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1. 发明申请

US20100074504A1 METHOD AND APPARATUS FOR ACQUIRING FUSION X-RAY IMAGES 审中-公开
标题翻译：用于获取融合X射线图像的方法和装置
公开(公告)号：US20100074504A1
公开(公告)日：2010-03-25
申请号：US12532459
申请日：2008-03-14
申请人： Antonius J.C. Bruijns , Ronaldus P.J. Hermans , Peter M.J. Rongen , Jarl J.P. Blijd , Herman Stegehuis , Joerg Bredno
发明人： Antonius J.C. Bruijns , Ronaldus P.J. Hermans , Peter M.J. Rongen , Jarl J.P. Blijd , Herman Stegehuis , Joerg Bredno
IPC分类号： G06K9/00 , G01N23/04
CPC分类号： A61B6/504 , A61B6/481 , A61B6/482 , A61B6/503 , A61B6/5235 , A61B6/541
摘要： A method for acquiring fusion images of a periodically moving body organ and an apparatus adapted to implement such method is described. In a preferred embodiment of the method, X-rays are irradiated to the body organ and a multiplicity of mask images is acquired by X-ray detection at a high image acquisition rate of at least 60 frames per second. Then, contrast medium is injected into vessels of the body organ and subsequently at least one contrast image of the body organ with the contrast medium included in the vessels is acquired by X-ray detection. A matching image from the multiplicity of mask images is determined which has been acquired at substantially the same stage of the movement of the body organ as the contrast image. By calculating the difference between the matching mask image and the at least one contrast image a subtraction image of the body organ can be obtained and displayed. Using different image acquisition rates during mask image acquisition and contrast image acquisition high quality subtraction images can be achieved while at the same time reducing the overall X-ray exposure dose.
摘要翻译：描述了一种用于获取定期移动的身体器官的融合图像的方法和适于实现这种方法的装置。在该方法的优选实施例中，将X射线照射到身体器官，并且通过以至少60帧/秒的高图像采集率的X射线检测获取多个掩模图像。然后，将造影剂注射到身体器官的血管中，随后通过X射线检测获得体内器官与包含在血管中的造影剂的至少一个对比图像。确定来自多个掩模图像的匹配图像，其在与对比图像的身体器官的移动的基本相同的阶段已被获取。通过计算匹配掩模图像和至少一个对比图像之间的差异，可以获得并显示身体器官的减影图像。在掩模图像采集和对比度图像采集期间使用不同的图像采集率可以实现高质量的减影图像，同时减少整个X射线曝光剂量。

2. 发明申请

US20080319309A1 System, Apparatus, and Method for Repreoducible and Comparable Flow Acquisitions 有权
标题翻译：可再生和可比流量采集的系统，仪器和方法
公开(公告)号：US20080319309A1
公开(公告)日：2008-12-25
申请号：US12096995
申请日：2006-12-08
申请人： Joerg Bredno , Alexandra Groth , Juergen Weese , Tom Bruijns , Peter M.J. Rongen , Roel Hermans , Heidrun Steinhauser
发明人： Joerg Bredno , Alexandra Groth , Juergen Weese , Tom Bruijns , Peter M.J. Rongen , Roel Hermans , Heidrun Steinhauser
IPC分类号： A61B5/055 , A61B6/00
CPC分类号： G01R33/5635 , A61B5/0275 , A61B5/0456 , A61B6/481 , A61B6/504 , A61B6/507 , A61B8/06 , A61M5/007 , A61M5/1723 , A61M2230/04 , G01R33/281 , G01R33/5601 , G06T7/0012 , G06T7/20 , G06T2207/30101
摘要： A system, apparatus and method are provided for measuring and removing the influence of pulsatility on contrast agent flow in a region of interest of a vascular system of a patient. Once the change of blood speed over the cardiac cycle is known (pulsatility), this influence is removed from acquired image sequence for outcome control such that “quasi-stationary”, regular flow acquisition is passed on to subsequent visualization and analysis processes. A contrast agent injector is also provided that simultaneously measures and uses ECG to inject a known contrast agent at a fixed point over the cardiac cycle or such that a known amount of contrast agent will arrive at a known time at a region of interest in the vasculature of a patient, thus controlling one of the main unwanted variables in an acquisition of blood flow sequences.
摘要翻译：提供了一种系统，装置和方法，用于测量和消除脉搏对患者血管系统感兴趣区域中造影剂流动的影响。一旦知道心搏周期的血液速度变化（脉动），这种影响就从获得的结果控制图像序列中消除，从而将“准静态”常规流量采集传递给随后的可视化和分析过程。还提供造影剂注射器，其同时测量并使用ECG在心脏周期上的固定点注入已知的造影剂，或使已知量的造影剂在脉管系统中的感兴趣区域的已知时间到达因此在获取血流序列时控制主要不需要的变量之一。

3. 发明授权

US08908939B2 Perfusion imaging 有权
标题翻译：灌注成像
公开(公告)号：US08908939B2
公开(公告)日：2014-12-09
申请号：US13062227
申请日：2009-09-10
申请人： Joerg Bredno , Max Wintermark
发明人： Joerg Bredno , Max Wintermark
IPC分类号： G06K9/00 , A61B6/00 , G06F19/00 , A61B6/03
CPC分类号： A61B6/504 , A61B6/032 , A61B6/481 , A61B6/507 , G06F19/00 , G06F19/321 , G16H40/63 , G16H50/50
摘要： A system includes a perfusion information determiner (124) that determines perfusion information based on a combination of pre-perfusion scan image data and perfusion scan image data.
摘要翻译：一种系统包括基于灌注前扫描图像数据和灌注扫描图像数据组合来确定灌注信息的灌注信息确定器（124）。

4. 发明申请

US20130243298A1 DIAGNOSTIC IMAGE FEATURES CLOSE TO ARTIFACT SOURCES 有权
标题翻译：诊断图像特征靠近文学来源
公开(公告)号：US20130243298A1
公开(公告)日：2013-09-19
申请号：US13989152
申请日：2011-11-22
申请人： Joerg Bredno , Sven Prevrhal , Eberhard Sevastian Hansis , David Sowards-Emmero
发明人： Joerg Bredno , Sven Prevrhal , Eberhard Sevastian Hansis , David Sowards-Emmero
IPC分类号： G06T5/00
CPC分类号： G06T5/00 , A61B6/5258 , G06T5/50 , G06T11/008 , G06T2207/10072
摘要： When correcting for artifacts on an attenuation map caused by an artifact source in a computed tomography image, nuclear images are reconstructed two or more times, each time using a different correction technique or uncorrected attenuation data. Corresponding voxels in the reconstructed images are compared to identify local areas that change, i.e., are fragile and therefore low-confidence, and areas that do not vary or exhibit little variance among the plurality of reconstructed images and are thus accorded a higher confidence. The reconstructed nuclear image is overlaid with color encoding indicative of the amount of confidence accorded to each voxel value obtained by attenuation-corrected tomographic reconstruction.
摘要翻译：当在计算机断层摄影图像中由伪像源引起的衰减图上的伪像进行校正时，每次使用不同的校正技术或未校正的衰减数据重建两次或更多次的核图像。将重构图像中的相应体素进行比较，以识别改变的局部区域，即易碎且因此低置信度，以及在多个重建图像之间不变化或显示很小变化的区域，并因此赋予更高的置信度。重建的核图像用表示通过衰减校正的断层摄影重建获得的每个体素值的置信度的颜色编码来叠加。

5. 发明申请

US20090116715A1 MOTION-COMPENSATED CORONARY FLOW FROM PROJECTION IMAGING 有权
标题翻译：运动补偿冠状动脉从投影成像流程
公开(公告)号：US20090116715A1
公开(公告)日：2009-05-07
申请号：US12301639
申请日：2007-05-14
申请人： Joerg Bredno , Juergen Weese , Alexandra Groth
发明人： Joerg Bredno , Juergen Weese , Alexandra Groth
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： A61B6/504 , A61B6/481 , A61B6/503 , A61B6/507 , A61B6/527 , A61B8/5276
摘要： Diagnostic angiograms only provide the projected lumen of a coronary, which is only an indirect measure of blood flow and pressure decline. According to an exemplary embodiment of the present invention, a motion compensated determination of a flow dynamics and a pressure decline for stenosis grading is provided, in which the motion compensation is performed on the basis of a tracking of a first position of a first marker and a second position of a second marker in the projection data set. This may provide for a robust and precise flow dynamics and pressure decline determination.
摘要翻译：诊断性血管造影仅提供冠状动脉的预计管腔，这仅是血流量和压力下降的间接测量值。根据本发明的示例性实施例，提供了针对狭窄分级的流动动力学和压力下降的运动补偿确定，其中基于第一标记的第一位置的跟踪和在投影数据集中的第二标记的第二位置。这可以提供鲁棒和精确的流动动力学和压力衰减测定。

6. 发明申请

US20080294038A1 Model-Based Flow Analysis and Visualization 审中-公开
标题翻译：基于模型的流量分析与可视化
公开(公告)号：US20080294038A1
公开(公告)日：2008-11-27
申请号：US12096436
申请日：2006-11-15
申请人： Juergen Weese , Alexandra Groth , Joerg Bredno , Tom Bruijns , Peter Rongen , Roel Hermans , Heidrun Steinhauser
发明人： Juergen Weese , Alexandra Groth , Joerg Bredno , Tom Bruijns , Peter Rongen , Roel Hermans , Heidrun Steinhauser
IPC分类号： A61B6/00 , G06G7/60
CPC分类号： A61B6/504 , A61B6/481 , A61B6/507 , G16H50/50
摘要： A system (900), method (100, 200) and apparatus (600, 700, 800) are provided for analyzing a blood flow in a vascular system from a dynamic diagnostic observation sequence (101) to determine blood flow parameters (112) for further determination of filters, replay speed and finally visualization of the replayed original and filtered sequences. A first embodiment (100) extracts features of the observation and uses these features to select an appropriate model from a database of pre-determined models of vascular system of interest which have associated parameters. These parameters are varied to create an instance of the model that best matches the original observation. A second embodiment (200) visualizes a replay of the original observation (101) and the observation (101′) predicted by the model to highlight differences therebetween. A third embodiment (800) provides filtering and control of the replay speed.
摘要翻译：提供了一种系统（900），方法（100,200）和装置（600,700,800），用于从动态诊断观察序列（101）分析血管系统中的血流，以确定血流参数（112）进一步确定滤镜，重放速度以及最终可重播的原始和过滤序列。第一实施例（100）提取观察的特征并且使用这些特征从具有相关参数的感兴趣的血管系统的预定模型的数据库中选择适当的模型。改变这些参数以创建与原始观察结果最匹配的模型实例。第二实施例（200）可视化通过模型预测的原始观察（101）和观察（101'）的重放以突出其间的差异。第三实施例（800）提供重放速度的过滤和控制。

7. 发明申请

US20080192887A1 System For The Determination Of Vessel Geometry And Flow Characteristics 有权
标题翻译：用于确定船舶几何和流量特性的系统
公开(公告)号：US20080192887A1
公开(公告)日：2008-08-14
申请号：US11815113
申请日：2006-01-31
申请人： Juergen Weese , Alexandra Groth , Joerg Bredno
发明人： Juergen Weese , Alexandra Groth , Joerg Bredno
IPC分类号： A61B6/03 , A61B6/00
CPC分类号： G06T11/003 , A61B6/481 , A61B6/504 , G06T7/0012 , G06T2207/10112 , G06T2207/10116 , G06T2207/30104 , G06T2211/404
摘要： The invention relates to a method and a system for the simultaneous reconstruction of the three-dimensional vessel geometry and the flow characteristics in a vessel system. According to one realization of the method, vessel segments (41) of a parametric models are fitted to differently oriented X-ray projections (Pl, Pk, PN) of the vessel system that are generated during the passage of a bolus of contrast agent, wherein the fitting takes the imaged contrast agent dynamics and physiological a priori knowledge into account. In an alternative embodiment, the vessel geometry is reconstructed progressively along each vessel, wherein a new segment of a vessel is added based on the continuity of the vessel direction, vessel radius and reconstructed contrast agent dynamics.
摘要翻译：本发明涉及用于同时重建血管系统中三维血管几何形状和流动特征的方法和系统。根据该方法的一个实现，参数模型的血管段（41）适合于不同取向的X射线投影（P ，P < 在造影剂团中通过期间产生的血管系统，其中拟合物考虑成像的造影剂动力学和生理学先验知识。在替代实施例中，血管几何沿着每个血管逐渐重建，其中基于血管方向，血管半径和重建的造影剂动力学的连续性，添加血管的新的部分。

8. 发明授权

US09600883B2 Plausible reference curves for dynamic, contrast-enhanced imaging studies 有权
公开(公告)号：US09600883B2
公开(公告)日：2017-03-21
申请号：US13262836
申请日：2010-03-09
申请人： Ingwer C. Carlsen , Kirsten Meetz , Joerg Bredno , Mark Olszewski
发明人： Ingwer C. Carlsen , Kirsten Meetz , Joerg Bredno , Mark Olszewski
IPC分类号： G06K9/00 , G06T7/00 , G01R33/563 , G01R33/56 , A61B6/00
CPC分类号： G06T7/0016 , A61B6/507 , G01R33/5601 , G01R33/56366 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20108 , G06T2207/30016 , G06T2207/30104
摘要： A comprehensive strategy is used to determine valid reference time-concentration curves (TCCs) from image data. The image data corresponds to a series of image scans acquired over time for an area of interest of a patient to which a contrast agent was previously administered. The image scans are initially registered to a common coordinate system. Then, observed potential reference TCCs in the image scans are compared to modeled reference TCCs to determine if the potential reference TCCs are plausible reference TCCs. Thereafter, any plausible reference TCCs are evaluated to determine if they contain residual, isolated motion artifacts. If a plausible reference TCC does not include any motion artifacts, the plausible reference TCC is considered a valid reference TCC. If a plausible reference TCC is determined to include motion artifacts, the plausible reference TCC is modified to a valid reference TCC by removing the motion artifacts, or otherwise the plausible reference TCC is rejected. The valid reference TCCs can be used to improve the effectiveness of dynamic, contrast-enhanced imaging studies.

9. 发明授权

US08491188B2 High-resolution quasi-static setup for X-ray imaging with distributed sources 有权
标题翻译：具有分布式源的X射线成像的高分辨率准静态设置
公开(公告)号：US08491188B2
公开(公告)日：2013-07-23
申请号：US12918092
申请日：2009-02-19
申请人： Gereon Vogtmeier , Joerg Bredno , Juergen Weese
发明人： Gereon Vogtmeier , Joerg Bredno , Juergen Weese
IPC分类号： H05G1/02
CPC分类号： A61B6/025 , A61B6/027 , A61B6/4007
摘要： A method for acquiring X-ray image data of an imaging volume is disclosed, the method using a detector and a distributed X-ray source structure having a plurality of single source elements, which are uniformly distributed with a common pitch to each other, the method comprises moving the distributed X-ray source structure and/or the detector with respect to the imaging volume, importantly, the maximum moving distance dmax of the distributed X-ray source structure during the acquisition of the X-ray image data is limited to the length lp of the pitch. Emitting of X-rays from the distributed X-ray source structure and generating a plurality of signals in response to the X-rays incident upon the detector are executed during the movement.
摘要翻译：公开了一种用于获取成像体积的X射线图像数据的方法，所述方法使用具有多个单个源元件的检测器和分布式X射线源结构，所述单个源元件以相同的间距均匀分布，方法包括相对于成像体积移动分布式X射线源结构和/或检测器，重要的是，在X射线图像数据的获取期间分布式X射线源结构的最大移动距离dmax被限制为音高的长度lp。在移动期间执行从分布式X射线源结构发射X射线并响应入射到检测器上的X射线产生多个信号。

10. 发明申请

US20120288180A1 FUNCTIONAL IMAGING 有权
标题翻译：功能成像
公开(公告)号：US20120288180A1
公开(公告)日：2012-11-15
申请号：US13503925
申请日：2010-10-14
申请人： Joerg Bredno , Max Wintermark
发明人： Joerg Bredno , Max Wintermark
IPC分类号： G06K9/46
CPC分类号： A61B6/5217 , A61B6/032 , A61B6/481 , A61B6/486 , A61B6/501 , A61B6/507 , G01R33/5601 , G01R33/56366
摘要： A method includes determining, via a processor, functional information about tissue of interest in image data for a functional image acquisition based on reference information generated based on non-tissue of interest.
摘要翻译：一种方法包括：基于基于非感兴趣组织生成的参考信息，经由处理器确定关于功能图像获取的图像数据中的感兴趣组织的功能信息。

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