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1. 发明专利

CA2693182A1 COMPOUNDS USEFUL AS RAF KINASE INHIBITORS 未知
公开(公告)号：CA2693182A1
公开(公告)日：2009-01-08
申请号：CA2693182
申请日：2008-06-30
申请人： SUNESIS PHARMACEUTICALS INC , BIOGEN IDEC INC
发明人： CHEN WEIRONG , COSSROW JENNIER , FRANKLIN LLOYD , GUAN BING , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LANE BENJAMIN , LITTKE ADAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI , COSSROW JENNIFER
IPC分类号： C07D417/14 , A61K31/506 , A61P29/00 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

2. 发明专利

AU2008273002A1 Pyrimidine derivatives useful as Raf kinase inhibitors 未知
公开(公告)号：AU2008273002A1
公开(公告)日：2009-01-08
申请号：AU2008273002
申请日：2008-06-30
申请人： BIOGEN IDEC INC , SUNESIS PHARMACEUTICALS INC
发明人： XIN ZHILI , TANAKA HIROKO , JONES JOHN HOWARD , POWELL NOEL , LANE BENJAMIN , COSSROW JENNIFER , LUGOVSKOY ALEXEY , GUAN BING , PENG HAIRUO , CHEN WEIRONG , WYNN THOMAS , VESSELS JEFFREY , LITTKE ADAM , FRANKLIN LIOYD , KUMARAVEL GNANASAMBANDAM , RAIMUNDO BRIAN
IPC分类号： C07D401/12 , A61K31/506 , A61P29/00 , A61P35/00 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

3. 发明专利

CA2694284A1 HETEROCYCLIC COMPOUNDS USEFUL AS RAF KINASE INHIBITORS 未知
公开(公告)号：CA2694284A1
公开(公告)日：2009-01-08
申请号：CA2694284
申请日：2008-06-30
申请人： SUNESIS PHARMACEUTICALS INC , BIOGEN IDEC INC
发明人： COSSROW JENNIFER , GUAN BING , ISHCHENKO ALEXEY , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI
IPC分类号： C07D413/12 , A61K31/505 , A61P35/00 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently se-lected ted from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydro-gen or an optionally substituted C1-6 aliphatic group; The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Cy1 is an optionally substituted phenyl or an optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; Cy2 is an optionally substituted 5-10 membered saturated, partially unsaturated, or aromatic monocyclic or bicyclic ring having 0-4 heteroatoms, independently se-lected from nitrogen, oxygen, or sulfur; L1 is a direct bond of an optionally substituted, straight or branched C1-6 alkylene chain; L2 is a direct bond, or is an optionally substituted, straight or branched C1-6 alkylene chain wherein 1 or 2 methylene units of L2 are optionally and independently replaced by -O-, -S-, -N(R)-, -C(O)-, -C(O)N(R)-, -N(R)C(O)N(R)-, -N(R)C(O)-, -N(R)C(O)O-, -OC(O)N(R)-, -SO2-, -SO2N(R)-, -N(R)SO2-, -OC(O)-, -C(O)O-, or a 3-6 membered cycloalkylene; each R is independently hydro-gen or an optionally substituted C1-6 aliphatic group;

5. 发明专利

BRPI0813499A2 未知
公开(公告)号：BRPI0813499A2
公开(公告)日：2015-01-06
申请号：BRPI0813499
申请日：2008-06-30
申请人： SUNESIS PHARMACEUTICALS INC , BIOGEN IDEC INC
发明人： CHEN WEIRONG , COSSROW JENNIFER , FRANKLIN LIOYD , GUAN BING , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LANE BENJAMIN , LITTKE ADAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI
IPC分类号： C07D401/12 , A61K31/506 , A61P29/00 , A61P35/00 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

6. 发明专利

CA2693182C PYRIMIDINE COMPOUNDS, METHODS OF SYNTHESIS THEREOF, AND USE THEREOF IN THE TREATMENT OF RAF KINASE-MEDIATED DISORDERS 未知
公开(公告)号：CA2693182C
公开(公告)日：2018-01-02
申请号：CA2693182
申请日：2008-06-30
申请人： SUNESIS PHARMACEUTICALS INC , BIOGEN IDEC INC
发明人： CHEN WEIRONG , COSSROW JENNIFER , FRANKLIN LIOYD , GUAN BING , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LANE BENJAMIN , LITTKE ADAM , LUGOVSKOY ALEXEY
IPC分类号： C07D417/14 , A61K31/506 , A61P29/00 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

7. 发明专利

JP2013256534A Compounds useful as raf kinase inhibitors 有权
标题翻译：化合物作为RAF激酶抑制剂有用
公开(公告)号：JP2013256534A
公开(公告)日：2013-12-26
申请号：JP2013195277
申请日：2013-09-20
申请人： Sunesis Pharmaceuticals Inc , サネシスファーマシューティカルズ, インコーポレイテッド , Biogen Idec Ma Inc , バイオジェン・アイデック・エムエイ・インコーポレイテッド
发明人： CHEN WEIRONG , COSSROW JENNIFER , FRANKLIN LIOYD , GUAN BING , JONES JOHN HOWARD , KUMARAVEL GNANASAMBANDAM , LANE BENJAMIN , LITTKE ADAM , LUGOVSKOY ALEXEY , PENG HAIRUO , POWELL NOEL , RAIMUNDO BRIAN , TANAKA HIROKO , VESSELS JEFFREY , WYNN THOMAS , XIN ZHILI
IPC分类号： C07D239/42 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/00 , A61P1/16 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P19/08 , A61P25/28 , A61P29/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/74 , C07D237/20 , C07D241/20 , C07D261/10 , C07D277/20 , C07D277/32 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D487/04 , C12N9/99
CPC分类号： C07D417/14 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/675 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07F9/65583
摘要： PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of Raf protein kinase.SOLUTION: The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. It has now been found that compounds, and pharmaceutically acceptable compositions thereof, are effective as inhibitors of one or more protein kinases. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound, wherein the compound is present in an amount effective to inhibit Raf activity. In certain other embodiments, the invention provides pharmaceutical compositions comprising a compound and optionally further comprising an additional therapeutic agent. In yet other embodiments, the additional therapeutic agent is an agent for the treatment of cancer.
摘要翻译：要解决的问题：提供可用作Raf蛋白激酶抑制剂的化合物。解决方案：本发明提供了可用作Raf蛋白激酶抑制剂的化合物。本发明还提供了其组合物，以及Raf介导的疾病的治疗方法。现已发现化合物及其药学上可接受的组合物作为一种或多种蛋白激酶的抑制剂是有效的。在某些其它实施方案中，本发明提供包含化合物的药物组合物，其中所述化合物以有效抑制Raf活性的量存在。在某些其他实施方案中，本发明提供包含化合物和任选地进一步包含另外的治疗剂的药物组合物。在其它实施方案中，另外的治疗剂是用于治疗癌症的药剂。

8. 发明申请

WO2007089601A8 NOGO RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007089601A8
公开(公告)日：2008-10-02
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： C07K7/64 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

9. 发明申请

WO2006130374A3 TWEAK BINDING ANTIBODIES 审中-公开
标题翻译： TWEAK BINDING抗体
公开(公告)号：WO2006130374A3
公开(公告)日：2007-12-13
申请号：PCT/US2006019706
申请日：2006-05-25
申请人： BIOGEN IDEC INC , BURKLY LINDA C , GARBER ELLEN , LUGOVSKOY ALEXEY
发明人： BURKLY LINDA C , GARBER ELLEN , LUGOVSKOY ALEXEY
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： Anti-Tweak antibodies are described.
摘要翻译：描述了抗调节抗体。

10. 发明申请

WO2007089601A9 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2007089601A9
公开(公告)日：2008-12-18
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/28 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码它们的核酸。还公开了Nogo受体拮抗剂多核苷酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码它们的核酸和拮抗多核苷酸的组合物以及制备和使用该组合物的方法。

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