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1. 发明授权

US08094430B2 Capacitors, couplers, devices including same and methods of manufacturing same 失效
标题翻译：电容器，耦合器，包括相同的器件和制造方法
公开(公告)号：US08094430B2
公开(公告)日：2012-01-10
申请号：US11962957
申请日：2007-12-21
申请人： Harvey J. Horowitz , Bernard Horowitz
发明人： Harvey J. Horowitz , Bernard Horowitz
IPC分类号： H01G4/06
CPC分类号： H01G4/01 , H01G4/005 , H01G4/35 , H01P5/187 , Y10T29/435
摘要： Capacitors are provided comprising a first plate, a second plate spaced from the first plate and a dielectric between the first and second plates. In certain embodiments the plates are arranged generally opposite each other and each is shaped in a periodically repeating pattern that is spatially out of phase with the other so that misregistration of the plates is compensated. In certain embodiments, a floating equipotential conductor is positioned between the plates and has a larger dimension than a corresponding dimension of the plates so that misregistration of the plates is compensated. Methods of manufacturing the capacitors are also provided.
摘要翻译：提供电容器，其包括第一板，与第一板间隔开的第二板和在第一板和第二板之间的电介质。在某些实施例中，板大致相互相对布置，并且每个板以周向重复的图案成形，其中空间上与另一个不同相，从而补偿板的不对准。在某些实施例中，浮动等电位导体位于板之间并且具有比板的对应尺寸更大的尺寸，从而补偿板的不对准。还提供了制造电容器的方法。

2. 发明申请

US20090121800A1 Apparatus for Low Phase Noise Oscillators 审中-公开
标题翻译：低相位噪声振荡器装置
公开(公告)号：US20090121800A1
公开(公告)日：2009-05-14
申请号：US11792733
申请日：2004-12-15
申请人： Harvey Horowitz , Bernard Horowitz
发明人： Harvey Horowitz , Bernard Horowitz
IPC分类号： H03B7/00
CPC分类号： H03B5/18 , H03B2200/0088
摘要： The present invention relates to an oscillator circuit. In the oscillator circuit, the level of the output signal is monitored and compared to a desired reference level. An error signal is then generated and used to modify the feedback so that the negative resistance of the active device presented to the resonator exactly equals the magnitude of the positive resistance of the resonator without having to rely upon saturation in the active device and for very linear operation of the device such that over the full swing of the output, the negative impedance presented to the resonator remain extremely constant—thus reducing the sensitivity of the oscillator to any noise present.
摘要翻译：本发明涉及振荡器电路。在振荡器电路中，监测输出信号的电平并将其与期望的参考电平进行比较。然后产生误差信号并用于修改反馈，使得提供给谐振器的有源器件的负电阻正好等于谐振器的正电阻的幅度，而不必依赖于有源器件中的饱和度，并且对于非常线性该器件的操作使得在输出的全部摆幅下，呈现给谐振器的负阻抗保持非常恒定，从而降低振荡器对存在的任何噪声的灵敏度。

3. 发明授权

US5858643A Red blood cell composition containing vitamin E or derivatives thereof which exhibits reduced potassium ion leakage after a photoinactivation process 失效
标题翻译：含有维生素E或其衍生物的红细胞组合物，其在光激活过程后显示出减少的钾离子渗漏
公开(公告)号：US5858643A
公开(公告)日：1999-01-12
申请号：US854878
申请日：1997-05-12
申请人： Ehud Ben-Hur , Shanti Rywkin , Bernard Horowitz
发明人： Ehud Ben-Hur , Shanti Rywkin , Bernard Horowitz
IPC分类号： A61K31/35 , A61K31/352 , A61K31/355 , A61K31/40 , A61K35/14 , A61K35/18 , A61K41/00 , A61L2/00 , A61P7/02 , A61P7/06 , A61P31/04 , C07D311/72 , C07D487/22 , C12N7/04 , C12N7/06 , C12N13/00 , A01N1/02
CPC分类号： A61L2/0047 , A61K31/355 , A61K35/18 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0042 , A61K41/0071 , A61L2/0011 , A61L2/0035 , A61L2/0052 , A61L2/0076 , C12N13/00 , C12N7/00 , A61L2202/22 , C12N2760/20261 , C12N2760/20263
摘要： A red blood cell containing composition is presented which has reduced potassium ion leakage after irradiation in a virus photoinactivation process. The irradiated red blood cell containing composition comprises red blood cells, a photosensitizer, and sufficient vitamin E or derivatives thereof to prevent potassium leakage. Preferred photosensitizers are aluminum phthalocyanines, AlPcS.sub.4 or Pc5. A preferred vitamin E derivative is Trolox.
摘要翻译：提出了含有红细胞的组合物，其在病毒光激活过程中照射后降低了钾离子渗漏。所照射的含有红细胞的组合物包含红细胞，光敏剂和足够的维生素E或其衍生物以防止钾泄漏。优选的光敏剂是铝酞菁铝，AlPcS4或Pc5。优选的维生素E衍生物是Trolox。

4. 发明授权

US5789150A Process for the sterilization of biological compositions using UVA1 irradiation 失效
标题翻译：使用UVA1照射灭菌生物组合物的方法
公开(公告)号：US5789150A
公开(公告)日：1998-08-04
申请号：US725594
申请日：1996-10-03
申请人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
发明人： Henrietta Margolis-Nunno , Ehud Ben-Hur , Bernard Horowitz
IPC分类号： A61K41/00 , A61L2/00 , C12N7/06 , A01N1/02 , A01N63/00 , C12N13/00 , C12N7/04
CPC分类号： A61K41/0019 , A61K41/0066 , A61L2/0011 , C12N7/00 , C12N2760/20263
摘要： An improvement in a process for inactivating extracellular and intracellular viruses in a platelet containing composition is presented. The improvement in the process comprises adding a sensitizer to the platelet containing composition and irradiating the composition containing the sensitizer with UVA1 in the absence of UVA2 for a period of time sufficient to inactivate the viruses while retaining the functionality of the platelet containing composition. A quencher or mixture of quenchers of type I and type II photodynamic reactions may be advantageously added to the composition prior to irradiation.
摘要翻译：提出了在含血小板组合物中灭活细胞外和细胞内病毒的方法的改进。该方法的改进包括在含有血小板的组合物中加入增敏剂并在不存在UVA2的情况下用含有该激素的组合物UVA1照射足以灭活病毒的时间，同时保留含血小板的组合物的功能。 I型和II型光动力学反应的淬灭剂或猝灭剂的混合物可以在照射之前有利地加入到组合物中。

5. 发明授权

US5541294A Removal of antibodies from blood-derived compositions while retaining coagulation factors 失效
标题翻译：从血液衍生的组合物中除去抗体，同时保留凝血因子
公开(公告)号：US5541294A
公开(公告)日：1996-07-30
申请号：US419836
申请日：1995-04-11
申请人： Bernard Horowitz , Sing N. Chin
发明人： Bernard Horowitz , Sing N. Chin
IPC分类号： A61K35/16 , A61K38/16 , A61K38/43 , C12S3/22 , G01N33/86 , C07K1/00 , B01D61/00
CPC分类号： A61K35/16 , G01N33/86
摘要： This invention relates to methods of removing undesired antibodies from blood-derived compositions containing both the antibodies and coagulation factors, such that the coagulation factors are substantially retained in the composition. The undesired antibodies may be blood group antibodies. This invention also relates to compositions in which undesired antibodies have been removed and desired coagulation factors are retained. This invention further relates to methods of inactivating virus and removing undesired antibodies from blood-derived compositions containing virus, antibodies and coagulation factors without removing coagulation factors therefrom, and to the resulting compositions.
摘要翻译：本发明涉及从含有抗体和凝血因子的血液衍生组合物中除去不期望的抗体的方法，使得凝血因子基本上保留在组合物中。不需要的抗体可以是血型抗体。本发明还涉及其中除去不期望的抗体并保留所需凝血因子的组合物。本发明还涉及灭活病毒和从含有病毒，抗体和凝血因子的血液衍生组合物中除去不需要的抗体而不从其中除去凝血因子的方法以及所得组合物。

6. 发明授权

US5120649A Photodynamic inactivation of viruses in blood cell-containing compositions 失效
标题翻译：含有血细胞的组合物的病毒的光动力灭活
公开(公告)号：US5120649A
公开(公告)日：1992-06-09
申请号：US524208
申请日：1990-05-15
申请人： Bernard Horowitz , Jay E. Valinsky , Nicholas E. Geacintov , Bolanle Williams , Shanti B. Rywkin
发明人： Bernard Horowitz , Jay E. Valinsky , Nicholas E. Geacintov , Bolanle Williams , Shanti B. Rywkin
IPC分类号： A61K31/35 , A61K31/555 , A61K35/14 , A61K41/00 , A61L2/00 , C12N7/04 , C12N7/06
CPC分类号： A61L2/0052 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0071 , A61L2/0011 , C12N7/00 , A61L2202/22 , C12N2760/20263
摘要： The present invention concerns a method of inactivating extracelluar lipid enveloped human pathogenic virus or intracelular human pathogenic virus in a blood cell-containing composition without incurring substantial disruption or inactivation of cells, comprising contacting a cell-containing composition having .gtoreq.1.times.10.sup.9 cells/ml and containing infectious virus with a virucidally effective amount of at least one photoreactive compound having an absorption maximum of .gtoreq.630 nm, light and an oxidizer to substantially inactivate the virus to effect a virus kill of at least 10.sup.4 and to result in a retention of intact cell functionality and structure of greater than 80%. The present invention also is directed to a composition comprising human red blood cells suitable for transfusion at a concentration of .gtoreq.1.times.10.sup.9 cells/ml and having all extracellular lipid enveloped and intracellular human pathogenic viruses in a non-infectious form.

7. 发明授权

US4841023A Inactivation of viruses in labile protein-containing compositions using fatty acids 失效
标题翻译：使用脂肪酸灭活含有不稳定蛋白质的组合物中的病毒
公开(公告)号：US4841023A
公开(公告)日：1989-06-20
申请号：US878446
申请日：1986-06-25
申请人： Bernard Horowitz
发明人： Bernard Horowitz
IPC分类号： A61L2/00
CPC分类号： A61L2/0088 , Y10S530/808 , Y10S530/809
摘要： There is disclosed a process for rendering a labile protein-containing composition, substantially free of lipid-containing viruses without incurring substantial protein denaturation comprising contacting said composition with an effective amount of a fatty acid or a soluble ester, alcohol or a salt thereof for a sufficient period of time to inactivate virus contained therein.
摘要翻译：公开了一种使不稳定的含蛋白质的组合物基本上不含含脂质的病毒而不引起显着的蛋白质变性的方法，包括使所述组合物与有效量的脂肪酸或其可溶性酯，醇或其盐接触，用于足够的时间来灭活其中所含的病毒。

8. 发明授权

US4820805A Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives 失效
标题翻译：未变质的无病毒三烷基磷酸盐处理的生物活性蛋白衍生物
公开(公告)号：US4820805A
公开(公告)日：1989-04-11
申请号：US726200
申请日：1985-04-22
申请人： Alexander R. Neurath , Bernard Horowitz
发明人： Alexander R. Neurath , Bernard Horowitz
IPC分类号： A61L2/00 , C07K15/00 , A61K37/02
CPC分类号： A61L2/0023 , A61L2/0088 , Y10S530/808 , Y10S530/829
摘要： A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.
摘要翻译：含有哺乳动物血液蛋白的组合物，例如全血，血浆，血清，血浆浓缩物，冷沉淀物，冷冻上清液，血浆分离沉淀物或基本上不含肝炎和其他脂质包被的病毒的血浆分离上清液，其总蛋白质的蛋白质活性的产量在至少有80％被披露。将含蛋白质的组合物与磷酸二烷基酯或磷酸三烷基酯，优选磷酸三烷基酯和洗涤剂的混合物接触，通常除去磷酸二烷基酯或三烷基磷酸酯。

9. 发明申请

US20080273288A1 CAPACITORS, COUPLERS, DEVICES INCLUDING SAME AND METHODS OF MANUFACTURING SAME 失效
标题翻译：电容器，耦合器，包括它们的器件及其制造方法
公开(公告)号：US20080273288A1
公开(公告)日：2008-11-06
申请号：US11962957
申请日：2007-12-21
申请人： Harvey J. Horowitz , Bernard Horowitz
发明人： Harvey J. Horowitz , Bernard Horowitz
IPC分类号： H01G4/005
CPC分类号： H01G4/01 , H01G4/005 , H01G4/35 , H01P5/187 , Y10T29/435
摘要： Capacitors are provided comprising a first plate, a second plate spaced from the first plate and a dielectric between the first and second plates. In certain embodiments the plates are arranged generally opposite each other and each is shaped in a periodically repeating pattern that is spatially out of phase with the other so that misregistration of the plates is compensated. In certain embodiments, a floating equipotential conductor is positioned between the plates and has a larger dimension than a corresponding dimension of the plates so that misregistration of the plates is compensated. Methods of manufacturing the capacitors are also provided.
摘要翻译：提供电容器，其包括第一板，与第一板间隔开的第二板和在第一板和第二板之间的电介质。在某些实施例中，板大致相互相对布置，并且每个板以周向重复的图案成形，其中空间上与另一个不同相，从而补偿板的不对准。在某些实施例中，浮动等电位导体位于板之间并且具有比板的对应尺寸更大的尺寸，从而补偿板的不对准。还提供了制造电容器的方法。

10. 发明授权

US06294361B1 Processes for photoreactive inactivation of a virus in blood cell or coagulation factor containing compositions and use thereof for preparing compositions useful for transfusion 失效
标题翻译：用于血液细胞中的病毒的光反应灭活或含凝血因子的组合物的方法及其用于制备用于输血的组合物的用途
公开(公告)号：US06294361B1
公开(公告)日：2001-09-25
申请号：US08958768
申请日：1997-10-26
申请人： Bernard Horowitz , Jay E. Valinsky , Nicholas E. Geacintov , Bolanle Williams , Shanti B. Rywkin , Henrietta Nunno
发明人： Bernard Horowitz , Jay E. Valinsky , Nicholas E. Geacintov , Bolanle Williams , Shanti B. Rywkin , Henrietta Nunno
IPC分类号： C12N1300
CPC分类号： C12N7/00 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61L2/0011 , C12N2740/16063 , C12N2760/20263
摘要： The present invention concerns a process for inactivating an extracellular lipid enveloped human pathogenic virus and/or an intracellular human pathogenic virus which may be present in a blood cell composition containing ≧1×109 cells/ml by contacting that composition with a virucidally effective amount of at least one photoreactive compound having an absorption maximum of ≧630 nm, light and oxygen and/or a quencher. In one embodiment of the invention, the process is conducted under conditions whereby a structural integrity of greater than 80% of at least one type of blood cell contained within said composition is retained. Another embodiment of the invention relates to a process for inactivating an extracellular lipid enveloped human pathogenic virus and/or an intracellular human pathogenic virus which may be present in a composition containing at least one coagulation factor while retaining at least 77% of said coagulation factor by contacting said composition with a virucidally effective amount of at least one photoreactive compound, light and a quencher. The processes of the invention can be used to prepare blood products, which, in turn, are suitable for transfusion into a recipient in need of such transfusion.
摘要翻译：本发明涉及一种灭活细胞外脂质包膜的人类病原体病毒和/或细胞内人类病原体病毒的方法，该方法可以存在于含有≥1×10 9个细胞/ ml的血液细胞组合物中，通过使该组合物与病毒有效量的至少一种光吸收最大值> 630nm的光反应性化合物，光和氧和/或猝灭剂。在本发明的一个实施方案中，该方法在保持所述组合物中所含的至少一种类型的血细胞的大于80％的结构完整性的条件下进行。本发明的另一个实施方案涉及用于灭活细胞外脂质包膜的人类病原体病毒和/或细胞内人致病性病毒的方法，所述细胞外脂质包封的人类病原体病毒和/或细胞内人致病性病毒可存在于含有至少一种凝血因子的组合物中，同时将至少77％的所述凝血因子保留使所述组合物与杀病毒有效量的至少一种光反应性化合物，光和猝灭剂接触。本发明的方法可以用于制备血液制品，血液制品又适合于输血到需要这种输血的接受者中。

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