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1. 发明申请

WO2007089601A2 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2007089601A2
公开(公告)日：2007-08-09
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY BLAKE R , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY BLAKE R , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： C07K7/64 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。还公开了Nogo受体拮抗剂多核苷酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的拮抗剂多核苷酸的核酸和制备和使用的组合物。

2. 发明申请

WO2007089601A9 NOGO RECEPTOR ANTAGONISTS 审中-公开
标题翻译： NOGO受体拮抗剂
公开(公告)号：WO2007089601A9
公开(公告)日：2008-12-18
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/28 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译：公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码它们的核酸。还公开了Nogo受体拮抗剂多核苷酸。还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码它们的核酸和拮抗多核苷酸的组合物以及制备和使用该组合物的方法。

3. 发明申请

WO2007089601A8 NOGO RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007089601A8
公开(公告)日：2008-10-02
申请号：PCT/US2007002199
申请日：2007-01-26
申请人： BIOGEN IDEC INC , LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
发明人： LEE DANIEL H S , WEN DINGYI , PEPINSKY R BLAKE , RELTON JANE K , WANG XINZHONG , LUGOVSKOY ALEXEY , MEIER WERNER , GARBER ELLEN A , SILVIAN LAURA , WEINREB PAUL H
IPC分类号： C07K7/64 , C12N15/113
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

4. 发明申请

WO2011139629A3 LIGHT TARGETING MOLECULES AND USES THEREOF 审中-公开
标题翻译：光靶向分子及其用途
公开(公告)号：WO2011139629A3
公开(公告)日：2012-04-19
申请号：PCT/US2011033752
申请日：2011-04-25
申请人： BIOGEN IDEC INC , WANG XINZHONG , BAILLY VERONIQUE , FARRINGTON GRAHAM K , LUGOVSKOY ALEXEY
发明人： WANG XINZHONG , BAILLY VERONIQUE , FARRINGTON GRAHAM K , LUGOVSKOY ALEXEY
IPC分类号： G01N33/68 , C07K14/00 , C12N15/09 , G01N33/52 , G01N33/53
CPC分类号： C07K16/30 , C07K14/525 , C07K14/7151 , C07K2319/01 , G01N33/57415
摘要： LIGHT-targeting molecules (e.g., LIGHT fusion molecules), compositions, e.g., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative, e.g., neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.
摘要翻译：公开了光靶向分子（例如，LIGHT融合分子），组合物，例如其药物组合物。还提供了使用这些分子来治疗，预防和/或诊断过度增殖，例如肿瘤性疾病或病症（包括但不限于癌症和转移）的方法。

5. 发明申请

WO2010051502A2 LIGHT TARGETING MOLECULES AND USES THEREOF 审中-公开
标题翻译：光靶分子及其用途
公开(公告)号：WO2010051502A2
公开(公告)日：2010-05-06
申请号：PCT/US2009062870
申请日：2009-10-30
申请人： BIOGEN IDEC INC , WANG XINZHONG , BAILLY VERONIQUE , GLASER SCOTT , LUGOVSKOY ALEXEY , FARRINGTON GRAHAM K , GRAFF CHRISTILYN
发明人： WANG XINZHONG , BAILLY VERONIQUE , GLASER SCOTT , LUGOVSKOY ALEXEY , FARRINGTON GRAHAM K , GRAFF CHRISTILYN
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30 , C07K19/00 , C12N15/62
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K16/2851 , C07K16/2869 , C07K2317/21 , C07K2317/55 , C07K2317/74 , C07K2317/77 , C07K2319/00 , C07K2319/32
摘要： LIGHT-targeting molecules (e.g., LIGHT fusion molecules), anti-HER2 antibody molecules, compositions, e.g., pharmaceutical compositions thereof, are disclosed. Methods of using these molecules to treat, prevent and/or diagnose hyperproliferative, e.g., neoplastic, diseases or conditions, including, but not limited to, cancer and metastasis are also provided.
摘要翻译：公开了靶向LIGHT的分子（例如LIGHT融合分子），抗HER2抗体分子，组合物，例如其药物组合物。还提供了使用这些分子来治疗，预防和/或诊断过度增殖性（例如肿瘤性）疾病或病症（包括但不限于癌症和转移瘤）的方法。

6. 发明申请

WO2012044684A3 INTERFERON-BETA FOR USE AS MONOTHERAPY OR IN COMBINATION WITH OTHER CANCER THERAPIES 审中-公开
标题翻译： INTERFERON-BETA用于单药治疗或与其他癌症治疗结合使用
公开(公告)号：WO2012044684A3
公开(公告)日：2012-06-28
申请号：PCT/US2011053681
申请日：2011-09-28
申请人： BIOGEN IDEC INC , BAKER DARREN P , JOSEPH INGRID B J K , WANG XINZHONG
发明人： BAKER DARREN P , JOSEPH INGRID B J K , WANG XINZHONG
IPC分类号： C07K1/00
CPC分类号： A61K38/215 , A61K31/166 , A61K31/337 , A61K31/4188 , A61K31/436 , A61K31/44 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , A61K2300/00 , C07K16/22 , C07K2317/24 , C07K2317/76
摘要： This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.
摘要翻译：该描述涉及聚合物缀合的干扰素-β作为单一疗法或与其他癌症疗法组合使用。

7. 发明申请

WO2006060089A3 NOVEL METHODS FOR PRODUCING ADENOVIRAL VECTOR PREPARATIONS WITH REDUCED REPLICATION-COMPETENT ADENOVIRUS CONTAMINATION AND NOVEL ADENOVIRAL VECTORS AND PREPARATIONS 审中-公开
标题翻译：用于生产具有降低的复制性腺病毒污染和新型腺病毒载体和制剂的腺病毒载体制备的新方法
公开(公告)号：WO2006060089A3
公开(公告)日：2007-01-11
申请号：PCT/US2005038714
申请日：2005-10-25
申请人： BIOGEN IDEC INC , WANG XINZHONG , KAYNOR GEORGE C , BARSOUM JAMES
发明人： WANG XINZHONG , KAYNOR GEORGE C , BARSOUM JAMES
IPC分类号： C12N15/861 , A61K48/00 , C12N5/10
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/53 , C12N2710/10343 , C12N2830/42 , C12N2840/203
摘要： This invention provides novel replication-defective adenoviral vectors comprising an adenoviral genome in which the protein IX gene, preferably under the control of its own promoter, is in an inverted orientation relative to the direction of transcription of the native protein IX gene at a location where the protein IX gene normally resides, for production of replication-competent adenovirus (RCA) free, or substantially RCA-free, adenovirus preparations. Said vector preferably encodes a gene of interest. The invention relates to viral particles, host cells and compositions comprising said adenoviral vector. This invention further relates a method for propagating adenovirus preparations, free, or substantially free, of replication-competent adenovirus (RCA) particles, from host cells comprising vectors of this invention, for use to treat a subject suffering from a disease or disorder or to prevent a subject from getting a disease or disorder, such as cancer. The invention also provides methods of treating such subjects and methods of prophylactically treating unaffected subjects. This invention further provides for vaccine compositions comprising the novel replication-defective adenoviral vectors of the present invention.
摘要翻译：本发明提供了包含腺病毒基因组的新型复制缺陷型腺病毒载体，其中优选在其自身启动子控制下的蛋白质IX基因相对于天然蛋白IX基因的转录方向处于倒置方向，蛋白IX基因通常存在，用于产生无复制的腺病毒（RCA）或基本上不含RCA的腺病毒制剂。所述载体优选编码感兴趣的基因。本发明涉及包含所述腺病毒载体的病毒颗粒，宿主细胞和组合物。本发明还涉及从包含本发明载体的宿主细胞中扩增游离或基本上游离的具有复制能力的腺病毒（RCA）颗粒的腺病毒制剂的方法，用于治疗患有疾病或病症的受试者或防止受试者患有疾病或病症，如癌症。本发明还提供了治疗这些受试者的方法和预防性治疗未受影响的受试者的方法。本发明进一步提供包含本发明的新型复制缺陷型腺病毒载体的疫苗组合物。

8. 发明申请

WO2008069942A3 NOVEL METHODS OF ENHANCING DELIVERY OF A GENE THERAPY VECTOR USING STEROIDS 审中-公开
标题翻译：使用STEROIDS增强基因治疗载体递送的新方法
公开(公告)号：WO2008069942A3
公开(公告)日：2008-09-12
申请号：PCT/US2007024526
申请日：2007-11-29
申请人： BIOGEN IDEC INC , WANG XINZHONG , PARR MICHAEL
发明人： WANG XINZHONG , PARR MICHAEL
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/0083 , C12N2710/10343
摘要： The invention provides methods for enhancing the delivery of a therapeutic gene product into a subject by administering a viral vector comprising a nucleic acid encoding the therapeutic gene product along with a steroid or a fragment, variant, derivative, or analog thereof that reduces the level of an inflammatory response and/or that modulates Kupffer cell function.
摘要翻译：本发明提供了通过施用包含编码治疗性基因产物的核酸的病毒载体以及降低其水平的类固醇或其片段，变体，衍生物或类似物来增强治疗性基因产物向受试者的递送的方法炎症反应和/或调节枯否细胞功能。

9. 发明专利

AU2011308906A1 Interferon-beta for use as monotherapy or in combination with other cancer therapies 未知
公开(公告)号：AU2011308906A1
公开(公告)日：2013-05-02
申请号：AU2011308906
申请日：2011-09-28
申请人： BIOGEN IDEC INC
发明人： BAKER DARREN P , JOSEPH INGRID B J K , WANG XINZHONG
IPC分类号： C07K1/00 , A61K38/21 , A61P35/00
摘要： This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.

10. 发明专利

NZ608630A Interferon-beta for use as monotherapy or in combination with other cancer therapies 未知
公开(公告)号：NZ608630A
公开(公告)日：2015-03-27
申请号：NZ60863011
申请日：2011-09-28
申请人： BIOGEN IDEC INC
发明人： BAKER DARREN P , JOSEPH INGRID B J K , WANG XINZHONG
IPC分类号： C07K1/00 , A61K38/21 , A61P35/00
摘要： Disclosed is the use of interferon beta and an inhibitor of a protein kinase in the Ras-Raf-MEK-ERK pathway in the manufacture of a combined preparation for concurrently or sequentially treating melanoma. Also disclosed is the use of interferon beta and an alkylating agent in the manufacture of a combined preparation for concurrently or sequentially treating melanoma.

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