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1. 发明申请

US20070213627A1 FETAL SURVEILLANCE 有权
标题翻译： FETAL监视
公开(公告)号：US20070213627A1
公开(公告)日：2007-09-13
申请号：US10595378
申请日：2004-10-13
申请人： David James , John Crowe , Barrie Hayes-Gill , Carl Barratt , Jean-Francois Pieri
发明人： David James , John Crowe , Barrie Hayes-Gill , Carl Barratt , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： Fetal behaviour is monitored by receiving ECG data from a set of electrodes attached to a materrial body. A waveform pre-processor identifies a succession of fetal ECG complex waveforms within the received data and a waveform processor determines differences in the processor succession of fetal ECG complex waveforms over time. An event logger determines from the determined differences a number of fetal movements during the period of time. Fetal spatial presentation and/or position within the uterus may also be determined from fetal ECG data acquired from a plurality of electrodes positioned on the maternal abdomen in a predetermined configuration. A number of fetal ECG complex waveforms are identified within the data, and each of the waveforms is compared with a set of predetermined fetal ECG complex templates ascribed to the predetermined electrode configuration to determine a template that best matches the identified fetal ECG waveforms.
摘要翻译：通过从连接到物质体的一组电极接收ECG数据来监测胎儿行为。波形预处理器识别接收到的数据中的一系列胎儿ECG复杂波形，并且波形处理器确定随着时间的推移，胎儿ECG复杂波形的处理器连续性的差异。事件记录器根据所确定的差异确定一段时间内的胎动。胎儿空间呈现和/或子宫内的位置也可以从以预定配置从位于母体腹部的多个电极获取的胎儿ECG数据确定。在数据内识别出许多胎儿ECG复杂波形，并且将每个波形与归因于预定电极配置的一组预定胎儿ECG复合模板进行比较，以确定与所识别的胎儿ECG波形最佳匹配的模板。

2. 发明申请

US20090192396A1 Apparatus and method for detecting a fetal heart rate 审中-公开
标题翻译：用于检测胎儿心率的装置和方法
公开(公告)号：US20090192396A1
公开(公告)日：2009-07-30
申请号：US12385068
申请日：2009-03-30
申请人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
发明人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： An apparatus and method for detecting the heart rate of a fetus. The apparatus includes three detectors detecting heart beats of the fetus, each detector including at least two electrodes detecting ECG signals, the detectors being positioned on an abdomen of a mother in use. The apparatus also includes a processor coupled to the detectors, the processor being adapted to process the ECG signals received from the detectors and determine a heart rate of the fetus. The method of determining the heart rate of the fetus includes determining a position of the fetus within a womb, placing the detectors on an abdomen of the mother, monitoring the ECG signals obtained from the detectors for a predetermined length of time, and processing the ECG signals obtained from the detectors positioned on the abdomen of the mother to determine heart beats of the mother.
摘要翻译：一种用于检测胎儿心率的装置和方法。该装置包括检测胎儿心跳的三个检测器，每个检测器包括检测ECG信号的至少两个电极，检测器位于正在使用的母亲的腹部上。该装置还包括耦合到检测器的处理器，该处理器适于处理从检测器接收的ECG信号并确定胎儿的心率。确定胎儿心率的方法包括确定胎儿在子宫内的位置，将检测器放置在母体的腹部上，监测从检测器获得的ECG信号达预定时间长度，以及处理ECG 从位于母亲腹部的检测器获得的信号，以确定母亲的心跳。

3. 发明授权

US07532923B1 Apparatus and method for detecting a fetal heart rate 有权
标题翻译：用于检测胎儿心率的装置和方法
公开(公告)号：US07532923B1
公开(公告)日：2009-05-12
申请号：US10089997
申请日：2000-10-06
申请人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
发明人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： The present invention relates to apparatus for detecting the heart rate of a fetus. The apparatus includes at least two detectors for detecting heart beats of the fetus, each detector comprising at least two electrodes for detecting ECG signals. A processor, which is coupled to the detectors, is used to process the ECG signals received from each detector and determine the heart rate of the fetus.
摘要翻译：本发明涉及用于检测胎儿心率的装置。该装置包括用于检测胎儿心跳的至少两个检测器，每个检测器包括用于检测ECG信号的至少两个电极。耦合到检测器的处理器用于处理从每个检测器接收的ECG信号并确定胎儿的心率。

4. 发明授权

US08768424B2 Photoplethysmography 有权
公开(公告)号：US08768424B2
公开(公告)日：2014-07-01
申请号：US12296513
申请日：2007-04-11
申请人： John Crowe , Mark Grubb , Barrie Hayes-Gill , Nicholas Miles
发明人： John Crowe , Mark Grubb , Barrie Hayes-Gill , Nicholas Miles
IPC分类号： A61B5/00
CPC分类号： A61B5/0295 , A61B5/02416 , A61B5/02433 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/7228 , A61B5/7235
摘要： A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output, insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarizing filters.
摘要翻译：光电体积描记器装置包括用于照射目标物体的光源。调制器驱动光源，使得输出强度作为调制频率处的调制信号的函数而变化。检测器从目标物体接收光并产生作为接收光强度的函数的电输出。具有本地振荡器的解调器接收检测器输出并产生解调输出，对调制信号和振荡器之间的任何相位差不敏感，指示作为时间和/或血液成分的函数的血容量。可以提供多个解调器来导出来自不同波长的多个光源或来自检测器阵列的信号。体积描记器可以在透射模式或反射模式下操作。当处于反射模式时，该装置可以使用光谱的绿色部分并且可以使用偏振滤光器。

5. 发明申请

US20100294917A1 Apparatus and Methods for Imaging 审中-公开
标题翻译：成像装置和方法
公开(公告)号：US20100294917A1
公开(公告)日：2010-11-25
申请号：US12740840
申请日：2008-10-30
申请人： Stephen Morgan , Barrie Hayes-Gill , John Crowe , Malcolm Woolfson
发明人： Stephen Morgan , Barrie Hayes-Gill , John Crowe , Malcolm Woolfson
IPC分类号： H01L31/102 , H01L31/09 , H03F3/08
CPC分类号： G01P5/26 , A61B5/0261 , A61B5/7242 , G01F1/661 , G01F1/663 , G01P3/366 , G01P5/001 , G01S17/58
摘要： For imaging, an electromagnetic radiation sensor is used to produce an output when illuminated by a modulated laser light. In use, the output is determined by a laser Doppler signal illuminating the sensor. Various examples are described for achieving integration of on-chip processing onto the substrate providing the sensor. In one example, the output of the sensor is a logarithmic function of the illuminating laser Doppler signal. In another example, the output of the sensor is normalized. In another example, an amplifier arrangement is provided to amplify the output of the sensor, the amplifier gain being lower at DC than at the frequency range of the laser Doppler signal. In another example, a filter is integrated into the semiconductor device. In another example, a bandpass filter and frequency weighted filter are provided, and their outputs are processed to average values over time.
摘要翻译：对于成像，使用电磁辐射传感器在被调制的激光照射时产生输出。在使用中，输出由照射传感器的激光多普勒信号决定。描述了用于实现将片上处理集成到提供传感器的基板上的各种示例。在一个示例中，传感器的输出是照明激光多普勒信号的对数函数。在另一示例中，传感器的输出被归一化。在另一示例中，提供放大器布置以放大传感器的输出，放大器增益在DC处比在激光多普勒信号的频率范围处更低。在另一示例中，将滤波器集成到半导体器件中。在另一示例中，提供带通滤波器和频率加权滤波器，并且它们的输出被处理成随时间的平均值。

6. 发明申请

US20090306487A1 PHOTOPLETHYSMOGRAPHY 有权
标题翻译：光电子学
公开(公告)号：US20090306487A1
公开(公告)日：2009-12-10
申请号：US12296513
申请日：2007-04-11
申请人： John Crowe , Mark Grubb , Barrie Hayes-Gill , Nicolas Miles
发明人： John Crowe , Mark Grubb , Barrie Hayes-Gill , Nicolas Miles
IPC分类号： A61B5/1455
CPC分类号： A61B5/0295 , A61B5/02416 , A61B5/02433 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/7228 , A61B5/7235
摘要： A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output,insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarising filters.
摘要翻译：光电体积描记器装置包括用于照射目标物体的光源。调制器驱动光源，使得输出强度作为调制频率处的调制信号的函数而变化。检测器从目标物体接收光并产生作为接收光强度的函数的电输出。具有本地振荡器的解调器接收检测器输出并产生解调输出，对调制信号和振荡器之间的任何相位差不敏感，指示作为时间和/或血液成分的函数的血容量。可以提供多个解调器来导出来自不同波长的多个光源或来自检测器阵列的信号。体积描记器可以在透射模式或反射模式下操作。当处于反射模式时，该装置可以使用光谱的绿色部分并且可以使用偏振滤光器。

7. 发明申请

US20070293855A1 Methods and devices for ablation 审中-公开
公开(公告)号：US20070293855A1
公开(公告)日：2007-12-20
申请号：US11878375
申请日：2007-07-24
申请人： John Sliwa , Matthias Vaska , Jonathan Podmore , Scott Anderson , Gerard Champsaur , John Crowe , Stephen Morse , Gary Miller
发明人： John Sliwa , Matthias Vaska , Jonathan Podmore , Scott Anderson , Gerard Champsaur , John Crowe , Stephen Morse , Gary Miller
IPC分类号： A61B18/18
CPC分类号： A61B17/22012 , A61B5/0422 , A61B8/429 , A61B17/2202 , A61B17/2251 , A61B18/00 , A61B18/02 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00023 , A61B2018/0016 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00375 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/142 , A61B2018/1467 , A61B2018/1472 , A61B2018/1861 , A61B2018/2283 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0078
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

8. 发明申请

US20070208395A1 Phototherapy Device and Method of Providing Phototherapy to a Body Surface 审中-公开
标题翻译：光疗设备和向身体表面提供光疗的方法
公开(公告)号：US20070208395A1
公开(公告)日：2007-09-06
申请号：US11686121
申请日：2007-03-14
申请人： Norbert Leclerc , Brendan Moran , James Flom , Michael Gertner , Jonathan Podmore , Michael Rode , John Crowe , Erica Rogers
发明人： Norbert Leclerc , Brendan Moran , James Flom , Michael Gertner , Jonathan Podmore , Michael Rode , John Crowe , Erica Rogers
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61B2017/00026 , A61B2017/00057 , A61B2018/00642 , A61B2018/00702 , A61B2018/00785 , A61N5/062 , A61N2005/007 , A61N2005/0628 , A61N2005/063 , A61N2005/0645 , A61N2005/0652
摘要： A method and apparatus is described for treating a target body surface using a radiation applicator. The therapeutic treatment apparatus adapted to conform to a patients body. The treatment apparatus comprises a plurality of light sources coupled with a flexible substrate, a light integrator in at least a portion of the optical path between the light source and the patient's body surface, a power supply, and a controller.
摘要翻译：描述了使用辐射施加器来治疗目标体表的方法和装置。该治疗设备适于符合患者身体。处理装置包括与柔性基板耦合的多个光源，在光源和患者体表之间的光路的至少一部分中的光积分器，电源和控制器。

9. 发明申请

US20070026377A1 Methods for preserving nucleated mammalian cells 审中-公开
标题翻译：保存有核哺乳动物细胞的方法
公开(公告)号：US20070026377A1
公开(公告)日：2007-02-01
申请号：US10575832
申请日：2004-10-18
申请人： John Crowe , Fern Tablin , Ann Oliver , Kamran Jamil , Xiaocui Ma , James Clegg , Willem Wolkers , Thurein Htoo
发明人： John Crowe , Fern Tablin , Ann Oliver , Kamran Jamil , Xiaocui Ma , James Clegg , Willem Wolkers , Thurein Htoo
IPC分类号： A01N1/02 , A61K31/7012
CPC分类号： A01N1/02 , A01N1/0221 , A61K31/7012
摘要： Methods and compositions are provided for increasing the survival of nucleated mammalian cells following drying and rehydration. The methods include introducing a disaccharide such as trehalose into said cells, optionally including heat shock proteins, apoptosis inhibitors, and arbutin, drying said cells, and rehydrating them. The invention further provides nucleated mammalian cells that have increased capacity to survive, divide and, in some cases, differentiate, following drying and rehydration. The cells comprise a disaccharide and one or more of the following: a heat shock protein, an apoptosis inhibitor, and arbutin.
摘要翻译：提供了用于在干燥和补液后增加有核哺乳动物细胞的存活的方法和组合物。所述方法包括将二糖如海藻糖引入所述细胞中，任选地包括热休克蛋白，凋亡抑制剂和熊果苷，干燥所述细胞并使其再水合。本发明进一步提供成核的哺乳动物细胞，其在干燥和补液后具有增加的存活能力，分裂能力以及在某些情况下区分。细胞包含二糖和一种或多种以下物质：热休克蛋白，凋亡抑制剂和熊果苷。

10. 发明申请

US20060135954A1 Methods and devices for ablation 失效
公开(公告)号：US20060135954A1
公开(公告)日：2006-06-22
申请号：US11237619
申请日：2005-09-27
申请人： John Sliwa , Matthias Vaska , Jonathan Podmore , Roxanne Richman , Scott Anderson , Gerard Champsaur , John Crowe
发明人： John Sliwa , Matthias Vaska , Jonathan Podmore , Roxanne Richman , Scott Anderson , Gerard Champsaur , John Crowe
IPC分类号： A61B18/04
CPC分类号： A61B18/00 , A61B5/0422 , A61B17/22012 , A61B17/2202 , A61B17/2251 , A61B18/02 , A61B18/04 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B34/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/2253 , A61B2017/3419 , A61B2018/00005 , A61B2018/00023 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/00898 , A61B2018/00982 , A61B2018/1213 , A61B2018/142 , A61B2018/1467 , A61B2018/147 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/056 , A61N1/06 , A61N1/362 , A61N7/02
摘要： An ablating device has a cover which holds an interface material such as a gel. The cover contains the interface material during initial placement of the device. The ablating device may also have a removable tip or a membrane filled with fluid. In still another aspect, the ablating device may be submerged in liquid during operation.

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