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1. 发明授权

US5204096A Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers 失效
标题翻译：前S基因编码肽乙型肝炎免疫原，疫苗，诊断和合成脂质囊泡载体
公开(公告)号：US5204096A
公开(公告)日：1993-04-20
申请号：US338028
申请日：1989-04-14
申请人： Alexander R. Neurath , Stephen B. H. Kent
发明人： Alexander R. Neurath , Stephen B. H. Kent
IPC分类号： A61K9/127 , A61K39/00 , A61K47/48 , C07K14/02 , C07K16/08 , G01N33/576
CPC分类号： C07K14/005 , A61K47/48176 , A61K47/48315 , A61K47/48815 , A61K47/48876 , A61K9/1271 , C07K16/082 , G01N33/5764 , A61K39/00 , C12N2730/10122 , Y10S530/81
摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen or hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
摘要翻译：一种乙型肝炎疫苗，其含有乙型肝炎病毒包膜前S基因编码区内具有至少六个连续氨基酸的氨基酸链的肽。该疫苗不含对应于乙型肝炎病毒的天然存在的包膜蛋白的氨基酸序列和生理上可接受的稀释剂。肽与载体无关或连接。载体是常规载体或包含通过交联稳定并在其外表面上具有共价键合的活性位点的脂质囊泡的新型载体。这种新型载体不仅用于将含有氨基酸链的新肽与表面抗原或乙型肝炎病毒的S前编码区之前的氨基酸连接，还可用于结合其他病毒的合成肽类似物蛋白质，以及人和动物的细菌，变应原和寄生蛋白。本发明的肽可用于诊断抗原和抗体的检测。

2. 发明授权

US3962421A Method for the disruption of lipid-containing viruses 失效
标题翻译：破坏含脂质病毒的方法
公开(公告)号：US3962421A
公开(公告)日：1976-06-08
申请号：US507306
申请日：1974-09-19
申请人： Alexander R. Neurath
发明人： Alexander R. Neurath
IPC分类号： A61K39/145 , A61K39/205 , C12N7/06 , A61K39/18
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16163 , C12N2760/16251 , C12N2760/20151
摘要： Virus-containing media are treated and the viruses broken down into sub-units by mixing with trialkyl phosphates in the presence of a wetting agent. In comparison with conventional means, sub-unit vaccines prepared therefrom have low toxic pyrogen content, and influenza viruses of Types A and B are disrupted without substantial decreases in neuraminidase level. The method can be used on viruses contained in relatively dilute allantoic fluids as well as those in concentrated centrifugates.
摘要翻译：处理含病毒的培养基，通过在润湿剂存在下与磷酸三烷基酯混合，将病毒分解为亚单位。与常规方法相比，由其制备的亚单位疫苗具有低毒性热原含量，A型和B型流感病毒破坏而神经氨酸酶水平没有显着降低。该方法可用于相对稀释的尿囊内液体以及浓缩离心液中的病毒。

3. 发明授权

US06727240B1 Methods for preventing HIV-1 or HIV-2 infection 失效
标题翻译：预防HIV-1或HIV-2感染的方法
公开(公告)号：US06727240B1
公开(公告)日：2004-04-27
申请号：US08342745
申请日：1994-10-21
申请人： Alexander R. Neurath , Shibo Jiang , Asim Kumar Debnath
发明人： Alexander R. Neurath , Shibo Jiang , Asim Kumar Debnath
IPC分类号： A61K31555
CPC分类号： A61K31/695 , A61K31/409 , A61K31/765 , A61K2300/00
摘要： A method of preventing HIV-1 or HIV-2 infection by administering to a human a pharmaceutically effective anti-HIV-1 or anti-HIV-2 amount of a tin or silicon protoporphyrin IX or tin or silicon mesoporphyrin IX, or a pharmaceutically acceptable salt thereof.
摘要翻译：一种通过向人施用药学有效的抗HIV-1或抗HIV-2量的锡或硅原卟啉IX或锡或硅中卟啉IX或其药学上可接受的方法来预防HIV-1或HIV-2感染的方法的盐。

4. 发明授权

US4877725A Immunoassays for antibodies which bind to the acquired immunodeficiency virus 失效
标题翻译：与获得性免疫缺陷病毒结合的抗体的免疫测定
公开(公告)号：US4877725A
公开(公告)日：1989-10-31
申请号：US718140
申请日：1985-04-01
申请人： Alexander R. Neurath , Nathan Strick
发明人： Alexander R. Neurath , Nathan Strick
IPC分类号： G01N33/569
CPC分类号： G01N33/56988 , Y10S435/81 , Y10S435/948 , Y10S435/974 , Y10S530/806 , Y10S530/811 , Y10S530/812 , Y10S530/826
摘要： A process for the detection of antibodies to HTLV III/LAV comprising:(A) mixing an unknown serum sample with a crude HTLV III/LAV viral antigen selected from the group consisting of(1) an antigen comprising P24 core protein and Penv protein;(2) a P24 antigen and(3) a Penv antigen,(B) incubating the resultant mixture from step (A);(C) contacting the mixture of step (B) with a solid substrate coated with antibody to HTLV III/LAV;(D) incubating the mass from step (C);(E) washing the mass from step (D);(F) contacting the mass from step (E) with a labeled antibody to HTLV III/LAV;(G) incubating the mass from step (F);(H) washing the mass from step (G);(I) assaying the label in the mass from step (H);(J) as a negative control, mixing a serum sample known to be negative to HTLV III/LAV antibody with a diluent;(K) subjecting the mass from step (J) to steps (B) to (I);(L) as a positive control, mixing a predetermined amount of the crude HTLV III/LAV viral antigen and the diluent;(M) subjecting the mass from step (L) to steps (B) to (I); and(N) comparing the results of the assay for the label from steps (I), (K) and (M).
摘要翻译：用于检测HTLV III / LAV的抗体的方法，包括：（A）将未知血清样品与选自（1）包含P24核心蛋白和Penv蛋白的抗原的粗HTLV III / LAV病毒抗原混合; （2）P24抗原和（3）Penv抗原，（B）温育来自步骤（A）的所得混合物; （C）使步骤（B）的混合物与涂覆有HTLV III / LAV抗体的固体基质接触; （D）将来自步骤（C）的质量孵育; （E）从步骤（D）洗涤质量; （F）使来自步骤（E）的质量与HTLV III / LAV的标记抗体接触; （G）温育步骤（F）的质量; （H）从步骤（G）洗涤质量; （I）测定步骤（H）中质量的标记物; （J）作为阴性对照，将已知为阴性的血清样品与稀释剂混合至HTLV III / LAV抗体; （K）使步骤（J）的步骤（B）至（I）（L）作为阳性对照，混合预定量的粗制HTLV III / LAV病毒抗原和稀释剂; （M）使来自步骤（L）的物质经历步骤（B）至（I）; 和（N）比较来自步骤（I），（K）和（M）的标记物的测定结果。

5. 发明授权

US4861588A Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers 失效
标题翻译：前S基因编码肽乙型肝炎免疫原，疫苗，诊断和合成脂质囊泡载体
公开(公告)号：US4861588A
公开(公告)日：1989-08-29
申请号：US856522
申请日：1986-04-28
申请人： Alexander R. Neurath , Stephen B. H. Kent
发明人： Alexander R. Neurath , Stephen B. H. Kent
IPC分类号： C12P21/00 , A61K9/127 , A61K39/00 , A61K39/29 , A61K47/48 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/705 , C07K16/08 , C12Q1/16 , G01N33/53 , G01N33/576
CPC分类号： C07K14/005 , A61K47/48176 , A61K47/48315 , A61K47/48815 , A61K9/1271 , C07K16/082 , G01N33/5761 , A61K39/00 , C12N2730/10122 , Y10S930/223
摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
摘要翻译：一种乙型肝炎疫苗，其含有乙型肝炎病毒包膜前S基因编码区内具有至少六个连续氨基酸的氨基酸链的肽。该疫苗不含对应于乙型肝炎病毒的天然存在的包膜蛋白的氨基酸序列和生理上可接受的稀释剂。肽与载体无关或连接。载体是常规载体或包含通过交联稳定并在其外表面上具有共价键合的活性位点的脂质囊泡的新型载体。这种新型载体不仅可用于将含有氨基酸链的新肽与乙型肝炎病毒表面抗原前S基因编码区内的氨基酸连接，还可用于结合其他病毒的合成肽类似物蛋白质，以及人和动物的细菌，变应原和寄生蛋白。本发明的肽可用于诊断抗原和抗体的检测。

6. 发明授权

US4847080A Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers 失效
标题翻译：前S基因编码肽乙型肝炎免疫原，疫苗，诊断和合成脂质囊泡载体
公开(公告)号：US4847080A
公开(公告)日：1989-07-11
申请号：US698499
申请日：1985-02-05
申请人： Alexander R. Neurath , Stephen B. H. Kent
发明人： Alexander R. Neurath , Stephen B. H. Kent
IPC分类号： G01N33/576 , A61K9/127 , A61K39/00 , A61K39/29 , A61K39/385 , A61K47/48 , C07K7/04 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/435 , C07K16/08 , C07K19/00 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/08 , G01N33/543 , G01N33/577
CPC分类号： C07K14/005 , A61K47/48176 , A61K47/48315 , A61K47/48815 , A61K9/1271 , C07K16/082 , G01N33/5764 , A61K39/00 , C12N2730/10122 , Y10S930/221 , Y10S930/222 , Y10S930/223 , Y10S930/26 , Y10S930/27
摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.V

7. 发明授权

US5565548A Pre-S gene coded peptide hepatitis B immunogens and synthetic lipid vesicle carriers 失效
标题翻译：前S基因编码肽乙型肝炎免疫原和合成脂质囊泡载体
公开(公告)号：US5565548A
公开(公告)日：1996-10-15
申请号：US31735
申请日：1993-03-15
申请人： Alexander R. Neurath , Stephen B. H. Kent
发明人： Alexander R. Neurath , Stephen B. H. Kent
IPC分类号： A61K9/127 , A61K39/00 , A61K47/48 , C07K14/02 , C07K16/08 , G01N33/576 , A61K38/00 , A61K45/00 , C17K5/00
CPC分类号： C07K14/005 , A61K47/48176 , A61K47/48315 , A61K47/48815 , A61K47/48876 , A61K9/1271 , C07K16/082 , G01N33/5764 , A61K39/00 , C12N2730/10122 , Y10S530/81
摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
摘要翻译：一种乙型肝炎疫苗，其含有乙型肝炎病毒包膜前S基因编码区内具有至少六个连续氨基酸的氨基酸链的肽。该疫苗不含对应于乙型肝炎病毒的天然存在的包膜蛋白的氨基酸序列和生理上可接受的稀释剂。肽与载体无关或连接。载体是常规载体或包含通过交联稳定并在其外表面上具有共价键合的活性位点的脂质囊泡的新型载体。这种新型载体不仅可用于将含有氨基酸链的新肽与乙型肝炎病毒表面抗原前S基因编码区内的氨基酸连接，还可用于结合其他病毒的合成肽类似物蛋白质，以及人和动物的细菌，变应原和寄生蛋白。本发明的肽可用于诊断抗原和抗体的检测。

8. 发明授权

US5158769A Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers 失效
标题翻译：前S基因编码肽乙型肝炎免疫原，疫苗，诊断和合成脂质囊泡载体
公开(公告)号：US5158769A
公开(公告)日：1992-10-27
申请号：US337784
申请日：1989-04-13
申请人： Alexander R. Neurath , Stephen B. H. Kent
发明人： Alexander R. Neurath , Stephen B. H. Kent
IPC分类号： A61K9/127 , A61K39/00 , A61K47/48 , C07K14/02 , C07K16/08 , G01N33/576
CPC分类号： C07K14/005 , A61K47/48176 , A61K47/48315 , A61K47/48815 , A61K9/1271 , B82Y5/00 , C07K16/082 , G01N33/5761 , G01N33/5764 , A61K39/00 , C12N2730/10122
摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.
摘要翻译：一种乙型肝炎疫苗，其含有乙型肝炎病毒包膜前S基因编码区内具有至少六个连续氨基酸的氨基酸链的肽。该疫苗不含对应于乙型肝炎病毒的天然存在的包膜蛋白的氨基酸序列和生理上可接受的稀释剂。肽与载体无关或连接。载体是常规载体或包含通过交联稳定并在其外表面上具有共价键合的活性位点的脂质囊泡的新型载体。这种新型载体不仅可用于将含有氨基酸链的新肽与乙型肝炎病毒表面抗原前S基因编码区内的氨基酸连接，还可用于结合其他病毒的合成肽类似物蛋白质，以及人和动物的细菌，变应原和寄生蛋白。本发明的肽可用于诊断抗原和抗体的检测。

9. 发明授权

US4820805A Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives 失效
标题翻译：未变质的无病毒三烷基磷酸盐处理的生物活性蛋白衍生物
公开(公告)号：US4820805A
公开(公告)日：1989-04-11
申请号：US726200
申请日：1985-04-22
申请人： Alexander R. Neurath , Bernard Horowitz
发明人： Alexander R. Neurath , Bernard Horowitz
IPC分类号： A61L2/00 , C07K15/00 , A61K37/02
CPC分类号： A61L2/0023 , A61L2/0088 , Y10S530/808 , Y10S530/829
摘要： A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.
摘要翻译：含有哺乳动物血液蛋白的组合物，例如全血，血浆，血清，血浆浓缩物，冷沉淀物，冷冻上清液，血浆分离沉淀物或基本上不含肝炎和其他脂质包被的病毒的血浆分离上清液，其总蛋白质的蛋白质活性的产量在至少有80％被披露。将含蛋白质的组合物与磷酸二烷基酯或磷酸三烷基酯，优选磷酸三烷基酯和洗涤剂的混合物接触，通常除去磷酸二烷基酯或三烷基磷酸酯。

10. 发明授权

US5230998A Method for the prescreening of drugs targeted to the V3 hypervariable loop of the HIV-1 envelope glycoprotein gp 120 失效
标题翻译：用于预先筛选针对HIV-1包膜糖蛋白gp120的V3高变环的药物的方法
公开(公告)号：US5230998A
公开(公告)日：1993-07-27
申请号：US735640
申请日：1991-07-25
申请人： Alexander R. Neurath , Nathan Strick , Paul Haberfield , Shibo Jiang
发明人： Alexander R. Neurath , Nathan Strick , Paul Haberfield , Shibo Jiang
IPC分类号： G01N33/50 , G01N33/569
CPC分类号： G01N33/56988 , G01N33/5008 , Y10S435/974
摘要： A method for the rapid screening of a drug targeted to the V3 hypervariable loop of the human immunodeficiency virus type 1 or type 2 envelope glycoprotein gp 120 comprising measuring the inhibitory effect of the drug on the interaction between gp 120 (or an antigen comprising the V3 hypervariable loop of HIV 1 gp 120 or HIV 2 gp 120) and antibodies specific for the V3 hypervariable loop, and anti-HIV chemotherapy with drugs binding to the V3 hypervariable loop.
摘要翻译：一种用于快速筛选靶向人类免疫缺陷病毒1型或2型包膜糖蛋白gp120的V3高变环的药物的方法，包括测量药物对gp120（或包含V3的抗原之间的相互作用）的抑制作用 HIV 1 gp 120或HIV 2 gp 120的高变环）和V3高变环特异性抗体，以及与V3高变环结合的药物的抗HIV化疗。

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