专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5876970A Surfactant compositions and methods 失效
标题翻译：表面活性剂组合物和方法
公开(公告)号：US5876970A
公开(公告)日：1999-03-02
申请号：US278189
申请日：1994-07-21
申请人： Bradley J. Benson , John H. Frenz , Cynthia P. Quan , Steven Shak , Kathleen A. Shiffer , Michael C. Venuti , John T. Stults , David Lesikar
发明人： Bradley J. Benson , John H. Frenz , Cynthia P. Quan , Steven Shak , Kathleen A. Shiffer , Michael C. Venuti , John T. Stults , David Lesikar
IPC分类号： A61K35/42 , A61K38/00 , A61K38/17 , C07K1/107 , C07K14/785 , G01N33/68 , C12P21/02 , C07H21/04 , C07K14/47
CPC分类号： C07K14/785 , A61K38/00
摘要： Stable lung surfactant compositions are provided, as well as methods for their preparation, modification, formulation, assay, and therapeutic use.
摘要翻译：提供稳定的肺表面活性剂组合物，以及其制备，修饰，制剂，测定和治疗用途的方法。

2. 发明授权

US5134161A Method for treating disease states in mammals with naphthalene lipoxygenase-inhibiting agents 失效
标题翻译：用萘脂氧合酶抑制剂治疗哺乳动物疾病状态的方法
公开(公告)号：US5134161A
公开(公告)日：1992-07-28
申请号：US181869
申请日：1988-04-15
申请人： Michael C. Venuti , John M. Young
发明人： Michael C. Venuti , John M. Young
IPC分类号： C07C46/00 , C07C50/10 , C07C50/24 , C07C50/32
CPC分类号： C07C46/00 , C07C50/10 , C07C50/24 , C07C50/32 , Y10S514/886 , Y10S514/887
摘要： Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy,R.sup.2 is the same as R.sup.1, or R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl,R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;both X groups are the same and X is either --C(O)OR.sup.4 or --C(O)NR.sup.5 R.sup.6, whereinR.sup.4 is alkyl, phenyl or benzyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo; andR.sup.5 and R.sup.6 are independently hydrogen, lower alkyl, cycloalkyl or phenyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo.The compounds of this invention are also useful for the treatment of disease-states caused by lipoxygenase activity in mammals, particularly 5-lipoxygenase activity, when administered systemically.
摘要翻译：哺乳动物中的牛皮癣通过局部施用下式的萘来减轻：其中：R 1是低级烷氧基或任选取代的苯氧基，R 2与R 1相同，或R 2是氢，低级烷基，任选取代的苯基或任选地取代的苯基烷基，R 3是氢，低级烷基，低级烷氧基，卤素，任选取代的苯基，任选取代的苯基 - 低级烷基或任选取代的苯基 - 低级烷氧基，m是1或2; 两个X基团相同，X是-C（O）OR 4或-C（O）NR 5 R 6，其中R 4是烷基，任选被一个或两个低级烷基，低级烷氧基或卤素取代的苯基或苄基; 且R 5和R 6独立地为氢，低级烷基，环烷基或任选被一个或两个低级烷基，低级烷氧基或卤素取代的苯基。当系统给药时，本发明的化合物也可用于治疗由哺乳动物的脂氧合酶活性引起的疾病状态，特别是5-脂氧合酶活性。

3. 发明授权

US4946845A Naphthalene anti-psoriatic agents 失效
标题翻译：萘抗牛皮癣药
公开(公告)号：US4946845A
公开(公告)日：1990-08-07
申请号：US248525
申请日：1988-11-25
申请人： D. V. Krishna Murthy , Michael C. Venuti , John M. Young
发明人： D. V. Krishna Murthy , Michael C. Venuti , John M. Young
IPC分类号： C12N9/99 , A61K20060101 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/265 , A61K31/33 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4418 , A61P17/00 , A61P29/00 , A61P43/00 , C07C20060101 , C07C50/32 , C07C69/013 , C07C69/16 , C07C69/28 , C07C69/635 , C07D209/30 , C07D213/70 , C07D213/71 , C07D215/36 , C07D233/84 , C07D239/38 , C07D521/00
CPC分类号： A61K31/22 , C07C50/32 , C07C69/017 , C07C69/16 , C07C69/28 , C07C69/63 , C07C69/635
摘要： Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy or optionally substituted phenoxy,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2;at least one of X or Y is C(O)W and the other X or Y is different and is hydrogen, C(O)W or R.sup.4 whereinW is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl; andR.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl.
摘要翻译：哺乳动物的银屑病通过局部施用下式的萘来减轻：其中：R1和R2相同，为低级烷氧基或任选取代的苯氧基，R3为低级烷基，低级烷氧基或卤素，m为0 ，1或2或R3是任选取代的苯基，任选取代的苯基低级烷基，任选取代的苯基低级烷氧基，氨基，低级烷基氨基，低级二烷基氨基，氰基或S（O）n R其中R是低级烷基; 任选取代的苯基; 任选取代的苯基低级烷基; 或含有一个或两个选自氮，氧和硫的杂原子的三至九个环原子的任选取代的杂环芳基及其药学上可接受的酸加成盐; m为1，n为0,1或2; X或Y中的至少一个为C（O）W，另一个X或Y为不同的且为氢，C（O）W或R 4，其中W为1至7个碳原子的烷基，任选取代的苯基或任选取代的苄基 ; 并且R 4是低级烷基或任选取代的苯基 - 低级 - 烷基。

4. 发明授权

US4840965A Naphthalene anti-psoriatic agents 失效
标题翻译：萘抗牛皮癣药
公开(公告)号：US4840965A
公开(公告)日：1989-06-20
申请号：US70456
申请日：1987-07-07
申请人： Gordon H. Jones , Michael C. Venuti , John M. Young
发明人： Gordon H. Jones , Michael C. Venuti , John M. Young
IPC分类号： C07D317/70 , C07D319/22 , C07D321/10
CPC分类号： C07D319/22 , C07D317/70 , C07D321/10
摘要： Naphthalenes of the formula: ##STR1## wherein: m is 1 or 2;n is 1, 2, or 3;R.sup.1 is alkyl of one to seven carbon atoms or an optionally substituted phenyl;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl, optionally substituted phenyl-lower-alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, hydroxy, or lower alkylthio are useful in relieving psoriasis.
摘要翻译：下式的萘：其中：m为1或2; n为1,2或3; R 1是1至7个碳原子的烷基或任选取代的苯基; R 2是氢，低级烷基，低级烷氧基，任选取代的苯基，任选取代的苯基 - 低级烷基，任选取代的苯基 - 低级烷氧基，氨基，低级烷基氨基，低级二烷基氨基，卤素，氰基，羟基或低级烷硫基可用于缓解牛皮癣

5. 发明授权

US4761416A N-N-disubstituted-.omega.-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds 失效
标题翻译： N-N-二取代-ω-[2-氨基-3-（羰基甲基）-3,4-二氢喹唑啉基]氧烷基酰胺和相关化合物
公开(公告)号：US4761416A
公开(公告)日：1988-08-02
申请号：US889641
申请日：1986-07-25
申请人： John H. Fried , Michael C. Venuti
发明人： John H. Fried , Michael C. Venuti
IPC分类号： A61K31/505 , A61K31/517 , A61P7/02 , A61P9/04 , A61P43/00 , C07D239/84
CPC分类号： C07D239/84
摘要： Pharmaceutical compositions comprising, or compositions consisting essentially of, compounds according to the formula ##STR1## or an optical isomer thereof are disclosed, wherein the substituents A, Z and R.sup.1 are defined herein. The invention is also directed to certain compounds of the above class. The compounds of Formula I are cyclic AMP phosphodiesterase inhibitors useful as antithrombotic and inotropic agents and the like in mammals.
摘要翻译：公开了包含或基本上由式（I）化合物或其旋光异构体组成的药物组合物，其中取代基A，Z和R 1在本文中定义。本发明还涉及上述类型的某些化合物。式I的化合物是用作哺乳动物中的抗血栓形成和变力剂等的环AMP磷酸二酯酶抑制剂。

6. 发明授权

US4970297A Transglutaminase inhibitors 失效
标题翻译：转谷氨酰胺酶抑制剂
公开(公告)号：US4970297A
公开(公告)日：1990-11-13
申请号：US25426
申请日：1987-03-13
申请人： Arlindo L. Castelhano , Diana H. Pliura , Michael C. Venuti
发明人： Arlindo L. Castelhano , Diana H. Pliura , Michael C. Venuti
IPC分类号： A61K38/00 , C07D261/04 , C07K5/06
CPC分类号： C07D261/04 , C07K5/06191 , A61K38/00 , Y02P20/55
摘要： This invention is directed to compounds of the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:n is 0, 1 or 2;p and q are independently 0, 1 or 2 and the sum of (p+q) is less than or equal to 3;X is selected from the group consisting of: halo; --OR.sup.2, --SR.sup.2, --S(O)R.sup.2, --S(O).sub.2 R.sup.2, and --S(O).sub.2 NHR.sup.2, wherein R.sup.2 is lower alkyl, mono-, di- or tri-fluoro alkyl of 2 or 3 carbon atoms, optionally substituted aryl;R is H or an N-protecting group;R.sup.1 is alkylthio, arylthio, amino, alkylamino, optionally substituted arylamino, or optionally substituted aralkylamino; and when the sum of n+p+q is greater than or equal to one, R.sup.1 is also hydroxy, alkoxy, or aralkoxy; andeach (aa) is independently an .alpha.-amino acid residue with an optionally protected amino acid side chain.
摘要翻译：本发明涉及下式的化合物：其中n为0,1或2;其中：n为0,1或2; p和q独立地为0,1或2，（p + q）的和小于或等于3; X选自：卤素; -OR 2，-SR 2，-S（O）R 2，-S（O）2 R 2和-S（O）2 NHR 2，其中R 2是低级烷基，2或3个碳原子的一，二或三氟烷基，任选取代的芳基; R为H或N-保护基; R 1是烷硫基，芳硫基，氨基，烷基氨基，任选取代的芳基氨基或任选取代的芳烷基氨基; 并且当n + p + q的总和大于或等于1时，R 1也是羟基，烷氧基或芳烷氧基; 并且每个（aa）独立地是具有任选保护的氨基酸侧链的α-氨基酸残基。

7. 发明授权

US4739056A N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihy droquinazolinyl)oxy-alkylamides and related compounds 失效
标题翻译： N-N-二取代-ω-（2-氨基-3-（羰基甲基）-3,4-二氢喹唑啉基）氧基 - 烷基酰胺和相关化合物
公开(公告)号：US4739056A
公开(公告)日：1988-04-19
申请号：US935659
申请日：1986-11-26
申请人： Michael C. Venuti
发明人： Michael C. Venuti
IPC分类号： C07D239/84 , A61K31/495
CPC分类号： C07D239/84
摘要： Compounds are disclosed according to the formula ##STR1## or an optical isomer thereof. The compounds of Formula I are cyclic AMP phosphodiesterase inhibitors useful as antithrombotic and inotropic agents and the like in mammals.
摘要翻译：根据式（I）或其旋光异构体公开化合物。式I的化合物是用作哺乳动物中的抗血栓形成和变力剂等的环AMP磷酸二酯酶抑制剂。

8. 发明授权

US4690925A (2-Oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl) oxyalkylamides properties having phosphodiosterase inhibiting 失效
标题翻译：（2-氧代-1,2,3,5-四氢咪唑并[2,1-B]喹唑啉基）氧烷基酰胺性质，其具有磷酸二酯酶抑制
公开(公告)号：US4690925A
公开(公告)日：1987-09-01
申请号：US734633
申请日：1985-05-15
申请人： John H. Fried , Michael C. Venuti
发明人： John H. Fried , Michael C. Venuti
IPC分类号： A61K31/505 , A61P7/02 , A61P9/00 , A61P35/00 , A61P43/00 , C07C205/44 , C07C205/56 , C07D487/04 , C12N9/99
CPC分类号： C07D487/04 , C07C205/44 , C07C205/56
摘要： Compounds according to the formula ##STR1## , its optical isomers, or a pharmaceutically acceptable salt thereof wherein:m and n are integers of 1 to 6;R.sub.1 is hydrogen or alkyl of 1 to 4 carbons;R.sub.2 is hydrogen or R.sub.1 and R.sub.2 are combined to form an oxo group;R.sub.3 is hydrogen, alkyl of 1 to 6 carbons, phenyl, benzyl, hydroxy lower alkyl and its aliphatic acylates of 1 to 6 carbon atoms or aryl acylates of 7 to 12 carbon atoms, carbamoyl alkyl, carboxyalkyl, alkoxycarbonylalkyl or .alpha.-amino acid side chains;R.sub.4 is hydrogen, alkyl of 1 to 6 carbons, benzyl, or hydroxy lower alkyl;R.sub.5 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms or cycloalkyl lower alkyl of 4 to 12 carbon atoms wherein the cycloalkyl ring is unsubstituted or substituted with a lower alkyl, lower alkoxy, --OH, --OCOR.sub.6, halo, --NH.sub.2, --N(R.sub.6).sub.2, --NHCOR.sub.6, --COOH, or --COO(R.sub.6) group wherein R.sub.6 is lower alkyl; phenyl or phenyl lower alkyl wherein phenyl is unsubstituted or substituted with 1 or more lower alkyl, halo or lower alkoxy groups or an --NH.sub.2, --N(R.sub.6).sub.2, --NHCOR.sub.6, --COOH, or --COOR.sub.6 group wherein R.sub.6 is lower alkyl;Y is hydrogen, alkyl of 1 to 4 carbon atoms, halo or lower alkoxy; andZ is --OR.sub.7 or --NR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl.
摘要翻译：式（I）的化合物，其旋光异构体或其药学上可接受的盐，其中：m和n为1至6的整数; R1是氢或1至4个碳的烷基; R2是氢或R1和R2组合形成氧代基团; R3为氢，1-6个碳原子的烷基，苯基，苄基，羟基低级烷基及其1至6个碳原子的脂族酰化物或7至12个碳原子的芳基酰化物，氨基甲酰基烷基，羧基烷基，烷氧基羰基烷基或α-氨基酸侧链条 R4是氢，1-6个碳原子的烷基，苄基或羟基低级烷基; R5是氢，1至6个碳原子的烷基，3至8个碳原子的环烷基或4-12个碳原子的环烷基低级烷基，其中环烷基环是未取代的或被低级烷基，低级烷氧基，-OH，-OCOR6 ，卤素，-NH 2，-N（R 6）2，-NHCOR 6，-COOH或-COO（R 6）基团，其中R 6是低级烷基; 苯基或苯基低级烷基，其中苯基未被取代或被1个或多个低级烷基，卤代或低级烷氧基或-NH 2，-N（R 6）2，-NHCOR 6，-COOH或-COOR 6基团取代，其中R 6是低级烷基 ; Y是氢，1-4个碳原子的烷基，卤代或低级烷氧基; 并且Z是-OR 7或-NR 7 R 8，其中R 7和R 8独立地是氢或低级烷基。

9. 发明授权

US4296042A Preparation of unsaturated aliphatic insect pheromones using cyclic phosphonium ylids 失效
标题翻译：使用环状onium叶来制备不饱和脂肪族昆虫信息素
公开(公告)号：US4296042A
公开(公告)日：1981-10-20
申请号：US160711
申请日：1980-06-18
申请人： Joseph M. Muchowski , Michael C. Venuti
发明人： Joseph M. Muchowski , Michael C. Venuti
IPC分类号： C07D309/06 , C07F9/53 , C07F9/6568 , C07C41/18 , C07F7/04
CPC分类号： C07D309/06 , C07F9/5316 , C07F9/65688
摘要： This process relates to the synthesis of unsaturated aliphatic esters useful as insect sex attractants, including gossyplure, the insect sex pheromone of the pink bollworm moth, Pectinophora gossypiella, and intermediates therefor. The process utilizes a cyclic phosphonium (Wittig) reagent.
摘要翻译：该方法涉及用作昆虫性引诱剂的不饱和脂肪族酯的合成，包括青霉素，粉红色棉铃蛾的昆虫性信息素，棉蚜属（Pectinophora gossypiella）及其中间体。该方法利用环状鏻（Wittig）试剂。

10. 发明授权

US4929630A Transglutaminase inhibitors 失效
标题翻译：转谷氨酰胺酶抑制剂
公开(公告)号：US4929630A
公开(公告)日：1990-05-29
申请号：US404791
申请日：1989-09-08
申请人： Arlindo L. Castelhano , Lawrence M. DeYoung , Alexander Krantz , Diana H. Pliura , Michael C. Venuti
发明人： Arlindo L. Castelhano , Lawrence M. DeYoung , Alexander Krantz , Diana H. Pliura , Michael C. Venuti
IPC分类号： C07D261/04 , C07D413/12 , C07K5/06 , C07K5/065
CPC分类号： C07D413/12 , C07D261/04 , C07K5/06026 , C07K5/06078 , C07K5/06191 , Y10S514/859 , Y10S514/863
摘要： The present invention is directed to certain 3,5 substituted, 4,5-dihydroisoxazoles, and methods for their use. These compounds are transglutaminase inhibitors, and are particularly effective in the inhibition of epidermal transglutaminase and the treatment of acne.
摘要翻译：本发明涉及某些3,5取代的4,5-二氢异恶唑及其使用方法。这些化合物是转谷氨酰胺酶抑制剂，并且在抑制表皮转谷氨酰胺酶和治疗痤疮方面特别有效。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式