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1. 发明授权

US4472631A Combination of time resolution and mass dispersive techniques in mass spectrometry 失效
标题翻译：时间分辨率和质谱分析技术在质谱中的组合
公开(公告)号：US4472631A
公开(公告)日：1984-09-18
申请号：US385114
申请日：1982-06-04
申请人： Christie G. Enke , John F. Holland , John T. Stults
发明人： Christie G. Enke , John F. Holland , John T. Stults
IPC分类号： B01D59/44 , H01J49/02 , H01J49/32 , H01J49/40
CPC分类号： H01J49/40 , B01D59/44 , H01J49/004 , H01J49/28
摘要： Time of flight mass spectrometry techniques are simultaneously combined with path-bending spatial dispersion in magnetic- or electric-sector mass spectrometers to improve the mass resolution or, with an ion fragmentation region, to rapidly obtain multidimensional mass spectral data previously only obtainable by tandem mass spectrometry. The instrumentation generates data defining relationships between parent ions and daughter ions produced by fragmentation, metastable or induced, data to differentiate stable from metastable ions, and data to improve mass resolution. The subject time-resolved mass spectrometers can be combined with chromatography apparatus to obtain multidimensional MS/MS-type data during the relatively short duration of a single chromatographic peak.
摘要翻译：飞行时间质谱技术与磁电或电扇区质谱仪中的路径弯曲空间色散同时组合以改善质量分辨率，或者利用离子碎片区域快速获得以前只能通过串联质量获得的多维质谱数据光谱测定。仪器产生的数据定义了通过断裂，亚稳态或诱导产生的亲本离子和子离子之间的关系，数据以区分稳定离子和亚稳态离子，并提供数据以改善质量分辨率。主题时间分辨质谱仪可以与色谱装置组合，以在单个色谱峰的相对短的持续时间内获得多维MS / MS型数据。

2. 发明授权

US5367162A Integrating transient recorder apparatus for time array detection in time-of-flight mass spectrometry 失效
标题翻译：在飞行时间质谱中集成瞬时记录仪用于时间阵列检测
公开(公告)号：US5367162A
公开(公告)日：1994-11-22
申请号：US81731
申请日：1993-06-23
申请人： John F. Holland , Christie G. Enke , Michael R. Davenport , Lawrence W. Janow
发明人： John F. Holland , Christie G. Enke , Michael R. Davenport , Lawrence W. Janow
IPC分类号： H01J49/02 , H01J49/40 , B01D59/04 , H01J49/00
CPC分类号： H01J49/025 , H01J49/40
摘要： An integrating transient recorder for time array detection of ions within an ion source extraction. The arrival times of all ions having various mass-to-charge ratios are calculated and integrating or peak detecting circuitry is activated just prior to the calculated time of arrival of each ion, and then only for a time duration in accordance with a predetermined data collection time window sufficient to enable each ion mass value to be completely measured. An analog-to-digital converter converts the area or peak analog signal for each ion into a corresponding digital signal and outputs the digital signals to a plurality of FIFO buffers. The FIFO buffers are read out for each successive transient by a digital signal processor and summed over a predetermined number of sequential transients in a mass locked registry creating a file of ion intensities versus mass-to-charge ratio of all ions detected. In a preferred embodiment the apparatus includes a mass defect detector which compares the actual arrival time of the ions with the calculated anticipated time of arrival and applies appropriate time delays from a selected one of a plurality of delta-mass tables. This causes the area or peak detection circuity to be turned on either slightly prior to or subsequent to the calculated times of arrival of each of the ions to thus cause each of the ions to be received clearly and completely within each data collection window. Preferred embodiments include combinations of analog or digital peak or area capture and analog or digital successive summations.
摘要翻译：用于时间阵列检测离子源提取中离子的积分瞬态记录仪。计算具有各种质荷比的所有离子的到达时间，并且在计算的每个离子的到达时间之前激活积分或峰值检测电路，然后仅根据预定数据收集的持续时间足以使每个离子质量值完全测量的时间窗。模数转换器将每个离子的面积或峰值模拟信号转换成相应的数字信号，并将数字信号输出到多个FIFO缓冲器。通过数字信号处理器对每个连续的瞬态读出FIFO缓冲器，并在质量锁定的注册表中的预定数量的顺序瞬变相加，从而产生离子强度的文件与检测到的所有离子的质荷比。在优选实施例中，装置包括质量缺陷检测器，其将离子的实际到达时间与计算的预计到达时间进行比较，并从多个delta质量表中选择的一个施加适当的时间延迟。这导致区域或峰值检测电路在计算出的每个离子的到达时间之前或之后稍微打开，从而使每个离子在每个数据收集窗口内被清楚和完全地接收。优选实施例包括模拟或数字峰值或区域捕获以及模拟或数字连续求和的组合。

3. 发明授权

US5175430A Time-compressed chromatography in mass spectrometry 失效
标题翻译：时间压缩色谱在质谱中的应用
公开(公告)号：US5175430A
公开(公告)日：1992-12-29
申请号：US702221
申请日：1991-05-17
申请人： Christie G. Enke , John F. Holland , Richard D. McLane , George E. Yefchak
发明人： Christie G. Enke , John F. Holland , Richard D. McLane , George E. Yefchak
IPC分类号： G01N30/72 , G01N27/62 , G01N30/86 , G06F17/00
CPC分类号： G01N30/8624 , G01N30/8679 , G01N30/7206 , G01N30/8631
摘要： A process and apparatus employing the time compression of chromatography in mass spectrometry with array detection in which the time compressed informatioin is deconvoluted by mathematical analysis for recovery of analytical information made inaccessible in the time compression and thereby resulting in a decrease in analysis time and improved component identification without loss of sensitivity.
摘要翻译：一种使用质谱法进行色谱法时间压缩的方法和装置，其中通过数据分析对时间压缩信息进行解卷积，以便在时间压缩中使得不可接近的分析信息的回收被解卷积，从而导致分析时间的减少和改进的组分识别而不失灵敏度。

4. 发明授权

US4490806A High repetition rate transient recorder with automatic integration 失效
标题翻译：高重复率瞬态记录仪具有自动整合功能
公开(公告)号：US4490806A
公开(公告)日：1984-12-25
申请号：US385115
申请日：1982-06-04
申请人： Christie G. Enke , Bruce H. Newcome , John F. Holland
发明人： Christie G. Enke , Bruce H. Newcome , John F. Holland
IPC分类号： G06F19/00 , G01R13/06 , G01R13/32 , G06F17/40 , H01J49/02 , G06F15/20
CPC分类号： H01J49/0036 , G01R13/06 , G01R13/32
摘要： A system for high speed acquisition and storage of data from transient electrical signal waveforms sampled in time at a multiplicity of points, and where it is desired to collect and store data in real time in a mass storage unit, but where the data rate is in excess of the apparent rate at which data can be transferred to mass storage. The overall system employs two levels of data reduction, the first being digital integration (summation) and the second being data processing. In the digital summation section memory read and write cycles overlap for higher speed. In one embodiment, a charge-coupled device is employed as an input element to reduce the data rate prior to subsequent digital processing. The system is capable of recording all the intensities of all transients continuously without loss of data significance.
摘要翻译：一种用于高速采集和存储来自在多个点上及时采样的瞬时电信号波形的数据的系统，并且其中期望在大容量存储单元中实时收集和存储数据，但是数据速率在数据可以转移到大容量存储的表观速率过多。整个系统采用两级数据缩减，首先是数字积分（summation），第二种是数据处理。在数字求和部分，存储器的读写周期重叠较快。在一个实施例中，电荷耦合器件被用作输入元件，以在随后的数字处理之前降低数据速率。该系统能够连续记录所有瞬变的所有强度，而不会损失数据的意义。

5. 发明授权

US4624915A Positive selection sorting of cells 失效
标题翻译：细胞的正选择分选
公开(公告)号：US4624915A
公开(公告)日：1986-11-25
申请号：US513995
申请日：1983-07-14
申请人： Melvin S. Schindler , John F. Holland
发明人： Melvin S. Schindler , John F. Holland
IPC分类号： B07C5/342 , C12M1/34 , G01N15/14 , C12N5/00 , C12Q1/00
CPC分类号： B07C5/342 , C12M47/04 , C12M47/06 , G01N2015/149
摘要： A method and apparatus for position selection of viable cells based upon differing chemical or physical properties or dynamic processes using a focussed radiant energy beam, such as a laser beam (11) to kill unwanted cells or to isolate wanted cells is described. The apparatus includes microscope means (14) and cell detection means (27) for identifying the cells to be killed or saved and attenuator means (12) for modifying the beam to prevent destruction of cells to be saved.
摘要翻译：描述了基于使用聚焦辐射能束（例如激光束（11））去除不需要的细胞或隔离所需细胞的不同化学或物理特性或动态过程的活细胞位置选择的方法和装置。该装置包括用于识别待杀死或保存的细胞的显微镜装置（14）和细胞检测装置（27）和用于修改光束的衰减装置（12），以防止要节省的细胞的破坏。

6. 发明授权

US4629687A Positive selection sorting of cells 失效
标题翻译：细胞的正选择分选
公开(公告)号：US4629687A
公开(公告)日：1986-12-16
申请号：US403154
申请日：1982-07-29
申请人： Melvin S. Schindler , John F. Holland
发明人： Melvin S. Schindler , John F. Holland
IPC分类号： B07C5/342 , C12M1/34 , C12M3/00 , C12N1/00 , C12Q1/04 , G01N15/14 , G01N33/48 , C12N5/00 , C12Q1/00
CPC分类号： C12M47/06 , B07C5/342 , C12M47/04 , G01N2015/149
摘要： A method and apparatus for positive selection of viable cells based upon differing chemical or physical properties or dynamic processes using a focussed radiant energy beam, such as a laser beam (11) to kill unwanted cells is described. The apparatus includes a microscope (14) with a photomultiplier (27) which is used to selectively detect light from certain cells produced by an attenuated laser beam irradiating the cells for identifying the cells to be killed or saved. Based upon identification, selected cells to be killed are exposed to the unattenuated laser beam.
摘要翻译：描述了基于不同的化学或物理性质或使用聚焦的辐射能量束（例如用于杀死不需要的细胞的激光束（11））的动态过程来正确选择活细胞的方法和装置。该装置包括具有光电倍增器（27）的显微镜（14），该显微镜用于选择性地检测由照射细胞的衰减激光束产生的某些细胞的光，以识别待杀死或保存的细胞。基于鉴定，待杀死的选定细胞暴露于未衰减的激光束。

7. 发明授权

US6119567A Method and apparatus for producing a shaped article 失效
标题翻译：用于制造成形制品的方法和装置
公开(公告)号：US6119567A
公开(公告)日：2000-09-19
申请号：US891353
申请日：1997-07-10
申请人： Melvin S. Schindler , John F. Holland , Marcos Dantus
发明人： Melvin S. Schindler , John F. Holland , Marcos Dantus
IPC分类号： B26F1/38 , B26F3/08 , B26D7/10
CPC分类号： B26F3/08 , B26F1/3806
摘要： A method and preferred apparatus (10) to cut a preform material which is biodegradable and preferably dispersible in water, to produce a shaped article, is described. The cut is produced without producing harmful fumes or leaving a harmful residue and preferably without charring at the cut. Preferably, only small amounts of carbon dioxide and water are produced at the cut. Shaped articles which are in sheet or block form or which are for 2-D or 3-D shaped article formation can be produced.
摘要翻译：描述了一种切割可生物降解且优选分散在水中的预成型材料的方法和优选设备（10），以生产成型制品。切割产生而不产生有害烟雾或留下有害残留物，优选在切割时不起焦作用。优选地，在切割处仅产生少量的二氧化碳和水。可以制造片状或块状的成形制品或用于形成二维或三维形状的制品。

8. 发明授权

US4665370A Method and apparatus for monitoring and indicating the condition of a battery and the related circuitry 失效
标题翻译：用于监测和指示电池状况和相关电路的方法和装置
公开(公告)号：US4665370A
公开(公告)日：1987-05-12
申请号：US187415
申请日：1980-09-15
申请人： John F. Holland
发明人： John F. Holland
IPC分类号： G01R31/36 , G01N27/46
CPC分类号： G01R19/16542 , G01R31/3682
摘要： A method and apparatus for testing the battery and the related circuitry of an internal combustion automobile every time the vehicle is started. The test is automatic and the results are available for visual interpretation at the discretion of the operator. The cranking motor furnishes the load for the battery and an electronic apparatus automatically measures the condition of the battery every time the engine is started. The battery tester compares the unloaded voltage of the battery with the voltage under load. If the difference is larger than a preset value, or if the voltage drops below a fixed level, an indicator on the dashboard of the vehicle shows that the battery is low in charge, or it is in a faulty condition, or because of faulty conductors its power is not being delivered to the engine.
摘要翻译：一种用于每次车辆启动时测试内燃机车的电池和相关电路的方法和装置。测试是自动的，结果可以由操作员自行决定进行视觉解释。起动马达为电池提供负载，电子设备每次起动时自动测量电池的状态。电池测试仪将电池的无负载电压与负载电压进行比较。如果差值大于预设值，或者电压下降到固定水平以下时，车辆仪表板上的指示灯显示电池电量不足或处于故障状态，或由于导体故障它的动力没有交付给发动机。

9. 发明授权

US4702111A Sonic wood testing apparatus and method 失效
标题翻译：声波木测试仪器及方法
公开(公告)号：US4702111A
公开(公告)日：1987-10-27
申请号：US851499
申请日：1986-04-01
申请人： John F. Holland
发明人： John F. Holland
IPC分类号： G01N29/04
CPC分类号： G01N29/045 , G01N2291/0238
摘要： An improved non-destructive sonic testing apparatus is disclosed which is specially adapted for use in assessing the integrity of wooden utility poles. In one embodiment, the sonic testing apparatus of the present invention operates to perform a Fourier analysis on a signal which has been transmitted through a pole to be tested. Two or more criteria selected from the group of mode, mean, median and range are then determined for the resulting waveform and compared in order to provide a visual display representative of the condition of the pole being tested. In another embodiment of the present invention a software peak seeking algorithm is utilized to provide an envelope waveform from which successive half lives are determined. The relative time duration for successive half lives are compared to provide an indication of the amount of decay.
摘要翻译：公开了一种改进的非破坏性声波测试装置，其特别适用于评估木制电线杆的完整性。在一个实施例中，本发明的声音测试装置用于对通过待测试的极点传输的信号执行傅立叶分析。然后对于所得到的波形确定从模式，平均值，中值和范围组中选择的两个或更多个标准，并进行比较，以便提供表示正在测试的极点的状态的视觉显示。在本发明的另一个实施例中，使用软件峰值寻找算法来提供确定连续半衰期的包络波形。比较连续半衰期的相对持续时间以提供衰减量的指示。

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