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1. 发明申请

US20100310673A1 SUBSTANCE AND COMPOSITION BOTH CAPABLE OF IMPARTING HEAT RESISTANCE 有权
标题翻译：具有耐腐蚀性的两种物质和组合物
公开(公告)号：US20100310673A1
公开(公告)日：2010-12-09
申请号：US12867979
申请日：2009-03-31
申请人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
发明人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
IPC分类号： A61K33/34 , C07H21/00 , A61K33/26 , A61K33/30 , A61K38/40 , C07K14/79 , A61P31/04 , A61P3/00 , A61P37/04 , A61P29/00 , A23L1/305
CPC分类号： A61K47/42 , A23L33/19 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/2063 , A61K9/4866 , A61K38/40 , A61K47/26
摘要： An agent for thermally stabilizing lactoferrin, which comprises a nucleic acid as an active ingredient, can be added to lactoferrin to impart thermal stability to lactoferrin. Thermally stabilized lactoferrin can be heat-sterilized at a pH value around a neutral pH value while keeping its activity.
摘要翻译：可以将含有核酸作为活性成分的用于热稳定的乳铁蛋白的试剂加入到乳铁蛋白中以赋予乳铁蛋白热稳定性。热稳定的乳铁蛋白可以在pH值约为中性pH值的同时保持其活性而被热灭菌。

2. 发明授权

US08420128B2 Method of imparting heat resistance to lactoferrin 有权
标题翻译：赋予乳铁蛋白耐热性的方法
公开(公告)号：US08420128B2
公开(公告)日：2013-04-16
申请号：US12867979
申请日：2009-03-31
申请人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
发明人： Ayako Horigome , Mai Murata , Koji Yamauchi , Mitsunori Takase , Yasuhiro Takeda , Junichi Hashimoto , Ikumi Kojima
IPC分类号： A01N59/20 , A61K33/34
CPC分类号： A61K47/42 , A23L33/19 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/2063 , A61K9/4866 , A61K38/40 , A61K47/26
摘要： An agent for thermally stabilizing lactoferrin, which comprises a nucleic acid as an active ingredient, can be added to lactoferrin to impart thermal stability to lactoferrin. Thermally stabilized lactoferrin can be heat-sterilized at a pH value around a neutral pH value while keeping its activity.
摘要翻译：可以将含有核酸作为活性成分的用于热稳定的乳铁蛋白的试剂加入到乳铁蛋白中以赋予乳铁蛋白热稳定性。热稳定的乳铁蛋白可以在pH值约为中性pH值的同时保持其活性而被热灭菌。

3. 发明授权

US5804555A Antioxidant 失效
标题翻译：抗氧化剂
公开(公告)号：US5804555A
公开(公告)日：1998-09-08
申请号：US381984
申请日：1995-04-11
申请人： Mamoru Tomita , Seiichi Shimamura , Kouzo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokida
发明人： Mamoru Tomita , Seiichi Shimamura , Kouzo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokida
IPC分类号： A61K8/96 , A23L3/3526 , A23L3/3571 , A61K8/00 , A61K8/64 , A61K8/66 , A61K8/98 , A61K38/00 , A61K38/16 , A61P39/06 , A61P43/00 , A61Q11/00 , A61Q19/00 , C09K15/18 , C09K15/22 , C11B5/00 , A61K38/01 , C07K14/79
CPC分类号： C09K15/18 , A23L3/3526 , A23L3/3571 , C09K15/22 , C11B5/0007
摘要： The present invention provides a safe antioxidant applicable for food, drug medicine, non-medical drug and other products. The antioxidant of the present invention contains, as an effective ingredient, an antioxidant substance selected from the group consisting of a hydrolysate of lactoferrin, one or more peptides isolated from a hydrolysate of lactoferrins, one or more synthetic peptides having the same sequence as that of the peptide isolated from the hydrolysate of lactoferrins, and any mixture thereof, or said antioxidant substance and oxidant preventive agent. This antioxidant has an excellent antioxidant action for various lipids, and is very safe even when used in foods and drug medicine. Scince it exhibits antioxidant effect with only small quantity, there is almost no adverse effect on flavor even when applied in foods and the like.
摘要翻译： PCT No.PCT / JP93 / 01090 Sec。 371日期1995年04月11日 102（e）日期1995年4月11日PCT提交1993年8月4日PCT公布。第WO94 / 03555号公报日期1994年2月17日本发明提供了适用于食品，药物，非医药等产品的安全抗氧化剂。本发明的抗氧化剂含有选自乳铁蛋白的水解产物，从乳铁蛋白水解产物分离的一种或多种肽的一种或多种肽，作为有效成分的一种或多种合成肽，具有与分离自乳铁蛋白的水解产物的肽，及其任何混合物，或所述抗氧化物质和氧化剂预防剂。这种抗氧化剂对各种脂质具有优异的抗氧化作用，即使用于食品和药物也非常安全。 Scince它仅具有少量的抗氧化作用，即使应用于食品等也几乎没有不利影响。

4. 发明授权

US5214028A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：用作抗菌剂和作为酪氨酸酶抑制剂的LACTOFERRIN水解产物
公开(公告)号：US5214028A
公开(公告)日：1993-05-25
申请号：US634763
申请日：1990-12-27
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

5. 发明授权

US5424396A Antimicrobial peptide and antimicrobial agent 失效
标题翻译：抗菌肽和抗菌剂
公开(公告)号：US5424396A
公开(公告)日：1995-06-13
申请号：US165545
申请日：1993-12-13
申请人： Mamoru Tomita , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
发明人： Mamoru Tomita , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
IPC分类号： A01N37/44 , A23L3/3526 , A61K38/00 , A61P31/04 , C07K5/08 , C07K5/10 , C07K7/06 , C07K14/79 , C11D3/48 , C11D9/50 , C07K7/00
CPC分类号： C07K14/79 , A61K38/00 , Y02P20/55
摘要： An antimicrobial peptide containing an amino acid sequence comprising at least from three to six arbitrary amino acid residues, or a derivative thereof, an antimicrobial agent containing said antimicrobial peptide or a derivative thereof as active components at a concentration of at least 2 .mu.M, an antimicrobial composition containing said antimicrobial peptide or a derivative thereof, and a method for processing products which uses the antimicrobial agent containing at least said antimicrobial peptide or a derivative thereof.
摘要翻译：含有至少3〜6个任意氨基酸残基的氨基酸序列或其衍生物的抗微生物肽，含有所述抗微生物肽或其衍生物的抗微生物剂为至少2μM的浓度的活性成分，含有所述抗微生物肽或其衍生物的抗微生物组合物，以及使用含有至少所述抗微生物肽或其衍生物的抗微生物剂的产品加工方法。

6. 发明授权

US5656591A Antimicrobial agents and method for treating products therewith 失效
标题翻译：抗微生物剂及其制品的处理方法
公开(公告)号：US5656591A
公开(公告)日：1997-08-12
申请号：US256771
申请日：1994-11-29
申请人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
发明人： Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Yasuo Fukuwatari , Mitsunori Takase , Wayne Robert Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukiko Tokita
IPC分类号： A01N63/02 , A61K38/00 , A61K38/01 , A61K38/12 , A61K38/40 , A61K38/47 , C07K14/79 , A61K37/16 , A23L3/34
CPC分类号： C07K14/79 , A01N63/02 , A61K31/43 , A61K38/12 , A61K45/06 , A61K38/00 , Y10S530/833
摘要： There is disclosed an antimicrobial agent comprising one or more of antimicrobial peptides derived from lactoferrins, and one or more of specific compounds and/or at least an antibiotic, and a method for treating matters with said antimicrobial agent. The antimicrobial agent has a potent antimicrobial activity against wide variety of microorganisms, thus it is useful not only as a medication, but also useful for making antimicrobial treatment of matters such as foods, non-medical products, and the like with safety and great efficiency.
摘要翻译： PCT No.PCT / JP92 / 01563。 371日期：1994年11月29日 102（e）日期1994年11月29日PCT 1991年11月30日PCT PCT。公开号WO93 / 14640 PCT 日本公开1993年8月5日公开了一种抗微生物剂，其包含一种或多种衍生自乳铁蛋白的抗微生物肽，以及一种或多种特定化合物和/或至少抗生素，以及用所述抗微生物剂处理物质的方法。抗微生物剂对各种微生物具有有效的抗微生物活性，因此不仅可用作药物，而且可用于以安全性和高效率对食品，非医药产品等物质进行抗菌处理。

7. 发明授权

US5428016A Antimicrobial peptide and antimicrobial agent 失效
标题翻译：抗菌肽和抗菌剂
公开(公告)号：US5428016A
公开(公告)日：1995-06-27
申请号：US851941
申请日：1992-03-13
申请人： Mamoru Tomita , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukio Tokita
发明人： Mamoru Tomita , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy , Koji Yamauchi , Hiroyuki Wakabayashi , Yukio Tokita
IPC分类号： A61K38/00 , C07K14/79 , C07K5/00 , C07K7/00
CPC分类号： C07K14/79 , A61K38/00
摘要： An antimicrobial peptide containing at least the following amino acid sequence, or a derivative thereof, an antimicrobial agent containing said antimicrobial peptide or a derivative thereof as active components at a concentration of at least 1 .mu.M, an antimicrobial composition containing said antimicrobial peptide or a derivative thereof, and a method for processing products which uses the antimicrobial agent containing at least said antimicrobial peptide or a derivative thereof:A--X--A(where, A is an arginine residue or a lysine residue; and X is an amino acid sequence comprising at least from three to nine arbitrary amino acid residues other than cysteine residues.)
摘要翻译：至少含有以下氨基酸序列的抗微生物肽或其衍生物，含有所述抗微生物肽或其衍生物作为活性组分的抗微生物剂，其浓度至少为1μM，含有所述抗微生物肽的抗微生物组合物或衍生物，以及使用含有至少所述抗微生物肽或其衍生物的抗微生物剂的产品的加工方法：AXA（其中，A为精氨酸残基或赖氨酸残基; X为至少包含三至九个任选的氨基酸残基，而不是半胱氨酸残基。

8. 发明授权

US5389611A Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效
标题翻译：乳铁蛋白水解物用作抗菌剂和酪氨酸酶抑制剂
公开(公告)号：US5389611A
公开(公告)日：1995-02-14
申请号：US803955
申请日：1991-12-09
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02 , C07K3/10 , C07K1/12
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
摘要翻译：乳铁蛋白水解物，通过甲酸滴定测定的分解率为6％-20％，用作抗菌剂，并且具有比未水解的乳铁蛋白显着更强的活性; 和通过甲酸滴定测定的分解率为4-50％的乳铁蛋白水解物，用作酪氨酸酶抑制剂，可通过用酸或酶水解的常规方法获得，并且对加热稳定。

9. 发明授权

US06867234B2 Fat composition for oral or enternal administration and hexacosanoic acid depressant 失效
标题翻译：脂肪组合物用于口服或内给药和二十六烷酸抑制剂
公开(公告)号：US06867234B2
公开(公告)日：2005-03-15
申请号：US10415412
申请日：2001-11-15
申请人： Yasunobu Antoku , Kosuke Tsukamoto , Fumihiko Koike , Takashi Tokuyama , Hirotoshi Hayasawa , Mitsunori Takase , Kyoichi Oshida
发明人： Yasunobu Antoku , Kosuke Tsukamoto , Fumihiko Koike , Takashi Tokuyama , Hirotoshi Hayasawa , Mitsunori Takase , Kyoichi Oshida
IPC分类号： A61K31/232 , A61P3/00 , A61P43/00 , A61K31/20 , A61K31/07 , A61K31/23 , A61K31/59
CPC分类号： A61K31/232
摘要： A fat composition for oral or enteral administration which contains eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof and functions to diminish hexacosanoic acid; and a hexacosanoic acid depressant which comprises as active ingredients eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C20 or higher monoenoic acid and/or a derivative thereof. They can be prepared by extraction from a fish oil or the like, purification, blending, etc. Based on the function of diminishing hexacosanoic acid, the composition and the depressant produce an aging-inhibitory effect on cell membranes, which is effective in the prevention and treatment of lifestyle-related diseases.
摘要翻译：用于口服或肠内给药的脂肪组合物，其包含二十碳五烯酸和/或其衍生物，二十二碳六烯酸和/或其衍生物，以及C20或更高级的单烯酸和/或其衍生物，并且具有减少二十六烷酸的功能; 和二十碳三烯酸抑制剂，其包含二十碳五烯酸和/或其衍生物，二十二碳六烯酸和/或其衍生物，以及C20或更高级的单烯酸和/或其衍生物作为活性成分。它们可以通过从鱼油等中提取，纯化，混合等制备。基于减少二十五烷酸的功能，组合物和抑制剂对细胞膜产生抑制老化的作用，这对预防有效和生活方式相关疾病的治疗。

10. 发明授权

US5466669A Immunostimulatory agent 失效
标题翻译：免疫刺激剂
公开(公告)号：US5466669A
公开(公告)日：1995-11-14
申请号：US971981
申请日：1993-02-19
申请人： Wolfgang Konig , Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy
发明人： Wolfgang Konig , Mamoru Tomita , Seiichi Shimamura , Kozo Kawase , Mitsunori Takase , Wayne R. Bellamy
IPC分类号： A61K38/16 , A61K8/64 , A61K38/00 , A61P37/04 , A61Q11/00 , A61Q19/00 , C07K14/475 , C07K14/79 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K14/79 , A61K8/64 , A61Q19/00 , A61K38/00 , A61Q11/00
摘要： There is disclosed an immunostimulatory agent comprising a peptide derived from lactoferrin having activity to modulate the release of inflammatory mediators from cells of the immune system. The peptide promotes the release of leukotriene B4 from polymorphonuclear neutrophils induced by activators such as the calcium ionophor A23187, It also promotes the release of histamine from mast cells induced by activators such as .alpha.-toxin-producing Staphylococcus aureus cells or the calcium ionophor A23187. The peptide is effective at low concentrations within the range of 1 to 100 ppm. By promoting the release of such inflammatory mediators the peptide can potentiate the cellular immune response and stimulate the host defense against infectious disease. This newly discovered immunostimulatory agent is useful as an active component of pharmaceuticals, hygiene products, clinical foods, etc., for prevention and treatment of bacterial, fungal, and viral infectious in humans and animals.
摘要翻译： PCT No.PCT / JP92 / 00275 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT提交1992年3月7日PCT公布。公开号WO93 / 18061 日本公报1993年9月16日。公开了包含衍生自乳铁蛋白的肽的免疫刺激剂，其具有调节炎症介质从免疫系统细胞释放的活性。该肽促进白三烯B4从诸如钙离子电极A23187的激活剂诱导的多形核嗜中性粒细胞的释放。它还促进由活化剂如产生α-毒素的金黄色葡萄球菌细胞或钙离子体A23187诱导的肥大细胞释放组胺。该肽在1至100ppm范围内的低浓度下是有效的。通过促进这种炎症介质的释放，肽可以增强细胞免疫应答并刺激宿主防止感染性疾病。这种新发现的免疫刺激剂可用作药物，卫生用品，临床食品等的活性成分，用于预防和治疗感染人类和动物的细菌，真菌和病毒。

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