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1. 发明授权

US5832165A Composite waveguide for solid phase binding assays 失效
标题翻译：用于固相结合测定的复合波导
公开(公告)号：US5832165A
公开(公告)日：1998-11-03
申请号：US705893
申请日：1996-08-28
申请人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
发明人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
IPC分类号： G01N21/77 , G01N33/543 , G02B6/12 , G02B6/34 , G02B6/10
CPC分类号： G01N21/7703 , G01N21/05 , G01N21/274 , G01N21/648 , G01N33/543 , G01N2021/058 , G01N2021/7709 , G01N2021/7763 , G01N2021/7786 , G02B2006/12038 , G02B2006/12107 , G02B2006/12173 , G02B2006/12176 , G02B6/34 , Y10S435/808 , Y10S436/805
摘要： A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one embodiment, the substrate is silicon dioxide and the thin film is silicon oxynitride. Specific binding molecules having the property of binding with specificity to an analyte are immobilized on the surface of the thin film channels. In preferred embodiments, the composite waveguide further includes light input coupling means integrally adapted to the thin film channels. Such light coupling means can be a grating etched into the substrate prior to deposition of the thin film, or a waveguide coupler affixed to the upper surface of the thin film. The waveguide coupler has a thick input waveguide of high refractive index which receives the laser light through one end and propagates it by total internal reflection. The propagated light is then coupled evanescently into the thin film waveguide across a spacer layer of precise thickness and having an index of refraction lower than either the input waveguide or the thin-film waveguide. The composite waveguide can be constructed by plasma vapor deposition of silicon oxynitride onto the silicon dioxide substrate, masking the channel waveguides with a photoresist, and using reactive ion etching to expose the substrate in the unmasked regions.
摘要翻译：在荧光结合测定中用于ev逝感测的梯度梯度复合波导包括其上沉积有一个或多个薄膜波导通道的厚基底层。在一个实施例中，衬底是二氧化硅，薄膜是氮氧化硅。具有与分析物特异性结合的特性的特异性结合分子被固定在薄膜通道的表面上。在优选实施例中，复合波导还包括与薄膜通道整体适配的光输入耦合装置。这种光耦合装置可以是在沉积薄膜之前蚀刻到基板中的光栅，或者固定到薄膜的上表面的波导耦合器。波导耦合器具有高折射率的厚输入波导，其通过一端接收激光并通过全内反射传播。然后将传播的光ev逝地穿过精确厚度的间隔层并且具有低于输入波导或薄膜波导的折射率的薄膜波导。复合波导可以通过将氧氮化硅等离子体气相沉积到二氧化硅衬底上，用光致抗蚀剂掩蔽通道波导，并且使用反应离子蚀刻来暴露未掩模区域中的衬底。

2. 发明授权

US5814565A Integrated optic waveguide immunosensor 失效
公开(公告)号：US5814565A
公开(公告)日：1998-09-29
申请号：US393450
申请日：1995-02-23
申请人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
发明人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
IPC分类号： G01N21/64 , G01N21/05 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/53 , G01N21/17
CPC分类号： G01N33/54373 , G01N21/648 , G01N21/7703 , G01N21/05
摘要： A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one embodiment, the substrate is silicon dioxide and the thin film is silicon oxynitride. Specific binding molecules having the property of binding with specificity to an analyte are immobilized on the surface of the thin film channels. In preferred embodiments, the composite waveguide further includes light input coupling means integrally adapted to the thin film channels. Such light coupling means can be a grating etched into the substrate prior to deposition of the thin film, or a waveguide coupler affixed to the upper surface of the thin film. The waveguide coupler has a thick input waveguide of high refractive index which receives the laser light through one end and propagates it by total internal reflection. The propagated light is then coupled evanescently into the thin film waveguide across a spacer layer of precise thickness and having an index of refraction lower than either the input waveguide or the thin-film waveguide. The composite waveguide can be constructed by plasma vapor deposition of silicon oxynitride onto the silicon dioxide substrate, masking the channel waveguides with a photoresist, and using reactive ion etching to expose the substrate in the unmasked regions.

3. 发明授权

US07537734B2 Integrated optic waveguide immunosensor 失效
标题翻译：集成光波导免疫传感器
公开(公告)号：US07537734B2
公开(公告)日：2009-05-26
申请号：US09973557
申请日：2001-10-10
申请人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
发明人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
IPC分类号： G01N21/00 , G01N33/53 , G01N33/552 , G01N21/55 , G01N21/41 , G02B6/00
CPC分类号： G01N33/54373 , G01N21/05 , G01N21/648 , G01N21/7703
摘要： A composite waveguide for evanescent sensing in fluorescent binding assays comprising a substrate layer having one or more thin-film waveguide channels deposited thereon. Binding molecules having the property of binding with specificity to an analyte are immobilized on the surface of the thin-film channels. In preferred embodiments, the composite waveguide includes integral light input coupling means adapted to the thin-film channels. Light coupling means may include a grating etched into the substrate prior to deposition of the thin film, or a waveguide coupler affixed to the upper surface of the thin film. The waveguide coupler has an input waveguide of high refractive index which receives the laser light through one end, propagating it by total internal reflection. Propagated light is coupled evanescently into the thin film across a spacer layer of precise thickness with a lower index of refraction than that of the input waveguide or the thin-film waveguide.
摘要翻译：一种用于荧光结合测定中的ev逝感测的复合波导，包括其上沉积有一个或多个薄膜波导通道的基底层。具有与分析物特异性结合的性质的结合分子固定在薄膜通道的表面上。在优选实施例中，复合波导包括适于薄膜通道的整体光输入耦合装置。光耦合装置可以包括在沉积薄膜之前蚀刻到衬底中的光栅，或者固定到薄膜的上表面的波导耦合器。波导耦合器具有高折射率的输入波导，其通过一端接收激光，通过全内反射传播。传播光通过具有比输入波导或薄膜波导的折射率更低的精确厚度的间隔层逐渐耦合到薄膜中。

4. 发明授权

US06350413B1 Integrated optic waveguide immunosensor 有权
标题翻译：集成光波导免疫传感器
公开(公告)号：US06350413B1
公开(公告)日：2002-02-26
申请号：US09412731
申请日：1999-10-05
申请人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
发明人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
IPC分类号： G01N3353
CPC分类号： G01N33/54373 , G01N21/05 , G01N21/648 , G01N21/7703
摘要： A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one embodiment, the substrate is silicon dioxide and the thin film is silicon oxynitride. Specific binding molecules having the property of binding with specificity to an analyte are immobilized on the surface of the thin film channels. In preferred embodiments, the composite waveguide further includes light input coupling means integrally adapted to the thin film channels. Such light coupling means can be a grating etched into the substrate prior to deposition of the thin film, or a waveguide coupler affixed to the upper surface of the thin film. The waveguide coupler has a thick input waveguide of high refractive index which receives the laser light through one end and propagates it by total internal reflection. The propagated light is then coupled evanescently into the thin film waveguide across a spacer layer of precise thickness and having an index of refraction lower than either the input waveguide or the thin-film waveguide. The composite waveguide can be constructed by plasma vapor deposition of silicon oxynitride onto the silicon dioxide substrate, masking the channel waveguides with a photoresist, and using reactive ion etching to expose the substrate in the unmasked regions.
摘要翻译：在荧光结合测定中用于ev逝感测的梯度梯度复合波导包括其上沉积有一个或多个薄膜波导通道的厚基底层。在一个实施例中，衬底是二氧化硅，薄膜是氮氧化硅。具有与分析物特异性结合的特性的特异性结合分子被固定在薄膜通道的表面上。在优选实施例中，复合波导还包括与薄膜通道整体适配的光输入耦合装置。这种光耦合装置可以是在沉积薄膜之前蚀刻到基板中的光栅，或者固定到薄膜的上表面的波导耦合器。波导耦合器具有高折射率的厚输入波导，其通过一端接收激光并通过全内反射传播。然后将传播的光ev逝地穿过精确厚度的间隔层并且具有低于输入波导或薄膜波导的折射率的薄膜波导。复合波导可以通过将氧氮化硅等离子体气相沉积到二氧化硅衬底上，用光致抗蚀剂掩蔽通道波导，并且使用反应离子蚀刻来暴露未掩模区域中的衬底。

5. 发明授权

US5961924A Integrated optic waveguide immunosensor 失效
公开(公告)号：US5961924A
公开(公告)日：1999-10-05
申请号：US961827
申请日：1997-10-31
申请人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
发明人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang
IPC分类号： G01N21/64 , G01N21/05 , G01N21/55 , G01N21/77 , G01N33/543 , G01N33/53 , G01N21/17
CPC分类号： G01N33/54373 , G01N21/648 , G01N21/7703 , G01N21/05
摘要： A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one embodiment, the substrate is silicon dioxide and the thin film is silicon oxynitride. Specific binding molecules having the property of binding with specificity to an analyte are immobilized on the surface of the thin film channels. In preferred embodiments, the composite waveguide further includes light input coupling means integrally adapted to the thin film channels. Such light coupling means can be a grating etched into the substrate prior to deposition of the thin film, or a waveguide coupler affixed to the upper surface of the thin film. The waveguide coupler has a thick input waveguide of high refractive index which receives the laser light through one end and propagates it by total internal reflection. The propagated light is then coupled evanescently into the thin film waveguide across a spacer layer of precise thickness and having an index of refraction lower than either the input waveguide or the thin-film waveguide. The composite waveguide can be constructed by plasma vapor deposition of silicon oxynitride onto the silicon dioxide substrate, masking the channel waveguides with a photoresist, and using reactive ion etching to expose the substrate in the unmasked regions.

6. 发明授权

US06911344B1 Composite waveguide for solid phase binding assays 失效
标题翻译：用于固相结合测定的复合波导
公开(公告)号：US06911344B1
公开(公告)日：2005-06-28
申请号：US09185318
申请日：1998-11-03
申请人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang , Jacob D. Durtschi
发明人： W. Monty Reichert , James N. Herron , Douglas A. Christensen , Hsu-Kun Wang , Jacob D. Durtschi
IPC分类号： G01N21/77 , G01N33/543 , G02B6/12 , G02B6/34
CPC分类号： G01N21/7703 , G01N21/05 , G01N21/274 , G01N21/648 , G01N33/543 , G01N2021/058 , G01N2021/7709 , G01N2021/7763 , G01N2021/7786 , G02B6/34 , G02B2006/12038 , G02B2006/12107 , G02B2006/12173 , G02B2006/12176 , Y10S435/808 , Y10S436/805
摘要： A step-gradient composite waveguide for evanescent sensing in fluorescent binding assays comprises a thick substrate layer having one or more thin film waveguide channels deposited thereon. In one embodiment, the substrate is silicon dioxide and the thin film is silicon oxynitride. Specific binding molecules having the property of binding with specificity to an analyte are immobilized on the surface of the thin film channels. In preferred embodiments, the composite waveguide further includes light input coupling means integrally adapted to the thin film channels. Such light coupling means can be a grating etched into the substrate prior to deposition of the thin film, or a waveguide coupler affixed to the upper surface of the thin film. The waveguide coupler has a thick input waveguide of high refractive index which receives the laser light through one end and propagates it by total internal reflection. The propagated light is then coupled evanescently into the thin film waveguide across a spacer layer of precise thickness and having an index of refraction lower than either the input waveguide or the thin-film waveguide. The composite waveguide can be constructed by plasma vapor deposition of silicon oxynitride onto the silicon dioxide substrate, masking the channel waveguides with a photoresist, and using reactive ion etching to expose the substrate in the unmasked regions.
摘要翻译：在荧光结合测定中用于ev逝感测的梯度梯度复合波导包括其上沉积有一个或多个薄膜波导通道的厚基底层。在一个实施例中，衬底是二氧化硅，薄膜是氮氧化硅。具有与分析物特异性结合的特性的特异性结合分子被固定在薄膜通道的表面上。在优选实施例中，复合波导还包括与薄膜通道整体适配的光输入耦合装置。这种光耦合装置可以是在沉积薄膜之前蚀刻到基板中的光栅，或者固定到薄膜的上表面的波导耦合器。波导耦合器具有高折射率的厚输入波导，其通过一端接收激光并通过全内反射传播。然后将传播的光ev逝地穿过精确厚度的间隔层并且具有低于输入波导或薄膜波导的折射率的薄膜波导。复合波导可以通过将氧氮化硅等离子体气相沉积到二氧化硅衬底上，用光致抗蚀剂掩蔽通道波导，并且使用反应离子蚀刻来暴露未掩模区域中的衬底。

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