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1. 发明授权

US06248542B1 Optoelectronic sensor 有权
标题翻译：光电传感器
公开(公告)号：US06248542B1
公开(公告)日：2001-06-19
申请号：US09169196
申请日：1998-10-09
申请人： Todd H. Rider , Laura Smith
发明人： Todd H. Rider , Laura Smith
IPC分类号： G01N33552
CPC分类号： G01N21/6454 , G01N21/76 , G01N21/77 , G01N33/54366 , G01N33/554 , G01N33/56972 , G01N33/582 , G01N2021/6482 , G01N2021/7786 , Y10S435/808 , Y10S436/805
摘要： A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.
摘要翻译：用于检测抗原存在的装置，包括（1）具有在细胞表面上表达且对待检测抗原特异的抗体的细胞，其中抗原与抗体的结合导致钙的增加浓度在细胞的细胞溶质中，细胞还具有发射分子，其响应于细胞质中钙浓度的增加而发射光子; （2）用于接收抗原的液体培养基，其中浸泡细胞; 和（3）布置成用于接收从该单元发射的光子的光学检测器。

2. 发明授权

US06677163B1 Functionalized silicon surfaces, and method for their production 失效
标题翻译：功能化硅表面及其生产方法
公开(公告)号：US06677163B1
公开(公告)日：2004-01-13
申请号：US09713300
申请日：2000-11-16
申请人： Rabah Boukherroub , Danial D. M. Wayner , James Wojtyk
发明人： Rabah Boukherroub , Danial D. M. Wayner , James Wojtyk
IPC分类号： G01N33552
CPC分类号： C07H15/26 , G01N33/54353 , G01N33/552 , Y10S436/823
摘要： Provided is a method for modifying silicon with an organic molecule, under mild conditions. If the attached molecule is bi-functional, it may be subsequently reacted with a bio-molecule, to form a covalently attached layer of bio-molecule on the silicon surface.
摘要翻译：提供了在温和条件下用有机分子改性硅的方法。如果连接的分子是双功能的，则其可以随后与生物分子反应，以在硅表面上形成共价连接的生物分子层。

3. 发明授权

US06242267B1 Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays 失效
标题翻译：用于多分析物均匀荧光免疫测定的振荡装置和方法
公开(公告)号：US06242267B1
公开(公告)日：2001-06-05
申请号：US09142946
申请日：1998-09-18
申请人： James N. Herron , Douglas A. Christensen , Scott D. Miles
发明人： James N. Herron , Douglas A. Christensen , Scott D. Miles
IPC分类号： G01N33552
CPC分类号： G01N33/54386 , G01N33/54373 , Y10S435/808 , Y10S436/807
摘要： An apparatus and method for rapidly analyzing samples for analytes of interest by an homogeneous immunofluorescence assay. The apparatus includes a sample test cartridge having a high control sample section, a low control sample section, and at least one test sample section. Each of these sections contain at least one pre-loaded reagent housed in a well within the cartridge wherein the low control sample section contains a known low amount of an analyte of interest and the high control sample section contains a known high amount of an analyte of interest. The cartridge includes a biosensor comprising a planar waveguide having first and second parallel plane surfaces and an edge extending between them, the edge having a receiving region for receiving a light beam. Each of the high control sample section, the low control sample section, and the test sample control sections have a well which includes a waveguide surface, wherein the contents of each section contacts capture molecules immobilized on the waveguide surface. The capture molecules are configured to specifically bind a chosen analyte and fluoresce when interacting with light passing through the waveguide surface. The concentration of said analyte of interest in said sample fluid is determined by a comparison of intensities of fluorescence of between said capture molecule areas of said sample capture molecule well, said low control capture molecule well, and said high control capture molecule well.
摘要翻译：用于通过均匀免疫荧光测定快速分析感兴趣的分析物的样品的装置和方法。该装置包括具有高控制样品部分，低对照样品部分和至少一个测试样品部分的样品测试盒。这些部分中的每一个包含至少一个预先加载的试剂，其容纳在筒内的孔中，其中低对照样品部分含有已知的低量感兴趣的分析物，并且高对照样品部分含有已知的大量分析物利益。所述盒包括生物传感器，所述生物传感器包括具有第一和第二平行平面的平面波导和在它们之间延伸的边缘，所述边缘具有用于接收光束的接收区域。高控制采样部分，低控制样品部分和测试样品控制部分中的每一个具有包括波导表面的阱，其中每个部分的内容物接触固定在波导表面上的捕获分子。捕获分子被配置为特异性地结合所选择的分析物并且当与通过波导表面的光相互作用时发出荧光。通过比较所述样品捕获分子阱的所述捕获分子区域，所述低对照捕获分子阱和所述高对照捕获分子阱之间的荧光强度来确定所述样品流体中所述目标分析物的浓度。

4. 发明授权

US06667180B2 Method of assaying pyrrole-containing biological compounds 失效
标题翻译：测定含吡咯生物化合物的方法
公开(公告)号：US06667180B2
公开(公告)日：2003-12-23
申请号：US09970328
申请日：2001-10-03
申请人： Jeffrey D. Brady , Simon P. Robins
发明人： Jeffrey D. Brady , Simon P. Robins
IPC分类号： G01N33552
CPC分类号： C07D495/04 , G01N33/6887 , Y10S436/815 , Y10T436/145555
摘要： This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method. The method involves contacting a biological compound with one of: a) a bound or bindable derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a detectable molecule which forms a complex with the reaction product; or b) a derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a bound binding agent specific to the biological compound in the reaction product; or c) a binding agent specific to the biological compound, followed by exposure to a derivatizing agent which forms a reaction product with the biological compound, and determining the amount of bound biological compound. There is also provided a method of preparing an antigen.
摘要翻译：本发明涉及可用于该方法的含吡咯生物化合物和化学组成的测定方法。该方法包括使生物化合物与以下物质之一接触：a）与生物化合物形成反应产物的结合或可结合的衍生化试剂，然后暴露于与反应产物形成络合物的可检测分子; orb）与生物化合物形成反应产物的衍生剂，然后暴露于反应产物中对生物化合物特异的结合结合剂; orc）对生物化合物特异性的结合剂，然后暴露于与生物化合物形成反应产物的衍生化试剂，并测定结合的生物化合物的量。还提供了制备抗原的方法。

5. 发明授权

US06485987B1 Sol-gel matrices for direct colorimetric detection of analytes 失效
标题翻译：用于直接比色检测分析物的溶胶凝胶基质
公开(公告)号：US06485987B1
公开(公告)日：2002-11-26
申请号：US09500295
申请日：2000-02-08
申请人： Deborah H. Charych , Darryl Sasaki , Stacey Yamanaka
发明人： Deborah H. Charych , Darryl Sasaki , Stacey Yamanaka
IPC分类号： G01N33552
CPC分类号： B82Y30/00 , C03C4/0007 , C03C14/008 , G01N33/54313 , G01N33/552 , Y10S436/805 , Y10S436/811 , Y10S436/815 , Y10S436/823 , Y10S436/829
摘要： The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.
摘要翻译：本发明涉及使用发生在固定的生物聚合物材料中的颜色变化直接检测分析物的方法和组合物，以响应于分析物与其表面的选择性结合。特别地，本发明提供了使用溶胶 - 凝胶法将生物聚合物材料包封在金属氧化物玻璃中的方法和组合物。

6. 发明授权

US06368877B1 Self-assembling peptide surfaces for cell patterning and interactions 失效
标题翻译：自组装肽表面用于细胞图案化和相互作用
公开(公告)号：US06368877B1
公开(公告)日：2002-04-09
申请号：US08882415
申请日：1997-06-25
申请人： Shuguang Zhang , Alexander Rich , Lin Yan , George Whitesides
发明人： Shuguang Zhang , Alexander Rich , Lin Yan , George Whitesides
IPC分类号： G01N33552
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/00743 , B82Y5/00 , B82Y10/00 , B82Y40/00 , C07K2/00 , C07K7/08 , C07K17/14 , C12N5/0068 , C12N2535/10 , C40B40/10 , C40B60/14 , G01N33/54353 , G01N2610/00 , G03F7/0002 , G03F7/165
摘要： This invention describes self assembled monolayers (SAMs) manufactured by imprinting reactive peptides onto solid supports. The invention further relates to methods of preparing and using these improved SAMs.
摘要翻译：本发明描述了通过将反应性肽印迹到固体支持物上制造的自组装单层（SAM）。本发明还涉及制备和使用这些改进的SAM的方法。

7. 发明授权

US06589799B2 Supported aldehydic silanes and method of manufacture 有权
公开(公告)号：US06589799B2
公开(公告)日：2003-07-08
申请号：US09847212
申请日：2001-05-02
申请人： Ann N. Coyne , John H. MacMillan , Michael J. Telepchak
发明人： Ann N. Coyne , John H. MacMillan , Michael J. Telepchak
IPC分类号： G01N33552
CPC分类号： C12N11/06 , C12N11/14
摘要： A method for producing a derivatized aldehydic support matrix material includes activating surface hydroxyl groups on the support matrix material and reacting the activated hydroxyl groups with an aldehydic alkoxy silane. The derivatized aldehydic support matrix material produced is useful for immobilizing bio-molecules in biological applications.

8. 发明授权

US06485986B1 Functionalized silicon surfaces 失效
标题翻译：功能化的硅表面
公开(公告)号：US06485986B1
公开(公告)日：2002-11-26
申请号：US09716614
申请日：2000-11-20
申请人： Jillian M. Buriak , Michael P. Stewart , Edward Robins
发明人： Jillian M. Buriak , Michael P. Stewart , Edward Robins
IPC分类号： G01N33552
CPC分类号： C07K17/14 , Y10S436/823 , Y10T428/31663
摘要： The present invention is directed to a silicon substrate having a monolayer formed by an electrochemically-induced reaction between silicon hydride moieties on the silicon surface and optionally substituted alkynes covalently bound to the surface of the silicon substrate and to a method for electrochemically producing such a functionalized silicon substrate. The method of forming a covalently bound monolayer on a silicon surface comprises the steps of contacting the silicon surface with a C2-C24 alkyne and electrografting optionally substituted alkynes to the silicon surface.
摘要翻译：本发明涉及具有通过硅表面上的硅氢化物部分和共价结合到硅衬底的表面上的任选取代的炔烃之间的电化学诱导反应形成的单层的硅衬底以及用于电化学生产这种官能化硅衬底。在硅表面上形成共价结合的单层的方法包括以下步骤：使硅表面与C2-C24炔烃接触，并将任选取代的炔烃电解至硅表面。

9. 发明授权

US06245578B1 Analytical apparatus 失效
标题翻译：分析仪器
公开(公告)号：US06245578B1
公开(公告)日：2001-06-12
申请号：US09027658
申请日：1998-02-23
申请人： James Oscar Molloy
发明人： James Oscar Molloy
IPC分类号： G01N33552
CPC分类号： B01F11/0034 , B01F11/0082 , G01N1/38 , G01N21/0332 , G01N21/552 , G01N2035/00534 , Y10S435/808 , Y10S436/805
摘要： An analytical apparatus comprises a biosensor device (3) which forms the base of a sample chamber. A stirrer (8) extends into the sample chamber and moves within the chamber so as to homogenize a sample contained within the chamber in contact with the biosensor (3). Movement of the stirrer (8) is preferably reciprocal movement along an axis perpendicular to the surface of the biosensor (3).
摘要翻译：分析装置包括形成样品室的基部的生物传感器装置（3）。搅拌器（8）延伸到样品室中并在室内移动，以使包含在室内的与生物传感器（3）接触的样品均匀化。搅拌器（8）的运动优选是沿着垂直于生物传感器（3）的表面的轴的往复运动。

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