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1. 发明授权

US08314796B2 Method of reconstructing a tomographic image using a graphics processing unit 有权
标题翻译：使用图形处理单元重建断层图像的方法
公开(公告)号：US08314796B2
公开(公告)日：2012-11-20
申请号：US11710273
申请日：2007-02-23
申请人： Guillem Pratx , Peter D. Olcott , Craig S. Levin
发明人： Guillem Pratx , Peter D. Olcott , Craig S. Levin
IPC分类号： G06T17/00 , G06K9/00
CPC分类号： G06T11/005 , A61B6/508
摘要： The present invention provides a method of reconstructing a tomographic image. In a first step, a tomographic image is forward-projected along a list of geometrical lines in a GPU. This list of geometrical lines may be list-mode event data acquired from a tomographic scanner. Alternatively, the list may be a list of weighted lines derived from a sinogram, a histogram, or a timogram acquired from a tomographic scanner. Next, the list of geometrical lines is back-projected into a 3-dimensional volume using the GPU. The results of the forward- and back-projection are then used to reconstruct the tomographic image, which is then provided as an output, e.g. to make the image available for further processing. Examples of output include storage on a storage medium and display on a display device.
摘要翻译：本发明提供一种重建断层图像的方法。在第一步中，断层图像沿着GPU中的几何线的列表向前投影。该几何线列表可以是从断层扫描仪获得的列表模式事件数据。或者，列表可以是从断层扫描仪获取的正弦图，直方图或时间图图导出的加权线列表。接下来，使用GPU将几何线的列表反投影到3维体积中。然后将前向和后向投影的结果用于重建断层图像，然后将其提供为输出，例如。以使图像可用于进一步处理。输出的示例包括在存储介质上的存储并显示在显示设备上。

2. 发明申请

US20140242600A1 IMAGING THE HETEROGENEOUS UPTAKE OF RADIOLABELED MOLECULES IN SINGLE LIVING CELLS 审中-公开
标题翻译：在单生动物细胞中成像放射性分子的异质摄取
公开(公告)号：US20140242600A1
公开(公告)日：2014-08-28
申请号：US13492606
申请日：2012-06-08
申请人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
发明人： Lei Xing , Colin Carpenter , Peter Olcott , Guillem Pratx , Conroy Sun
IPC分类号： G01N33/50
CPC分类号： G01N21/6458
摘要： A radioluminescence microscopy system and method for imaging the distribution of radiolabeled molecules in live cell cultures and tissue sections. Cells are grown and incubated with radiolabeled molecules on a scintillator plate or a scintillator plate is placed adjacent to the cells after incubation. Scintillation light produced by decay of radiolabeled molecules inside, bound to, or surrounding the cells, is recorded on an imaging device. Fluorescence microscopy of the same cells with other types of molecules of interest that are labeled with different fluorophores can be conducted concurrently and the biological activity of the labeled molecules can be correlated.
摘要翻译：放射性显微镜系统和用于在活细胞培养和组织切片中成像放射性标记分子的分布的方法。将细胞生长并与闪烁体板上的放射性标记的分子一起孵育，或者在孵育后将闪烁体板放置在与细胞相邻的位置。在成像装置上记录由放射性标记的分子内部，结合或围绕细胞的衰变产生的闪烁光。可以同时进行用不同荧光团标记的其他类型感兴趣的分子的相同细胞的荧光显微镜检查，并且标记分子的生物学活性可以相关。

3. 发明申请

US20110251484A1 Molecular imaging using radioluminescent nanoparticles 有权
标题翻译：使用放射性发光纳米粒子的分子成像
公开(公告)号：US20110251484A1
公开(公告)日：2011-10-13
申请号：US13066190
申请日：2011-04-08
申请人： Colin M. Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
发明人： Colin M. Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
IPC分类号： A61B6/00
CPC分类号： A61B6/4057 , A61B6/032 , A61B6/425 , A61B6/508
摘要： Molecular imaging of radioluminescent nanoparticle probes injected into biological tissue is performed by irradiated the tissue with ionizing radiation to induce radioluminescence at optical wavelengths, preferably at predetermined near infrared wavelengths. The optical light is detected and processed to determine a spatial distribution of the probes. The radioluminescent nanoparticles may be inorganic or organic phosphors, scintillators, or quantum dots. Imaging systems realizing this technique include tomographic systems using an x-ray beam to sequentially irradiate selected regions, systems with a radioactive source producing the ionizing radiation from outside the tissue, such as with a beam, or inside the tissue, such as with an endoscope or injected radiopharmaceutical. The optical signals may be detected by a photodetector array external to the tissue, a photodetector integrated with an endoscope or mammographic paddle, integrated into a capsule endoscope, or an array positioned near the biological tissue.
摘要翻译：注射到生物组织中的放射性发光纳米颗粒探针的分子成像通过用电离辐射照射组织来进行，以在光波长下诱导放射性发光，优选在预定的近红外波长处。检测和处理光学光以确定探针的空间分布。放射性发光纳米颗粒可以是无机或有机磷光体，闪烁体或量子点。实现该技术的成像系统包括使用X射线束依次照射所选择的区域的断层摄影系统，具有从组织外部产生电离辐射的放射源的系统，例如用光束或在组织内部，例如用内窥镜或注射放射性药物。光信号可以通过组织外部的光电检测器阵列检测，与内窥镜或乳房X射线检查器集成的光电检测器集成到胶囊型内窥镜中，或者位于靠近生物组织的阵列中。

4. 发明申请

US20110182491A1 Shift-Varing Line Projection using graphics hardware 有权
标题翻译： Shift-Varing Line投影使用图形硬件
公开(公告)号：US20110182491A1
公开(公告)日：2011-07-28
申请号：US12931263
申请日：2011-01-27
申请人： Craig S. Levin , Guillem Pratx , Jingyu Cul , Sven P. Prevrhal
发明人： Craig S. Levin , Guillem Pratx , Jingyu Cul , Sven P. Prevrhal
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T15/005 , G06T2211/421 , G06T2211/428
摘要： Line segments are classified according to orientation to improve list mode reconstruction of tomography data using graphics processing units (GPUs). The new approach addresses challenges which include compute thread divergence and random memory access by exploiting GPU capabilities such as shared memory and atomic operations. The benefits of the GPU implementation are compared with a reference CPU-based code. When applied to positron emission tomography (PET) image reconstruction, the GPU implementation is 43× faster, and images are virtually identical. In particular, the deviation between the GPU and the CPU implementation is less than 0.08% (RMS) after five iterations of the reconstruction algorithm, which is of negligible consequence in typical clinical applications.
摘要翻译：线段根据方向进行分类，以使用图形处理单元（GPU）来改进层析成像数据的列表模式重建。新方法解决了通过利用GPU功能（如共享内存和原子操作）来计算线程发散和随机存储器访问的挑战。将GPU实现的好处与基于CPU的代码进行比较。当应用于正电子发射断层扫描（PET）图像重建时，GPU实现速度提高43倍，图像几乎相同。特别地，在重建算法的五次迭代之后，GPU和CPU实现之间的偏差小于0.08％（RMS），这在典型的临床应用中可以忽略不计。

5. 发明申请

US20070201611A1 Method of reconstructing a tomographic image using a graphics processing unit 有权
标题翻译：使用图形处理单元重建断层图像的方法
公开(公告)号：US20070201611A1
公开(公告)日：2007-08-30
申请号：US11710273
申请日：2007-02-23
申请人： Guillem Pratx , Peter Olcott , Craig Levin
发明人： Guillem Pratx , Peter Olcott , Craig Levin
IPC分类号： H05G1/60 , A61B6/00 , G01N23/00 , G21K1/12
CPC分类号： G06T11/005 , A61B6/508
摘要： The present invention provides a method of reconstructing a tomographic image. In a first step, a tomographic image is forward-projected along a list of geometrical lines in a GPU. This list of geometrical lines may be list-mode event data acquired from a tomographic scanner. Alternatively, the list may be a list of weighted lines derived from a sinogram, a histogram, or a timogram acquired from a tomographic scanner. Next, the list of geometrical lines is back-projected into a 3-dimensional volume using the GPU. The results of the forward- and back-projection are then used to reconstruct the tomographic image, which is then provided as an output, e.g. to make the image available for further processing. Examples of output include storage on a storage medium and display on a display device.
摘要翻译：本发明提供一种重建断层图像的方法。在第一步中，断层图像沿着GPU中的几何线的列表向前投影。该几何线列表可以是从断层扫描仪获得的列表模式事件数据。或者，列表可以是从断层扫描仪获取的正弦图，直方图或时间图图导出的加权线列表。接下来，使用GPU将几何线的列表反投影到3维体积中。然后将前向和后向投影的结果用于重建断层图像，然后将其提供为输出，例如。以使图像可用于进一步处理。输出的示例包括在存储介质上的存储并显示在显示设备上。

6. 发明授权

US09456794B2 Molecular imaging using radioluminescent nanoparticles 有权
标题翻译：使用放射性发光纳米粒子的分子成像
公开(公告)号：US09456794B2
公开(公告)日：2016-10-04
申请号：US13066190
申请日：2011-04-08
申请人： Colin M Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
发明人： Colin M Carpenter , Lei Xing , Guillem Pratx , Conroy Ghin Chee Sun
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/4057 , A61B6/032 , A61B6/425 , A61B6/508
摘要： Molecular imaging of radioluminescent nanoparticle probes injected into biological tissue is performed by irradiated the tissue with ionizing radiation to induce radioluminescence at optical wavelengths, preferably at predetermined near infrared wavelengths. The optical light is detected and processed to determine a spatial distribution of the probes. The radioluminescent nanoparticles may be inorganic or organic phosphors, scintillators, or quantum dots. Imaging systems realizing this technique include tomographic systems using an x-ray beam to sequentially irradiate selected regions, systems with a radioactive source producing the ionizing radiation from outside the tissue, such as with a beam, or inside the tissue, such as with an endoscope or injected radiopharmaceutical. The optical signals may be detected by a photodetector array external to the tissue, a photodetector integrated with an endoscope or mammographic paddle, integrated into a capsule endoscope, or an array positioned near the biological tissue.
摘要翻译：注射到生物组织中的放射性发光纳米颗粒探针的分子成像通过用电离辐射照射组织来进行，以在光波长下诱导放射性发光，优选在预定的近红外波长处。检测和处理光学光以确定探针的空间分布。放射性发光纳米颗粒可以是无机或有机磷光体，闪烁体或量子点。实现该技术的成像系统包括使用X射线束依次照射所选择的区域的断层摄影系统，具有从组织外部产生电离辐射的放射源的系统，例如用光束或在组织内部，例如用内窥镜或注射放射性药物。光信号可以通过组织外部的光电检测器阵列检测，与内窥镜或乳房X射线检查器集成的光电检测器集成到胶囊型内窥镜中，或者位于靠近生物组织的阵列中。

7. 发明申请

US20110250128A1 Method for tissue characterization based on beta radiation and coincident Cherenkov radiation of a radiotracer 审中-公开
标题翻译：基于β辐射的组织表征方法和放射性示踪剂的符合Cherenkov辐射的方法
公开(公告)号：US20110250128A1
公开(公告)日：2011-10-13
申请号：US13066351
申请日：2011-04-12
申请人： Colin M Carpenter , Lei Xing , Conroy Ghin Chee Sun , Guillem Pratx
发明人： Colin M Carpenter , Lei Xing , Conroy Ghin Chee Sun , Guillem Pratx
IPC分类号： A61K51/00 , C12Q1/02
CPC分类号： A61K51/04
摘要： A method of characterizing a tissue sample is provided that includes injecting a tissue sample with radiotracers, where the radiotracers include beta-emitter radio tracers, the beta-emitter radio tracers emit beta particles according to a decay of the beta-emitter radio tracers, and measuring the beta particles or Cherenkov radiation from the beta particles in the tissue sample, and determining a condition of the radio tracers in the tissue sample according to the measured beta particles or the measured Cherenkov radiation, where the determined condition includes a depth and/or a concentration of the radiotracers in the tissue sample.
摘要翻译：提供了表征组织样本的方法，其包括用放射性示踪剂注射组织样本，其中放射性示踪剂包括β-发射体无线电示踪剂，β-发射体无线电示踪剂根据β-发射体无线电示踪剂的衰变发射β粒子，以及测量来自组织样本中的β粒子的β粒子或切伦科夫辐射，以及根据测量的β粒子或所测量的切伦科夫辐射来确定组织样本中的无线电示踪剂的状态，其中所确定的条件包括深度和/或组织样品中放射性示踪剂的浓度。

8. 发明授权

US09111381B2 Shift-varying line projection using graphics hardware 有权
标题翻译：使用图形硬件的变化线投影
公开(公告)号：US09111381B2
公开(公告)日：2015-08-18
申请号：US12931263
申请日：2011-01-27
申请人： Craig S. Levin , Guillem Pratx , Jingyu Cui , Sven P. Prevrhal
发明人： Craig S. Levin , Guillem Pratx , Jingyu Cui , Sven P. Prevrhal
IPC分类号： G06T15/00 , G06T11/00
CPC分类号： G06T11/006 , G06T15/005 , G06T2211/421 , G06T2211/428
摘要： Line segments are classified according to orientation to improve list mode reconstruction of tomography data using graphics processing units (GPUs). The new approach addresses challenges which include compute thread divergence and random memory access by exploiting GPU capabilities such as shared memory and atomic operations. The benefits of the GPU implementation are compared with a reference CPU-based code. When applied to positron emission tomography (PET) image reconstruction, the GPU implementation is 43× faster, and images are virtually identical. In particular, the deviation between the GPU and the CPU implementation is less than 0.08% (RMS) after five iterations of the reconstruction algorithm, which is of negligible consequence in typical clinical applications.
摘要翻译：线段根据方向进行分类，以使用图形处理单元（GPU）来改进层析成像数据的列表模式重建。新方法解决了通过利用GPU功能（如共享内存和原子操作）来计算线程发散和随机存储器访问的挑战。将GPU实现的好处与基于CPU的代码进行比较。当应用于正电子发射断层扫描（PET）图像重建时，GPU实现速度提高43倍，图像几乎相同。特别地，在重建算法的五次迭代之后，GPU和CPU实现之间的偏差小于0.08％（RMS），这在典型的临床应用中可以忽略不计。

9. 发明授权

US08274054B2 Method and apparatus for imaging using robust bayesian sequence reconstruction 失效
标题翻译：使用鲁棒贝叶斯序列重建的成像方法和装置
公开(公告)号：US08274054B2
公开(公告)日：2012-09-25
申请号：US12607853
申请日：2009-10-28
申请人： Guillem Pratx , Craig S. Levin
发明人： Guillem Pratx , Craig S. Levin
IPC分类号： G01T1/00
CPC分类号： G01T1/2985 , A61B6/037 , A61B6/508
摘要： Methods and systems for determining a sequence of energy interactions in a detector. A plurality of discrete energy interactions is received in a plurality of detector voxels. A plurality of possible sequences of interaction is formed based on the received plurality of discrete energy interactions. For each of the plurality of possible sequences of interaction, an a posteriori probability is computed, where the a posteriori probability is based on a likelihood that the possible sequence of interaction is consistent with the received plurality of discrete energy interactions. Additionally or alternatively, the a posteriori probability may be based on an a priori probability. One of the formed plurality of possible sequences of interaction is selected based on the computed a posteriori probability.
摘要翻译：用于确定检测器中能量相互作用序列的方法和系统。在多个检测器体素中接收多个离散能量相互作用。基于所接收的多个离散能量相互作用形成多个可能的相互作用序列。对于多个可能的交互序列中的每一个，计算后验概率，其中后验概率基于可能的交互序列与所接收的多个离散能量相互作用一致的可能性。另外或替代地，后验概率可以基于先验概率。基于所计算的后验概率来选择所形成的多个可能的交互序列中的一个。

10. 发明申请

US20100108894A1 METHOD AND APPARATUS FOR IMAGING USING ROBUST BAYESIAN SEQUENCE RECONSTRUCTION 失效
标题翻译：使用稳健的BAYESIAN序列重建成像的方法和装置
公开(公告)号：US20100108894A1
公开(公告)日：2010-05-06
申请号：US12607853
申请日：2009-10-28
申请人： Guillem Pratx , Craig S. Levin
发明人： Guillem Pratx , Craig S. Levin
IPC分类号： G01T1/20 , G01T1/24
CPC分类号： G01T1/2985 , A61B6/037 , A61B6/508
摘要： Methods and systems for determining a sequence of energy interactions in a detector. A plurality of discrete energy interactions is received in a plurality of detector voxels. A plurality of possible sequences of interaction is formed based on the received plurality of discrete energy interactions. For each of the plurality of possible sequences of interaction, an a posteriori probability is computed, where the a posteriori probability is based on a likelihood that the possible sequence of interaction is consistent with the received plurality of discrete energy interactions. Additionally or alternatively, the a posteriori probability may be based on an a priori probability. One of the formed plurality of possible sequences of interaction is selected based on the computed a posteriori probability.
摘要翻译：用于确定检测器中能量相互作用序列的方法和系统。在多个检测器体素中接收多个离散能量相互作用。基于所接收的多个离散能量相互作用形成多个可能的相互作用序列。对于多个可能的交互序列中的每一个，计算后验概率，其中后验概率基于可能的交互序列与所接收的多个离散能量相互作用一致的可能性。另外或替代地，后验概率可以基于先验概率。基于所计算的后验概率来选择所形成的多个可能的交互序列中的一个。

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