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1. 发明申请

WO2007089601A9 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2007089601A9
公开(公告)日：2008-12-18
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/28 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码它们的核酸。还公开了Nogo受体拮抗剂多核苷酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码它们的核酸和拮抗多核苷酸的组合物以及制备和使用该组合物的方法。

2. 发明申请

WO2007089601A8 NOGO RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007089601A8
公开(公告)日：2008-10-02
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： C07K7/64 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

3. 发明申请

WO2007089601A2 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2007089601A2
公开(公告)日：2007-08-09
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY BLAKE R , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY BLAKE R , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： C07K7/64 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。还公开了Nogo受体拮抗剂多核苷酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的拮抗剂多核苷酸的核酸和制备和使用的组合物。

4. 发明申请

WO9928876A3 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO9928876A3
公开(公告)日：1999-09-23
申请号：PCT/US9825585
申请日：1998-12-03
申请人： BIOGEN INC , PEPINSKY R BLAKE , ZENG CHENHUI , BAKER DARREN P , WEN DINGYI , WILLIAMS KEVIN P , GARBER ELLEN A , STRAUCH KATHRYN L , TAYLOR FREDERICK R , WEINREB PAUL H , PETTER RUSSELL C , GALDES ALPHONSE
发明人： PEPINSKY R BLAKE , ZENG CHENHUI , BAKER DARREN P , WEN DINGYI , WILLIAMS KEVIN P , GARBER ELLEN A , STRAUCH KATHRYN L , TAYLOR FREDERICK R , WEINREB PAUL H , PETTER RUSSELL C , GALDES ALPHONSE
IPC分类号： A61K38/00 , C07K14/46 , C07K14/435 , A61K38/18
CPC分类号： C07K14/46 , A61K38/00 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.

5. 发明申请

WO2007025219A3 NOGO RECEPTOR POLYPEPTIDES AND POLYPEPTIDE FRAGMENTS AND USES THEREOF 审中-公开
标题翻译： NOGO受体多肽和多肽片段及其用途
公开(公告)号：WO2007025219A3
公开(公告)日：2007-05-31
申请号：PCT/US2006033369
申请日：2006-08-25
申请人： BIOGEN IDEC INC , WEN DINGYI , LEE DANIEL H S , PEPINSKY R BLAKE
发明人： WEN DINGYI , LEE DANIEL H S , PEPINSKY R BLAKE
IPC分类号： C07K5/00 , A61K38/00 , A61K39/00 , A61K39/395
CPC分类号： C07K14/705
摘要： Nogo receptor 1 (NgR1) is a leucine rich repeat protein that forms part of a signaling complex that modulates axon regeneration. Previous studies have shown that the entire LRR region of Nogo receptor-1, including the C-terminal cap of LRR, LRRCT, is needed for ligand binding, and that the adjacent CT stalk of the Nogo receptor-1 contributes to interaction with its co-receptors. The present invention is directed to the use of certain Nogo receptor-1 and Nogo receptor-2 polypeptides and polypeptide fragments for promoting neurite outgrowth, neuronal survival, and axonal regeneration in CNS neurons. The invention features molecules and methods useful for inhibiting neurite outgrowth inhibition, promoting neuronal survival, and/or promoting axonal regeneration in CNS neurons.
摘要翻译： Nogo受体1（NgR1）是富含亮氨酸的重复蛋白，其形成调节轴突再生的信号复合物的一部分。先前的研究已经表明，Nogo受体-1的整个LRR区域（包括LRR的C末端帽子LRRCT）是配体结合所必需的，并且Nogo受体-1的相邻CT茎杆有助于与其相互作用受体拮抗剂。本发明涉及某些Nogo受体-1和Nogo受体-2多肽和多肽片段用于促进CNS神经元中神经突生长，神经元存活和轴突再生的用途。本发明的特征在于用于抑制神经突生长抑制，促进神经元存活和/或促进CNS神经元中的轴突再生的分子和方法。

6. 发明申请

WO9928343A9 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS 审中-公开
标题翻译：疏水改性的蛋白质组合物和方法
公开(公告)号：WO9928343A9
公开(公告)日：1999-10-14
申请号：PCT/US9825676
申请日：1998-12-03
申请人： BIOGEN INC , ONTOGENY INC , PEPINSKY R BLAKE , ZENG CHENHUI , BAKER DARREN P , WEN DINGYI , WILLIAMS KEVIN P , GARBER ELLEN A , STRAUCH KATHRYN L , TAYLOR FREDERICK R , WEINRUB PAUL H , PETTER RUSSELL C , GALDES ALPHONSE , PORTER JEFFREY
发明人： PEPINSKY R BLAKE , ZENG CHENHUI , BAKER DARREN P , WEN DINGYI , WILLIAMS KEVIN P , GARBER ELLEN A , STRAUCH KATHRYN L , TAYLOR FREDERICK R , WEINRUB PAUL H , PETTER RUSSELL C , GALDES ALPHONSE , PORTER JEFFREY
IPC分类号： A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61P25/00 , A61P43/00 , C07K1/107 , C07K14/00 , C07K14/46 , C07K14/435 , A61K38/18
CPC分类号： A61K38/1709 , C07K1/1077 , C07K14/46 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译：描述了疏水改性的蛋白质及其制备方法。疏水部分与蛋白质的表面氨基酸残基连接。疏水部分可以是脂质或肽。或者，蛋白质可以通过将各种疏水性结构附加到蛋白质上的各种化学反应衍生化。优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。疏水性部分用作方便的绳索，可以连接囊泡如细胞膜，脂质体或胶束。

7. 发明申请

WO9928343A2 HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS 审中-公开
标题翻译：水解性蛋白质组合物和方法
公开(公告)号：WO9928343A2
公开(公告)日：1999-06-10
申请号：PCT/US9825676
申请日：1998-12-03
申请人： BIOGEN INC , ONTOGENY INC , PEPINSKY R BLAKE , ZENG CHENHUI , BAKER DARREN P , WEN DINGYI , WILLIAMS KEVIN P , GARBER ELLEN A , STRAUCH KATHRYN L , TAYLOR FREDERICK R , WEINRUB PAUL H , PETTER RUSSELL C , GALDES ALPHONSE , PORTER JEFFREY
发明人： PEPINSKY R BLAKE , ZENG CHENHUI , BAKER DARREN P , WEN DINGYI , WILLIAMS KEVIN P , GARBER ELLEN A , STRAUCH KATHRYN L , TAYLOR FREDERICK R , WEINRUB PAUL H , PETTER RUSSELL C , GALDES ALPHONSE , PORTER JEFFREY
IPC分类号： A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61P25/00 , A61P43/00 , C07K1/107 , C07K14/00 , C07K14/46
CPC分类号： A61K38/1709 , C07K1/1077 , C07K14/46 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译：描述了疏水性修饰的蛋白质及其制备方法。疏水部分连接到蛋白质的表面氨基酸残基。疏水部分可以是脂质或肽。或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。

8. 发明申请

WO9804589A3 PRODUCTION OF RECOMBINANT PLASMA GELSOLIN CONTAINING A DISULFIDE BOND 审中-公开
标题翻译：含有崩解粘结剂的重结晶等离子体凝胶的生产
公开(公告)号：WO9804589A3
公开(公告)日：1998-03-26
申请号：PCT/US9713277
申请日：1997-07-30
申请人： BIOGEN INC , PEPINSKY R BLAKE , MILLER STEPHAN , HURKMANS KAREN , WEN DINGYI
发明人： PEPINSKY R BLAKE , MILLER STEPHAN , HURKMANS KAREN , WEN DINGYI
IPC分类号： A61K38/00 , C07K14/47 , A61K38/17 , C12N5/20
CPC分类号： C07K14/4702 , A61K38/00
摘要： A method is provided for producing recombinant gelsolin containing a disulfide bond. The oxidized gelsolin may be produced by treating intracellular recombinant gelsolin with an oxidant, or by denaturing gelsolin and then refolding gelsolin.

9. 发明申请

WO2004094620A3 TRUNCATED BAFF RECEPTORS 审中-公开
标题翻译：截断BAFF受体
公开(公告)号：WO2004094620A3
公开(公告)日：2006-01-19
申请号：PCT/US2004007692
申请日：2004-03-26
申请人： BIOGEN IDEC INC , AMBROSE CHRISTINE , THOMPSON JEFFREY , HSU YEN-MING , WEN DINGYI , SUN YAPING
发明人： AMBROSE CHRISTINE , THOMPSON JEFFREY , HSU YEN-MING , WEN DINGYI , SUN YAPING
IPC分类号： A61K38/00 , A61K38/17 , A61K39/395 , A61P37/00 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/18 , C07K19/00 , C12N20060101 , C12N1/00 , C12N15/00 , C12N15/12 , C12N15/13 , C12N15/62 , A61K38/18 , A61K38/19 , C07H21/04 , C07K14/475 , C07K14/52 , C12N5/18 , C12P21/00
CPC分类号： C07K14/715 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/2866 , C07K2317/52 , C07K2317/73 , C07K2319/30
摘要： The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.
摘要翻译：本公开提供在细胞外结构域中具有缺失的非天然存在的BAFF-R糖蛋白，其导致改变的O-连接的糖基化模式。本公开还提供了用于治疗B细胞和T细胞介导的病症的方法和药物组合物。

10. 发明公开

EP1940446A4 NOGO RECEPTOR POLYPEPTIDES AND POLYPEPTIDE FRAGMENTS AND USES THEREOF 审中-公开
标题翻译： Nogo受体多肽和多肽片段和用途
公开(公告)号：EP1940446A4
公开(公告)日：2009-08-05
申请号：EP06813792
申请日：2006-08-25
申请人： BIOGEN IDEC INC
发明人： WEN DINGYI , LEE DANIEL H S , PEPINSKY R BLAKE
IPC分类号： A61K38/17 , C07K14/705
CPC分类号： C07K14/705

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