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1. 发明专利

AU2022202916A1 Polycyclic amines as opioid receptor modulators 未知
公开(公告)号：AU2022202916A1
公开(公告)日：2022-05-26
申请号：AU2022202916
申请日：2022-05-02
申请人： WANG XIAODONG
发明人： WANG XIAODONG , ZHONG HUA
IPC分类号： C07D207/00 , A61K31/4025 , A61K31/4427
摘要： The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

2. 发明专利

CA3055215A1 POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS 未知
公开(公告)号：CA3055215A1
公开(公告)日：2018-09-20
申请号：CA3055215
申请日：2018-03-12
申请人： WANG XIAODONG
发明人： WANG XIAODONG , ZHONG HUA
IPC分类号： A61K31/4427 , A61K31/4025 , C07D207/00
摘要： The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

3. 发明公开

EP3595661A1 POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS 审中-公开
公开(公告)号：EP3595661A1
公开(公告)日：2020-01-22
申请号：EP18767997.2
申请日：2018-03-12
申请人： Wang, Xiaodong
发明人： WANG, Xiaodong , ZHONG, Hua
IPC分类号： A61K31/4427 , A61K31/4025 , C07D207/00

4. 发明专利

AU2018236130A1 Polycyclic amines as opioid receptor modulators 未知
公开(公告)号：AU2018236130A1
公开(公告)日：2019-09-19
申请号：AU2018236130
申请日：2018-03-12
申请人： WANG XIAODONG
发明人： ZHONG HUA , WANG XIAODONG
IPC分类号： C07D207/00 , A61K31/4025 , A61K31/4427
摘要： The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

5. 发明公开

EP3321371A1 NOVEL METHODS FOR RAPID DRUG SUSCEPTIBILITY TESTING AND DRUG SCREENS FOR GROWING AND NON-GROWING CELLS OF PROKARYOTIC AND EUKARYOTIC ORIGIN 审中-公开
标题翻译：用于快速药物敏感性试验和药物屏障的新方法用于生长和非生长的原核和真核生成细胞
公开(公告)号：EP3321371A1
公开(公告)日：2018-05-16
申请号：EP17159022.7
申请日：2017-03-02
申请人： Zhang, Ying , Feng, Jie , Yee, Rebecca , Zhang, Shuo , Zhang, Wenhong , Wang, Xiaodong
发明人： ZHANG, Ying , FENG, Jie , YEE, Rebecca , ZHANG, Wenhong , ZHANG, Shuo
IPC分类号： C12Q1/18 , G01N33/50
CPC分类号： G01N33/5014 , C12Q1/18 , Y02A50/57
摘要： The presently disclosed subject matter provides methods, compositions, and kits for extremely rapid assessment of drug susceptibility of growing as well as non-growing cells of prokaryotic and also eukaryotic origins, without the need for organism growth, which is in contrast to the current growth-dependent methods.This growth-independent new methodology achieves extremely rapid drug susceptibility testing results previously not possible. Methods for rapidly identifying compounds with inhibitory activity against both growing and non-growing cells in real-time continuous manner with previously unachievable efficiency in drug screens using the novel methodology are also provided. Cell cultures are incubated with a drug or test agent and with a staining mixture containing a first fluorescent dye indicative the emission of which is indicative of live cells (e.g. SYBR Green I) and a second fluorescent dye indicative emitting a different color, the emission of which is indicative of dead cells (e.g. Propidium iodide). The ratio of the intensities of the emitted fluorescence of the dyes is indicative of the percentage live and dead cells in the culture.
摘要翻译：本发明公开的主题提供了方法，组合物和试剂盒，用于非常快速评估原核生物和真核生物起源的生长以及非生长细胞的药物敏感性，而不需要生物体生长，这与目前的生长相反这种独立于生长的新方法实现了以前不可能的极快的药物敏感性测试结果。还提供了用实时连续方式迅速鉴定具有抑制生长和非生长细胞的活性的化合物的方法，以及使用新方法在药物筛选中以前无法实现的效率。将细胞培养物与药物或测试试剂以及含有第一荧光染料和第二荧光染料的染色混合物孵育，所述第一荧光染料指示其发射指示活细胞（例如SYBR Green I），第二荧光染料指示发射不同颜色，这是死细胞的指示（例如碘化丙锭）。染料荧光发射强度的比例表明培养物中活细胞和死细胞的百分比。

6. 发明申请

WO2012106651A3 DATA EXCHANGE BETWEEN A WIRELESS SOURCE AND A SINK DEVICE FOR DISPLAYING IMAGES 审中-公开
标题翻译：无线源之间的数据交换和用于显示图像的SINK设备
公开(公告)号：WO2012106651A3
公开(公告)日：2012-11-08
申请号：PCT/US2012023851
申请日：2012-02-03
申请人： QUALCOMM INC , RAVEENDRAN VIJAYALAKSHMI R , WANG XIAODONG , SHAUKAT FAWAD , HUANG XIAOLONG
发明人： RAVEENDRAN VIJAYALAKSHMI R , WANG XIAODONG , SHAUKAT FAWAD , HUANG XIAOLONG
IPC分类号： G06F3/048 , G06F3/14
CPC分类号： G06F3/1407 , G09G2340/0407 , G09G2370/04 , G09G2370/16
摘要： In one example, this disclosure describes a method that includes, in an example determining, by a source device (120), that display data rendered by the source device comprises one or more displayable graphical objects. The method also includes in response to determining an event, selecting, by the source device, set of the one or more graphical objects for rendering at a sink device (160). The method also includes generating, by the source device, configuration data based at least in part on the set of the one or more graphical objects, wherein the configuration data is usable by the sink device to render representations o graphical objects in the set of one or more graphical objects based at least in part on one or more display parameters associated with the sink device. The method also includes sending, by the source device, the configuration data to the sink device.
摘要翻译：在一个示例中，本公开描述了在源设备（120）的示例确定中包括由源设备呈现的显示数据包括一个或多个可显示图形对象的方法。该方法还包括响应于确定事件，由源设备选择用于在宿设备处呈现的一个或多个图形对象的集合（160）。所述方法还包括至少部分地基于所述一个或多个图形对象的集合，由所述源设备生成配置数据，其中所述配置数据可由所述宿设备用于呈现所述一组中的图形对象的表示至少部分地基于与宿设备相关联的一个或多个显示参数。该方法还包括由源设备将配置数据发送到宿设备。

7. 发明申请

WO2012149576A1 SYSTEMS, METHODS, AND MEDIA FOR SELECTING ANTENNAS AND BEAMFORMERS 审中-公开
标题翻译：用于选择天线和波束形成器的系统，方法和媒体
公开(公告)号：WO2012149576A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035899
申请日：2012-04-30
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , WANG, Xiaodong
发明人： WANG, Xiaodong
IPC分类号： H04M1/00
CPC分类号： H04B7/0456 , H04B7/0413 , H04B7/061 , H04B7/0617 , H04B7/0634 , H04B7/0691 , H04B7/0848 , H04B7/0874
摘要： Systems that: (a) select a current antenna subset; (b) receive signals in response to a transmission of pi lot symbols using the current antenna subset: (c) determine a current objecti ve function for the current antenna subset; (d) replace an antenna in the current antenna subset with another antenna not. in the current antenna subset, to form a next antenna subset; (e) receive signals in response to a transmission of pilot symbols using the next antenna subset; (f) determines a next objective function for the current antenna subset; (g) determines whether the next objective function is better than the current objective function, and if so creates a corresponding next occupation probability vector entry; and (h) determines whether the value for the corresponding next occupation probability vector entry is larger than a value for an optimal occupation probability vector entry, and if so sets the second antenna subset as the optimal antenna subset.
摘要翻译：系统：（a）选择当前的天线子集; （b）响应于使用当前天线子集的pi批号的传输来接收信号：（c）确定当前天线子集的当前目标函数; （d）用另一个天线替换当前天线子集中的天线。在当前的天线子集中，形成下一个天线子集; （e）响应于使用下一个天线子集的导频符号的传输来接收信号; （f）确定当前天线子集的下一个目标函数; （g）确定下一个目标函数是否比当前目标函数更好，如果是，则创建相应的下一个占用概率向量入口; 和（h）确定对应的下一个占用概率向量项的值是否大于最佳占用概率向量入口的值，如果是，则将第二天线子集设置为最佳天线子集。

8. 发明申请

WO2012100204A1 USER INPUT BACK CHANNEL FOR WIRELESS DISPLAYS 审中-公开
标题翻译：用户输入无线显示的后置通道
公开(公告)号：WO2012100204A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/022090
申请日：2012-01-20
申请人： QUALCOMM INCORPORATED , HUANG, Xiaolong , RAVEENDRAN, Vijayalakshmi R. , WANG, Xiaodong , SHAUKAT, Fawad
发明人： HUANG, Xiaolong , RAVEENDRAN, Vijayalakshmi R. , WANG, Xiaodong , SHAUKAT, Fawad
IPC分类号： G06F3/00
CPC分类号： H04L65/4092 , G06F3/14 , G06F2203/04104 , G09G2370/10 , G09G2370/16
摘要： As part of a communication session, a wireless source device can transmit audio and video data to a wireless sink device, and the wireless sink device can transmit user input data received at the wireless sink device back to the wireless source device. In this manner, a user of the wireless sink device can control the wireless source device and control the content that is being transmitted from the wireless source device to the wireless sink device. The input data received at the wireless sink device can be a multi-touch gesture.
摘要翻译：作为通信会话的一部分，无线源设备可以将音频和视频数据传输到无线宿设备，并且无线宿设备可以将在无线宿设备处接收的用户输入数据发送回无线源设备。以这种方式，无线接收设备的用户可以控制无线源设备并且控制正在从无线源设备发送到无线接收设备的内容。在无线接收设备处接收的输入数据可以是多点触摸手势。

9. 发明申请

WO2012100201A1 USER INPUT BACK CHANNEL FOR WIRELESS DISPLAYS 审中-公开
标题翻译：用户输入无线显示的后置通道
公开(公告)号：WO2012100201A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/022087
申请日：2012-01-20
申请人： QUALCOMM INCORPORATED , HUANG, Xiaolong , RAVEENDRAN, Vijayalakshmi R. , WANG, Xiaodong , SHAUKAT, Fawad
发明人： HUANG, Xiaolong , RAVEENDRAN, Vijayalakshmi R. , WANG, Xiaodong , SHAUKAT, Fawad
IPC分类号： H04L29/06
CPC分类号： H04L65/608 , H04L69/22
摘要： As part of a communication session, a wireless source device can transmit audio and video data to a wireless sink device, and the wireless sink device can transmit user input data received at the wireless sink device back to the wireless source device. In this manner, a user of the wireless sink device can control the wireless source device and control the content that is being transmitted from the wireless source device to the wireless sink device. The input data received at the wireless sink device can be a voice command.
摘要翻译：作为通信会话的一部分，无线源设备可以将音频和视频数据传输到无线宿设备，并且无线宿设备可以将在无线宿设备处接收的用户输入数据发送回无线源设备。以这种方式，无线接收设备的用户可以控制无线源设备并且控制正在从无线源设备发送到无线接收设备的内容。在无线接收设备处接收的输入数据可以是语音命令。

10. 发明申请

WO2012079080A1 METHODS, SYSTEMS, AND MEDIA FOR DETECTING USAGE OF A RADIO CHANNEL 审中-公开
标题翻译：用于检测无线电信道的使用的方法，系统和媒体
公开(公告)号：WO2012079080A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/064434
申请日：2011-12-12
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , WANG, Xiaodong
发明人： WANG, Xiaodong
IPC分类号： H04W72/04
CPC分类号： H04W24/08 , H04L5/00 , H04L5/0023 , H04L27/0006 , H04W16/14 , H04W24/10
摘要： Methods, systems, and media for detecting usage of a radio channel are provided. In some embodiments, methods for detecting usage of a radio channel are provided, the methods comprising: collecting noise samples on the radio channel from a radio receiver; determining a noise empirical cumulative distribution function using a hardware processor; collecting signal samples on the radio channel from the radio receiver; determining a signal empirical cumulative distribution function using a hardware processor; calculating a largest absolute difference between the noise empirical cumulative distribution function and the signal empirical cumulative distribution function using a hardware processor; and determining that the radio channel is being used when the largest absolute difference is greater than a threshold using a hardware processor.
摘要翻译：提供了用于检测无线电信道的使用的方法，系统和媒体。在一些实施例中，提供了用于检测无线电信道的使用的方法，所述方法包括：从无线电接收机收集无线电信道上的噪声样本; 使用硬件处理器确定噪声经验累积分布函数; 从无线电接收机收集无线电信道上的信号样本; 使用硬件处理器确定信号经验累积分布函数; 使用硬件处理器计算噪声经验累积分布函数和信号经验累积分布函数之间的最大绝对差; 并且当使用硬件处理器来确定最大绝对差大于阈值时正在使用无线电信道。

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