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1. 发明申请

US20110168630A1 GRAFT COPOLYMERS, METHODS FOR GRAFTING HYDROPHILIC CHAINS ONTO HYDROPHOBIC POLYMERS, AND ARTICLES THEREOF 有权
标题翻译：聚合物共聚物，将疏水性链链接在疏水性聚合物上的方法及其制品
公开(公告)号：US20110168630A1
公开(公告)日：2011-07-14
申请号：US12957064
申请日：2010-11-30
申请人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul , Glenn C. Mailand
发明人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul , Glenn C. Mailand
IPC分类号： B01D61/00 , C08F283/06
CPC分类号： B01D67/0018 , B01D69/02 , B01D69/141 , B01D71/30 , B01D71/34 , B01D71/40 , B01D71/52 , B01D71/78 , B01D2323/02 , B01D2325/28 , B01D2325/32 , C08G81/00 , C08G81/021
摘要： The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.
摘要翻译：本发明涉及将亲水链接枝到聚合物，特别是疏水性聚合物如聚（氯乙烯）（PVC），聚（偏二氟乙烯）（PVDF）和氯化聚丙烯（cPP））上的合成方法。得到的聚合物包括梳状聚合物，其可以具有由亲水链提供的亲水结构域的微相分离结构。由这些梳形聚合物制备的，特别是衍生自PVDF的制品包括用于水过滤的膜，其中亲水域提供水输送途径。 PVC可以通过亲水链接PVC来增塑。此外，这些制品，特别是具有生物医学应用的制品，可以显示抗血栓形成性质。

2. 发明授权

US06399700B2 Comb copolymers for regulating cell-surface interactions 有权
标题翻译：用于调节细胞表面相互作用的梳状共聚物
公开(公告)号：US06399700B2
公开(公告)日：2002-06-04
申请号：US09817887
申请日：2001-03-26
申请人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
发明人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
IPC分类号： C08J524
CPC分类号： A61K47/48 , A61K47/50 , A61K47/56 , A61K47/641 , C08G81/00 , C08G81/024 , C08J5/24
摘要： Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents. In another embodiment, the combs can be blended in small quantities to a hydrophobic matrix polymer and processed to affect the surface segregation of the comb. The comb copolymers are formed in one embodiment by providing a biodegradable polyester backbone that includes reactive groups, and reacting the reactive groups in the backbone with reactive chain ends on a low molecular weight hydrophilic polymer. In another embodiment, non-biodegradable comb copolymers are formed by free radical synthesis of a hydrophobic monomer and a hydrophilic macromonomer. In all of the above embodiments, a portion of the hydrophilic polymer side chains can be covalently coupled to cell-signaling ligands such as adhesion peptides or growth factors to control cellular response.
摘要翻译：提供引起受控细胞反应的合成梳状共聚物，将这些聚合物应用于各种表面的方法，以及使用聚合物改性生物材料表面的方法，在组织工程应用中以及作为药物递送装置。梳状共聚物由疏水性聚合物主链和亲水性非细胞结合侧链组成，其可以用引导细胞反应的细胞信号传导配体封端。通过将非细胞结合梳与含配体的梳子混合，可以在表面上调节一种或多种类型的配体（包括粘附肽和生长因子）的表面浓度和空间分布，以实现所需的细胞反应。在一个实施方案中，梳子用作胶乳分散聚合的稳定剂。梳状稳定的胶乳可以通过标准涂布操作施加到基底上以产生生物调节表面，或用作药物递送剂。在另一个实施方案中，梳子可以少量混合到疏水性基质聚合物中并进行处理以影响梳子的表面分离。梳状共聚物在一个实施方案中通过提供包含反应性基团的可生物降解的聚酯主链，并使主链中的反应性基团与低分子量亲水聚合物上的反应性链端端反应形成。在另一个实施方案中，通过自由基合成疏水性单体和亲水性大分子单体形成不可生物降解的梳状共聚物。在所有上述实施方案中，一部分亲水性聚合物侧链可共价偶联至细胞信号传导配体如粘附肽或生长因子以控制细胞反应。

3. 发明授权

US06207749B1 Comb copolymers for regulating cell-surface interactions 有权
标题翻译：用于调节细胞表面相互作用的梳状共聚物
公开(公告)号：US06207749B1
公开(公告)日：2001-03-27
申请号：US09634095
申请日：2000-08-08
申请人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
发明人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
IPC分类号： C08J524
CPC分类号： A61K47/48 , A61K47/50 , A61K47/56 , A61K47/641 , C08G81/00 , C08G81/024 , C08J5/24
摘要： Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents. In another embodiment, the combs can be blended in small quantities to a hydrophobic matrix polymer and processed to affect the surface segregation of the comb. The comb copolymers are formed in one embodiment by providing a biodegradable polyester backbone that includes reactive groups, and reacting the reactive groups in the backbone with reactive chain ends on a low molecular weight hydrophilic polymer. In another embodiment, non-biodegradable comb copolymers are formed by free radical synthesis of a hydrophobic monomer and a hydrophilic macromonomer. In all of the above embodiments, a portion of the hydrophilic polymer side chains can be covalently coupled to cell-signaling ligands such as adhesion peptides or growth factors to control cellular response.
摘要翻译：提供引起受控细胞反应的合成梳状共聚物，将这些聚合物应用于各种表面的方法，以及使用聚合物改性生物材料表面的方法，在组织工程应用中以及作为药物递送装置。梳状共聚物由疏水性聚合物主链和亲水性非细胞结合侧链组成，其可以用引导细胞反应的细胞信号传导配体封端。通过将非细胞结合梳与含配体的梳子混合，可以在表面上调节一种或多种类型的配体（包括粘附肽和生长因子）的表面浓度和空间分布，以实现所需的细胞反应。在一个实施方案中，梳子用作胶乳分散聚合的稳定剂。梳状稳定的胶乳可以通过标准涂布操作施加到基底上以产生生物调节表面，或用作药物递送剂。在另一个实施方案中，梳子可以少量混合到疏水性基质聚合物中并进行处理以影响梳子的表面分离。梳状共聚物在一个实施方案中通过提供包含反应性基团的可生物降解的聚酯主链，并使主链中的反应性基团与低分子量亲水聚合物上的反应性链端端反应形成。在另一个实施方案中，通过自由基合成疏水性单体和亲水性大分子单体形成不可生物降解的梳状共聚物。在所有上述实施方案中，一部分亲水性聚合物侧链可共价偶联至细胞信号传导配体如粘附肽或生长因子以控制细胞反应。

4. 发明授权

US6150459A Comb polymers for regulating cell surface interactions 有权
标题翻译：梳状聚合物用于调节细胞表面相互作用
公开(公告)号：US6150459A
公开(公告)日：2000-11-21
申请号：US290140
申请日：1999-04-13
申请人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
发明人： Anne M. Mayes , Linda G. Griffith , Darrell J. Irvine , Pallab Banerjee , Terry D. Johnson
IPC分类号： A61L27/00 , A61K47/48 , A61L33/00 , C08G81/00 , C08G81/02 , C08G85/00
CPC分类号： C08G81/024 , A61K47/48169 , A61K47/48253 , C08G81/00
摘要： Synthetic comb copolymers which elicit controlled cellular response, methods of applying these polymers to various surfaces, and methods of using the polymers for modifying biomaterial surfaces, in tissue engineering applications and as drug delivery devices are provided. The comb copolymers are comprised of hydrophobic polymer backbones and hydrophilic, non-cell binding side chains which can be end-capped with cell-signaling ligands that guide cellular response. By mixing non-cell binding combs with ligand-bearing combs, the surface concentration and spatial distribution of one or more types of ligands, including adhesion peptides and growth factors, can be tuned on a surface to achieve desired cellular response. In one embodiment, the combs are used as stabilizing agents for dispersion polymerization of latexes. The comb-stabilized latexes can be applied to substrates by standard coating operations to create a bioregulating surface, or used as drug delivery agents. In another embodiment, the combs can be blended in small quantities to a hydrophobic matrix polymer and processed to affect the surface segregation of the comb. The comb copolymers are formed in one embodiment by providing a biodegradable polyester backbone that includes reactive groups, and reacting the reactive groups in the backbone with reactive chain ends on a low molecular weight hydrophilic polymer. In another embodiment, non-biodegradable comb copolymers are formed by free radical synthesis of a hydrophobic monomer and a hydrophilic macromonomer. In all of the above embodiments, a portion of the hydrophilic polymer side chains can be covalently coupled to cell-signaling ligands such as adhesion peptides or growth factors to control cellular response.
摘要翻译：提供引起受控细胞反应的合成梳状共聚物，将这些聚合物应用于各种表面的方法，以及使用聚合物改性生物材料表面的方法，在组织工程应用中以及作为药物递送装置。梳状共聚物由疏水性聚合物主链和亲水性非细胞结合侧链组成，其可以用引导细胞反应的细胞信号传导配体封端。通过将非细胞结合梳与含配体的梳子混合，可以在表面上调节一种或多种类型的配体（包括粘附肽和生长因子）的表面浓度和空间分布，以实现所需的细胞反应。在一个实施方案中，梳子用作胶乳分散聚合的稳定剂。梳状稳定的胶乳可以通过标准涂布操作施加到基底上以产生生物调节表面，或用作药物递送剂。在另一个实施方案中，梳子可以少量混合到疏水性基质聚合物中并进行处理以影响梳子的表面分离。梳状共聚物在一个实施方案中通过提供包含反应性基团的可生物降解的聚酯主链，并使主链中的反应性基团与低分子量亲水聚合物上的反应性链端端反应形成。在另一个实施方案中，通过自由基合成疏水性单体和亲水性大分子单体形成不可生物降解的梳状共聚物。在所有上述实施方案中，一部分亲水性聚合物侧链可共价偶联至细胞信号传导配体如粘附肽或生长因子以控制细胞反应。

5. 发明授权

US07868087B2 Graft copolymers, methods for grafting hydrophilic chains onto hydrophobic polymers, and articles thereof 有权
标题翻译：接枝共聚物，将亲水链接枝到疏水性聚合物上的方法及其制品
公开(公告)号：US07868087B2
公开(公告)日：2011-01-11
申请号：US11541629
申请日：2006-09-29
申请人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul
发明人： Anne M. Mayes , Jonathan F. Hester , Pallab Banerjee , Ariya Akthakul
IPC分类号： B01D67/00 , B01D69/02 , B01D71/34 , B01D71/78
CPC分类号： B01D67/0018 , B01D69/02 , B01D69/141 , B01D71/30 , B01D71/34 , B01D71/40 , B01D71/52 , B01D71/78 , B01D2323/02 , B01D2325/28 , B01D2325/32 , C08G81/00 , C08G81/021
摘要： The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include comb polymers which can have a microphase-separated structure of hydrophilic domains provided by the hydrophilic chains. Articles prepared from these comb polymers, particularly derived from PVDF, include membranes for water filtration in which the hydrophilic domains provide a pathway for water transport. PVC can be plasticized by grafting the PVC with hydrophilic chains. In addition, such articles, particularly articles having biomedical applications, can display anti-thrombogenic properties.
摘要翻译：本发明涉及将亲水链接枝到聚合物，特别是疏水性聚合物如聚（氯乙烯）（PVC），聚（偏二氟乙烯）（PVDF）和氯化聚丙烯（cPP））上的合成方法。得到的聚合物包括梳状聚合物，其可以具有由亲水链提供的亲水结构域的微相分离结构。由这些梳形聚合物制备的，特别是衍生自PVDF的制品包括用于水过滤的膜，其中亲水域提供水输送途径。 PVC可以通过亲水链接PVC来增塑。此外，这些制品，特别是具有生物医学应用的制品，可以显示抗血栓形成性质。

6. 发明授权

US06893705B2 Large area orientation of block copolymer microdomains in thin films 失效
标题翻译：嵌段共聚物微区在薄膜中的大面积取向
公开(公告)号：US06893705B2
公开(公告)日：2005-05-17
申请号：US10156700
申请日：2002-05-28
申请人： Edwin L. Thomas , Claudio DeRosa , Cheolmin Park , Michael Fasolka , Bernard Lotz , Anne M. Mayes , Jongsesung Yoon
发明人： Edwin L. Thomas , Claudio DeRosa , Cheolmin Park , Michael Fasolka , Bernard Lotz , Anne M. Mayes , Jongsesung Yoon
IPC分类号： C08L53/00 , C08L53/02 , C09D153/00 , C09D153/02 , B82B1/00 , B82B3/00
CPC分类号： C08L53/00 , C08L53/02 , C08L53/025 , C09D153/00 , C09D153/02 , C09D153/025 , G03F7/0002 , Y10T428/24058 , Y10T428/24074 , Y10T428/24355 , Y10T428/24372 , Y10T428/24967 , Y10T428/249921 , Y10T428/31
摘要： A method and apparatus for orientation of block copolymer microdomains via rapid solidification. Rapid solidification from a solvent may include directional solidification and/or epitaxy to form patterns of microdomains in a film of block copolymer. Microdomains may include various structures formed by components of a block copolymer, such as vertical lamellae, in-plane cylinders, and vertical cylinders, and may depend on film thickness. Orientation of structures in microdomains may be controlled to be approximately uniform, and spatial arrangement of microdomains may be controlled.
摘要翻译：一种通过快速固化取代嵌段共聚物微区的方法和装置。来自溶剂的快速固化可以包括定向凝固和/或外延以在嵌段共聚物的膜中形成微区域的图案。微畴可以包括由嵌段共聚物的组分形成的各种结构，例如垂直薄片，平面内圆柱体和垂直圆柱体，并且可以取决于膜厚度。可以将微区域中的结构的取向控制为近似均匀，并且可以控制微区域的空间排列。

7. 发明授权

US07368505B2 Graft copolymers 失效
标题翻译：接枝共聚物
公开(公告)号：US07368505B2
公开(公告)日：2008-05-06
申请号：US11030576
申请日：2005-01-05
申请人： Anne M. Mayes , Jane Y. Park , Metin H. Acar , Ariya Akthakul
发明人： Anne M. Mayes , Jane Y. Park , Metin H. Acar , Ariya Akthakul
IPC分类号： C08L71/02 , C08F259/00 , C08J5/22
CPC分类号： C08L71/02 , C08F265/04 , C08F273/00 , C08F289/00 , C08F297/02 , C08G81/00 , C08J5/18 , C08J2381/06 , C08L51/003 , C08L51/08 , C08L81/06 , C08L81/00 , C08L2666/22 , C08L2666/02
摘要： This invention relates to methods of making graft copolymers, and articles having such graft copolymers. The methods may provide better control than in radicalization or photoinitiated polymerization techniques. For example, a graft copolymer can be prepared by reacting an alkoxide ion with a polymer. The alkoxide, in turn, can be provided by any suitable technique, for example, by reacting an alcohol with a base. In some embodiments of the invention, the graft copolymers may be a normally hydrophobic polymer, such as a polysulfone, that has been made more hydrophilic due to the attachment of hydrophilic side groups such as polyethylene glycol or polypropylene glycol. The copolymers of the invention have many uses, for example, in films or porous membranes.
摘要翻译：本发明涉及制备接枝共聚物的方法和具有这种接枝共聚物的制品。该方法可以提供比在自由基化或光引发聚合技术更好的控制。例如，可以通过使醇盐离子与聚合物反应来制备接枝共聚物。醇盐又可以通过任何合适的技术提供，例如通过使醇与碱反应。在本发明的一些实施方案中，接枝共聚物可以是通常疏水的聚合物，例如聚砜，由于亲水性侧基如聚乙二醇或聚丙二醇的附着而使其变得更亲水。本发明的共聚物在膜或多孔膜中具有许多用途。

8. 发明授权

US07026071B2 Non-crosslinked, amorphous, block copolymer electrolyte for batteries 有权
公开(公告)号：US07026071B2
公开(公告)日：2006-04-11
申请号：US09862916
申请日：2001-05-22
申请人： Anne M. Mayes , Gerbrand Ceder , Yet-Ming Chiang , Donald R. Sadoway , Mehmet K. Aydinol , Philip P. Soo , Young-Il Jang , Biying Huang
发明人： Anne M. Mayes , Gerbrand Ceder , Yet-Ming Chiang , Donald R. Sadoway , Mehmet K. Aydinol , Philip P. Soo , Young-Il Jang , Biying Huang
IPC分类号： H01M6/00 , B32B27/30
CPC分类号： H01M4/133 , C01B13/14 , C01D15/02 , C01G45/1228 , C01G51/42 , C01G53/42 , C01P2002/02 , C01P2002/08 , C01P2002/20 , C01P2002/30 , C01P2002/52 , C01P2002/54 , C01P2002/72 , C01P2004/04 , C01P2006/40 , C01P2006/80 , H01B1/122 , H01M4/13 , H01M4/131 , H01M4/362 , H01M4/382 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/624 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M2300/0085 , H01M2300/0091 , Y10T428/31 , Y10T428/31935
摘要： Solid battery components are provided. A block copolymeric electrolyte is non-crosslinked and non-glassy through the entire range of typical battery service temperatures, that is, through the entire range of at least from about 0° C. to about 70° C. The chains of which the copolymer is made each include at least one ionically-conductive block and at least one second block immiscible with the ionically-conductive block. The chains form an amorphous association and are arranged in an ordered nanostructure including a continuous matrix of amorphous ionically-conductive domains and amorphous second domains that are immiscible with the ionically-conductive domains. A compound is provided that has a formula of LixMyNzO2. M and N are each metal atoms or a main group elements, and x, y and z are each numbers from about 0 to about 1. y and z are chosen such that a formal charge on the MyNz portion of the compound is (4-x). In certain embodiments, these compounds are used in the cathodes of rechargeable batteries. The present invention also includes methods of predicting the potential utility of metal dichalgogenide compounds for use in lithium intercalation compounds. It also provides methods for processing lithium intercalation oxides with the structure and compositional homogeneity necessary to realize the increased formation energies of said compounds. An article is made of a dimensionally-stable, interpenetrating microstructure of a first phase including a first component and a second phase, immiscible with the first phase, including a second component. The first and second phases define interphase boundaries between them, and at least one particle is positioned between a first phase and a second phase at an interphase boundary. When the first and second phases are electronically-conductive and ionically-conductive polymers, respectively, and the particles are ion host particles, the arrangement is an electrode of a battery.

9. 发明授权

US06413621B1 Polymeric membranes and other polymer articles having desired surface characteristics and method for their preparation 有权
标题翻译：聚合物膜和具有所需表面特性的其它聚合物制品及其制备方法
公开(公告)号：US06413621B1
公开(公告)日：2002-07-02
申请号：US09258526
申请日：1999-02-26
申请人： Anne M. Mayes , David G. Walton , Jonathan F. Hester
发明人： Anne M. Mayes , David G. Walton , Jonathan F. Hester
IPC分类号： B01D6700
CPC分类号： C08J3/005 , B01D67/0011 , B01D69/141 , B01D71/34 , B01D71/40 , B01D71/82 , B01D2323/12 , B01D2323/30 , B01D2325/38 , B01J45/00 , Y10T428/24942 , Y10T428/249953 , Y10T428/249961 , Y10T428/249978 , Y10T428/31 , Y10T428/31928 , Y10T428/31935
摘要： Polymeric articles, including membranes, with surfaces having a desired chemical functionality are created by surface segregation of a branched component blended with a compatible, matrix base component, the branched component having the desired chemical functionality. In particular, hydrophilic surfaces are created via surface segregation of a branched hydrophilic copolymer blended into a polymer matrix. The use of branched molecular architecture provides a thermodynamic mechanism for the segregation of the hydrophilic species to the surface and a means for achieving a high surface coverage of the hydrophilic moiety. The branched hydrophilic copolymer can be defined by a random copolymer including two or more methacrylate or acrylate monomers, at least one of which features a short hydrophilic side chain, such as a polyethylene glycol side chain. The branched hydrophilic copolymer is compatible, and well-entangled, with the acrylate polymer matrix.
摘要翻译：通过与相容的基质基质组分共混的支化组分的表面分离产生具有所需化学官能度的表面的聚合制品，包括膜，所述支化组分具有所需的化学官能度。特别地，亲水性表面是通过共聚到聚合物基质中的支化亲水共聚物的表面偏析产生的。支链分子结构的使用为亲水性物质与表面的分离提供了一种热力学机制，也是实现亲水部分高表面覆盖度的手段。支链亲水共聚物可以通过包括两种或更多种甲基丙烯酸酯或丙烯酸酯单体的无规共聚物来限定，其中至少一种具有短亲水侧链如聚乙二醇侧链。支链亲水共聚物与丙烯酸酯聚合物基质相容并且良好缠结。

10. 发明申请

US20110198288A1 Fouling Resistant Membranes Formed with Polyacrylonitrile Graft Copolymers 有权
标题翻译：用聚丙烯腈接枝共聚物形成的防污膜
公开(公告)号：US20110198288A1
公开(公告)日：2011-08-18
申请号：US12226121
申请日：2007-04-10
申请人： Anne M. Mayes , Ayse Asatekin Alexiou
发明人： Anne M. Mayes , Ayse Asatekin Alexiou
IPC分类号： B01D71/42 , B01D71/82 , B01D71/78
CPC分类号： B01D65/08 , B01D61/145 , B01D61/147 , B01D67/0093 , B01D69/02 , B01D71/42 , B01D71/78 , B01D2321/16 , B01D2323/02 , B01D2323/38 , B01D2325/20 , B01D2325/36
摘要： The present application is generally directed towards polyacrylonitrile— (PAN—) based, amphophilic graft copolymers, for example, for the production of membranes for liquid filtration. In one aspect, the present invention provides systems and methods for preparing high flux, fouling resistant nanofiltration membranes whose pore size can be readily tuned. In some cases, microphase separation of a graft copolymer comprising a backbone comprising polyacrylonitrile (PAN) and hydrophilic side-chains is used. In some cases, nanochannels of tunable width are formed, which may give the membrane permselective properties and/or anti-fouling character. In some cases, a copoylmer may be used as an additive in the immersion precipitation casting of ultrafiltration or microfiltration membranes. In certain instances, the additive can segregate to the membrane exterior and/or pore surfaces, e.g., due to favorable interactions between the hydrophilic side chains and the surrounding environment, which may create a surface that resists fouling, e.g., by biological molecules.
摘要翻译：本申请一般针对基于聚丙烯腈（PAN-）的两亲性接枝共聚物，例如用于生产用于液体过滤的膜。一方面，本发明提供了制备高通量，耐污垢的纳滤膜的系统和方法，其孔径可以容易地调节。在一些情况下，使用包含包含聚丙烯腈（PAN）和亲水侧链的骨架的接枝共聚物的微相分离。在某些情况下，可形成可调宽度的纳米通道，这可以提供膜选择性和/或抗结垢特性。在一些情况下，可以在超滤或微滤膜的浸渍沉淀浇铸中使用共酰基树脂作为添加剂。在某些情况下，例如由于亲水性侧链和周围环境之间的有利相互作用，添加剂可以分离到膜外部和/或孔表面，这可能产生例如通过生物分子阻止结垢的表面。

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