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1. 发明授权

US08498465B2 Accurate determination of the shape and localization of metallic object(s) in X-ray CT imaging 失效
标题翻译：准确测定X射线CT成像中金属物体的形状和定位
公开(公告)号：US08498465B2
公开(公告)日：2013-07-30
申请号：US12924327
申请日：2010-09-23
申请人： Lei Xing , Jing Wang
发明人： Lei Xing , Jing Wang
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/30052
摘要： A binary image reconstruction method is provided to identify metal objects in a computer tomography (CT) image. The method includes providing a suitably programmed computer, providing a CT image, where the CT image includes intensity data, and the suitably programmed computer is used to determine a first range of attenuation coefficient values and a second range of attenuation coefficient values in the intensity data, where when a difference between the first range of attenuation coefficient values and the second range of attenuation coefficient values is less than a pre-determined gradient threshold value, a boundary of a metal object in the CT image is determined.
摘要翻译：提供二值图像重建方法来识别计算机断层摄影（CT）图像中的金属物体。该方法包括提供适当编程的计算机，提供CT图像，其中CT图像包括强度数据，并且适当编程的计算机用于确定强度数据中的衰减系数值的第一范围和衰减系数值的第二范围其中，当第一衰减系数值范围和第二衰减系数值范围之间的差小于预定梯度阈值时，确定CT图像中的金属物体的边界。

2. 发明申请

US20100316259A1 Using a moving imaging system to monitor anatomical position as a function of time 审中-公开
标题翻译：使用移动成像系统来监测解剖位置作为时间的函数
公开(公告)号：US20100316259A1
公开(公告)日：2010-12-16
申请号：US12802952
申请日：2010-06-16
申请人： Wu Liu , Rodney D. Wiersma , Nadeem Raiz , Jing Wang , Lei Xing
发明人： Wu Liu , Rodney D. Wiersma , Nadeem Raiz , Jing Wang , Lei Xing
IPC分类号： G06K9/00
CPC分类号： A61N5/1047 , A61N5/1042 , A61N5/1067 , A61N2005/1054 , A61N2005/1061 , G06T7/246 , G06T7/55 , G06T2207/10112 , G06T2207/30081
摘要： Real-time 3D tracking of anatomical positions during radiation therapy uses acquired image data from an MV treatment beam as it is rotated around the patient during arc radiotherapy treatment. The acquired image data and associated angular positions are computationally combined during the arc radiotherapy treatment to estimate in real time 3D positions of anatomical features of the patient, e.g., combining present image data and prior image data at earlier times. Supplementary image data from a kV imaging system may be acquired on an as-needed basis if MV position estimates indicate movement exceeding a predetermined threshold, and the supplementary kV image data combined with the acquired MV image data to improve an accuracy of the estimated 3D positions.
摘要翻译：放射治疗期间解剖学位置的实时3D跟踪使用来自MV治疗束的获取的图像数据，因为它们在电弧放疗期间围绕患者旋转。所获取的图像数据和相关的角位置在电弧放射治疗期间被计算地组合以估计患者的解剖特征的实时3D位置，例如在较早时间组合当前图像数据和先前图像数据。如果MV位置估计指示超过预定阈值的移动，并且与所获取的MV图像数据组合的辅助kV图像数据以提高估计的3D位置的精度，则可以根据需要在需要的基础上获取来自kV成像系统的补充图像数据。

3. 发明申请

US20110075911A1 Accurate determination of the shape and localization of metallic object(s) in X-ray CT imaging 失效
标题翻译：准确测定X射线CT成像中金属物体的形状和定位
公开(公告)号：US20110075911A1
公开(公告)日：2011-03-31
申请号：US12924327
申请日：2010-09-23
申请人： Lei Xing , Jing Wang
发明人： Lei Xing , Jing Wang
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/30052
摘要： A binary image reconstruction method is provided to identify metal objects in a computer tomography (CT) image. The method includes providing a suitably programmed computer, providing a CT image, where the CT image includes intensity data, and the suitably programmed computer is used to determine a first range of attenuation coefficient values and a second range of attenuation coefficient values in the intensity data, where when a difference between the first range of attenuation coefficient values and the second range of attenuation coefficient values is less than a pre-determined gradient threshold value, a boundary of a metal object in the CT image is determined.
摘要翻译：提供二值图像重建方法来识别计算机断层摄影（CT）图像中的金属物体。该方法包括提供适当编程的计算机，提供CT图像，其中CT图像包括强度数据，并且适当编程的计算机用于确定强度数据中的衰减系数值的第一范围和衰减系数值的第二范围其中，当第一衰减系数值范围和第二衰减系数值范围之间的差小于预定梯度阈值时，确定CT图像中的金属物体的边界。

4. 发明授权

US09227085B2 Including fiducial markers in radiation therapy planning to facilitate real-time position monitoring during treatment delivery 有权
公开(公告)号：US09227085B2
公开(公告)日：2016-01-05
申请号：US12932666
申请日：2011-03-02
申请人： Yunzhi Ma , Paul J. Keall , Lei Xing
发明人： Yunzhi Ma , Paul J. Keall , Lei Xing
IPC分类号： G21K1/02 , A61N5/10 , A61B19/00
CPC分类号： A61N5/1031 , A61B2090/3966 , A61N5/1036 , A61N5/1037 , A61N5/1045 , A61N5/1047 , A61N5/1077 , A61N2005/1035 , A61N2005/1061
摘要： An inverse planning method that is capable of controlling the appearance of the implanted fiducial(s) in segmented IMRT fields for cine MV or combined MV/kV image-guided IMRT is provided. The method for radiation treatment includes computing a radiation treatment plan and delivering beams to a target in accordance with the radiation treatment plan, where computing the radiation treatment plan includes introducing a penalty in an inverse planning objective function optimization calculation to discourage or avoid blockage of one or more fiducials in optimized multi-leaf collimator (MLC) apertures.

5. 发明授权

US08121368B2 3D real-time tracking of human anatomy using combined kV and MV imaging 有权
标题翻译：使用组合的kV和MV成像对人体解剖结构的3D实时跟踪
公开(公告)号：US08121368B2
公开(公告)日：2012-02-21
申请号：US12291829
申请日：2008-11-12
申请人： Rodney D. Wiersma , Lei Xing , Weihua Mao
发明人： Rodney D. Wiersma , Lei Xing , Weihua Mao
IPC分类号： G06K9/00
CPC分类号： G06T7/251 , G06T2207/10081 , G06T2207/10116 , G06T2207/30096 , G06T2207/30204
摘要： A medical imaging-based system and method uses both kV and MV images captured during a treatment period for organ motion tracking. 3D geometric locations of internal features are computationally tracked as a function of time from internal features, such as natural biological features or implanted fiducials, which are computationally extracted from the captured kV and MV images. A partial information method allows 3D tracking to be maintained in the event that imaging information is temporarily not available.
摘要翻译：基于医学成像的系统和方法使用在治疗期间捕获的用于器官运动跟踪的kV和MV图像。内部特征的3D几何位置作为时间的函数从内部特征（例如自然生物特征或植入的基准）计算地跟踪，其从捕获的kV和MV图像计算地提取。如果成像信息暂时不可用，则部分信息方法允许维护3D跟踪。

6. 发明授权

US06697452B2 Verification method of monitor units and fluence map in intensity modulated radiation therapy 有权
标题翻译：强度调制放射治疗监测单位和能量密度图的验证方法
公开(公告)号：US06697452B2
公开(公告)日：2004-02-24
申请号：US10077825
申请日：2002-02-15
申请人： Lei Xing
发明人： Lei Xing
IPC分类号： A61N510
CPC分类号： A61N5/1031 , A61N5/1042 , Y10S378/901
摘要： A general computer-implemented method and computer program for an independent MU or dose and fluence calculation of an intensity modulated photon field in intensity modulated radiation therapy (IMRT) is provided. The present invention provides for the verification MU or dose calculation in high dose regions or low dose regions. In general, the dose at an arbitrary spatial point is expressed as a summation of the contributions from all the beamlets in a treatment field, each modulated by a dynamic modulation factor. The verification of a low dose region is based on using the inverted field of the low dose region. The advantage of the present invention that it is an independent method and therefore generally applicable and useful irrespective of the type of leaf sequence algorithm and delivery machines. It provides an automated computer-implemented method or program that generalizes and simplifies dose verification in IMRT.
摘要翻译：提供了一种用于强度调制放射治疗（IMRT）中的强度调制光子场的独立MU或剂量和注量计算的通用计算机实现的方法和计算机程序。本发明提供了在高剂量区域或低剂量区域中的验证MU或剂量计算。通常，在任意空间点处的剂量被表示为处理场中所有子束的贡献的总和，每个子束由动态调制因子调制。低剂量区域的验证是基于使用低剂量区域的反转场。本发明的优点是它是一种独立的方法，因此无论叶序算法和递送机器的类型是多么适用和有用的。它提供了一种自动计算机实现的方法或程序，可以概括和简化IMRT中的剂量验证。

7. 发明授权

US09270159B2 EMI filter using active damping with frequency dependant impedance 有权
标题翻译： EMI滤波器采用具有频率相关阻抗的主动阻尼
公开(公告)号：US09270159B2
公开(公告)日：2016-02-23
申请号：US13568578
申请日：2012-08-07
申请人： Miaosen Shen , Ming Li , Lei Xing
发明人： Miaosen Shen , Ming Li , Lei Xing
IPC分类号： H02M1/12
CPC分类号： H02M1/12 , H02M2001/123
摘要： A circuit for providing damping in an electromagnetic interference (EMI) filter with an inductor-capacitor (LC) circuit, includes at least one capacitor connected to receive a common-mode current from the LC circuit; a current sensor that senses the common-mode current; a linear amplifier that amplifies the sensed common-mode current; and a power amplifier that receives the amplified sensed common-mode current and outputs a voltage which creates a damping impedance for frequencies of the common-mode current less than a threshold frequency and absorbs the common-mode current for frequencies greater than the threshold frequency.
摘要翻译：用于在具有电感器 - 电容器（LC）电路的电磁干扰（EMI）滤波器中提供阻尼的电路包括至少一个连接以接收来自LC电路的共模电流的电容器; 感测共模电流的电流传感器; 放大感测的共模电流的线性放大器; 以及功率放大器，其接收放大的感测到的共模电流并且输出产生小于阈值频率的共模电流的频率的阻尼阻抗的电压，并且对于大于阈值频率的频率吸收共模电流。

8. 发明申请

US20140242600A1 IMAGING THE HETEROGENEOUS UPTAKE OF RADIOLABELED MOLECULES IN SINGLE LIVING CELLS 审中-公开
标题翻译：在单生动物细胞中成像放射性分子的异质摄取
公开(公告)号：US20140242600A1
公开(公告)日：2014-08-28
申请号：US13492606
申请日：2012-06-08
申请人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
发明人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
IPC分类号： G01N33/50
CPC分类号： G01N21/6458
摘要： A radioluminescence microscopy system and method for imaging the distribution of radiolabeled molecules in live cell cultures and tissue sections. Cells are grown and incubated with radiolabeled molecules on a scintillator plate or a scintillator plate is placed adjacent to the cells after incubation. Scintillation light produced by decay of radiolabeled molecules inside, bound to, or surrounding the cells, is recorded on an imaging device. Fluorescence microscopy of the same cells with other types of molecules of interest that are labeled with different fluorophores can be conducted concurrently and the biological activity of the labeled molecules can be correlated.
摘要翻译：放射性显微镜系统和用于在活细胞培养和组织切片中成像放射性标记分子的分布的方法。将细胞生长并与闪烁体板上的放射性标记的分子一起孵育，或者在孵育后将闪烁体板放置在与细胞相邻的位置。在成像装置上记录由放射性标记的分子内部，结合或围绕细胞的衰变产生的闪烁光。可以同时进行用不同荧光团标记的其他类型感兴趣的分子的相同细胞的荧光显微镜检查，并且标记分子的生物学活性可以相关。

9. 发明申请

US20140043871A1 EMI FILTER USING ACTIVE DAMPING WITH FREQUENCY DEPENDANT IMPEDANCE 有权
标题翻译： EMI滤波器使用具有频率相关阻抗的主动阻尼
公开(公告)号：US20140043871A1
公开(公告)日：2014-02-13
申请号：US13568578
申请日：2012-08-07
申请人： Miaosen Shen , Ming Li , Lei Xing
发明人： Miaosen Shen , Ming Li , Lei Xing
IPC分类号： H02M1/12
CPC分类号： H02M1/12 , H02M2001/123
摘要： A circuit for providing damping in an electromagnetic interference (EMI) filter with an inductor-capacitor (LC) circuit, includes at least one capacitor connected to receive a common-mode current from the LC circuit; a current sensor that senses the common-mode current; a linear amplifier that amplifies the sensed common-mode current; and a power amplifier that receives the amplified sensed common-mode current and outputs a voltage which creates a damping impedance for frequencies of the common-mode current less than a threshold frequency and absorbs the common-mode current for frequencies greater than the threshold frequency.
摘要翻译：用于在具有电感器 - 电容器（LC）电路的电磁干扰（EMI）滤波器中提供阻尼的电路包括至少一个连接以接收来自LC电路的共模电流的电容器; 感测共模电流的电流传感器; 放大感测的共模电流的线性放大器; 以及功率放大器，其接收放大的感测到的共模电流并且输出产生小于阈值频率的共模电流的频率的阻尼阻抗的电压，并且对于大于阈值频率的频率吸收共模电流。

10. 发明授权

US08144829B2 Cone-beam CT imaging scheme 有权
标题翻译：锥束CT成像方案
公开(公告)号：US08144829B2
公开(公告)日：2012-03-27
申请号：US12380585
申请日：2009-02-27
申请人： Lei Zhu , Lei Xing
发明人： Lei Zhu , Lei Xing
IPC分类号： A61B6/03
CPC分类号： G21K1/02 , A61B6/032 , A61B6/466 , A61B6/542 , A61N5/103 , G06T11/005
摘要： A general imaging scheme is proposed for applications of CBCT. The approach provides a superior CBCT image quality by effective scatter correction and noise reduction. Specifically, in its implementation of CBCT imaging for radiation therapy, the proposed approach achieves an accurate patient setup using a partially blocked CBCT with a significantly reduced radiation dose. The image quality improvement due to the proposed scatter correction and noise reduction also makes CBCT-based dose calculation a viable solution to adaptive treatment planning.
摘要翻译：提出了CBCT应用的一般成像方案。该方法通过有效的散射校正和降噪来提供卓越的CBCT图像质量。具体来说，在实施用于放射治疗的CBCT成像时，所提出的方法使用部分阻断的CBCT具有显着降低的辐射剂量的精确的患者设置。由于所提出的散射校正和降噪的图像质量改善也使基于CBCT的剂量计算成为适应性治疗计划的可行解决方案。

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