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1. 发明授权

US08989469B2 Systems and methods for simultaneous acquisition of scatter and image projection data in computed tomography 有权
标题翻译：用于在计算机断层扫描中同时采集散射和图像投影数据的系统和方法
公开(公告)号：US08989469B2
公开(公告)日：2015-03-24
申请号：US13332212
申请日：2011-12-20
申请人： Benjamin Pooya Fahimian , Lei Xing , Bowen Meng
发明人： Benjamin Pooya Fahimian , Lei Xing , Bowen Meng
IPC分类号： G06K9/00 , A61B6/03 , A61B6/00 , G06T11/00 , A61N5/10
CPC分类号： A61B6/032 , A61B6/4021 , A61B6/4085 , A61B6/484 , A61B6/5282 , A61B6/583 , A61N5/1067 , A61N2005/1061 , G06T11/005 , G06T11/006 , G06T2211/421
摘要： A method of acquiring scatter data and image projection data in computed tomography is provided that includes attenuating a radiation source using a pattern of blockers arranged to provide blocked and unblocked regions of the radiation source, and acquiring image data and scatter data of a target using an imaging device. A scatter map in the projection image can be estimated by interpolation and/or extrapolation of the projection image using an appropriately programmed computer, subtracting the estimated scatter map from the projection image to obtain scatter-corrected projections, reconstructing a CBCT volume using a total variation regularization algorithm, and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume. Reconstructing a CBCT volume can include using a total variation regularization algorithm and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume, where scatter-induced artifacts are corrected in the projection image.
摘要翻译：提供了一种在计算机断层摄影中获取散射数据和图像投影数据的方法，其包括使用布置成提供辐射源的阻挡和未阻挡区域的阻挡器的图案来衰减辐射源，以及使用成像装置。可以通过使用适当编程的计算机的投影图像的插值和/或外推来估计投影图像中的散射图，从投影图像中减去估计的散射图以获得散射校正的投影，使用总变化重建CBCT体积正则化算法，并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平。重建CBCT卷可以包括使用总变差规则化算法并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平，其中在投影图像中校正散射引起的伪像。

2. 发明申请

US20120207370A1 Systems and Methods for Simultaneous Acquisition of Scatter and Image Projection Data in Computed Tomography 有权
标题翻译：在计算机断层扫描中同时采集散射和图像投影数据的系统和方法
公开(公告)号：US20120207370A1
公开(公告)日：2012-08-16
申请号：US13332212
申请日：2011-12-20
申请人： BENJAMIN Pooya FAHIMIAN , Lei Xing , Bowen Meng
发明人： BENJAMIN Pooya FAHIMIAN , Lei Xing , Bowen Meng
IPC分类号： G06K9/40 , A61B6/03
CPC分类号： A61B6/032 , A61B6/4021 , A61B6/4085 , A61B6/484 , A61B6/5282 , A61B6/583 , A61N5/1067 , A61N2005/1061 , G06T11/005 , G06T11/006 , G06T2211/421
摘要： A method of acquiring scatter data and image projection data in computed tomography is provided that includes attenuating a radiation source using a pattern of blockers arranged to provide blocked and unblocked regions of the radiation source, and acquiring image data and scatter data of a target using an imaging device. A scatter map in the projection image can be estimated by interpolation and/or extrapolation of the projection image using an appropriately programmed computer, subtracting the estimated scatter map from the projection image to obtain scatter-corrected projections, reconstructing a CBCT volume using a total variation regularization algorithm, and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume. Reconstructing a CBCT volume can include using a total variation regularization algorithm and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume, where scatter-induced artifacts are corrected in the projection image.
摘要翻译：提供了一种在计算机断层摄影中获取散射数据和图像投影数据的方法，其包括使用布置成提供辐射源的阻挡和未阻挡区域的阻挡器的图案来衰减辐射源，以及使用成像装置。可以通过使用适当编程的计算机的投影图像的插值和/或外推来估计投影图像中的散射图，从投影图像中减去估计的散射图以获得散射校正的投影，使用总变化重建CBCT体积正则化算法，并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平。重建CBCT卷可以包括使用总变差规则化算法并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平，其中在投影图像中校正散射引起的伪像。

3. 发明申请

US20120292534A1 Multi-phase Gating for Radiation Treatment Delivery and Imaging 审中-公开
标题翻译：用于放射治疗输送和成像的多相门控
公开(公告)号：US20120292534A1
公开(公告)日：2012-11-22
申请号：US13475231
申请日：2012-05-18
申请人： Sarah Geneser , Benjamin Pooya Fahimian , Lei Xing
发明人： Sarah Geneser , Benjamin Pooya Fahimian , Lei Xing
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1069 , A61N5/1042 , A61N2005/1061
摘要： A multi-phase radiation therapy treatment method is provided that includes computational software to simultaneously optimize radiation plans for each phase of delivery. A specific realization of multi-phase therapy, dual gating, is described where the first radiation therapy treatment plan provides treatment during an inhale phase of a patient breathing cycle and the second radiation therapy treatment plan provides treatment during an exhale phase of the patient breathing cycle. Using a radiation therapy machine, the first radiation therapy treatment plan is delivered during the inhale phase and the second radiation therapy treatment plan is delivered during the exhale phase of the patient breathing cycle. An associated imaging method is provided for gated volumetric image guidance at multiple different phases in a single imaging acquisition.
摘要翻译：提供了一种多相放射治疗方法，其包括计算软件，以同时优化每个递送阶段的辐射计划。描述了多相治疗双重选通的具体实现，其中第一放射治疗治疗计划在患者呼吸循环的吸气阶段期间提供治疗，并且第二放射治疗治疗计划在患者呼吸循环的呼气阶段期间提供治疗。使用放射治疗机，在吸气阶段期间输送第一次放射疗法治疗计划，并且在患者呼吸周期的呼气阶段期间传送第二次放射治疗治疗计划。提供了一种相关的成像方法，用于在单个成像采集中的多个不同阶段的门控体积图像引导。

4. 发明申请

US20130142310A1 DYNAMIC MULTI-AXES TRAJECTORY OPTIMIZATION AND DELIVERY METHOD FOR RADIATION TREATMENT 审中-公开
标题翻译：用于辐射处理的动态多轴测距优化和传送方法
公开(公告)号：US20130142310A1
公开(公告)日：2013-06-06
申请号：US13490450
申请日：2012-06-06
申请人： Benjamin Pooya Fahimian , Lei Xing , Sarah Geneser , Dimitre Hristov
发明人： Benjamin Pooya Fahimian , Lei Xing , Sarah Geneser , Dimitre Hristov
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1047 , A61N5/1082
摘要： Embodiments of the present invention provide methods for improved radiation treatment and imaging of solid cancers utilizing radiation beam trajectory optimization techniques to obtain conformal radiation coverage of tissue that is targeted to receive radiation, while minimizing exposure of healthy tissue and organs to harmful, unnecessary radiation.
摘要翻译：本发明的实施例提供了用于利用辐射束轨迹优化技术改进放射治疗和固体癌成像的方法，以获得靶向接受辐射的组织的适形辐射覆盖，同时使健康组织和器官暴露于有害的不必要的辐射最小化。

5. 发明授权

US09227085B2 Including fiducial markers in radiation therapy planning to facilitate real-time position monitoring during treatment delivery 有权
公开(公告)号：US09227085B2
公开(公告)日：2016-01-05
申请号：US12932666
申请日：2011-03-02
申请人： Yunzhi Ma , Paul J. Keall , Lei Xing
发明人： Yunzhi Ma , Paul J. Keall , Lei Xing
IPC分类号： G21K1/02 , A61N5/10 , A61B19/00
CPC分类号： A61N5/1031 , A61B2090/3966 , A61N5/1036 , A61N5/1037 , A61N5/1045 , A61N5/1047 , A61N5/1077 , A61N2005/1035 , A61N2005/1061
摘要： An inverse planning method that is capable of controlling the appearance of the implanted fiducial(s) in segmented IMRT fields for cine MV or combined MV/kV image-guided IMRT is provided. The method for radiation treatment includes computing a radiation treatment plan and delivering beams to a target in accordance with the radiation treatment plan, where computing the radiation treatment plan includes introducing a penalty in an inverse planning objective function optimization calculation to discourage or avoid blockage of one or more fiducials in optimized multi-leaf collimator (MLC) apertures.

6. 发明授权

US08498465B2 Accurate determination of the shape and localization of metallic object(s) in X-ray CT imaging 失效
标题翻译：准确测定X射线CT成像中金属物体的形状和定位
公开(公告)号：US08498465B2
公开(公告)日：2013-07-30
申请号：US12924327
申请日：2010-09-23
申请人： Lei Xing , Jing Wang
发明人： Lei Xing , Jing Wang
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/30052
摘要： A binary image reconstruction method is provided to identify metal objects in a computer tomography (CT) image. The method includes providing a suitably programmed computer, providing a CT image, where the CT image includes intensity data, and the suitably programmed computer is used to determine a first range of attenuation coefficient values and a second range of attenuation coefficient values in the intensity data, where when a difference between the first range of attenuation coefficient values and the second range of attenuation coefficient values is less than a pre-determined gradient threshold value, a boundary of a metal object in the CT image is determined.
摘要翻译：提供二值图像重建方法来识别计算机断层摄影（CT）图像中的金属物体。该方法包括提供适当编程的计算机，提供CT图像，其中CT图像包括强度数据，并且适当编程的计算机用于确定强度数据中的衰减系数值的第一范围和衰减系数值的第二范围其中，当第一衰减系数值范围和第二衰减系数值范围之间的差小于预定梯度阈值时，确定CT图像中的金属物体的边界。

7. 发明授权

US08121368B2 3D real-time tracking of human anatomy using combined kV and MV imaging 有权
标题翻译：使用组合的kV和MV成像对人体解剖结构的3D实时跟踪
公开(公告)号：US08121368B2
公开(公告)日：2012-02-21
申请号：US12291829
申请日：2008-11-12
申请人： Rodney D. Wiersma , Lei Xing , Weihua Mao
发明人： Rodney D. Wiersma , Lei Xing , Weihua Mao
IPC分类号： G06K9/00
CPC分类号： G06T7/251 , G06T2207/10081 , G06T2207/10116 , G06T2207/30096 , G06T2207/30204
摘要： A medical imaging-based system and method uses both kV and MV images captured during a treatment period for organ motion tracking. 3D geometric locations of internal features are computationally tracked as a function of time from internal features, such as natural biological features or implanted fiducials, which are computationally extracted from the captured kV and MV images. A partial information method allows 3D tracking to be maintained in the event that imaging information is temporarily not available.
摘要翻译：基于医学成像的系统和方法使用在治疗期间捕获的用于器官运动跟踪的kV和MV图像。内部特征的3D几何位置作为时间的函数从内部特征（例如自然生物特征或植入的基准）计算地跟踪，其从捕获的kV和MV图像计算地提取。如果成像信息暂时不可用，则部分信息方法允许维护3D跟踪。

8. 发明授权

US06697452B2 Verification method of monitor units and fluence map in intensity modulated radiation therapy 有权
标题翻译：强度调制放射治疗监测单位和能量密度图的验证方法
公开(公告)号：US06697452B2
公开(公告)日：2004-02-24
申请号：US10077825
申请日：2002-02-15
申请人： Lei Xing
发明人： Lei Xing
IPC分类号： A61N510
CPC分类号： A61N5/1031 , A61N5/1042 , Y10S378/901
摘要： A general computer-implemented method and computer program for an independent MU or dose and fluence calculation of an intensity modulated photon field in intensity modulated radiation therapy (IMRT) is provided. The present invention provides for the verification MU or dose calculation in high dose regions or low dose regions. In general, the dose at an arbitrary spatial point is expressed as a summation of the contributions from all the beamlets in a treatment field, each modulated by a dynamic modulation factor. The verification of a low dose region is based on using the inverted field of the low dose region. The advantage of the present invention that it is an independent method and therefore generally applicable and useful irrespective of the type of leaf sequence algorithm and delivery machines. It provides an automated computer-implemented method or program that generalizes and simplifies dose verification in IMRT.
摘要翻译：提供了一种用于强度调制放射治疗（IMRT）中的强度调制光子场的独立MU或剂量和注量计算的通用计算机实现的方法和计算机程序。本发明提供了在高剂量区域或低剂量区域中的验证MU或剂量计算。通常，在任意空间点处的剂量被表示为处理场中所有子束的贡献的总和，每个子束由动态调制因子调制。低剂量区域的验证是基于使用低剂量区域的反转场。本发明的优点是它是一种独立的方法，因此无论叶序算法和递送机器的类型是多么适用和有用的。它提供了一种自动计算机实现的方法或程序，可以概括和简化IMRT中的剂量验证。

9. 发明授权

US09270159B2 EMI filter using active damping with frequency dependant impedance 有权
标题翻译： EMI滤波器采用具有频率相关阻抗的主动阻尼
公开(公告)号：US09270159B2
公开(公告)日：2016-02-23
申请号：US13568578
申请日：2012-08-07
申请人： Miaosen Shen , Ming Li , Lei Xing
发明人： Miaosen Shen , Ming Li , Lei Xing
IPC分类号： H02M1/12
CPC分类号： H02M1/12 , H02M2001/123
摘要： A circuit for providing damping in an electromagnetic interference (EMI) filter with an inductor-capacitor (LC) circuit, includes at least one capacitor connected to receive a common-mode current from the LC circuit; a current sensor that senses the common-mode current; a linear amplifier that amplifies the sensed common-mode current; and a power amplifier that receives the amplified sensed common-mode current and outputs a voltage which creates a damping impedance for frequencies of the common-mode current less than a threshold frequency and absorbs the common-mode current for frequencies greater than the threshold frequency.
摘要翻译：用于在具有电感器 - 电容器（LC）电路的电磁干扰（EMI）滤波器中提供阻尼的电路包括至少一个连接以接收来自LC电路的共模电流的电容器; 感测共模电流的电流传感器; 放大感测的共模电流的线性放大器; 以及功率放大器，其接收放大的感测到的共模电流并且输出产生小于阈值频率的共模电流的频率的阻尼阻抗的电压，并且对于大于阈值频率的频率吸收共模电流。

10. 发明申请

US20140242600A1 IMAGING THE HETEROGENEOUS UPTAKE OF RADIOLABELED MOLECULES IN SINGLE LIVING CELLS 审中-公开
标题翻译：在单生动物细胞中成像放射性分子的异质摄取
公开(公告)号：US20140242600A1
公开(公告)日：2014-08-28
申请号：US13492606
申请日：2012-06-08
申请人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
发明人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
IPC分类号： G01N33/50
CPC分类号： G01N21/6458
摘要： A radioluminescence microscopy system and method for imaging the distribution of radiolabeled molecules in live cell cultures and tissue sections. Cells are grown and incubated with radiolabeled molecules on a scintillator plate or a scintillator plate is placed adjacent to the cells after incubation. Scintillation light produced by decay of radiolabeled molecules inside, bound to, or surrounding the cells, is recorded on an imaging device. Fluorescence microscopy of the same cells with other types of molecules of interest that are labeled with different fluorophores can be conducted concurrently and the biological activity of the labeled molecules can be correlated.
摘要翻译：放射性显微镜系统和用于在活细胞培养和组织切片中成像放射性标记分子的分布的方法。将细胞生长并与闪烁体板上的放射性标记的分子一起孵育，或者在孵育后将闪烁体板放置在与细胞相邻的位置。在成像装置上记录由放射性标记的分子内部，结合或围绕细胞的衰变产生的闪烁光。可以同时进行用不同荧光团标记的其他类型感兴趣的分子的相同细胞的荧光显微镜检查，并且标记分子的生物学活性可以相关。

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