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    • 1. 发明申请
    • FURANOPYRIDINE DERIVATIVES AND METHODS OF USE
    • 呋喃并吡啶衍生物及其使用方法
    • WO2006130160A2
    • 2006-12-07
    • PCT/US2005/025725
    • 2005-07-19
    • AMGEN INC.NUNES, Joseph, J.MARTIN, Matthew, W.WHITE, RyanMCGOWAN, DavidBEMIS, Jean, E.KAYSER, FrankFU, JiashengLIU, JinqianJIAO, XianYun
    • NUNES, Joseph, J.MARTIN, Matthew, W.WHITE, RyanMCGOWAN, DavidBEMIS, Jean, E.KAYSER, FrankFU, JiashengLIU, JinqianJIAO, XianYun
    • C07D491/04C07D491/14
    • The present invention relates to furanopyridine compounds having the general Formula I (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.
    • 本发明涉及具有通式I(I)的呋喃并吡啶化合物及其立体异构体,互变异构体,溶剂合物,药学上可接受的盐和衍生物及其前药。 本发明还包括药物组合物,其包含式I化合物,调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症,包括炎症,T细胞活化抑制,增殖,关节炎,器官移植,缺血或再灌注 损伤,心肌梗塞,中风,多发性硬化,炎性肠病,克罗恩病,狼疮,超敏反应,1型糖尿病,牛皮癣,皮炎,桥本氏甲状腺炎,干燥综合征,自身免疫性甲状腺功能亢进,艾迪生病,自身免疫性疾病,肾小球肾炎,过敏性疾病,哮喘 ,干草组织,湿疹,癌症,结肠癌,胸腺瘤,仅举几个例子,在哺乳动物中,包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法: 一级方程式
    • 10. 发明公开
    • FURANOPYRIDINE DERIVATIVES AS ACK1 AND LCK MODULATORS
    • 呋喃基吡啶衍生物作为ACK1和LCK调节剂
    • EP1791845A2
    • 2007-06-06
    • EP05857894.9
    • 2005-07-19
    • AMGEN INC.
    • NUNES, Joseph, J.MARTIN, Matthew, W.WHITE, RyanMCGOWAN, DavidBEMIS, Jean, E.KAYSER, FrankFU, JiashengLIU, JinqianJIAO, XianYun
    • C07D491/04
    • C07D491/04C07D491/14
    • The present invention relates to furanopyridine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula (I).
    • 本发明涉及具有通式(I)的呋喃并吡啶化合物及其立体异构体,互变异构体,溶剂化物,药学上可接受的盐和衍生物以及前药。 本发明还包括含有式I化合物的药物组合物,调节Lck和ACK-1酶以及治疗各种相关疾病和病症(包括炎症,抑制T细胞活化,增殖,关节炎,器官移植,局部缺血或再灌注 损伤,心肌梗塞,中风,多发性硬化,炎性肠病,克罗恩氏病,狼疮,超敏反应,1型糖尿病,牛皮癣,皮炎,桥本氏甲状腺炎,干燥综合征,自身免疫性甲亢,艾迪生病,自身免疫性疾病,肾小球肾炎,过敏性疾病,哮喘 包括向哺乳动物施用治疗有效量的如上所述的式I化合物的药物组合物,以及制备包含式I化合物的药物的方法,所述药物包含 公式(I)。