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1. 发明授权

US5876970A Surfactant compositions and methods 失效
标题翻译：表面活性剂组合物和方法
公开(公告)号：US5876970A
公开(公告)日：1999-03-02
申请号：US278189
申请日：1994-07-21
申请人： Bradley J. Benson , John H. Frenz , Cynthia P. Quan , Steven Shak , Kathleen A. Shiffer , Michael C. Venuti , John T. Stults , David Lesikar
发明人： Bradley J. Benson , John H. Frenz , Cynthia P. Quan , Steven Shak , Kathleen A. Shiffer , Michael C. Venuti , John T. Stults , David Lesikar
IPC分类号： A61K35/42 , A61K38/00 , A61K38/17 , C07K1/107 , C07K14/785 , G01N33/68 , C12P21/02 , C07H21/04 , C07K14/47
CPC分类号： C07K14/785 , A61K38/00
摘要： Stable lung surfactant compositions are provided, as well as methods for their preparation, modification, formulation, assay, and therapeutic use.
摘要翻译：提供稳定的肺表面活性剂组合物，以及其制备，修饰，制剂，测定和治疗用途的方法。

2. 发明申请

US20110315552A1 Systems and Methods for Discovery and Analysis of Markers 审中-公开
标题翻译：用于发现和分析标记的系统和方法
公开(公告)号：US20110315552A1
公开(公告)日：2011-12-29
申请号：US13018622
申请日：2011-02-01
申请人： John T. Stults , Alfred Greenquist , Alexander Sassi
发明人： John T. Stults , Alfred Greenquist , Alexander Sassi
IPC分类号： G01N27/447
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G16B20/00 , G16B40/00 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.
摘要翻译：用于分类患者样本的商业方法。该方法包括收集代表临床表型状态的病例样本和对照样品的步骤，所述样品代表没有所述临床表型状态的患者。优选地，系统使用质谱平台系统来鉴定所述病例样品和对照样品中多肽的模式，而不考虑至少一些所述多肽的特异性同一性。基于确定的状态的代表性模式，业务方法使用代表性模式提供诊断产品的营销。本发明涉及用于鉴定新标记，诊断具有生物学感兴趣的患者的系统和方法，以及销售/商业化这种诊断。本发明涉及具有更大灵敏度，特异性和/或成本效益的系统和方法。

3. 发明申请

US20140374584A1 SYSTEMS AND METHODS FOR DISCOVERY AND ANALYSIS OF MARKERS 审中-公开
标题翻译：用于发现和分析标记的系统和方法
公开(公告)号：US20140374584A1
公开(公告)日：2014-12-25
申请号：US14166626
申请日：2014-01-28
申请人： John T. Stults , Alfred Greenquist , Alexander Sassi
发明人： John T. Stults , Alfred Greenquist , Alexander Sassi
IPC分类号： G01N33/50 , G01N27/26 , A61B5/15 , H01J49/00
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G16B20/00 , G16B40/00 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.
摘要翻译：用于分类患者样本的商业方法。该方法包括收集代表临床表型状态的病例样本和对照样品的步骤，所述样品代表没有所述临床表型状态的患者。优选地，系统使用质谱平台系统来鉴定所述病例样品和对照样品中多肽的模式，而不考虑至少一些所述多肽的特异性同一性。基于确定的状态的代表性模式，业务方法使用代表性模式提供诊断产品的营销。本发明涉及用于鉴定新标记，诊断具有生物学感兴趣的患者的系统和方法，以及销售/商业化这种诊断。本发明涉及具有更大灵敏度，特异性和/或成本效益的系统和方法。

4. 发明授权

US4472631A Combination of time resolution and mass dispersive techniques in mass spectrometry 失效
标题翻译：时间分辨率和质谱分析技术在质谱中的组合
公开(公告)号：US4472631A
公开(公告)日：1984-09-18
申请号：US385114
申请日：1982-06-04
申请人： Christie G. Enke , John F. Holland , John T. Stults
发明人： Christie G. Enke , John F. Holland , John T. Stults
IPC分类号： B01D59/44 , H01J49/02 , H01J49/32 , H01J49/40
CPC分类号： H01J49/40 , B01D59/44 , H01J49/004 , H01J49/28
摘要： Time of flight mass spectrometry techniques are simultaneously combined with path-bending spatial dispersion in magnetic- or electric-sector mass spectrometers to improve the mass resolution or, with an ion fragmentation region, to rapidly obtain multidimensional mass spectral data previously only obtainable by tandem mass spectrometry. The instrumentation generates data defining relationships between parent ions and daughter ions produced by fragmentation, metastable or induced, data to differentiate stable from metastable ions, and data to improve mass resolution. The subject time-resolved mass spectrometers can be combined with chromatography apparatus to obtain multidimensional MS/MS-type data during the relatively short duration of a single chromatographic peak.
摘要翻译：飞行时间质谱技术与磁电或电扇区质谱仪中的路径弯曲空间色散同时组合以改善质量分辨率，或者利用离子碎片区域快速获得以前只能通过串联质量获得的多维质谱数据光谱测定。仪器产生的数据定义了通过断裂，亚稳态或诱导产生的亲本离子和子离子之间的关系，数据以区分稳定离子和亚稳态离子，并提供数据以改善质量分辨率。主题时间分辨质谱仪可以与色谱装置组合，以在单个色谱峰的相对短的持续时间内获得多维MS / MS型数据。

5. 发明授权

US07425700B2 Systems and methods for discovery and analysis of markers 失效
标题翻译：用于发现和分析标记的系统和方法
公开(公告)号：US07425700B2
公开(公告)日：2008-09-16
申请号：US11178262
申请日：2005-07-08
申请人： John T. Stults , Alfred Greenquist , Alexander Sassi
发明人： John T. Stults , Alfred Greenquist , Alexander Sassi
IPC分类号： H01J49/04 , H01J49/10 , B01D59/44
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G06F19/18 , G06F19/24 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.
摘要翻译：本发明涉及用于鉴定新标记，诊断具有生物学感兴趣的患者的系统和方法，以及销售/商业化这种诊断。本发明涉及具有更大灵敏度，特异性和/或成本效益的系统和方法。

6. 发明申请

US20170328885A1 Systems and Methods for Discovery and Analysis of Markers 审中-公开
公开(公告)号：US20170328885A1
公开(公告)日：2017-11-16
申请号：US15388954
申请日：2016-12-22
申请人： John T. Stults , Alfred Greenquist , Alexander Sassi
发明人： John T. Stults , Alfred Greenquist , Alexander Sassi
IPC分类号： G01N33/50 , H01J49/00 , A61B5/15 , G01N27/26 , H01J49/16 , G06F19/24 , G06F19/18
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G16B20/00 , G16B40/00 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.

7. 发明申请

US20090057550A1 SYSTEMS AND METHODS FOR DISCOVERY AND ANALYSIS OF MARKERS 有权
标题翻译：用于发现和分析标记的系统和方法
公开(公告)号：US20090057550A1
公开(公告)日：2009-03-05
申请号：US12172988
申请日：2008-07-14
申请人： John T. Stults , Alfred Greenquist , Alexander Sassi
发明人： John T. Stults , Alfred Greenquist , Alexander Sassi
IPC分类号： B01D59/44
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G06F19/18 , G06F19/24 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns.The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.
摘要翻译：用于分类患者样本的商业方法。该方法包括收集代表临床表型状态的病例样本和对照样品的步骤，所述样品代表没有所述临床表型状态的患者。优选地，系统使用质谱平台系统来鉴定所述病例样品和对照样品中多肽的模式，而不考虑至少一些所述多肽的特异性同一性。基于确定的状态的代表性模式，业务方法使用代表性模式提供诊断产品的营销。本发明涉及用于鉴定新标记，诊断具有生物学感兴趣的患者的系统和方法，以及销售/商业化这种诊断。本发明涉及具有更大灵敏度，特异性和/或成本效益的系统和方法。

8. 发明授权

US06803568B2 Multi-channel microfluidic chip for electrospray ionization 失效
标题翻译：用于电喷雾离子化的多通道微流控芯片
公开(公告)号：US06803568B2
公开(公告)日：2004-10-12
申请号：US10649350
申请日：2003-08-26
申请人： Luc Bousse , John T. Stults
发明人： Luc Bousse , John T. Stults
IPC分类号： H01J4904
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502715 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/027 , B81B1/008 , B81B2201/058 , G01N27/44717 , H01J49/0018
摘要： A microfluidic chip formed with multiple fluid channels terminating at a common electrospray ionization tip for mass spectrometric analysis. The fluid channels may be formed within a substrate plate that are in fluid communication with corresponding reservoirs. The electrospray tip can be formed along a defined portion of the substrate plate, wherein the electrospray tip includes an open-tip region at which the fluid channels converge. A top laminate plate may substantially enclose most portions of the fluid channels formed in the bottom polymer plate except for the open-tip region. Another aspect of the invention provides methods for conducting mass spectrometric analysis of multiple samples flowing through individual fluid channels in a single microfluidic chip that is formed with a convergent electrospray tip. The convergent electrospray tip includes an open or exposed distal pointed tip region.
摘要翻译：形成有多个流体通道的微流体芯片，其终止于通用电喷雾离子化尖端用于质谱分析。流体通道可以形成在与相应的储存器流体连通的衬底板内。电喷雾尖端可以沿着衬底板的限定部分形成，其中电喷雾尖端包括流体通道会聚的开口尖端区域。顶部层压板可以基本上封闭形成在底部聚合物板中的除了开口尖端区域之外的流体通道的大部分。本发明的另一方面提供了用形成有会聚电喷雾尖端的单个微流体芯片中流过各个流体通道的多个样品进行质谱分析的方法。收敛的电喷雾尖端包括开放或暴露的远端尖端区域。

9. 发明授权

US07906758B2 Systems and method for discovery and analysis of markers 有权
标题翻译：用于发现和分析标记物的系统和方法
公开(公告)号：US07906758B2
公开(公告)日：2011-03-15
申请号：US12172988
申请日：2008-07-14
申请人： John T. Stults , Alfred Greenquist , Alexander Sassi
发明人： John T. Stults , Alfred Greenquist , Alexander Sassi
IPC分类号： B01D59/44
CPC分类号： G01N33/50 , A61B5/150755 , G01N27/26 , G06F19/18 , G06F19/24 , H01J49/00 , H01J49/0027 , H01J49/165 , Y02A90/22 , Y02A90/26 , Y10T436/117497
摘要： The present invention relates to a charged particle beam apparatus which employs a scanning electron microscope for sample inspection and defect review. The present invent provides solution of improving imaging resolution by utilizing a field emission cathode tip with a large tip radius, applying a large accelerating voltage across ground potential between the cathode and anode, positioning the beam limit aperture before condenser lens, utilizing condenser lens excitation current to optimize image resolution, applying a high tube bias to shorten electron travel time, adopting and modifying SORIL objective lens to ameliorate aberration at large field of view and under electric drifting and reduce the urgency of water cooling objective lens while operating material analysis. The present invent provides solution of improving throughput by utilizing fast scanning ability of SORIL and providing a large voltage difference between sample and detectors.
摘要翻译：本发明涉及采用扫描电子显微镜进行样品检查和缺陷检查的带电粒子束装置。本发明提供了通过利用具有大的尖端半径的场致发射阴极尖端来提高成像分辨率的解决方案，在阴极和阳极之间的地电位上施加大的加速电压，将光束极限孔定位在聚光透镜之前，利用聚光透镜激发电流优化图像分辨率，应用高管偏压缩短电子行进时间，采用和修正SORIL物镜，在大视场和电漂移下改善像差，降低水冷物镜在操作材料分析时的紧迫性。本发明提供了通过利用SORIL的快速扫描能力并在样品和检测器之间提供大的电压差来提高产量的解决方案。

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