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1. 发明授权

US07914768B2 Stabiliser for radiopharmaceuticals 有权
标题翻译：放射性药物稳定剂
公开(公告)号：US07914768B2
公开(公告)日：2011-03-29
申请号：US10296952
申请日：2001-06-18
申请人： Anthony E. Storey , Georg Brauers , Koichi Hanaoka , Yoshihito Minosako , Koichi Homma , Yoshifumi Shirakami
发明人： Anthony E. Storey , Georg Brauers , Koichi Hanaoka , Yoshihito Minosako , Koichi Homma , Yoshifumi Shirakami
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0489
摘要： A stabilized radiopharmaceutical composition, a kit including same, and a method for making same, where the radiopharmaceutical is (i) susceptible to either reductive degradation or radiolysis and which includes a metal complex of a radionuclide with a ligand, (ii) a first stabilizer for the radiopharmaceutical which is an amino-substituted aromatic carboxylic acid or a salt, ester or amide thereof, and (iii) a second stabilizer for the radiopharmaceutical which is a diphosphonic acid or salt thereof. The first and second stabilizers are present in an amount effective to stabilize the radiopharmaceutical, and the radiopharmaceutical is not a metal complex of the diphosphonic acid.
摘要翻译：稳定的放射性药物组合物，包含其的试剂盒及其制备方法，其中放射性药物是（i）易于还原降解或放射分解，并且其包含放射性核素与配体的金属络合物，（ii）第一稳定剂对于作为氨基取代的芳族羧酸或其盐，酯或酰胺的放射性药物，和（iii）作为二膦酸的放射性药物的第二稳定剂或其盐。第一和第二稳定剂以有效稳定放射性药物的量存在，并且放射性药物不是二膦酸的金属络合物。

2. 发明申请

US20050063902A1 Stabiliser for radiopharmaceuticals 有权
标题翻译：放射性药物稳定剂
公开(公告)号：US20050063902A1
公开(公告)日：2005-03-24
申请号：US10296952
申请日：2001-06-18
申请人： Anthony Storey , Georg Brauers , Koichi Hanaoka , Yoshihito Minosako , Koichi Homma , Yoshifumi Shirakami
发明人： Anthony Storey , Georg Brauers , Koichi Hanaoka , Yoshihito Minosako , Koichi Homma , Yoshifumi Shirakami
IPC分类号： A61K47/02 , A61K47/16 , A61K47/18 , A61K47/22 , A61K47/24 , A61K51/00 , A61K51/04 , A61P43/00 , A61K31/66
CPC分类号： A61K51/0489
摘要： The present invention provides an improved stabiliser for radiopharmaceuticals which inhibits impurities from being produced by two kinds of decomposition mechanisms and exhibits such an effect that the shelf life of a radiopharmaceutical after its preparation is prolonged as compared with conventional ones. The improvement comprises a combination of an amino-substituted aromatic carboxylic acid or its salt, ester or amide in combination with a diphosphonic acid or its salt.
摘要翻译：本发明提供一种用于放射性药物的改进的稳定剂，其通过两种分解机制抑制杂质的产生，并且表现出与常规放射性药物相比，其制备后放射性药物的保质期延长的效果。改进包括氨基取代的芳族羧酸或其盐，酯或酰胺与二膦酸或其盐的组合。

3. 发明授权

US5659584A Data receiving system for receiving data signal faded and delayed 失效
标题翻译：用于接收数据信号的数据接收系统褪色和延迟
公开(公告)号：US5659584A
公开(公告)日：1997-08-19
申请号：US593956
申请日：1996-01-30
申请人： Mitsuru Uesugi , Sadaki Futagi , Koichi Homma
发明人： Mitsuru Uesugi , Sadaki Futagi , Koichi Homma
IPC分类号： H03H21/00 , H04B1/12 , H04B3/04 , H04B7/005 , H04B7/08 , H04L1/06 , H04L25/03 , H04B7/10
CPC分类号： H04L25/03057 , H04B1/126 , H04B7/0845 , H04L1/06 , H04L2025/0349
摘要： A data signal composed of a desired signal faded and delayed and an interference signal faded and delayed is received by a pair of antennas. A direct component of the interference signal and a delay component of the desired signal are removed from the data signals received by the antennas in a decision-feedback type of desired signal equalizing unit, and the direct component of the desired signal and the delay component of the interference signal are removed from the data signals in a decision-feedback type of interference signal equalizing unit. Also, a delay component of the interference signal is removed in the desired signal equalizing unit by subtracting a replica of the delay component of the interference signal produced in a backward tap from a demodulated interference signal produced in the interference signal equalizing unit in a previous operation, and a delay component of the desired signal is removed in the interference signal equalizing unit by subtracting a replica of the delay component of the desired signal produced in another backward tap from a demodulated desired signal produced in the desired signal equalizing unit in the previous operation. Therefore, the demodulated desired signal agreeing with the desired signal is output from the desired signal equalizing unit, and the demodulated interference signal agreeing with the interference signal is output from the interference signal equalizing unit.
摘要翻译：由一对天线接收由期望信号褪色和延迟组成的数据信号和衰落和延迟的干扰信号。干扰信号的直接分量和期望信号的延迟分量从期望信号均衡单元的判决反馈类型中的天线接收的数据信号中去除，并且期望信号和延迟分量的直接分量干扰信号在干扰信号均衡单元的判决反馈型中从数据信号中去除。此外，通过从先前的操作中在干扰信号均衡单元中产生的解调干扰信号中减去在后向抽头中产生的干扰信号的延迟分量的副本，在期望的信号均衡单元中去除干扰信号的延迟分量并且在干扰信号均衡单元中通过从先前操作中在所需信号均衡单元中产生的解调的期望信号中减去在另一个反向抽头中产生的期望信号的延迟分量的副本来去除所需信号的延迟分量。因此，从期望信号均衡单元输出与期望信号一致的解调的期望信号，并且从干扰信号均衡单元输出与干扰信号一致的解调干扰信号。

4. 发明授权

US5001344A Scanning electron microscope and method of processing the same 失效
标题翻译：扫描电子显微镜及其加工方法
公开(公告)号：US5001344A
公开(公告)日：1991-03-19
申请号：US390731
申请日：1989-08-08
申请人： Makoto Kato , Koichi Homma , Fuminobu Komura , Toshihiro Furuya , Shinobu Otsuka
发明人： Makoto Kato , Koichi Homma , Fuminobu Komura , Toshihiro Furuya , Shinobu Otsuka
IPC分类号： H01J37/22 , G01B15/04 , H01J37/28 , H01J49/06
CPC分类号： H01J37/28
摘要： An image generated by the detected signals of a scanning electron microscope is divided, for example, into a plurality of rectangular small areas with the boundaries parallel to the y-axis. The relative height in the boundary is obtained by conducting one dimensional integration for respectively boundaries. Thereafter, the relative height difference between the boundaries is determined by conducting one dimensional integration for each area in the direction perpendicular to the boundary. Thereby, the surface three dimensional topography having less distortion can be measured, even in case errors are included in the normal distribution which indicates the surface topography of the specimen, by adjusting and determining the height in the area by the interporating operation.
摘要翻译：由扫描电子显微镜的检测信号产生的图像被划分为多个具有与y轴平行的矩形小区域。通过对边界进行一维积分获得边界中的相对高度。此后，通过对垂直于边界的方向上的每个区域进行一维积分来确定边界之间的相对高度差。因此，即使在表示样本的表面形貌的正态分布中包含错误的情况下，也可以通过调整和确定通过交错操作确定该区域的高度，来测量具有较小失真的表面三维形貌。

5. 发明授权

US4682300A Image correction processing method and apparatus 失效
标题翻译：图像校正处理方法及装置
公开(公告)号：US4682300A
公开(公告)日：1987-07-21
申请号：US571742
申请日：1984-01-18
申请人： Youichi Seto , Koichi Homma , Fuminobu Komura , Shimbu Yamagata , Yutaka Kubo , Hirotaka Mizuno
发明人： Youichi Seto , Koichi Homma , Fuminobu Komura , Shimbu Yamagata , Yutaka Kubo , Hirotaka Mizuno
IPC分类号： G06T3/00 , G01C11/04 , G06T1/00 , G01C25/00 , G03B27/68 , G06K9/40 , H04N7/18
CPC分类号： G01C11/04
摘要： By using a low-frequency component of attitude data of an uncorrected image resulting from scanning the ground by means of a sensor mounted on a satellite, low-frequency distortion correction coefficients are calculated. By using a high-frequency component of attitude data, a change rate is calculated. From said low-frequency distortion correction coefficients and said change rate, distortion correction coefficients covering a high frequency are calculated. By applying bidirectional resampling to the uncorrected image by using said distortion correction coefficients covering a high frequency, a corrected image is obtained.
摘要翻译：通过使用通过安装在卫星上的传感器扫描地面而产生的未校正图像的姿态数据的低频分量，计算低频失真校正系数。通过使用姿态数据的高频分量，计算变化率。根据所述低频失真校正系数和所述变化率，计算覆盖高频的失真校正系数。通过使用覆盖高频的所述失真校正系数对未校正图像应用双向重采样，获得校正图像。

6. 发明授权

US4663319A 3-(1,3-dithiol-2-ylidene)-2,4-dioxopyrrolidines, -piperidines, and -hexahydroazepines and use thereof against hepatic diseases 失效
标题翻译： 3-（1,3-二硫醇-2-亚基）-2,4-二氧代吡咯烷，哌啶和六氢吖庚因及其用于肝病
公开(公告)号：US4663319A
公开(公告)日：1987-05-05
申请号：US689261
申请日：1985-01-07
申请人： Ikuo Iijima , Koichi Homma , Yutaka Saiga , Yuzo Matsuoka , Mamoru Matsumoto
发明人： Ikuo Iijima , Koichi Homma , Yutaka Saiga , Yuzo Matsuoka , Mamoru Matsumoto
IPC分类号： C07D211/58 , A61K31/45 , A61K31/4523 , A61P1/16 , C07D207/38 , C07D211/86 , C07D211/90 , C07D213/02 , C07D213/38 , C07D213/40 , C07D213/69 , C07D223/10 , C07D295/06 , C07D339/06 , C07D401/06 , C07D409/04 , C07D409/12 , C07D409/14 , A61K31/55 , A61K31/445
CPC分类号： C07D213/40 , C07D207/38 , C07D211/86 , C07D211/90 , C07D213/38 , C07D213/69 , C07D223/10 , C07D339/06 , C07D401/06 , C07D409/04 , C07D409/12 , C07D409/14
摘要： Novel thioketene derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, an alkyl group, a lower alkenyl group, a phenyl group or a group of the formula: --B--Y;Y is a nitrogen-containing monocyclic heterocyclic group or a substituted or unsubstituted phenyl group;B is a straight or branched lower alkylene group;R.sup.2 and R.sup.3 are both a lower alkyl group or are combined together to form a group of the formula: --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--;R.sup.4 is hydrogen atom, a lower alkyl group or a (lower alkoxy)carbonyl group;A is a group of the formula: --(CH.sub.2).sub.n -- or --CH(COOR.sup.5)--;n is an integer of 0, 1 or 2 andR.sup.5 is a lower alkyl group,are disclosed. The compound (I) is useful as an agent for treating and protecting various liver diseases.
摘要翻译：具有下式的新型硫代烯酮衍生物：其中R 1是氢原子，烷基，低级烯基，苯基或下式基团：-B-Y; Y是含氮单环杂环基或取代或未取代的苯基; B是直链或支链低级亚烷基; R 2和R 3都是低级烷基或被结合在一起形成下式的基团：-CH 2 CH 2 - 或-CH = CH-; R4是氢原子，低级烷基或（低级烷氧基）羰基; A是下式的基团： - （CH 2）n - 或-CH（COOR 5） - ; n是0或1或2的整数，R5是低级烷基。化合物（I）可用作治疗和保护各种肝脏疾病的药剂。

7. 发明授权

US5812421A System for cooperatively operating river management facilities 失效
标题翻译：合作经营河道管理设施体系
公开(公告)号：US5812421A
公开(公告)日：1998-09-22
申请号：US633098
申请日：1996-04-16
申请人： Kenji Fujii , Koichi Homma , Fuminobu Komura , Kunio Takada
发明人： Kenji Fujii , Koichi Homma , Fuminobu Komura , Kunio Takada
IPC分类号： E02B3/00 , G01F23/00
CPC分类号： E02B3/00
摘要： A river management system for controllably operating devices of management facilities installed at pluralities of rivers and waterways to manage water volumes in a river network including the pluralities of rivers and waterways. The river management system includes an operation plan database for storing therein a plurality of sets of the contents of operations of the river management facility devices in the form of operation modes when the values of water levels, flow rates, precipitations and change rates thereof at a plurality of points of the river network satisfy predetermined conditions; an operation plan decider, when the values of water levels, flow rates, precipitations and change rates thereof at the points of the river network satisfy the predetermined conditions, for selecting one of the operation modes corresponding to the conditions and determining the operation contents of the river management facility devices; and a monitor/input section for inputting values of water levels, flow rates and precipitations of the points of the river network to the system.
摘要翻译：一套河道管理系统，用于可控地运行安装在多条河流和水道上的管理设施，管理包括多条河流和水道在内的河网水量。河流管理系统包括操作计划数据库，用于在运行模式的形式中存储河流管理设备装置的操作内容的多组，当水位，流量，沉降和其变化率在河网多点满足预定条件; 操作方案决定器，当在河网的点处的水位，流量，沉降和其变化率的值满足预定条件时，用于选择与条件相对应的操作模式之一并确定其中的操作内容河流管理设备; 以及用于输入河网点到系统的水位，流量和沉降值的监视器/输入部分。

8. 发明授权

US5739132A Pyridazinone derivatives and processes for preparing the same 失效
标题翻译：哒嗪酮衍生物及其制备方法
公开(公告)号：US5739132A
公开(公告)日：1998-04-14
申请号：US767444
申请日：1996-12-16
申请人： Akihiko Ishida , Koichi Homma , Harumichi Kono , Koji Tamura , Yasuhiko Sasaki
发明人： Akihiko Ishida , Koichi Homma , Harumichi Kono , Koji Tamura , Yasuhiko Sasaki
IPC分类号： C07D237/04 , A61K31/50
CPC分类号： C07D237/04
摘要： Disclosed are a pyridazinone compound represented by the formula: ##STR1## wherein (1) R.sup.1 is a substituted or unsubstituted C.sub.1-10 alkyl, a C.sub.3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R.sup.3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R.sup.1 and R.sup.3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: ##STR2## where n is 1 or 2; and D is hydrogen or a halogen; or (2) R.sup.1 is a substituted or unsubstituted C.sub.1-10 alkyl, a substituted or unsubstituted phenyl, a C.sub.3-6 cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R.sup.3 is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R.sup.1 and R.sup.3 are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula: ##STR3## and R.sup.2 is hydrogen, a substituted or unsubstituted lower alkyl, an aryl or a lower alkenyl; and --A--B-- is an ethylene or vinylene each of which may be substituted by 1 or 2 groups selected from the group consisting of a lower alkyl and phenyl group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same.
摘要翻译：公开了由下式表示的哒嗪酮化合物：其中（1）R1是取代或未取代的C1-10烷基，C3-6环烷基，低级烯基，具有N，O或S的杂环基原子或樟脑-10-基; R3是氢，取代或未取代的低级烷基或低级烯基; 或者R 1和R 3在其末端键合形成低级亚烷基; Z为由下式表示的基团：其中n为1或2; D为氢或卤素; 或（2）R1是取代或未取代的C1-10烷基，取代或未取代的苯基，C3-6环烷基，低级链烯基，具有N，O或S原子的杂环基或樟脑-10-基; R3是氢，取代或未取代的低级烷基或低级烯基; 或者R 1和R 3在其末端键合形成低级亚烷基; Z是由下式表示的基团：＆lt; IMAGE＆gt; R2是氢，取代或未取代的低级烷基，芳基或低级烯基; 并且-A-B-是各自可以被选自低级烷基和苯基的1或2个基团取代的乙烯或亚乙烯基，或其药学上可接受的盐及其制备方法。

9. 发明授权

US5686452A Indane derivative and processes for preparing the same 失效
标题翻译：吲哚衍生物及其制备方法
公开(公告)号：US5686452A
公开(公告)日：1997-11-11
申请号：US767392
申请日：1996-12-16
申请人： Akihiko Ishida , Koichi Homma , Michihisa Yato , Shinsuke Nishiyama , Fumikazu Okumura
发明人： Akihiko Ishida , Koichi Homma , Michihisa Yato , Shinsuke Nishiyama , Fumikazu Okumura
IPC分类号： C07D237/14 , C07D401/12 , A61K31/50
CPC分类号： C07D401/12 , C07D237/14
摘要： Disclosed are an indane compound represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkyl group, a lower alkenyl group or a substituted or unsubstituted mono-cyclic aromatic heterocyclic group having nitrogen atom as a hetero atom; R.sup.2 represents hydrogen atom or a lower alkyl group; and A represents a lower alkylene group, or a pharmaceutically acceptable salt thereof and processes for preparing the same.
摘要翻译：公开了下式表示的二氢化茚化合物：其中R 1表示低级烷基，低级链烯基或具有氮原子作为杂原子的取代或未取代的单环芳族杂环基; R2表示氢原子或低级烷基; A表示低级亚烷基或其药学上可接受的盐及其制备方法。

10. 发明授权

US09032925B2 Phase varying apparatus for automobile engine 有权
标题翻译：汽车发动机相变装置
公开(公告)号：US09032925B2
公开(公告)日：2015-05-19
申请号：US14238380
申请日：2011-08-12
申请人： Michihiro Kameda , Masaaki Niiro , Koichi Homma
发明人： Michihiro Kameda , Masaaki Niiro , Koichi Homma
IPC分类号： F01L1/34 , F01L1/344 , F01L1/352
CPC分类号： F01L1/344 , F01L1/352 , F01L2001/3522
摘要： A phase varying apparatus capable of smoothly varying the phase angle of a camshaft relative to a drive rotor by comprising: a drive rotor supported by a camshaft and driven by a crankshaft; a first control rotor integral with the camshaft; a first torquing mechanism for providing the first drive rotor with a torque in one direction, and a reverse rotation mechanism for proving the first control rotor with a torque in the opposite direction, wherein the reverse rotation mechanism comprises a first radius-decreasing guide groove formed in the control rotor, a crank member adapted to rotate about a position offset from the rotational axis of the drive rotor, and a first pin mechanism mounted on the crank member and movable in the radius-decreasing guide groove, and a second operative mechanism for rotating the first control rotor in the opposite rotational direction relative to the drive rotor.
摘要翻译：一种能够相对于驱动转子平滑地改变凸轮轴的相位角的相变装置，包括：由凸轮轴支撑并由曲轴驱动的驱动转子; 与凸轮轴成一体的第一控制转子; 第一扭转机构，用于向第一驱动转子提供一个方向的扭矩;以及反向旋转机构，用于以相反方向的扭矩证明第一控制转子，其中反向旋转机构包括形成的第一半径减小导向槽在所述控制转子中，曲柄构件适于围绕从所述驱动转子的旋转轴线偏移的位置旋转;以及第一销机构，其安装在所述曲柄构件上并且可在所述半径减小的导向槽中移动，以及第二操作机构，使第一控制转子相对于驱动转子在相反的旋转方向旋转。

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