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2. 发明申请

WO2007024680A1 PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS 审中-公开
标题翻译：用作激酶酶调节剂的吡唑并吡啶和吡唑并嘧啶化合物有用
公开(公告)号：WO2007024680A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/032314
申请日：2006-08-18
申请人： AMGEN INC. , BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
发明人： BUCHANAN, John L. , BUCKNER, William H. , CARDOZO, Mario G. , DIMAURO, Erin F. , FU, Jiasheng , HAO, Xiaolin , JIAO, XianYun , KAYSER, Frank , KOPECKY, David J. , MASSE, Craig E. , TOMLINSON, Susan A. , WHITE, Ryan , ZHU, Xiaotian
IPC分类号： C07D487/04 , C07D231/56 , C07D403/06 , C07D405/06 , C07D401/14 , A61K31/519 , A61K31/416 , A61P19/00 , A61P17/00 , A61P35/00
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula (I) or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式（I）的化合物或立体异构体，互变异构体，溶剂化物，药学上可接受的盐或其前药，含有该化合物的药物制剂，使用该化合物的治疗方法，例如蛋白酪氨酸激酶 - 相关疾病如免疫学和肿瘤学疾病以及制备包含该化合物的药物的方法。

3. 发明申请

WO2010045258A2 SPIROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：螺旋GPR40调制器
公开(公告)号：WO2010045258A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/060549
申请日：2009-10-13
申请人： AMGEN INC. , BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式IA，IB，I'A或I'B，其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

4. 发明申请

WO2006004703A2 PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY 审中-公开
标题翻译： PYRROLO [2,3-d]调节ACK1和LCK活性的吡咯烷
公开(公告)号：WO2006004703A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022836
申请日：2005-06-29
申请人： AMGEN INC. , FARTHING, Christopher N. , FAULDER, Paul , FRENKEL, Alexander David , HARRISON, Martin James , JIAO, Xianyun , KAYSER, Frank , KOPECKY, David J. , LIU, Jinqian , LIVELY, Sarah E. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph
发明人： FARTHING, Christopher N. , FAULDER, Paul , FRENKEL, Alexander David , HARRISON, Martin James , JIAO, Xianyun , KAYSER, Frank , KOPECKY, David J. , LIU, Jinqian , LIVELY, Sarah E. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph
IPC分类号： C07D487/00
CPC分类号： C07D487/04
摘要： Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.
摘要翻译：描述了调节ACK1和LCK的作用的化合物以及用于治疗ACK1和LCK介导的疾病的相关组合物方法。在一个方面，化合物具有一般结构：其中本文提供取代基的值。

5. 发明申请

WO2010093849A3 PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS 审中-公开
标题翻译：用于治疗胰岛素相关疾病和病症的苯丙氨酸酰胺衍生物
公开(公告)号：WO2010093849A3
公开(公告)日：2010-10-28
申请号：PCT/US2010023988
申请日：2010-02-12
申请人： AMGEN INC , DU XIAOHUI , FU ZICE , HOUZE JONATHAN B , JIAO XIANYUN , KIM YONG-JAE , LI LEPING , LIU JINQIAN , LIZARZABURU MIKE , MEDINA JULIO , SHEN WANG , TURCOTTE SIMON , YU MING
发明人： DU XIAOHUI , FU ZICE , HOUZE JONATHAN B , JIAO XIANYUN , KIM YONG-JAE , LI LEPING , LIU JINQIAN , LIZARZABURU MIKE , MEDINA JULIO , SHEN WANG , TURCOTTE SIMON , YU MING
IPC分类号： C07D213/24 , A61K31/4427 , A61K31/506 , A61P3/00 , C07D239/26 , C07D277/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of formula I: wherein A, B, X, R1, R2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.
摘要翻译：本文提供了式I的化合物：其中A，B，X，R 1，R 2和下标n如以下公开内容所定义。还提供了包含该化合物的组合物，以及其用于例如治疗2型糖尿病和2型糖尿病相关病症的方法。

6. 发明申请

WO2006130160A3 FURANOPYRIDINE DERIVATIVES AS ACK1 AND LCK MODULATORS 审中-公开
标题翻译：作为ACK1和LCK调节剂的呋喃亚胺衍生物
公开(公告)号：WO2006130160A3
公开(公告)日：2007-02-22
申请号：PCT/US2005025725
申请日：2005-07-19
申请人： AMGEN INC , NUNES JOSEPH J , MARTIN MATTHEW W , WHITE RYAN , MCGOWAN DAVID , BEMIS JEAN E , KAYSER FRANK , FU JIASHENG , LIU JINQIAN , JIAO XIANYUN
发明人： NUNES JOSEPH J , MARTIN MATTHEW W , WHITE RYAN , MCGOWAN DAVID , BEMIS JEAN E , KAYSER FRANK , FU JIASHENG , LIU JINQIAN , JIAO XIANYUN
IPC分类号： C07D491/04 , A61K31/4355 , C07D491/14
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention relates to furanopyridine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula (I).
摘要翻译：本发明涉及具有通式（I）的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂化物，药学上可接受的盐和衍生物及其前药。本发明还包括药物组合物，其包含式I化合物，调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症，包括炎症，T细胞活化抑制，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘，干草组织，湿疹，癌症，结肠癌，胸腺瘤，仅举几个例子，在哺乳动物中，包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法：式（I）。

7. 发明申请

WO2006004703A3 PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY 审中-公开
标题翻译：吡咯并[2,3-d]嘧啶类化合物调节ACK1和LCK活性
公开(公告)号：WO2006004703A3
公开(公告)日：2006-03-09
申请号：PCT/US2005022836
申请日：2005-06-29
申请人： AMGEN INC , FARTHING CHRISTOPHER N , FAULDER PAUL , FRENKEL ALEXANDER DAVID , HARRISON MARTIN JAMES , JIAO XIANYUN , KAYSER FRANK , KOPECKY DAVID J , LIU JINQIAN , LIVELY SARAH E , SHARMA RAJIV , SHUTTLEWORTH STEPHEN JOSEPH
发明人： FARTHING CHRISTOPHER N , FAULDER PAUL , FRENKEL ALEXANDER DAVID , HARRISON MARTIN JAMES , JIAO XIANYUN , KAYSER FRANK , KOPECKY DAVID J , LIU JINQIAN , LIVELY SARAH E , SHARMA RAJIV , SHUTTLEWORTH STEPHEN JOSEPH
IPC分类号： C07D487/00 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.
摘要翻译：描述了调节ACK1和LCK作用的化合物，以及用于治疗ACK1-和LCK介导的疾病的相关组合物方法。在一个方面，化合物具有通式结构：其中取代基的值在本文中提供。

8. 发明申请

WO2010093849A2 PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS 审中-公开
标题翻译：用于治疗胰岛素相关疾病和病症的苯丙氨酸酰胺衍生物
公开(公告)号：WO2010093849A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/023988
申请日：2010-02-12
申请人： AMGEN INC. , DU, Xiaohui , FU, Zice , HOUZE, Jonathan, B. , JIAO, Xianyun , KIM, Yong-jae , LI, Leping , LIU, Jinqian , LIZARZABURU, Mike , MEDINA, Julio , SHEN, Wang , TURCOTTE, Simon , YU, Ming
发明人： DU, Xiaohui , FU, Zice , HOUZE, Jonathan, B. , JIAO, Xianyun , KIM, Yong-jae , LI, Leping , LIU, Jinqian , LIZARZABURU, Mike , MEDINA, Julio , SHEN, Wang , TURCOTTE, Simon , YU, Ming
IPC分类号： C07D213/24 , C07D239/26 , C07D277/30 , C07D401/04 , C07D401/12 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of formula I: wherein A, B, X, R 1 , R 2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.
摘要翻译：本文提供了式I的化合物：其中A，B，X，R 1，R 2和上标n如本文所定义。披露后。还提供了包含这些化合物的组合物以及它们的使用方法，例如，用于治疗2型糖尿病和2型糖尿病相关病症。

9. 发明申请

WO2010045258A3 SPIROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译： SPIROCYCLIC GPR40调节剂
公开(公告)号：WO2010045258A3
公开(公告)日：2010-07-01
申请号：PCT/US2009060549
申请日：2009-10-13
申请人： AMGEN INC , BROWN SEAN P , DRANSFIELD PAUL , DU XIAOHUI , FU ZICE , HOUZE JONATHAN , JIAO XIANYUN , LAI SUJEN , LI AN-RONG , LIU JIWEN , MA ZHIHUA , MEDINA JULIO C , PATTAROPONG VATEE , SHEN WANG , VIMOLRATANA MARC , WANG YINGCAI , WANG ZHONGYU , YU MING , ZHU LIUSHENG
发明人： BROWN SEAN P , DRANSFIELD PAUL , DU XIAOHUI , FU ZICE , HOUZE JONATHAN , JIAO XIANYUN , LAI SUJEN , LI AN-RONG , LIU JIWEN , MA ZHIHUA , MEDINA JULIO C , PATTAROPONG VATEE , SHEN WANG , VIMOLRATANA MARC , WANG YINGCAI , WANG ZHONGYU , YU MING , ZHU LIUSHENG
IPC分类号： C07C62/34 , A61K31/185 , A61K31/33 , A61P3/10 , C07D221/00 , C07D231/00 , C07D249/00 , C07D271/00 , C07D277/00 , C07D311/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供可用于例如治疗受试者的代谢紊乱的化合物。这样的化合物具有通式IA，IB，I'A或I'B，其中变量的定义在本文中提供。本发明还提供组合物，其包括所述化合物在制备药物和用于治疗代谢病症例如II型糖尿病中的用途以及所述化合物的使用方法。

10. 发明申请

WO2008030520A1 HETEROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：杂环GPR40调制器
公开(公告)号：WO2008030520A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/019454
申请日：2007-09-06
申请人： AMGEN INC. , BECK, Hilary , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , KOHN, Todd, J. , LAI, SuJen , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , SCHMITT, Michael, J. , SHARMA, Rajiv , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu
发明人： BECK, Hilary , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , KOHN, Todd, J. , LAI, SuJen , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , SCHMITT, Michael, J. , SHARMA, Rajiv , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu
IPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , A61K31/42 , A61K31/422 , A61P3/10 , A61P3/04 , A61P9/00 , A61P9/10
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

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