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1. 发明申请

WO2008030618A1 BENZO-FUSED COMPOUNDS FOR USE IN TREATING METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的苯并呋喃化合物
公开(公告)号：WO2008030618A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/019662
申请日：2007-09-06
申请人： AMGEN INC. , BROWN, Sean P. , DRANSFIELD, Paul , HOUZE, Jonathan B. , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SCHMITT, Michael J. , SHARMA, Rajiv , WANG, Yingcai
发明人： BROWN, Sean P. , DRANSFIELD, Paul , HOUZE, Jonathan B. , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SCHMITT, Michael J. , SHARMA, Rajiv , WANG, Yingcai
IPC分类号： C07D213/55 , C07D231/12 , C07D233/64 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D285/12 , C07D333/24 , C07D207/327 , C07D277/587 , C07C59/72 , C07C233/65 , A61K31/192 , A61K31/40
CPC分类号： C07D233/64 , C07C51/09 , C07C51/367 , C07C51/47 , C07C235/34 , C07C2602/10 , C07D207/327 , C07D213/55 , C07D231/12 , C07D239/26 , C07D249/10 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/587 , C07D285/12 , C07D333/24 , C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L 1 , ℗, L 2 , M, X, L 3 , and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中变量Q，L 1，...，L 2，M，X，L 3，...的定义 >和A。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

2. 发明申请

WO2007033002A1 CONFORMATIONALLY CONSTRAINED 3- (4-HYDROXY-PHENYL) - SUBSTITUTED-PROPANOIC ACIDS USEFUL FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译：具有约束力的3-（4-羟基苯基） - 用于治疗代谢紊乱的替代丙酸
公开(公告)号：WO2007033002A1
公开(公告)日：2007-03-22
申请号：PCT/US2006/034995
申请日：2006-09-08
申请人： AMGEN INC. , AKERMAN, Michelle , BROWN, Sean , HOUZE, Jonathan, B. , LIU, Jinqian , MA, Zhihua , MEDINA, Julio, C. , QIU, Wei , SCHMITT, Michael, J. , WANG, Yingcai , ZHU, Liusheng
发明人： AKERMAN, Michelle , BROWN, Sean , HOUZE, Jonathan, B. , LIU, Jinqian , MA, Zhihua , MEDINA, Julio, C. , QIU, Wei , SCHMITT, Michael, J. , WANG, Yingcai , ZHU, Liusheng
IPC分类号： C07C59/72 , C07D333/16 , C07D333/24 , C07D263/32 , C07D231/12 , C07D233/54 , C07D317/54 , C07D249/08 , C07D261/08 , C07D239/26 , C07D257/04 , C07D261/04 , A61K31/381 , A61P3/10
CPC分类号： C07D333/24 , C07C59/72 , C07D231/12 , C07D233/26 , C07D233/64 , C07D239/26 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D317/54 , C07D333/16
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: (F) where the definitions of the variables Q, L 1 , , L 2 , M, X, L 3 , and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I（F），其中变量Q，L 1，L 2，M，X，L 3， / SUP>和A。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

3. 发明申请

WO2007106469A2 BICYCLIC CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢障碍的双环羧酸衍生物
公开(公告)号：WO2007106469A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006279
申请日：2007-03-12
申请人： AMGEN INC. , SHARMA, Rajiv , AKERMAN, Michelle , CARDOZO, Mario, G. , HOUZE, Jonathan, B. , LI, An-Rong , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , MEDINA, Julio, C. , SCHMITT, Michael, J. , SUN, Ying , WANG, Yingcai , WANG, Zhongyu , ZHU, Liusheng
发明人： SHARMA, Rajiv , AKERMAN, Michelle , CARDOZO, Mario, G. , HOUZE, Jonathan, B. , LI, An-Rong , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , MEDINA, Julio, C. , SCHMITT, Michael, J. , SUN, Ying , WANG, Yingcai , WANG, Zhongyu , ZHU, Liusheng
IPC分类号： C07D209/08 , C07D209/46 , C07D215/22 , C07D277/24 , C07D311/74 , C07D313/08 , C07D417/12 , C07D498/04 , C07C59/54 , C07C59/72 , A61K31/426 , A61P3/10
CPC分类号： C07C57/62 , C07C59/64 , C07C59/72 , C07D209/08 , C07D209/46 , C07D215/20 , C07D215/227 , C07D277/24 , C07D311/58 , C07D311/74 , C07D311/76 , C07D313/08 , C07D417/12 , C07D498/04
摘要： Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject formula (I) (II) where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.
摘要翻译：具有通式I和/或通式II的化合物可用于例如本文提供变量的主题式（I）（II）中的代谢紊乱。公开了用于制备药物和用于治疗代谢性疾病例如II型糖尿病的化合物的组合物和方法。

4. 发明申请

WO2006004703A2 PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY 审中-公开
标题翻译： PYRROLO [2,3-d]调节ACK1和LCK活性的吡咯烷
公开(公告)号：WO2006004703A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022836
申请日：2005-06-29
申请人： AMGEN INC. , FARTHING, Christopher N. , FAULDER, Paul , FRENKEL, Alexander David , HARRISON, Martin James , JIAO, Xianyun , KAYSER, Frank , KOPECKY, David J. , LIU, Jinqian , LIVELY, Sarah E. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph
发明人： FARTHING, Christopher N. , FAULDER, Paul , FRENKEL, Alexander David , HARRISON, Martin James , JIAO, Xianyun , KAYSER, Frank , KOPECKY, David J. , LIU, Jinqian , LIVELY, Sarah E. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph
IPC分类号： C07D487/00
CPC分类号： C07D487/04
摘要： Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.
摘要翻译：描述了调节ACK1和LCK的作用的化合物以及用于治疗ACK1和LCK介导的疾病的相关组合物方法。在一个方面，化合物具有一般结构：其中本文提供取代基的值。

5. 发明申请

WO2010093849A2 PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS 审中-公开
标题翻译：用于治疗胰岛素相关疾病和病症的苯丙氨酸酰胺衍生物
公开(公告)号：WO2010093849A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/023988
申请日：2010-02-12
申请人： AMGEN INC. , DU, Xiaohui , FU, Zice , HOUZE, Jonathan, B. , JIAO, Xianyun , KIM, Yong-jae , LI, Leping , LIU, Jinqian , LIZARZABURU, Mike , MEDINA, Julio , SHEN, Wang , TURCOTTE, Simon , YU, Ming
发明人： DU, Xiaohui , FU, Zice , HOUZE, Jonathan, B. , JIAO, Xianyun , KIM, Yong-jae , LI, Leping , LIU, Jinqian , LIZARZABURU, Mike , MEDINA, Julio , SHEN, Wang , TURCOTTE, Simon , YU, Ming
IPC分类号： C07D213/24 , C07D239/26 , C07D277/30 , C07D401/04 , C07D401/12 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of formula I: wherein A, B, X, R 1 , R 2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.
摘要翻译：本文提供了式I的化合物：其中A，B，X，R 1，R 2和上标n如本文所定义。披露后。还提供了包含这些化合物的组合物以及它们的使用方法，例如，用于治疗2型糖尿病和2型糖尿病相关病症。

6. 发明申请

WO2008030520A1 HETEROCYCLIC GPR40 MODULATORS 审中-公开
标题翻译：杂环GPR40调制器
公开(公告)号：WO2008030520A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/019454
申请日：2007-09-06
申请人： AMGEN INC. , BECK, Hilary , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , KOHN, Todd, J. , LAI, SuJen , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , SCHMITT, Michael, J. , SHARMA, Rajiv , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu
发明人： BECK, Hilary , DRANSFIELD, Paul , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , KOHN, Todd, J. , LAI, SuJen , LIU, Jinqian , LIU, Jiwen , MA, Zhihua , SCHMITT, Michael, J. , SHARMA, Rajiv , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu
IPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12 , A61K31/42 , A61K31/422 , A61P3/10 , A61P3/04 , A61P9/00 , A61P9/10
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

7. 发明申请

WO2006130160A2 FURANOPYRIDINE DERIVATIVES AND METHODS OF USE 审中-公开
标题翻译：呋喃并吡啶衍生物及其使用方法
公开(公告)号：WO2006130160A2
公开(公告)日：2006-12-07
申请号：PCT/US2005/025725
申请日：2005-07-19
申请人： AMGEN INC. , NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
发明人： NUNES, Joseph, J. , MARTIN, Matthew, W. , WHITE, Ryan , MCGOWAN, David , BEMIS, Jean, E. , KAYSER, Frank , FU, Jiasheng , LIU, Jinqian , JIAO, XianYun
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention relates to furanopyridine compounds having the general Formula I (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.
摘要翻译：本发明涉及具有通式I（I）的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂合物，药学上可接受的盐和衍生物及其前药。本发明还包括药物组合物，其包含式I化合物，调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症，包括炎症，T细胞活化抑制，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘，干草组织，湿疹，癌症，结肠癌，胸腺瘤，仅举几个例子，在哺乳动物中，包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法：一级方程式

8. 发明申请

WO2006004658A3 FURANOPYRIMIDINES 审中-公开
公开(公告)号：WO2006004658A3
公开(公告)日：2006-01-12
申请号：PCT/US2005/022727
申请日：2005-06-29
申请人： AMGEN INC. , BUCHANAN, John L. , BUCKNER, William H. , BURKITT, Simon A. , DIMAURO, Erin F. , FARTHING, Christopher N. , FRENKEL, Alexander David , HARRISON, Martin J. , KAYSER, Frank , LIU, Jinqian , LIVELY, Sarah E. , MARSHALL, Teresa L. , MCGOWAN, David C. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph , ZHU, Xiaotian
发明人： BUCHANAN, John L. , BUCKNER, William H. , BURKITT, Simon A. , DIMAURO, Erin F. , FARTHING, Christopher N. , FRENKEL, Alexander David , HARRISON, Martin J. , KAYSER, Frank , LIU, Jinqian , LIVELY, Sarah E. , MARSHALL, Teresa L. , MCGOWAN, David C. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph , ZHU, Xiaotian
IPC分类号： C07D498/04 , A61K31/519
摘要： The present invention relates to furanopyrimidine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula (I), methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula (I). The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula (I).

9. 发明公开

EP1768986A2 FURANOPYRIMIDINES 审中-公开
标题翻译：呋喃并嘧啶
公开(公告)号：EP1768986A2
公开(公告)日：2007-04-04
申请号：EP05763716.7
申请日：2005-06-29
申请人： Amgen Inc.
发明人： BUCHANAN, John L. , BUCKNER, William H. , BURKITT, Simon A. , DIMAURO, Erin F. , FARTHING, Christopher N. , FRENKEL, Alexander David , HARRISON, Martin J. , KAYSER, Frank , LIU, Jinqian , LIVELY, Sarah E. , MARSHALL, Teresa L. , MCGOWAN, David C. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph , ZHU, Xiaotian
IPC分类号： C07D498/04 , A61K31/519
CPC分类号： C07D491/04 , C07D495/04
摘要： The present invention relates to furanopyrimidine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula (I), methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula (I). The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula (I).

10. 发明公开

EP1768982A2 PYROLO [2,3-D] PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY 审中-公开
标题翻译： Pyrolo [2,3-D]嘧啶类，所述ACK1-及LCK活性而调节
公开(公告)号：EP1768982A2
公开(公告)日：2007-04-04
申请号：EP05768263.5
申请日：2005-06-29
申请人： Amgen Inc.
发明人： FARTHING, Christopher N. , FAULDER, Paul , FRENKEL, Alexander David , HARRISON, Martin James , JIAO, Xianyun , KAYSER, Frank , KOPECKY, David J. , LIU, Jinqian , LIVELY, Sarah E. , SHARMA, Rajiv , SHUTTLEWORTH, Stephen Joseph
IPC分类号： C07D487/00 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.

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