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1. 发明申请

US20130102620A1 PYRAZOLOPYRIMIDINE DERIVATIVE 有权
标题翻译：吡唑并嘧啶衍生物
公开(公告)号：US20130102620A1
公开(公告)日：2013-04-25
申请号：US13582992
申请日：2011-03-04
申请人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
IPC分类号： C07D487/04 , C07D487/10 , C07D491/107
CPC分类号： C07D487/04 , C07D487/10 , C07D491/107 , C07D519/00
摘要： The invention provides a pyrazolopyrimidine derivative of formula (I), wherein, for example, R1 represents —NR1aR1b (wherein R1a and R1b are the same or different and each is a hydrogen atom or aralkyl), R2 represents formula (Ya) [wherein k and m each represents an integer of 0-2, n represents an integer of 0-4, L represents a single bond, R5 represents halogen, R6 represents aryl, X represents —CR8 (wherein R8 represents a hydrogen atom), and R7 represents a hydrogen], R3 represents —SO2R13a [wherein R13a represents lower alkoxy, —NR13dC(═O)R13e (wherein R13d represents a hydrogen atom, and R13e represents lower alkyl)], and R4 represents a hydrogen atom, or a pharmaceutically acceptable salt thereof. The invention also provides a medicament containing the pyrazolopyrimidine derivative, as well as a method of using the pyrazolopyrimidine derivative to prevent and/or treat skin diseases.
摘要翻译：本发明提供式（I）的吡唑并嘧啶衍生物，其中，例如，R1表示-NR1aR1b（其中R1a和R1b相同或不同，各自为氢原子或芳烷基），R2表示式（Ya）[其中k m表示0-2的整数，n表示0-4的整数，L表示单键，R5表示卤素，R6表示芳基，X表示-CR8（其中R8表示氢原子），R7表示氢]，R3表示-SO2R13a [其中R13a表示低级烷氧基，-NR13dC（= O）R13e（其中R13d表示氢原子，R13e表示低级烷基）]，R4表示氢原子或药学上可接受的盐其中。本发明还提供含有吡唑并嘧啶衍生物的药物，以及使用吡唑并嘧啶衍生物预防和/或治疗皮肤病的方法。

2. 发明授权

US08729264B2 Agent for prevention and/or treatment of skin diseases 有权
标题翻译：预防和/或治疗皮肤病的药剂
公开(公告)号：US08729264B2
公开(公告)日：2014-05-20
申请号：US12680484
申请日：2008-09-26
申请人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
摘要翻译：本发明提供含有式（I）表示的吡唑并嘧啶衍生物（其中各符号如说明书中的定义）作为活性成分的皮肤病的预防和/或治疗药剂或其药理学上可接受的盐，等等。

3. 发明申请

US20140221340A1 CHEMOKINE RECEPTOR ACTIVITY REGULATOR 审中-公开
标题翻译：化学受体活性调节剂
公开(公告)号：US20140221340A1
公开(公告)日：2014-08-07
申请号：US14241065
申请日：2012-08-31
申请人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi , Mirai Mizutani , Yuko Seno
发明人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi , Mirai Mizutani , Yuko Seno
IPC分类号： C07D491/107 , C07D487/10 , C07D487/04
CPC分类号： C07D491/107 , A61K31/519 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention provides a chemokine receptor activity modulator containing a pyrazolopyrimidine derivative represented by the formula (I) wherein R1, R2, R3, and R4 are as described herein.
摘要翻译：本发明提供含有式（I）表示的吡唑并嘧啶衍生物的趋化因子受体活性调节剂，其中R 1，R 2，R 3和R 4如本文所述。

4. 发明申请

US20090176760A1 TRICYCLIC COMPOUNDS 有权
标题翻译：三聚体化合物
公开(公告)号：US20090176760A1
公开(公告)日：2009-07-09
申请号：US12162119
申请日：2008-02-07
申请人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
发明人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
IPC分类号： A61K31/55 , C07D471/04 , A61P3/10
CPC分类号： C07D403/14 , A61K31/4245 , A61K31/437 , A61K31/55 , C07D413/10 , C07D413/14 , C07D471/04
摘要： The present invention provides a PPAR γ agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH═CH—CH═CH or the like, Y represents a single bond or the like, Z1-Z2 represents C═CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
摘要翻译：本发明提供一种PPARγ激动剂，其包含作为活性成分的由式（I）表示的三环化合物（其中R 1表示任选具有取代基的低级烷基等），R2和R3相同或不同，各自表示任选具有取代基等的低级烷基，R4和R5相同或不同，各自表示氢原子等，Q1-Q2-Q3表示CH-CH-CH-CH等，Y 表示单键或类似物，Z1-Z2表示C-CR13（其中R13表示氢原子等）等，A表示-COOH等）或其药学上可接受的盐等。

5. 发明授权

US08815874B2 Pyrazolopyrimidine derivative 有权
标题翻译：吡唑并嘧啶衍生物
公开(公告)号：US08815874B2
公开(公告)日：2014-08-26
申请号：US13582992
申请日：2011-03-04
申请人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
IPC分类号： A01N43/90 , A61K31/519 , A61K38/00 , A61P17/00 , C07D491/107 , C07D487/04 , C07D519/00 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10 , C07D491/107 , C07D519/00
摘要： The invention provides a pyrazolopyrimidine derivative of formula (I), wherein, for example, R1 represents —NR1aR1b (wherein R1a and R1b are the same or different and each is a hydrogen atom or aralkyl), R2 represents formula (Ya) [wherein k and m each represents an integer of 0-2, n represents an integer of 0-4, L represents a single bond, R5 represents halogen, R6 represents aryl, X represents —CR8 (wherein R8 represents a hydrogen atom), and R7 represents a hydrogen], R3 represents —SO2R13a [wherein R13a represents lower alkoxy, —NR13dC(═O)R13e (wherein R13d represents a hydrogen atom, and R13e represents lower alkyl)], and R4 represents a hydrogen atom, or a pharmaceutically acceptable salt thereof. The invention also provides a medicament containing the pyrazolopyrimidine derivative, as well as a method of using the pyrazolopyrimidine derivative to prevent and/or treat skin diseases.
摘要翻译：本发明提供式（I）的吡唑并嘧啶衍生物，其中，例如，R1表示-NR1aR1b（其中R1a和R1b相同或不同，各自为氢原子或芳烷基），R2表示式（Ya）[其中k m表示0-2的整数，n表示0-4的整数，L表示单键，R5表示卤素，R6表示芳基，X表示-CR8（其中R8表示氢原子），R7表示氢]，R 3表示-SO 2 R 13 a [其中R 13a表示低级烷氧基，-NR 13 d C（= O）R 13e（其中R 13d表示氢原子，R 13e表示低级烷基）]，R 4表示氢原子或其药学上可接受的盐其中。本发明还提供含有吡唑并嘧啶衍生物的药物，以及使用吡唑并嘧啶衍生物预防和/或治疗皮肤病的方法。

6. 发明申请

US20100256134A1 AGENT FOR PREVENTION AND/OR TREATMENT OF SKIN DISEASES 有权
标题翻译：防止和/或治疗皮肤疾病的药剂
公开(公告)号：US20100256134A1
公开(公告)日：2010-10-07
申请号：US12680484
申请日：2008-09-26
申请人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/497 , A61P17/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
摘要翻译：本发明提供含有式（I）表示的吡唑并嘧啶衍生物（其中各符号如说明书中的定义）作为活性成分的皮肤病的预防和/或治疗药剂或其药理学上可接受的盐，等等。

7. 发明授权

US08242151B2 Tricyclic compounds 有权
标题翻译：三环化合物
公开(公告)号：US08242151B2
公开(公告)日：2012-08-14
申请号：US12162119
申请日：2008-02-07
申请人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
发明人： Arata Yanagisawa , Takeshi Kuboyama , Seiji Aratake , Kazuki Hemmi , Kimihisa Ueno , Michihiko Suzuki , Masahiro Matsubara , Kozo Yao , Akinori Hamaguchi , Yukihito Tsukumo
IPC分类号： A01N43/82 , A01N61/00 , A01N43/50 , A61K31/41 , A61K31/00 , A61K31/415
CPC分类号： C07D403/14 , A61K31/4245 , A61K31/437 , A61K31/55 , C07D413/10 , C07D413/14 , C07D471/04
摘要： The present invention provides a PPAR γ agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein R1 represents lower alkyl optionally having substituent(s) or the like, R2 and R3 are the same or different and each represents lower alkyl optionally having substituent(s) or the like, R4 and R5 are the same or different and each represents a hydrogen atom or the like, Q1-Q2-Q3 represents CH═CH—CH═CH or the like, Y represents a single bond or the like, Z1-Z2 represents C═CR13 (wherein R13 represents a hydrogen atom or the like), or the like, and A represents —COOH or the like), or a pharmaceutically acceptable salt thereof and the like.
摘要翻译：本发明提供一种PPARγ激动剂，其包含作为活性成分的由式（I）表示的三环化合物（其中R 1表示任选具有取代基的低级烷基等），R2和R3相同或不同，各自表示任选具有取代基等的低级烷基，R4和R5相同或不同，各自表示氢原子等，Q1-Q2-Q3表示CH = CH-CH = CH等，Y 表示单键或类似物，Z1-Z2表示C = CR13（其中R13表示氢原子等）等，A表示-COOH等）或其药学上可接受的盐等。

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