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1. 发明授权

US08486980B2 Tricyclic compound 有权
标题翻译：三环化合物
公开(公告)号：US08486980B2
公开(公告)日：2013-07-16
申请号：US13057599
申请日：2009-08-06
申请人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
发明人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
IPC分类号： A61K31/4245 , A61K31/335 , A61K31/4184 , A61K31/4188 , C07D271/07 , C07D313/10 , C07D235/00 , C07D235/04
CPC分类号： C07D471/04 , A61K31/335 , A61K31/4184 , A61K31/422 , A61K31/4353 , A61K31/4409 , C07C255/34 , C07C255/44 , C07D235/08 , C07D235/16 , C07D257/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14
摘要： Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
摘要翻译：本发明提供具有PPARγ激动剂活性的三环化合物，其通式（I）表示，其中Z表示单键等，Y表示氢原子，任选具有取代基的低级烷基等， X表示氢原子等，A表示芳基等，B和C相同或不同，各自表示芳香族碳环等，R4-R9相同或不同，表示氢等， V表示单键等，R 10和R 11相同或不同，各自表示氢等，或其药学上可接受的盐等：

2. 发明申请

US20110201640A1 TRICYCLIC COMPOUND 有权
标题翻译：三聚体化合物
公开(公告)号：US20110201640A1
公开(公告)日：2011-08-18
申请号：US13057599
申请日：2009-08-06
申请人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
发明人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
IPC分类号： A61K31/4184 , C07D235/16 , C07D403/06 , C07D413/10 , A61K31/4245 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/41 , C07D405/14 , A61K31/422 , C07D491/044 , A61K31/4353 , A61P3/10 , A61P9/12 , A61P3/04 , A61P35/00
CPC分类号： C07D471/04 , A61K31/335 , A61K31/4184 , A61K31/422 , A61K31/4353 , A61K31/4409 , C07C255/34 , C07C255/44 , C07D235/08 , C07D235/16 , C07D257/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14
摘要： Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
摘要翻译：本发明提供具有PPARγ激动剂活性的三环化合物，其通式（I）表示，其中Z表示单键等，Y表示氢原子，任选具有取代基的低级烷基等， X表示氢原子等，A表示芳基等，B和C相同或不同，各自表示芳香族碳环等，R4-R9相同或不同，表示氢等， V表示单键等，R 10和R 11相同或不同，各自表示氢等，或其药学上可接受的盐等：

3. 发明授权

US08242151B2 Tricyclic compounds 有权
标题翻译：三环化合物
公开(公告)号：US08242151B2
公开(公告)日：2012-08-14
申请号：US12162119
申请日：2008-02-07
申请人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
发明人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
IPC分类号： A01N43/82 , A01N61/00 , A01N43/50 , A61K31/41 , A61K31/00 , A61K31/415
CPC分类号： C07D403/14 , A61K31/4245 , A61K31/437 , A61K31/55 , C07D413/10 , C07D413/14 , C07D471/04
摘要： The present invention provides a PPAR γ agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH═CH—CH═CH or the like, Y represents a single bond or the like, Z1-Z2 represents C═CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
摘要翻译：本发明提供一种PPARγ激动剂，其包含作为活性成分的由式（I）表示的三环化合物（其中R 1表示任选具有取代基的低级烷基等），R2和R3相同或不同，各自表示任选具有取代基等的低级烷基，R4和R5相同或不同，各自表示氢原子等，Q1-Q2-Q3表示CH = CH-CH = CH等，Y 表示单键或类似物，Z1-Z2表示C = CR13（其中R13表示氢原子等）等，A表示-COOH等）或其药学上可接受的盐等。

4. 发明申请

US20090176760A1 TRICYCLIC COMPOUNDS 有权
标题翻译：三聚体化合物
公开(公告)号：US20090176760A1
公开(公告)日：2009-07-09
申请号：US12162119
申请日：2008-02-07
申请人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
发明人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
IPC分类号： A61K31/55 , C07D471/04 , A61P3/10
CPC分类号： C07D403/14 , A61K31/4245 , A61K31/437 , A61K31/55 , C07D413/10 , C07D413/14 , C07D471/04
摘要： The present invention provides a PPAR γ agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH═CH—CH═CH or the like, Y represents a single bond or the like, Z1-Z2 represents C═CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
摘要翻译：本发明提供一种PPARγ激动剂，其包含作为活性成分的由式（I）表示的三环化合物（其中R 1表示任选具有取代基的低级烷基等），R2和R3相同或不同，各自表示任选具有取代基等的低级烷基，R4和R5相同或不同，各自表示氢原子等，Q1-Q2-Q3表示CH-CH-CH-CH等，Y 表示单键或类似物，Z1-Z2表示C-CR13（其中R13表示氢原子等）等，A表示-COOH等）或其药学上可接受的盐等。

5. 发明申请

US20070191402A1 Method of searching substrate having antidiabetic activity 审中-公开
标题翻译：检索具有抗糖尿病活性的底物的方法
公开(公告)号：US20070191402A1
公开(公告)日：2007-08-16
申请号：US10514119
申请日：2003-05-16
申请人： Hiroki Ishiguro , Yuko Saeki , Seiji Sugimoto , Masahiro Matsubara , Kimihisa Ueno , Kiyotoshi Mori , Satoshi Nakanishi , Hiroshi Yano
发明人： Hiroki Ishiguro , Yuko Saeki , Seiji Sugimoto , Masahiro Matsubara , Kimihisa Ueno , Kiyotoshi Mori , Satoshi Nakanishi , Hiroshi Yano
IPC分类号： A61K31/519 , A61K31/53 , C07D487/12 , G01N33/53
CPC分类号： C12Q1/32 , A61K31/53 , A61K31/5377 , A61K31/55 , C07D487/14 , G01N33/56966 , G01N2333/90209 , G01N2500/00
摘要： The present invention provides a screening method of a substance which inhibits binding of a condensed purine derivative to a pancreatic β cell or a treated product of the cell, a substance which inhibits binding of a condensed purine derivative to a protein capable of the condensed purine derivative, and a substance which inhibits the expression or enzymatic activity of a protein capable of a condensed purine derivative, which comprises using the condensed purine derivative and a pancreatic β cell or a treated product of the cell or a protein capable of binding to the condensed purine derivative.
摘要翻译：本发明提供了抑制冷凝的嘌呤衍生物与胰腺β细胞或细胞的处理产物的结合的物质的筛选方法，抑制结合的嘌呤衍生物与能够产生缩合嘌呤衍生物的蛋白质结合的物质以及抑制能够结合嘌呤衍生物的蛋白质的表达或酶活性的物质，其包括使用稠合的嘌呤衍生物和胰β细胞或能够结合浓缩的嘌呤的细胞或蛋白质的处理产物衍生物。

6. 发明申请

US20080298256A1 Distributed System 审中-公开
标题翻译：分布式系统
公开(公告)号：US20080298256A1
公开(公告)日：2008-12-04
申请号：US12128934
申请日：2008-05-29
申请人： Masahiro Matsubara , Kohei Sakurai
发明人： Masahiro Matsubara , Kohei Sakurai
IPC分类号： G06F11/00
CPC分类号： G06F11/182 , G06F11/0709 , G06F11/0739 , G06F11/076
摘要： There is known a method for identifying faults in a distributed system, in which multiple nodes mutually monitor one another and identify faults using two different fault identification conditions and majority voting in order to share information and achieve high reliability fault identification. However, in such configuration, abnormality occurrences are counted irrespective of the abnormality types, and as a result the application cannot grasp accurate and detailed fault situations, and therefore cannot handle faults depending on the fault type.There is provided a distributed system having a plurality of nodes connected via a network. Each node in the distributed system includes: an error monitor unit for monitoring an error in each of the other nodes; a send/receive processing unit for sending and receiving data to and from each of the other nodes in order to exchange error monitor results among the nodes via the network; an abnormality determination unit for determining, for each node, presence or absence of an abnormality based on an abnormality determination condition; and a counter unit for counting occurrences of the abnormality for each node and each abnormality determination condition.
摘要翻译：已知一种用于识别分布式系统中的故障的方法，其中多个节点彼此相互监视并且使用两个不同的故障识别条件和多数投票来识别故障，以便共享信息并实现高可靠性故障识别。然而，在这种配置中，不管异常类型如何，都会对异常进行计数，结果应用不能掌握精确而详细的故障情况，因此不能根据故障类型处理故障。提供了一种具有通过网络连接的多个节点的分布式系统。分布式系统中的每个节点包括：用于监视每个其他节点中的错误的错误监视单元; 发送/接收处理单元，用于向每个其他节点发送数据和从每个其他节点接收数据，以便经由网络在节点之间交换错误监视结果; 异常判定单元，其针对每个节点，基于异常判定条件来确定是否存在异常; 以及计数器单元，用于计数每个节点的异常的发生和每个异常确定条件。

7. 发明授权

US06877428B2 Regenerative plate making and printing process, and plate making and printing apparatus 失效
标题翻译：再生制版印刷工艺，制版印刷装置
公开(公告)号：US06877428B2
公开(公告)日：2005-04-12
申请号：US10323852
申请日：2002-12-20
申请人： Mitsuru Tabuchi , Masahiro Matsubara , Hiroaki Ikeda , Toshiyuki Urano , Takuya Uematsu , Yuji Mizuho
发明人： Mitsuru Tabuchi , Masahiro Matsubara , Hiroaki Ikeda , Toshiyuki Urano , Takuya Uematsu , Yuji Mizuho
IPC分类号： B41C1/10 , B41F7/02 , B41N1/08 , B41N3/00 , B41N3/03 , B41N3/06 , G03F7/16 , G03F7/18 , G03F7/24 , G03F7/30 , G03F7/42
CPC分类号： B41N3/006 , B41C1/1008 , B41C2210/02 , B41C2210/04 , B41C2210/08 , B41C2210/22 , B41C2210/24 , B41C2210/262 , B41F7/02 , B41N1/083 , B41N3/036 , B41N3/06 , B41P2227/70 , G03F7/16 , G03F7/18 , G03F7/24 , G03F7/3035 , G03F7/422 , G03F7/425
摘要： The regenerative plate making and printing process, and plate making and printing apparatus of the present invention are applied to a printing system requiring a separate developing step independent of a printing step. In accordance with the present invention, by repeatedly conducting (A) a photosensitive layer-coating step of coating a photosensitive plate material onto a substrate to prepare a photosensitive lithographic plate having a photosensitive layer thereon; (B) an exposure step of exposing the photosensitive layer to image light; (C) a development step of supplying a plate-treating agent to the photosensitive layer to form developed images thereon; (D) a printing step of supplying a printing ink and dampening water to surfaces of the thus obtained images to conduct printing; and (E) a substrate regeneration step of removing the image portions from the substrate to regenerate the substrate, on the same rotary drum or conveyer, it is possible to considerably improve the working efficiency and stably provide high-quality images.
摘要翻译：本发明的再生制版印刷工艺以及制版和印刷装置应用于独立于印刷步骤的独立显影步骤的印刷系统。根据本发明，通过反复进行（A）感光层涂覆步骤，将感光板材料涂覆在基材上以制备其上具有感光层的光敏平版印刷板; （B）将感光层曝光于图像光的曝光步骤; （C）向感光层供给平板处理剂以在其上形成显影图像的显影步骤; （D）将印刷油墨和润版水供给到如此获得的图像的表面进行印刷的印刷步骤; 和（E）基板再生步骤，在相同的转鼓或输送机上从基板上除去图像部分以再生基板，可以显着地提高工作效率并稳定地提供高质量的图像。

8. 发明申请

US20090040934A1 Distributed System 审中-公开
标题翻译：分布式系统
公开(公告)号：US20090040934A1
公开(公告)日：2009-02-12
申请号：US12184447
申请日：2008-08-01
申请人： Masahiro Matsubara , Kohei Sakurai , Kotaro Shimamura
发明人： Masahiro Matsubara , Kohei Sakurai , Kotaro Shimamura
IPC分类号： G06F11/00
CPC分类号： G06F11/0709 , G05B23/0237 , G06F11/0739 , G06F11/076
摘要： Mutual node-fault monitoring keeps the values of abnormality counters, which keep track of error occurrences, consistent among all nodes. However, in some cases, the counter values may become inconsistent among the nodes depending on the error situation.In a distributed system having a plurality of nodes connected via a network, each of the plurality of nodes includes: an error monitor unit for monitoring an error in each of the other nodes; a send/receive unit for sending and receiving data for detecting abnormalities in the other nodes, to and from each of the other nodes via the network, thereby exchanging error monitor results; an abnormality determination unit for determining a node abnormality based on the exchanged error monitor results; a counter unit for counting occurrences of the abnormality for the node determined as having the abnormality; and a counter synchronization unit for synchronizing abnormality counter values after exchanging the counter values with each of the other nodes.
摘要翻译：相互节点故障监控保持跟踪错误发生的异常计数器的值在所有节点之间一致。然而，在某些情况下，根据错误情况，计数器值可能在节点之间变得不一致。在具有通过网络连接的多个节点的分布式系统中，所述多个节点中的每一个包括：用于监视每个其他节点中的错误的错误监视单元; 发送/接收单元，用于经由网络发送和接收来自其他节点的其他节点中的异常的数据，从而交换错误监视结果; 异常判定单元，其基于所交换的误差监视结果来确定节点异常; 用于计数被确定为具有异常的节点的异常的发生的计数器单元; 以及计数器同步单元，用于在将计数器值与每个其他节点交换之后使异常计数器值同步。

9. 发明申请

US20070181024A1 Plate making apparatus and regenerative printing plate management method as well as interstage sleeve 审中-公开
标题翻译：制版设备和再生印版管理方法以及级间套管
公开(公告)号：US20070181024A1
公开(公告)日：2007-08-09
申请号：US10565671
申请日：2004-04-28
申请人： Mitsuru Tabuchi , Hideaki Sakurai , Masahiro Matsubara , Shoichi Furukawa
发明人： Mitsuru Tabuchi , Hideaki Sakurai , Masahiro Matsubara , Shoichi Furukawa
IPC分类号： B41C3/08
CPC分类号： B41C1/1075 , B41N6/00
摘要： The invention relates to a print making apparatus and provides a technique which makes it possible to achieve a generally high processing speed without depending upon enhancement of the processing speed of individual processing apparatus. A number of stations (S1 to S4) at least equal to the number of steps of a plate making procedure are arranged in order, and a plurality of processing apparatus (30 to 34) corresponding one by one to the steps of the plate making procedure are disposed in order of the plate making procedure at the stations (S1 to S4). A transport apparatus (11) successively transports a plurality of printing plates (1) from one to another one of the stations in order of the plate making procedure.
摘要翻译：本发明涉及一种打印制作装置，并且提供了一种使得可以实现大体上高处理速度而不依赖于增强各处理装置的处理速度的技术。至少等于制版过程的步骤数的多个工位（S 1至S 4）按顺序排列，并且多个处理装置（30至34）逐个对应于板的步骤（S1〜S4）的制版过程顺序排列。输送装置（11）按照制版过程的顺序依次将多个印版（1）从一个到另一个站传送。

10. 发明申请

US20090089627A1 Distributed Control System 有权
标题翻译：分布式控制系统
公开(公告)号：US20090089627A1
公开(公告)日：2009-04-02
申请号：US12194575
申请日：2008-08-20
申请人： Masahiro Matsubara , Kohei Sakurai , Kotaro Shimamura , Nobuyasu Kanekawa
发明人： Masahiro Matsubara , Kohei Sakurai , Kotaro Shimamura , Nobuyasu Kanekawa
IPC分类号： G06F11/00
CPC分类号： G06F11/182 , G06F11/0709 , G06F11/076 , H04L41/0677
摘要： There is provided a distributed system having a plurality of nodes connected by a network. Each of the nodes includes: a common-parameter-value determining unit for determining a common-parameter-value from values of a parameter (each value being possessed by a corresponding one of the nodes); a common-operation execution unit for executing a common-operation using, as its input, a value of the parameter or the common-parameter-value; a send/receive unit for exchanging, via the network, the parameter values used for the determination of the common-parameter-value and the results of the common-operation execution with the other nodes; and a fault identification unit that compares the common-operation execution results collected from all the nodes and determines that an error occurs if not all the results are the same.
摘要翻译：提供了具有通过网络连接的多个节点的分布式系统。每个节点包括：公共参数值确定单元，用于根据参数的值（由相应的一个节点拥有的每个值）确定公共参数值; 公共执行单元，用于使用参数或公共参数值的值作为其输入来执行公共操作; 用于经由网络交换用于确定公共参数值的参数值和与其他节点的共同操作执行结果的发送/接收单元; 以及故障识别单元，其比较从所有节点收集的共同操作执行结果，并且如果不是全部结果相同，则确定出现错误。

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