专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006130160A2 FURANOPYRIDINE DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：呋喃并吡啶衍生物及其使用方法
公开(公告)号：WO2006130160A2
公开(公告)日：2006-12-07
申请号：PCT/US2005/025725
申请日：2005-07-19
申请人： AMGEN INC. , NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
发明人： NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention relates to furanopyridine compounds having the general Formula I (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.
摘要翻译：本发明涉及具有通式I（I）的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂合物，药学上可接受的盐和衍生物及其前药。本发明还包括药物组合物，其包含式I化合物，调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症，包括炎症，T细胞活化抑制，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘，干草组织，湿疹，癌症，结肠癌，胸腺瘤，仅举几个例子，在哺乳动物中，包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法：一级方程式

2. 发明申请

WO2009085185A1 FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS 审中-公开
标题翻译：熔融吡啶，吡嗪和三嗪化合物作为细胞周期抑制剂
公开(公告)号：WO2009085185A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/013849
申请日：2008-12-18
申请人： AMGEN INC. , CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong , MCMINN, Dustin , MIHALIC, Jeffrey , DEIGNAN, Jeffrey
发明人： CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong , MCMINN, Dustin , MIHALIC, Jeffrey , DEIGNAN, Jeffrey
IPC分类号： C07D417/14 , C07D487/04 , C07D487/14 , C07D498/10 , C07D513/14 , A61P35/00 , A61K31/519
CPC分类号： C07D471/14 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/147 , C07D498/04 , C07D498/10 , C07D513/14
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
摘要翻译：提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。本发明化合物是吡啶，吡嗪酰亚胺和三嗪衍生物。

3. 发明申请

WO2013049250A1 HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：作为MDM2抑制剂治疗癌症的杂环化合物
公开(公告)号：WO2013049250A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057389
申请日：2012-09-26
申请人： AMGEN INC. , BARTBERGER, Michael D. , BECK, Hilary Plake , CHEN, Xiaoqi , CONNORS, Richard V. , DEIGNAN, Jeffrey , DUQUETTE, Jason A. , EKSTEROWICZ, John , FOX, Brian M. , FU, Jiasheng , GONZALEZ BUENROSTRO, Ana , GONZALEZ LOPEZ DE TURISO, Felix , GUSTIN, Darin J. , HEATH, Julie A. , JOHNSON, Michael G. , KAYSER, Frank , KOPECKY, David J. , LI, Yihong , LI, Zhihong , MA, Zhihua , MCINTOSH, Joel , MEDINA, Julio C. , MIHALIC, Jeffrey T. , OLSON, Steven H. , REW, Yosup , ROVETO, Philip M. , SCHMITT, Michael J. , SUN, Daqing , WANG, Xiaodong , WANSKA, Malgorzata , WEATHERS, Christine , YAN, Xuelei
发明人： BARTBERGER, Michael D. , BECK, Hilary Plake , CHEN, Xiaoqi , CONNORS, Richard V. , DEIGNAN, Jeffrey , DUQUETTE, Jason A. , EKSTEROWICZ, John , FOX, Brian M. , FU, Jiasheng , GONZALEZ BUENROSTRO, Ana , GONZALEZ LOPEZ DE TURISO, Felix , GUSTIN, Darin J. , HEATH, Julie A. , JOHNSON, Michael G. , KAYSER, Frank , KOPECKY, David J. , LI, Yihong , LI, Zhihong , MA, Zhihua , MCINTOSH, Joel , MEDINA, Julio C. , MIHALIC, Jeffrey T. , OLSON, Steven H. , REW, Yosup , ROVETO, Philip M. , SCHMITT, Michael J. , SUN, Daqing , WANG, Xiaodong , WANSKA, Malgorzata , WEATHERS, Christine , YAN, Xuelei
IPC分类号： C07D265/06 , C07D413/04 , C07D413/10 , C07D417/04 , C07D413/12
CPC分类号： C07D413/04 , C07D265/06 , C07D265/32 , C07D413/10 , C07D413/12 , C07D417/04
摘要： The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
摘要翻译：本发明提供式I或II的MDM2抑制剂化合物或其药学上可接受的盐，其中变量如上所定义，哪些化合物可用作治疗剂，特别是用于治疗癌症。本发明还涉及含有MDM2抑制剂的药物组合物。

4. 发明申请

WO2009126584A1 GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS 审中-公开
标题翻译：作为细胞周期抑制剂的GEM-分离的和螺旋的氨基吡啶/吡啶
公开(公告)号：WO2009126584A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/039678
申请日：2009-04-06
申请人： AMGEN INC. , CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong
发明人： CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong
IPC分类号： A61K31/517 , A61K31/519 , A61K31/527 , C07D239/70 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/052 , C07D491/20 , C07D491/22 , C07D491/107 , C07D491/147 , A61P35/00
CPC分类号： C07D471/04 , C07D239/70 , C07D401/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
摘要翻译：提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。主题化合物是偕二取代或螺环吡啶，嘧啶和三嗪衍生物。

6. 发明申请

WO2007024680A1 PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS 审中-公开
标题翻译：用作激酶酶调节剂的吡唑并吡啶和吡唑并嘧啶化合物有用
公开(公告)号：WO2007024680A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/032314
申请日：2006-08-18
申请人： AMGEN INC. , BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
发明人： BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
IPC分类号： C07D487/04 , C07D231/56 , C07D403/06 , C07D405/06 , C07D401/14 , A61K31/519 , A61K31/416 , A61P19/00 , A61P17/00 , A61P35/00
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula (I) or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式（I）的化合物或立体异构体，互变异构体，溶剂化物，药学上可接受的盐或其前药，含有该化合物的药物制剂，使用该化合物的治疗方法，例如蛋白酪氨酸激酶 - 相关疾病如免疫学和肿瘤学疾病以及制备包含该化合物的药物的方法。

7. 发明公开

EP2278973A1 GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS 有权
标题翻译：创业板和二取代螺环氨基吡啶/嘧啶类ALS细胞周期抑制剂
公开(公告)号：EP2278973A1
公开(公告)日：2011-02-02
申请号：EP09730921.5
申请日：2009-04-06
申请人： Amgen Inc.
发明人： CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong
IPC分类号： A61K31/517 , A61K31/519 , A61K31/527 , C07D239/70 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/052 , C07D491/20 , C07D491/22 , C07D491/107 , C07D491/147 , A61P35/00
CPC分类号： C07D471/04 , C07D239/70 , C07D401/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.

8. 发明公开

EP2231656A1 FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS 审中-公开
标题翻译： CONDENSED吡啶，嘧啶化合物和三嗪化合物THAN细胞周期抑制剂
公开(公告)号：EP2231656A1
公开(公告)日：2010-09-29
申请号：EP08867586.3
申请日：2008-12-18
申请人： Amgen Inc.
发明人： CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong , MCMINN, Dustin , MIHALIC, Jeffrey , DEIGNAN, Jeffrey
IPC分类号： C07D417/14 , C07D487/04 , C07D487/14 , C07D498/10 , C07D513/14 , A61P35/00 , A61K31/519
CPC分类号： C07D471/14 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/147 , C07D498/04 , C07D498/10 , C07D513/14
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

9. 发明公开

EP1926734A1 PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS 审中-公开
标题翻译：吡唑并吡啶和吡唑并嘧啶类化合物作为激酶调节剂
公开(公告)号：EP1926734A1
公开(公告)日：2008-06-04
申请号：EP06789860.1
申请日：2006-08-18
申请人： Amgen Inc.
发明人： BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
IPC分类号： C07D487/04 , C07D231/56 , C07D403/06 , C07D405/06 , C07D401/14 , A61K31/519 , A61K31/416 , A61P19/00 , A61P17/00 , A61P35/00
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula (I) or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式（I）化合物或其立体异构体，互变异构体，溶剂化物，药学上可接受的盐或前药，含有该化合物的药物制剂，使用该化合物的治疗方法，例如蛋白酪氨酸激酶相关疾病如免疫和肿瘤疾病以及制备包含该化合物的药物的方法。

10. 发明公开

EP1791845A2 FURANOPYRIDINE DERIVATIVES AS ACK1 AND LCK MODULATORS 审中-公开
标题翻译：呋喃基吡啶衍生物作为ACK1和LCK调节剂
公开(公告)号：EP1791845A2
公开(公告)日：2007-06-06
申请号：EP05857894.9
申请日：2005-07-19
申请人： AMGEN INC.
发明人： NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
IPC分类号： C07D491/04
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention relates to furanopyridine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula (I).
摘要翻译：本发明涉及具有通式（I）的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂化物，药学上可接受的盐和衍生物以及前药。本发明还包括含有式I化合物的药物组合物，调节Lck和ACK-1酶以及治疗各种相关疾病和病症（包括炎症，抑制T细胞活化，增殖，关节炎，器官移植，局部缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩氏病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲亢，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘包括向哺乳动物施用治疗有效量的如上所述的式I化合物的药物组合物，以及制备包含式I化合物的药物的方法，所述药物包含公式（I）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式