专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0486296A1 Power generator circuit 失效
标题翻译： Stromgeneratorkreis。
公开(公告)号：EP0486296A1
公开(公告)日：1992-05-20
申请号：EP91310507.8
申请日：1991-11-14
申请人： Meier, Werner Andreas
发明人： Meier, Werner Andreas
IPC分类号： H02J7/14
CPC分类号： H02J7/1438 , Y02T10/7005
摘要： A power generator circuit is adapted to be driven by the output of a vehicle alternator (10). The circuit includes an input (22) for receiving a rectified DC output from the alternator, and a pair of step-up transformers (TFR1, TFR2) which are connected to the AC output from the alternator. Rectifiers are connected to the outputs of the step-up transformers, and are connected in series with the rectified DC output from the alternator to provide a relatively high voltage DC output. This output can be used to operate power tools, for example. The circuit includes a welding output (18, 20), and allows normal charging of the vehicle battery (32) when not being used as a power source.
摘要翻译：发电机电路适于由车辆交流发电机（10）的输出驱动。电路包括用于接收来自交流发电机的整流DC输出的输入端（22）和连接到交流发电机的AC输出的一对升压变压器（TFR1，TFR2）。整流器连接到升压变压器的输出，并与交流发电机的整流直流输出串联，提供相对高压的直流输出。例如，该输出可用于操作电动工具。电路包括焊接输出（18,20），并且当不用作电源时允许车辆电池（32）正常充电。

2. 发明申请

WO2008112325A3 TREATMENT OF AUTOIMMUNE DISORDERS 审中-公开
标题翻译：治疗自身免疫性疾病
公开(公告)号：WO2008112325A3
公开(公告)日：2009-12-23
申请号：PCT/US2008003548
申请日：2008-03-17
申请人： BIOGEN IDEC INC , FARRINGTON GRAHAM K , BECKMAN EVAN , BROWNING JEFFREY L , MEIER WERNER
发明人： FARRINGTON GRAHAM K , BECKMAN EVAN , BROWNING JEFFREY L , MEIER WERNER
IPC分类号： C07K14/715
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. Improved LTBR-Ig fusion proteins, and pharmaceutical compositions thereof, are also described.
摘要翻译：用可改善性质的淋巴毒素途径的可溶性抑制剂治疗疾病的方法。还描述了改进的LTBR-Ig融合蛋白及其药物组合物。

3. 发明申请

WO2009111347A1 PURIFIED IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF THEIR PURIFICATION 审中-公开
标题翻译：纯化的免疫球蛋白融合蛋白及其纯化方法
公开(公告)号：WO2009111347A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/035581
申请日：2009-02-27
申请人： BIOGEN IDEC MA INC. , MCCUE, Justin , ROMERO, Jonathan , MEIER, Werner , NOTARNICOLA, Stephen , EVANS, David , MACNIVEN, Richard
发明人： MCCUE, Justin , ROMERO, Jonathan , MEIER, Werner , NOTARNICOLA, Stephen , EVANS, David , MACNIVEN, Richard
IPC分类号： C07K14/715 , C07K1/20 , C12N15/62 , C07K1/16
CPC分类号： C07K14/7151 , A61K47/6811 , A61K47/6835 , C07K2319/30 , C07K2319/32
摘要： The invention provides methods and compositions for separating impurities during the manufacture of immunoglobulin (Ig) fusion proteins. Examples of impurities which may be removed in accordance with the methods of the invention include inactive forms of the Ig fusion protein and/or aggregates.
摘要翻译：本发明提供了在制造免疫球蛋白（Ig）融合蛋白期间分离杂质的方法和组合物。根据本发明的方法可以除去的杂质的实例包括Ig融合蛋白和/或聚集体的无活性形式。

4. 发明申请

WO2008012008A1 EINRICHTUNG ZUM ENTFERNEN VON FESTSTOFFPARTIKELN AUS DEM IM PRIMÄRKREIS EINES KERNREAKTORS UMGEWÄLZTEN KÜHLMEDIUM 审中-公开
标题翻译：装置脱除固体颗粒初级电路核反应堆的循环冷却
公开(公告)号：WO2008012008A1
公开(公告)日：2008-01-31
申请号：PCT/EP2007/006317
申请日：2007-07-17
申请人： AREVA NP GMBH , LELICKENS, Hartmut , HUQ, Reazul , MEIER, Werner , HEINECKE, Jochen
发明人： LELICKENS, Hartmut , HUQ, Reazul , MEIER, Werner , HEINECKE, Jochen
IPC分类号： G21C3/32
CPC分类号： G21C3/3206 , G21Y2002/201 , G21Y2004/30 , Y02E30/40
摘要： Eine Einrichtung zum Entfernen von Feststoffpartikeln aus dem im Primärkreis eines Kernreaktors, insbesondere eines Siedewasserkernreaktors, umgewälzten Kühlmedium (K) ist in ihren geometrischen Abmessungen und Formen derart gestaltet, dass sie wie ein für diesen Kernreaktor konfiguriertes Brennelement und an Stelle eines solchen Brennelementes in eine leere Brennelementposition des Reaktorkerns (40) des Kernreaktors einsetzbar ist.
摘要翻译：装置，用于从一个核反应堆的初级电路中的除去的固体颗粒，特别是沸水反应器中，循环冷却介质（K）在其几何尺寸被构造和形状，使得它们排入一个等构成该核反应堆燃料元件，并且在适当位置这样的燃料组件的是核反应堆的反应堆堆芯（40）的可用的燃料元件的位置。

5. 发明申请

WO0036092A2 A METHOD FOR THE HIGH LEVEL EXPRESSION OF ACTIVE LYMPHOTOXIN- beta RECEPTOR IMMUNOGLOBULIN CHIMERIC PROTEINS AND THEIR PURIFICATION 审中-公开
标题翻译：一种高效表达活性LYMPHOTOXIN-β受体免疫球蛋白半胱氨酸蛋白质的方法及其纯化
公开(公告)号：WO0036092A2
公开(公告)日：2000-06-22
申请号：PCT/US9929873
申请日：1999-12-16
申请人： BIOGEN INC , BROWNING JEFFREY , MIATKOWSKI KONRAD , MEIER WERNER
发明人： BROWNING JEFFREY , MIATKOWSKI KONRAD , MEIER WERNER
IPC分类号： C12N15/09 , A61K38/00 , A61P37/02 , C07K14/705 , C07K14/715 , C07K16/00 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12R1/91
CPC分类号： C12P21/00 , A61K38/00 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C12P21/02
摘要： The invention relates to methods for the expression of high yields of the form protein-immunoglobulin fusions having high affinity binding to its ligand, by culturing hosts transformed with DNA encoding the desired fusions in a cultutre system at a low temperature thereby minimizing the amount of misfolded or misbridged protein forms. Said host cells may be transformed mammalian, insect, yeast or bacterial cells. The protein-immunoglobulin fusion may comprises a member of the TNF or TNF-receptor family, such as lymphotoxin-beta or lymphotoxin-beta receptor. The invention also relates to pharmaceutical composition comprising said protein-immunoglobulin fusions.
摘要翻译：本发明涉及通过在低温下培养在编码系统中编码所需融合物的DNA转化的宿主，通过培养具有高亲和力结合其配体的蛋白质 - 免疫球蛋白形式的高产率的方法，从而使错误折叠的量最小化或错配蛋白质形式。所述宿主细胞可以是转化的哺乳动物，昆虫，酵母或细菌细胞。蛋白质 - 免疫球蛋白融合物可以包含TNF或TNF受体家族的成员，例如淋巴毒素-β或淋巴毒素-β受体。本发明还涉及包含所述蛋白质 - 免疫球蛋白融合物的药物组合物。

6. 发明申请

WO2007089601A8 NOGO RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007089601A8
公开(公告)日：2008-10-02
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： C07K7/64 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

7. 发明申请

WO2008112325A2 TREATMENT OF AUTOIMMUNE DISORDERS 审中-公开
标题翻译：治疗自身免疫性疾病
公开(公告)号：WO2008112325A2
公开(公告)日：2008-09-18
申请号：PCT/US2008/003548
申请日：2008-03-17
申请人： BIOGEN IDEC MA INC. , FARRINGTON, Graham, K. , BECKMAN, Evan , BROWNING, Jeffrey, L. , MEIER, Werner
发明人： FARRINGTON, Graham, K. , BECKMAN, Evan , BROWNING, Jeffrey, L. , MEIER, Werner
IPC分类号： A61K38/17 , A61P37/00 , C12N5/10 , A61K39/395
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. Improved LTBR-Ig fusion proteins, and pharmaceutical compositions thereof, are also described.
摘要翻译：用可改善性质的淋巴毒素途径的可溶性抑制剂治疗疾病的方法。还描述了改进的LTBR-Ig融合蛋白及其药物组合物。

8. 发明申请

WO2007089601A3 NOGO RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007089601A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/002199
申请日：2007-01-26
申请人： BIOGEN IDEC MA INC. , LEE, Daniel, H.S. , WEN, Dingyi , PEPINSKY, R., Blake , RELTON, Jane, K. , WANG, Xinzhong , LUGOVSKOY, Alexey , MEIER, Werner , GARBER, Ellen, A. , SILVIAN, Laura , WEINREB, Paul, H.
发明人： LEE, Daniel, H.S. , WEN, Dingyi , PEPINSKY, R., Blake , RELTON, Jane, K. , WANG, Xinzhong , LUGOVSKOY, Alexey , MEIER, Werner , GARBER, Ellen, A. , SILVIAN, Laura , WEINREB, Paul, H.
IPC分类号： A61K39/395 , A61K38/17 , C07K16/28 , C07K14/705
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

9. 发明申请

WO03067606A2 FUEL ELEMENT FOR A BOILING WATER REACTOR 审中-公开
标题翻译：燃料元件用于沸水反应堆
公开(公告)号：WO03067606A2
公开(公告)日：2003-08-14
申请号：PCT/EP0300708
申请日：2003-01-24
申请人： FRAMATOME ANP GMBH , KREUTER DIETER , RAU PETER , ZIMMERMANN REINHART , BENDER DIETER , UEBELHACK WALTER , MEIER WERNER
发明人： KREUTER DIETER , RAU PETER , ZIMMERMANN REINHART , BENDER DIETER , UEBELHACK WALTER , MEIER WERNER
IPC分类号： G21C1/08 , G21C3/322 , G21C3/326 , G21C3/328 , G21C3/34 , G21C3/344 , G21C
CPC分类号： G21C3/328 , G21C1/084 , G21C3/322 , G21C2003/3432 , Y02E30/31 , Y02E30/38
摘要： Disclosed is a fuel element for a boiling water reactor, comprising a plurality of fuel rods (1 to 3) which are mounted in a plurality of spacers (11 to 18) placed at a distance from each other in the axial direction of the fuel element. At least one (1, 2) of said fuel rods has a reduced length. Deflecting element (48) are arranged at least in the top portion (B) of the fuel element in order to improve dryout behavior. The inventive fuel element also comprises means for reducing the loss of pressure caused in said portion (B) by the deflecting elements so as to improve thermohydraulic stability and shutdown behavior.
摘要翻译：对于一个沸水反应器，其包括多个燃料棒1至3，它们安装在燃料组件隔离物11至18和其中至少一个燃料棒1的轴向方向上间隔开的多个的燃料组件，2是部分地长。至少在燃料棒束B的上部区域被布置成提高行为干涸第48偏转根据本发明，为了提高热工水力稳定性和关断提供装置，用于减小由偏转器48的压力损失在这方面的B.

10. 发明申请

WO1997028535A1 NUCLEAR FUEL ASSEMBLY HAVING A TRANSITION PIECE WITH REDUCED FLOW RESISTANCE 审中-公开
标题翻译：具有降低流动阻力的过渡段的核燃料组件
公开(公告)号：WO1997028535A1
公开(公告)日：1997-08-07
申请号：PCT/US1996001275
申请日：1996-02-02
申请人： SIEMENS AKTIENGESELLSCHAFT , BARKHURST, David, J. , DRECKER, Stefan , MENGES, Dieter , MEIER, Werner , ALTER, Dietrich , EMMERT, Knut
发明人： SIEMENS AKTIENGESELLSCHAFT
IPC分类号： G21C03/322
CPC分类号： G21C5/06 , G21C3/322 , G21Y2002/201 , G21Y2002/304 , G21Y2004/302 , Y02E30/31 , Y02E30/38
摘要： In order to reduce the flow resistance of a coolant flowing through a passage (63) in the support plate (64) of a boiling water reactor and entering the transition piece (50) at the lower end of a fuel assembly resting on said support plate (64), the lower rim (60) of the transition piece (50) forms a conically tapered surface which fits into a corresponding conical counter-surface (62) at the upper edge of said passage (63). The lower rim (60) of the transition piece (50) forms a circular inlet which is concentric with the passage (63) and has a size equal or slightly larger than the passage opening. Fingers (70) protruding laterally into said opening and extending down into said passage (63) are used to center the low rim (60) within the passage (63). Additionally, the end caps (90) of the fuel rods may be stream-lined and the lower tie plate (53) of the fuel assembly may be spaced apart from the inner surface of a fuel channel (52) by a plurality of ribs (86) which form a plurality of peripheral through holes (86') on each of the four inner surfaces (84) of the rectangular fuel channel (52).
摘要翻译：为了降低流过沸水反应堆的支撑板（64）中的通道（63）的冷却剂的流动阻力，并进入位于所述支撑板上的燃料组件的下端的过渡件（50）（64）中，过渡件（50）的下边缘（60）形成锥形锥形表面，该锥形表面装配在所述通道（63）的上边缘处的对应锥形对置表面（62）中。过渡件（50）的下边缘（60）形成与通道（63）同心的圆形入口，其尺寸等于或稍大于通道开口。用于将侧边突出到所述开口并向下延伸到所述通道（63）中的手指70将所述低边缘（60）定位在所述通道（63）内。另外，燃料棒的端盖（90）可以是流线型的，并且燃料组件的下连接板（53）可以通过多个肋（...）与燃料通道（52）的内表面间隔开 86），其在矩形燃料通道（52）的四个内表面（84）中的每一个上形成多个周边通孔（86'）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式