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1. 发明申请

WO2007089601A9 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2007089601A9
公开(公告)日：2008-12-18
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/28 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码它们的核酸。还公开了Nogo受体拮抗剂多核苷酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码它们的核酸和拮抗多核苷酸的组合物以及制备和使用该组合物的方法。

2. 发明申请

WO2007025219A2 NOGO RECEPTOR POLYPEPTIDES AND POLYPEPTIDE FRAGMENTS AND USES THEREOF 审中-公开
标题翻译： NOGO受体多肽和多肽片段及其用途
公开(公告)号：WO2007025219A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/033369
申请日：2006-08-25
申请人： BIOGEN IDEC MA INC. , WEN, Dingyi , LEE, Daniel, H., S. , PEPINSKY, R., Blake
发明人： WEN, Dingyi , LEE, Daniel, H., S. , PEPINSKY, R., Blake
IPC分类号： A61K38/17 , C07K14/705
CPC分类号： C07K14/705
摘要： Nogo receptor 1 (NgR1) is a leucine rich repeat protein that forms part of a signaling complex that modulates axon regeneration. Previous studies have shown that the entire LRR region of Nogo receptor-1, including the C-terminal cap of LRR, LRRCT, is needed for ligand binding, and that the adjacent CT stalk of the Nogo receptor-1 contributes to interaction with its co-receptors. The present invention is directed to the use of certain Nogo receptor-1 and Nogo receptor-2 polypeptides and polypeptide fragments for promoting neurite outgrowth, neuronal survival, and axonal regeneration in CNS neurons. The invention features molecules and methods useful for inhibiting neurite outgrowth inhibition, promoting neuronal survival, and/or promoting axonal regeneration in CNS neurons.
摘要翻译： Nogo受体1（NgR1）是富含亮氨酸的重复蛋白，其形成调节轴突再生的信号复合物的一部分。以前的研究表明，配体结合需要Nogo受体-1的整个LRR区域，包括LRR的C端帽，LRRCT，Nogo受体-1的相邻CT茎与其co 受体拮抗剂。本发明涉及某些Nogo受体-1和Nogo受体-2多肽和多肽片段在CNS神经元中促进神经突生长，神经元存活和轴突再生的用途。本发明的特征在于可用于抑制神经突增生抑制，促进神经元存活和/或促进CNS神经元中的轴突再生的分子和方法。

3. 发明申请

WO2005016955A3 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2005016955A3
公开(公告)日：2006-07-20
申请号：PCT/US2004002702
申请日：2004-01-30
申请人： BIOGEN IDEC INC , UNIV YALE , LEE DANIEL H S , PEPINSKY R BLAKE , LI WEIWEI , RABACCHI SYLVIA A , RELTON JANE K , WORLEY DANE S , STRITTMATTER STEPHEN M , SAH DINAH Y W
发明人： LEE DANIEL H S , PEPINSKY R BLAKE , LI WEIWEI , RABACCHI SYLVIA A , RELTON JANE K , WORLEY DANE S , STRITTMATTER STEPHEN M , SAH DINAH Y W
IPC分类号： C07K5/00 , A61K38/00 , A61K39/395 , C07H21/04 , C07K20060101 , C07K14/00 , C07K14/705 , C07K16/28 , C12N15/00 , C12N15/11 , C12N15/85
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2319/30
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白以及编码其的核酸的制备和使用方法。

4. 发明申请

WO2007089601A8 NOGO RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007089601A8
公开(公告)日：2008-10-02
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： C07K7/64 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

5. 发明申请

WO9962505A3 METHOD FOR TREATING NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：治疗神经损伤性疾病的方法
公开(公告)号：WO9962505A3
公开(公告)日：2000-04-06
申请号：PCT/US9911702
申请日：1999-05-27
申请人： ORTHO MCNEIL PHARM INC , REITZ ALLEN B , DEMETER DAVID A , LEE DANIEL H S , WANG HOAU YAN , CHEN ROBERT H , ROSS TINA MORGAN , SCOTT MALCOLM K , PLATA SALAMAN CARLOS R
发明人： REITZ ALLEN B , DEMETER DAVID A , LEE DANIEL H S , WANG HOAU-YAN , CHEN ROBERT H , ROSS TINA MORGAN , SCOTT MALCOLM K , PLATA-SALAMAN CARLOS R
IPC分类号： G01N33/566 , A61K31/00 , A61K31/135 , A61K31/223 , A61K31/4453 , A61K31/5375 , A61K31/662 , A61K45/00 , A61P9/10 , A61P19/02 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , C07C215/64 , C07C217/74 , C07C229/14 , C07C323/25 , C07D295/08 , C07D295/092 , C07D295/096 , C07D333/20 , C07F9/32 , G01N33/68 , A61K31/535 , C07C215/74
CPC分类号： C07D295/096 , A61K31/00 , A61K31/135 , A61K31/5375 , C07C215/64 , C07C217/74 , C07C229/14 , C07C323/25 , C07C2602/10 , C07D295/088 , C07D333/20 , C07F9/3282
摘要： The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.
摘要翻译：本发明涉及一种在有需要的受试者中治疗神经变性疾病的方法，该方法包括向受试者施用一定量的有效抑制淀粉样蛋白-β与α-7烟碱乙酰胆碱受体相互作用的化合物。

6. 发明申请

WO2006124627A3 METHODS OF TREATING CONDITIONS INVOLVING NEURONAL DEGENERATION 审中-公开
标题翻译：治疗涉及神经衰弱的病症的方法
公开(公告)号：WO2006124627A3
公开(公告)日：2008-10-30
申请号：PCT/US2006018484
申请日：2006-05-12
申请人： BIOGEN IDEC INC , UNIV HONG KONG , LEE DANIEL H S , SAH DINAH W Y , SO KWOK FAI , WU WUTIAN
发明人： LEE DANIEL H S , SAH DINAH W Y , SO KWOK FAI , WU WUTIAN
IPC分类号： A61K38/00 , A01N37/18 , A01N61/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/55 , C07K2317/76
摘要： The invention provides methods for treating conditions of the eye involving death or degeneration of retinal ganglion cells, including glaucoma, by the administration of Nogo receptor-1 antagonists.
摘要翻译：本发明提供了通过施用Nogo受体-1拮抗剂来治疗涉及视网膜神经节细胞（包括青光眼）的死亡或退化的眼睛病症的方法。

7. 发明申请

WO2007098283A3 USE OF ANTAGONISTS OF MAIF RECEPTOR COMPLEX MOLECULES AND NEUROTROPHIC FACTORS FOR TREATMENT OF NEUROLOGICAL DISEASES AND DISORDERS 审中-公开
标题翻译：使用MAIF受体复合分子和神经营养因子拮抗剂治疗神经疾病和疾病
公开(公告)号：WO2007098283A3
公开(公告)日：2008-10-09
申请号：PCT/US2007005078
申请日：2007-02-27
申请人： BIOGEN IDEC INC , LEE DANIEL H S , ROSSOMANDO ANTHONY , WEINREB PAUL H
发明人： LEE DANIEL H S , ROSSOMANDO ANTHONY , WEINREB PAUL H
IPC分类号： A61K38/18
CPC分类号： A61K38/17
摘要： The invention provides methods of treating diseases, disorders, injuries, or conditions involving modulating neurite outgrowth and/or survival, and axonal regeneration including CNS disorders, stroke, or spinal injury, by administration of a MAIF receptor complex molecule antagonist and a neurotrophic factor.
摘要翻译：本发明提供了通过施用MAIF受体复合物分子拮抗剂和神经营养因子来治疗疾病，病症，损伤或涉及调节神经突生长和/或存活以及轴突再生（包括CNS病症，中风或脊髓损伤）的方法。

8. 发明申请

WO2008027526A1 METHODS RELATING TO PERIPHERAL ADMINISTRATION OF NOGO RECEPTOR POLYPEPTIDES 审中-公开
标题翻译：关于NOGO受体多聚体外周施用的方法
公开(公告)号：WO2008027526A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/019158
申请日：2007-08-31
申请人： BIOGEN IDEC MA INC. , YALE UNIVERSITY , STRITTMATTER, Stephen, M. , LEE, Daniel, H., S.
发明人： STRITTMATTER, Stephen, M. , LEE, Daniel, H., S.
IPC分类号： A01N37/18 , A61K38/00 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/70571 , A61K38/00 , A61K38/17 , A61K38/1703 , A61K45/06 , A61K47/60 , C07K14/4711 , C07K14/705 , A61K2300/00
摘要： This invention relates to methods of treating diseases involving accumulation of Aβ plaques, including Alzheimer's Disease by the peripheral administration of soluble Nogo receptor polypeptides. The invention also provides methods of increasing the plasma to brain ratio of Aβ peptide and enhancing Aβ peptide clearance via peripheral administration of soluble Nogo receptor polypeptides. This invention also provides methods of improving memory function or inhibiting memory loss via the peripheral administration of soluble Nogo receptor polypeptides. The invention also provides methods of decreasing the size and number of Aβ plaques in a mammal via peripheral administration of soluble Nogo receptor polypeptides.
摘要翻译：本发明涉及通过外周施用可溶性Nogo受体多肽治疗涉及Aß斑块累积（包括阿尔茨海默氏病）的疾病的方法。本发明还提供了通过外周施用可溶性Nogo受体多肽来增加Aβ肽的血浆与脑比例并增强Aβ肽清除率的方法。本发明还提供了通过外周施用可溶性Nogo受体多肽来改善记忆功能或抑制记忆丧失的方法。本发明还提供了通过外周施用可溶性Nogo受体多肽来减少哺乳动物中Aß噬斑的大小和数量的方法。

9. 发明申请

WO2007025219A3 NOGO RECEPTOR POLYPEPTIDES AND POLYPEPTIDE FRAGMENTS AND USES THEREOF 审中-公开
标题翻译： NOGO受体多肽和多肽片段及其用途
公开(公告)号：WO2007025219A3
公开(公告)日：2007-05-31
申请号：PCT/US2006033369
申请日：2006-08-25
申请人： BIOGEN IDEC INC , WEN DINGYI , LEE DANIEL H S , PEPINSKY R BLAKE
发明人： WEN DINGYI , LEE DANIEL H S , PEPINSKY R BLAKE
IPC分类号： C07K5/00 , A61K38/00 , A61K39/00 , A61K39/395
CPC分类号： C07K14/705
摘要： Nogo receptor 1 (NgR1) is a leucine rich repeat protein that forms part of a signaling complex that modulates axon regeneration. Previous studies have shown that the entire LRR region of Nogo receptor-1, including the C-terminal cap of LRR, LRRCT, is needed for ligand binding, and that the adjacent CT stalk of the Nogo receptor-1 contributes to interaction with its co-receptors. The present invention is directed to the use of certain Nogo receptor-1 and Nogo receptor-2 polypeptides and polypeptide fragments for promoting neurite outgrowth, neuronal survival, and axonal regeneration in CNS neurons. The invention features molecules and methods useful for inhibiting neurite outgrowth inhibition, promoting neuronal survival, and/or promoting axonal regeneration in CNS neurons.
摘要翻译： Nogo受体1（NgR1）是富含亮氨酸的重复蛋白，其形成调节轴突再生的信号复合物的一部分。先前的研究已经表明，Nogo受体-1的整个LRR区域（包括LRR的C末端帽子LRRCT）是配体结合所必需的，并且Nogo受体-1的相邻CT茎杆有助于与其相互作用受体拮抗剂。本发明涉及某些Nogo受体-1和Nogo受体-2多肽和多肽片段用于促进CNS神经元中神经突生长，神经元存活和轴突再生的用途。本发明的特征在于用于抑制神经突生长抑制，促进神经元存活和/或促进CNS神经元中的轴突再生的分子和方法。

10. 发明申请

WO2005016955A2 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2005016955A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/002702
申请日：2004-01-30
申请人： LEE, Daniel, H., S. , PEPINSKY, R., Blake , LI, Weiwei , RABACCHI, Sylvia, A. , RELTON, Jane, K. , WORLEY, Dane, S. , STRITTMATTER, Stephen, M. , SAH, Dinah, Y., W.
发明人： LEE, Daniel, H., S. , PEPINSKY, R., Blake , LI, Weiwei , RABACCHI, Sylvia, A. , RELTON, Jane, K. , WORLEY, Dane, S. , STRITTMATTER, Stephen, M. , SAH, Dinah, Y., W.
IPC分类号： C07K
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2319/30
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白以及编码其的核酸的制备和使用方法。

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