. The sensor assembly may be disposed within an elongated, flexible, protective sheath and secured to a graphically marked cover to facilitate orientation of the sensor assembly on the patient and guidance of a needle towards a desired target vessel during the cannulation procedure. The cover may also include associated structure to cooperate with a reference location element to place, align and secure the sensor assembly to the patient's skin at a desired location.
摘要翻译：用于插管血管的装置，方法和系统。该装置包括传感器组件，其包括彼此垂直取向以形成“T”形状的两个线性换能器阵列，以在两个垂直平面中的患者身体的一部分中提供至少一个血管的基本上同时的超声图像。所述装置还可以包括一个或多个多普勒换能器元件，以在所述换能器阵列中的一个的入射角度下发射和接收一个或多个多普勒波束并与其对准，以确定所述至少一个血管内的血流方向和速度。传感器组件可以设置在细长的，柔性的保护性护套内并且固定到图形标记的盖子上，以便于在插管过程期间传感器组件在患者身上的取向并且针朝向期望的目标血管的引导。盖还可以包括相关联的结构，以与参考位置元件配合，以将传感器组件放置，对准并将其固定到患者的皮肤上的所需位置。

4. 发明授权

US06242267B1 Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays 失效
标题翻译：用于多分析物均匀荧光免疫测定的振荡装置和方法
公开(公告)号：US06242267B1
公开(公告)日：2001-06-05
申请号：US09142946
申请日：1998-09-18
申请人： James N. Herron , Douglas A. Christensen , Scott D. Miles
发明人： James N. Herron , Douglas A. Christensen , Scott D. Miles
IPC分类号： G01N33552
CPC分类号： G01N33/54386 , G01N33/54373 , Y10S435/808 , Y10S436/807
摘要： An apparatus and method for rapidly analyzing samples for analytes of interest by an homogeneous immunofluorescence assay. The apparatus includes a sample test cartridge having a high control sample section, a low control sample section, and at least one test sample section. Each of these sections contain at least one pre-loaded reagent housed in a well within the cartridge wherein the low control sample section contains a known low amount of an analyte of interest and the high control sample section contains a known high amount of an analyte of interest. The cartridge includes a biosensor comprising a planar waveguide having first and second parallel plane surfaces and an edge extending between them, the edge having a receiving region for receiving a light beam. Each of the high control sample section, the low control sample section, and the test sample control sections have a well which includes a waveguide surface, wherein the contents of each section contacts capture molecules immobilized on the waveguide surface. The capture molecules are configured to specifically bind a chosen analyte and fluoresce when interacting with light passing through the waveguide surface. The concentration of said analyte of interest in said sample fluid is determined by a comparison of intensities of fluorescence of between said capture molecule areas of said sample capture molecule well, said low control capture molecule well, and said high control capture molecule well.
摘要翻译：用于通过均匀免疫荧光测定快速分析感兴趣的分析物的样品的装置和方法。该装置包括具有高控制样品部分，低对照样品部分和至少一个测试样品部分的样品测试盒。这些部分中的每一个包含至少一个预先加载的试剂，其容纳在筒内的孔中，其中低对照样品部分含有已知的低量感兴趣的分析物，并且高对照样品部分含有已知的大量分析物利益。所述盒包括生物传感器，所述生物传感器包括具有第一和第二平行平面的平面波导和在它们之间延伸的边缘，所述边缘具有用于接收光束的接收区域。高控制采样部分，低控制样品部分和测试样品控制部分中的每一个具有包括波导表面的阱，其中每个部分的内容物接触固定在波导表面上的捕获分子。捕获分子被配置为特异性地结合所选择的分析物并且当与通过波导表面的光相互作用时发出荧光。通过比较所述样品捕获分子阱的所述捕获分子区域，所述低对照捕获分子阱和所述高对照捕获分子阱之间的荧光强度来确定所述样品流体中所述目标分析物的浓度。

5. 外观设计

USD426783S Waveguide lens 失效
公开(公告)号：USD426783S
公开(公告)日：2000-06-20
申请号：US103670
申请日：1999-04-19
申请人： Douglas A. Christensen , James N. Herron , Eric M. Simon
设计人： Douglas A. Christensen , James N. Herron , Eric M. Simon

6. 发明授权

US5846842A Waveguide immunosensor with coating chemistry and providing enhanced sensitivity 失效
公开(公告)号：US5846842A
公开(公告)日：1998-12-08
申请号：US640141
申请日：1996-04-30
申请人： James N. Herron , Douglas A. Christensen , Karin D. Caldwell , Vera Janatova , Shao-Chie Huang , Hsu-Kun Wang
发明人： James N. Herron , Douglas A. Christensen , Karin D. Caldwell , Vera Janatova , Shao-Chie Huang , Hsu-Kun Wang
IPC分类号： G01N21/25 , G01N21/55 , G01N21/64 , G01N21/77 , G01N33/543 , G01N33/552
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.

7. 发明授权

US07022515B2 Waveguide immunosensor with coating chemistry and providing enhanced sensitivity 失效
公开(公告)号：US07022515B2
公开(公告)日：2006-04-04
申请号：US09971467
申请日：2001-10-05
申请人： James N. Herron , Douglas A. Christensen , Karin D. Caldwell , Vera Janatová , Shao-Chie Huang , Hsu-Kun Wang
发明人： James N. Herron , Douglas A. Christensen , Karin D. Caldwell , Vera Janatová , Shao-Chie Huang , Hsu-Kun Wang
IPC分类号： C12M3/00
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/54373 , Y10S435/808 , Y10S436/805
摘要： Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.

8. 发明授权

US06611634B2 Lens and associatable flow cell 有权
公开(公告)号：US06611634B2
公开(公告)日：2003-08-26
申请号：US10095540
申请日：2002-03-11
申请人： James N. Herron , Douglas A. Christensen , Victor A. Pollak , Richard D. McEachern , Eric M. Simon
发明人： James N. Herron , Douglas A. Christensen , Victor A. Pollak , Richard D. McEachern , Eric M. Simon
IPC分类号： G02B600
CPC分类号： G01N21/0303 , G01N21/05 , G01N2021/0346 , G01N2021/058
摘要： Improvements in a biosensor are disclosed. A biosensor includes a waveguide, at least a portion of which is substantially planar. One or more reservoirs may be formed adjacent to a chemistry-bearing surface of the waveguide. The biosensor may include a gasket to form a seal between the waveguide and side walls of the reservoir. A sample solution may be introduced into the reservoir or otherwise onto the surface of a waveguide through an input port. Waveguides of varying composition (e.g., plastic, quartz, glass, or other suitable waveguide materials) may be used in the biosensor. Also disclosed is a sled-shaped waveguide, which includes a planar portion and a lens at an end thereof and angled relative thereto for coupling light into the waveguide.

9. 发明授权

US5814565A Integrated optic waveguide immunosensor 失效
公开(公告)号：US5814565A
公开(公告)日：1998-09-29
申请号：US393450
申请日：1995-02-23
申请人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
发明人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
IPC分类号： G01N21/64 , G01N21/05 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/53 , G01N21/17
CPC分类号： G01N33/54373 , G01N21/648 , G01N21/7703 , G01N21/05
摘要： A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one embodiment, the substrate is silicon dioxide and the thin film is silicon oxynitride. Specific binding molecules having the property of binding with specificity to an analyte are immobilized on the surface of the thin film channels. In preferred embodiments, the composite waveguide further includes light input coupling means integrally adapted to the thin film channels. Such light coupling means can be a grating etched into the substrate prior to deposition of the thin film, or a waveguide coupler affixed to the upper surface of the thin film. The waveguide coupler has a thick input waveguide of high refractive index which receives the laser light through one end and propagates it by total internal reflection. The propagated light is then coupled evanescently into the thin film waveguide across a spacer layer of precise thickness and having an index of refraction lower than either the input waveguide or the thin-film waveguide. The composite waveguide can be constructed by plasma vapor deposition of silicon oxynitride onto the silicon dioxide substrate, masking the channel waveguides with a photoresist, and using reactive ion etching to expose the substrate in the unmasked regions.

10. 发明授权

US5751415A Raman spectroscopy apparatus and method for continuous chemical analysis of fluid streams 失效
标题翻译：拉曼光谱仪和流体流连续化学分析方法
公开(公告)号：US5751415A
公开(公告)日：1998-05-12
申请号：US647586
申请日：1996-05-13
申请人： Lee M. Smith , Robert E. Benner , Douglas A. Christensen , Joel M. Harris , Carl W. Johnson , Richard D. Rallison
发明人： Lee M. Smith , Robert E. Benner , Douglas A. Christensen , Joel M. Harris , Carl W. Johnson , Richard D. Rallison
IPC分类号： G01J3/02 , G01J3/18 , G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/18 , G01J3/44 , G01N21/65 , G01N2021/651 , G01N21/658
摘要： Apparatus and methods for analyzing the chemical composition of fluid streams using Raman spectroscopy are disclosed. The invention is particularly useful in continuously analyzing a fluid stream containing petroleum products, aqueous or biological fluids. The apparatus includes a laser source for producing light having an excitation wavelength. The light is introduced into a bundle of optical fibers connected to a tubular Raman enhancement cell. A transparent optical element (lens and/or window) acts as a barrier element to isolate the flowing sample stream from the optical components. The Raman enhancement cell is configured to allow continuous sample fluid flow therethrough, and it is preferably lined with a material having an index of refraction less than the index of refraction of the fluid stream. Scattered light from the enhancement cell preferably exits the optical fibers as a linear optical signal. A Raman spectrometer passes the optical signal through an excitation wavelength filter, an optical slit, and a volume holographic transmission grating with an aberration correction device before transmitting the optical signal to a charge coupled device array which converts the optical signal into a corresponding electronic signal. The electronic signal is analyzed and converted by computer into a representation of the chemical analysis of the fluid stream.
摘要翻译：公开了使用拉曼光谱分析流体流的化学组成的装置和方法。本发明特别可用于连续分析含有石油产品，含水或生物流体的流体物流。该装置包括用于产生具有激发波长的光的激光源。将光引入连接到管状拉曼增强单元的一束光纤中。透明光学元件（透镜和/或窗口）用作屏障元件以将流动的样品流与光学部件隔离。拉曼增强单元被配置为允许连续的样品流体流过其中，并且其优选地衬有折射率小于流体流的折射率的材料。来自增强细胞的散射光优选作为线性光信号离开光纤。拉曼光谱仪将光信号通过激发波长滤波器，光学狭缝和具有像差校正装置的体积全息透射光栅，然后将光信号传输到将光信号转换成相应的电子信号的电荷耦合器件阵列。电子信号由计算机分析和转换成流体流的化学分析的表示。

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