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1. 发明授权

US06361901B1 Self-doped microphase separated block copolymer electrolyte 有权
标题翻译：自掺杂微相分离嵌段共聚物电解质
公开(公告)号：US06361901B1
公开(公告)日：2002-03-26
申请号：US09360427
申请日：1999-07-23
申请人： Anne M. Mayes , Donald R. Sadoway , Pallab Banerjee , Philip Soo , Biying Huang
发明人： Anne M. Mayes , Donald R. Sadoway , Pallab Banerjee , Philip Soo , Biying Huang
IPC分类号： H01M618
CPC分类号： H01M10/052 , H01M4/13 , H01M10/0525 , H01M10/054 , H01M10/0565
摘要： A polymer electrolyte includes a self-doped microphase separated block copolymer including at least one ionically conductive block and at least one second block that is immiscible in the ionically conductive block, an anion immobilized on the polymer electrolyte and a cationic species. The ionically conductive block provides a continuous ionically conductive pathway through the electrolyte. The electrolyte may be used as an electrolyte in an electrochemical cell.
摘要翻译：聚合物电解质包括自掺杂微相分离的嵌段共聚物，其包括至少一个离子导电嵌段和至少一个在离子导电嵌段中不混溶的第二嵌段，固定在聚合物电解质上的阴离子和阳离子物质。离子导电嵌段提供通过电解质的连续离子导电通路。电解质可以用作电化学电池中的电解质。

2. 发明授权

US07868087B2 Graft copolymers, methods for grafting hydrophilic chains onto hydrophobic polymers, and articles thereof 有权
标题翻译：接枝共聚物，将亲水链接枝到疏水性聚合物上的方法及其制品
公开(公告)号：US07868087B2
公开(公告)日：2011-01-11
申请号：US11541629
申请日：2006-09-29
申请人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul
发明人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul
IPC分类号： B01D67/00 , B01D69/02 , B01D71/34 , B01D71/78
CPC分类号： B01D67/0018 , B01D69/02 , B01D69/141 , B01D71/30 , B01D71/34 , B01D71/40 , B01D71/52 , B01D71/78 , B01D2323/02 , B01D2325/28 , B01D2325/32 , C08G81/00 , C08G81/021
摘要： The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.
摘要翻译：本发明涉及将亲水链接枝到聚合物，特别是疏水性聚合物如聚（氯乙烯）（PVC），聚（偏二氟乙烯）（PVDF）和氯化聚丙烯（cPP））上的合成方法。得到的聚合物包括梳状聚合物，其可以具有由亲水链提供的亲水结构域的微相分离结构。由这些梳形聚合物制备的，特别是衍生自PVDF的制品包括用于水过滤的膜，其中亲水域提供水输送途径。 PVC可以通过亲水链接PVC来增塑。此外，这些制品，特别是具有生物医学应用的制品，可以显示抗血栓形成性质。

3. 发明授权

US06632883B2 Baroplastic materials 失效
标题翻译：陶瓷材料
公开(公告)号：US06632883B2
公开(公告)日：2003-10-14
申请号：US09788324
申请日：2001-02-16
申请人： Anne M. Mayes , Anne Valerie Ruzette , Thomas P. Russell , Pallab Banerjee
发明人： Anne M. Mayes , Anne Valerie Ruzette , Thomas P. Russell , Pallab Banerjee
IPC分类号： C08L5300
CPC分类号： C09J153/00 , C08F293/005 , C08L53/00 , G03F7/0002
摘要： The present invention relates to block copolymer compositions capable of being processed by the application of pressure. The invention also provides methods for predicting phase diagrams of polymer blends and block copolymers, particularly block copolymers comprising hard and soft blocks having properties described herein. The methods of the invention allow prediction of polymeric systems which can be processed under conditions that do not promote polymer degradation.
摘要翻译：本发明涉及能够通过施加压力加工的嵌段共聚物组合物。本发明还提供了用于预测聚合物共混物和嵌段共聚物的相图的方法，特别是包含具有本文所述性质的硬和软嵌段的嵌段共聚物。本发明的方法允许预测可在不促进聚合物降解的条件下加工的聚合物体系

4. 发明申请

US20110168630A1 GRAFT COPOLYMERS, METHODS FOR GRAFTING HYDROPHILIC CHAINS ONTO HYDROPHOBIC POLYMERS, AND ARTICLES THEREOF 有权
标题翻译：聚合物共聚物，将疏水性链链接在疏水性聚合物上的方法及其制品
公开(公告)号：US20110168630A1
公开(公告)日：2011-07-14
申请号：US12957064
申请日：2010-11-30
申请人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul , Glenn C. Mailand
发明人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul , Glenn C. Mailand
IPC分类号： B01D61/00 , C08F283/06
CPC分类号： B01D67/0018 , B01D69/02 , B01D69/141 , B01D71/30 , B01D71/34 , B01D71/40 , B01D71/52 , B01D71/78 , B01D2323/02 , B01D2325/28 , B01D2325/32 , C08G81/00 , C08G81/021
摘要： The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.
摘要翻译：本发明涉及将亲水链接枝到聚合物，特别是疏水性聚合物如聚（氯乙烯）（PVC），聚（偏二氟乙烯）（PVDF）和氯化聚丙烯（cPP））上的合成方法。得到的聚合物包括梳状聚合物，其可以具有由亲水链提供的亲水结构域的微相分离结构。由这些梳形聚合物制备的，特别是衍生自PVDF的制品包括用于水过滤的膜，其中亲水域提供水输送途径。 PVC可以通过亲水链接PVC来增塑。此外，这些制品，特别是具有生物医学应用的制品，可以显示抗血栓形成性质。

5. 发明授权

US06399700B2 Comb copolymers for regulating cell-surface interactions 有权
标题翻译：用于调节细胞表面相互作用的梳状共聚物
公开(公告)号：US06399700B2
公开(公告)日：2002-06-04
申请号：US09817887
申请日：2001-03-26
申请人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
发明人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
IPC分类号： C08J524
CPC分类号： A61K47/48 , A61K47/50 , A61K47/56 , A61K47/641 , C08G81/00 , C08G81/024 , C08J5/24
摘要： Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents. In another embodiment, the combs can be blended in small quantities to a hydrophobic matrix polymer and processed to affect the surface segregation of the comb. The comb copolymers are formed in one embodiment by providing a biodegradable polyester backbone that includes reactive groups, and reacting the reactive groups in the backbone with reactive chain ends on a low molecular weight hydrophilic polymer. In another embodiment, non-biodegradable comb copolymers are formed by free radical synthesis of a hydrophobic monomer and a hydrophilic macromonomer. In all of the above embodiments, a portion of the hydrophilic polymer side chains can be covalently coupled to cell-signaling ligands such as adhesion peptides or growth factors to control cellular response.
摘要翻译：提供引起受控细胞反应的合成梳状共聚物，将这些聚合物应用于各种表面的方法，以及使用聚合物改性生物材料表面的方法，在组织工程应用中以及作为药物递送装置。梳状共聚物由疏水性聚合物主链和亲水性非细胞结合侧链组成，其可以用引导细胞反应的细胞信号传导配体封端。通过将非细胞结合梳与含配体的梳子混合，可以在表面上调节一种或多种类型的配体（包括粘附肽和生长因子）的表面浓度和空间分布，以实现所需的细胞反应。在一个实施方案中，梳子用作胶乳分散聚合的稳定剂。梳状稳定的胶乳可以通过标准涂布操作施加到基底上以产生生物调节表面，或用作药物递送剂。在另一个实施方案中，梳子可以少量混合到疏水性基质聚合物中并进行处理以影响梳子的表面分离。梳状共聚物在一个实施方案中通过提供包含反应性基团的可生物降解的聚酯主链，并使主链中的反应性基团与低分子量亲水聚合物上的反应性链端端反应形成。在另一个实施方案中，通过自由基合成疏水性单体和亲水性大分子单体形成不可生物降解的梳状共聚物。在所有上述实施方案中，一部分亲水性聚合物侧链可共价偶联至细胞信号传导配体如粘附肽或生长因子以控制细胞反应。

6. 发明授权

US06207749B1 Comb copolymers for regulating cell-surface interactions 有权
标题翻译：用于调节细胞表面相互作用的梳状共聚物
公开(公告)号：US06207749B1
公开(公告)日：2001-03-27
申请号：US09634095
申请日：2000-08-08
申请人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
发明人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
IPC分类号： C08J524
CPC分类号： A61K47/48 , A61K47/50 , A61K47/56 , A61K47/641 , C08G81/00 , C08G81/024 , C08J5/24
摘要： Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents. In another embodiment, the combs can be blended in small quantities to a hydrophobic matrix polymer and processed to affect the surface segregation of the comb. The comb copolymers are formed in one embodiment by providing a biodegradable polyester backbone that includes reactive groups, and reacting the reactive groups in the backbone with reactive chain ends on a low molecular weight hydrophilic polymer. In another embodiment, non-biodegradable comb copolymers are formed by free radical synthesis of a hydrophobic monomer and a hydrophilic macromonomer. In all of the above embodiments, a portion of the hydrophilic polymer side chains can be covalently coupled to cell-signaling ligands such as adhesion peptides or growth factors to control cellular response.
摘要翻译：提供引起受控细胞反应的合成梳状共聚物，将这些聚合物应用于各种表面的方法，以及使用聚合物改性生物材料表面的方法，在组织工程应用中以及作为药物递送装置。梳状共聚物由疏水性聚合物主链和亲水性非细胞结合侧链组成，其可以用引导细胞反应的细胞信号传导配体封端。通过将非细胞结合梳与含配体的梳子混合，可以在表面上调节一种或多种类型的配体（包括粘附肽和生长因子）的表面浓度和空间分布，以实现所需的细胞反应。在一个实施方案中，梳子用作胶乳分散聚合的稳定剂。梳状稳定的胶乳可以通过标准涂布操作施加到基底上以产生生物调节表面，或用作药物递送剂。在另一个实施方案中，梳子可以少量混合到疏水性基质聚合物中并进行处理以影响梳子的表面分离。梳状共聚物在一个实施方案中通过提供包含反应性基团的可生物降解的聚酯主链，并使主链中的反应性基团与低分子量亲水聚合物上的反应性链端端反应形成。在另一个实施方案中，通过自由基合成疏水性单体和亲水性大分子单体形成不可生物降解的梳状共聚物。在所有上述实施方案中，一部分亲水性聚合物侧链可共价偶联至细胞信号传导配体如粘附肽或生长因子以控制细胞反应。

7. 发明授权

US6150459A Comb polymers for regulating cell surface interactions 有权
标题翻译：梳状聚合物用于调节细胞表面相互作用
公开(公告)号：US6150459A
公开(公告)日：2000-11-21
申请号：US290140
申请日：1999-04-13
申请人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
发明人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
IPC分类号： A61L27/00 , A61K47/48 , A61L33/00 , C08G81/00 , C08G81/02 , C08G85/00
CPC分类号： C08G81/024 , A61K47/48169 , A61K47/48253 , C08G81/00
摘要： Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents. In another embodiment, the combs can be blended in small quantities to a hydrophobic matrix polymer and processed to affect the surface segregation of the comb. The comb copolymers are formed in one embodiment by providing a biodegradable polyester backbone that includes reactive groups, and reacting the reactive groups in the backbone with reactive chain ends on a low molecular weight hydrophilic polymer. In another embodiment, non-biodegradable comb copolymers are formed by free radical synthesis of a hydrophobic monomer and a hydrophilic macromonomer. In all of the above embodiments, a portion of the hydrophilic polymer side chains can be covalently coupled to cell-signaling ligands such as adhesion peptides or growth factors to control cellular response.
摘要翻译：提供引起受控细胞反应的合成梳状共聚物，将这些聚合物应用于各种表面的方法，以及使用聚合物改性生物材料表面的方法，在组织工程应用中以及作为药物递送装置。梳状共聚物由疏水性聚合物主链和亲水性非细胞结合侧链组成，其可以用引导细胞反应的细胞信号传导配体封端。通过将非细胞结合梳与含配体的梳子混合，可以在表面上调节一种或多种类型的配体（包括粘附肽和生长因子）的表面浓度和空间分布，以实现所需的细胞反应。在一个实施方案中，梳子用作胶乳分散聚合的稳定剂。梳状稳定的胶乳可以通过标准涂布操作施加到基底上以产生生物调节表面，或用作药物递送剂。在另一个实施方案中，梳子可以少量混合到疏水性基质聚合物中并进行处理以影响梳子的表面分离。梳状共聚物在一个实施方案中通过提供包含反应性基团的可生物降解的聚酯主链，并使主链中的反应性基团与低分子量亲水聚合物上的反应性链端端反应形成。在另一个实施方案中，通过自由基合成疏水性单体和亲水性大分子单体形成不可生物降解的梳状共聚物。在所有上述实施方案中，一部分亲水性聚合物侧链可共价偶联至细胞信号传导配体如粘附肽或生长因子以控制细胞反应。

8. 发明申请

US20050079149A1 Hyperbranched dendron and methods of synthesis and use thereof 失效
标题翻译：超分支树突及其合成和使用方法
公开(公告)号：US20050079149A1
公开(公告)日：2005-04-14
申请号：US10806025
申请日：2004-03-22
申请人： Pallab Banerjee , Wilfried Reichardt , Ralph Weissleder , Alexei Bogdanov
发明人： Pallab Banerjee , Wilfried Reichardt , Ralph Weissleder , Alexei Bogdanov
IPC分类号： A61K31/74 , A61K31/785 , C08F8/32 , C08F285/00 , C08G63/48 , C08G63/91 , C12Q20060101
CPC分类号： C08F283/00 , C08F271/00 , C08F283/04 , C08G73/0206 , C08G83/003 , C12N15/87 , Y10T428/31848
摘要： Hyperbranched dendron (HD) polymers are synthesized using low molecular weight polyethyleneimine (BPEI-L) as a core and used for gene delivery. The obtained polymers display low toxicity and efficient gene delivery at low nitrogen-to-phosphate (N/P) ratios. Using successive attachment of ethyleneimine moieties to a PEI core, the polymer has a lower relative ratio of linear-to-branched structures than in the core PEI. The more extensive branching enables the polymer to condense plasmid DNA into nanostructure complexes with a size of less than or equal to about 100 nm. The complexes are stable and efficient in transfecting cells in the presence of serum. Bioluminescent imaging of in vivo gene expression using a luciferase reporter gene performed in live mice showed gene expression in the liver and in submandibular lymph nodes.
摘要翻译：使用低分子量聚乙烯亚胺（BPEI-L）作为核心并用于基因递送合成超支化树突（HD）聚合物。所获得的聚合物在低氮磷酸盐（N / P）比低的情况下显示低毒性和有效的基因递送。使用乙烯亚胺部分连续连接到PEI芯上，该聚合物具有比在芯PEI中更低的线性至支化结构的相对比例。更广泛的分支使得聚合物能够将质粒DNA冷凝成尺寸小于或等于约100nm的纳米结构复合物。复合物在血清存在下转染细胞是稳定和有效的。使用在活鼠中进行的荧光素酶报告基因的体内基因表达的生物发光成像显示在肝脏和下颌下淋巴结中的基因表达。

9. 发明授权

US08999661B2 Compositions for detecting cell death and methods of use thereof 有权
标题翻译：用于检测细胞死亡的组合物及其使用方法
公开(公告)号：US08999661B2
公开(公告)日：2015-04-07
申请号：US12511478
申请日：2009-07-29
申请人： Andrew Kung , Pallab Banerjee
发明人： Andrew Kung , Pallab Banerjee
IPC分类号： C12Q1/32 , G01N33/50 , C07K14/00 , C12N9/04
CPC分类号： C12Q1/32 , G01N33/5011 , G01N2510/00
摘要： The invention provides compounds and methods of their use in the detection of apoptosis and necrosis both in vitro and in vivo. Also provided are compounds and methods of their use in selective delivery of agents to cells undergoing apoptosis or necrosis. The compounds and methods are based on conjugates formed with a dehydrogenase such as lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, and malate dehydrogenase. The compounds and methods are useful in the diagnosis and treatment of conditions characterized by apoptosis, including cancer, cardiac disease, neurologic disease including stroke, and autoimmunity. The compounds and methods offer distinct advantages over corresponding compounds and methods based on Annexin V. Also provided are methods for screening for compounds that modulate, i.e., inhibit or promote, apoptosis.
摘要翻译：本发明提供了它们用于体外和体内检测凋亡和坏死的化合物和方法。还提供了它们用于选择性递送药物至经历凋亡或坏死的细胞的化合物和方法。化合物和方法基于与脱氢酶形成的缀合物，例如乳酸脱氢酶，醇脱氢酶，醛脱氢酶和苹果酸脱氢酶。该化合物和方法可用于诊断和治疗特征为细胞凋亡的病症，包括癌症，心脏病，神经系统疾病，包括中风和自身免疫。化合物和方法相对于基于膜联蛋白V的相应化合物和方法提供明显的优点。还提供了筛选调节，即抑制或促进凋亡的化合物的方法。

10. 发明申请

US20060258804A1 Hyperbranched dendron and methods of synthesis and use thereof 审中-公开
公开(公告)号：US20060258804A1
公开(公告)日：2006-11-16
申请号：US11431996
申请日：2006-05-11
申请人： Pallab Banerjee , Wilfried Reichardt , Ralph Weissleder , Alexei Bogdanov
发明人： Pallab Banerjee , Wilfried Reichardt , Ralph Weissleder , Alexei Bogdanov
IPC分类号： C08L53/00
CPC分类号： C08F283/00 , C08F271/00 , C08F283/04 , C08G73/0206 , C08G83/003 , C12N15/87 , Y10T428/31848
摘要： Hyperbranched dendron (HD) polymers are synthesized using low molecular weight polyethyleneimine (BPEI-L) as a core and used for gene delivery. The obtained polymers display low toxicity and efficient gene delivery at low nitrogen-to-phosphate (N/P) ratios. Using successive attachment of ethyleneimine moieties to a PEI core, the polymer has a lower relative ratio of linear-to-branched structures than in the core PEI. The more extensive branching enables the polymer to condense plasmid DNA into nanostructure complexes with a size of less than or equal to about 100 nm. The complexes are stable and efficient in transfecting cells in the presence of serum. Bioluminescent imaging of in vivo gene expression using a luciferase reporter gene performed in live mice showed gene expression in the liver and in submandibular lymph nodes.

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