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2. 发明专利

IL272681D0 Macrocyclic mcl-1 inhibitors and methods of use 未知
公开(公告)号：IL272681D0
公开(公告)日：2020-03-31
申请号：IL27268120
申请日：2020-02-14
申请人： ABBVIE DEUTSCHLAND , BRAJE WILFRIED , ABBVIE INC , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
发明人： BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI-FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
IPC分类号： C07D20060101
摘要： The present disclosure provides for compounds of formula (I)wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , A 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

3. 发明专利

SG11202001182QA MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE 未知
公开(公告)号：SG11202001182QA
公开(公告)日：2020-03-30
申请号：SG11202001182Q
申请日：2018-08-15
申请人： ABBVIE INC , ABBVIE DEUTSCHLAND , BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
发明人： BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI-FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
摘要： The present disclosure provides for compounds of formula (I)wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , A 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

4. 发明专利

AU2018318692A1 Macrocyclic MCL-1 inhibitors and methods of use 未知
公开(公告)号：AU2018318692A1
公开(公告)日：2020-03-12
申请号：AU2018318692
申请日：2018-08-15
申请人： ABBVIE DEUTSCHLAND , ABBVIE INC
发明人： BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI-FU , LAI CHUNQIU , KLING ANDREAS , POHLKI FRAUKE , TESKE JESSC , WENDT MICHAEL , BRADY PATRICK , WANG XILU , PENNING THOMAS , MICHAELIDES MICHAEL
IPC分类号： C07D515/22 , A61K31/395 , A61P35/00
摘要： The present disclosure provides for compounds of Formula (I) wherein A

5. 发明专利

AU2018316620A1 Macrocyclic MCL-1 inhibitors and methods of use 未知
公开(公告)号：AU2018316620A1
公开(公告)日：2020-03-12
申请号：AU2018316620
申请日：2018-08-15
申请人： ABBVIE DEUTSCHLAND , ABBVIE INC
发明人： BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI-FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQIU , KLING ANDREAS , POHLKI FRAUKE
IPC分类号： C07D515/22 , A61K31/395 , A61P35/00
摘要： The present disclosure provides for compounds of formula (I), wherein A

6. 发明专利

MX2015012153A INHIBIDORES DE LA QUINASA PIRROLOPIRIMIDINA CDK9. 未知
公开(公告)号：MX2015012153A
公开(公告)日：2015-12-01
申请号：MX2015012153
申请日：2014-03-13
申请人： ABBVIE INC
发明人： TAO ZHI-FU , PENNING THOMAS , SOUERS ANDREW J , FLORJANCIC ALAN S , GOSWAMI RAJEEV , TONG YUNSONG
IPC分类号： C07D487/04 , A61K31/519 , A61K35/00
摘要： Se describen compuestos de Fórmula (la), (ver Fórmula) en donde R1, R2 y R3 son como se definen en la descripción, y las sales farmacéuticamente aceptables de los mismos. Los compuestos se pueden usar como agentes en el tratamiento de enfermedades, incluyendo el cáncer. También se proporcionan composiciones farmacéuticas, que comprenden uno o más compuestos de Fórmula (la).

7. 发明专利

CA2903538A1 PYRROLOPYRIMINDINE CDK9 KINASE INHIBITORS 未知
公开(公告)号：CA2903538A1
公开(公告)日：2014-10-02
申请号：CA2903538
申请日：2014-03-13
申请人： ABBVIE INC
发明人： FLORJANCIC ALAN S , TONG YUNSONG , PENNING THOMAS , SOUERS ANDREW J , GOSWAMI RAJEEV , TAO ZHI-FU
IPC分类号： C07D487/04 , A61K31/519 , A61K35/00
摘要： Disclosed are compound of Formula (Ia), wherein R1, R2, and R3 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions, comprising one or more compounds of Formula (Ia).

8. 发明专利

CA2905935A1 PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS 未知
公开(公告)号：CA2905935A1
公开(公告)日：2014-09-25
申请号：CA2905935
申请日：2014-03-13
申请人： ABBVIE INC
发明人： GONG JIANCHUN , TAO ZHI-FU , TONG YUNSONG , ZHU GUIDONG , PENNING THOMAS , SOUERS ANDREW J
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Disclosed are compounds of Formula (IIIa), wherein R1, R2, R3, X1, X2, X3, X4, X5, have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof. The compounds may be used as agents in the treatment of diseases, including cancer. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (IIIa).

9. 发明专利

ES2473344T3 Las pirazoloquinolonas son potentes inhibidoras de la PARP 未知
公开(公告)号：ES2473344T3
公开(公告)日：2014-07-04
申请号：ES07757073
申请日：2007-02-15
申请人： ABBOTT LAB , ABBVIE INC
发明人： PENNING THOMAS , ZHU GUI-DONG , GANDHI VIRAJKUMAR , GONG JIANCHUN , GIRANDA VINCENT
IPC分类号： C07D471/04 , A61K31/438 , A61P35/00 , C07D491/04 , C07D495/04
摘要： Un compuesto de Fórmula (I)**Fórmula** o una sal terapéuticamente aceptable del mismo, donde R1 y R2 junto con los átomos a los que están unidos forman un cicloalquilo de 5, 6, 7 ó 8 miembros, el cicloalquilo puede estar sin sustituir o sustituido con 1, 2 ó 3 sustituyentes seleccionados independientemente entre el grupo que consiste en alquenilo, alcoxi, alcoxialquilo, alcoxicarbonilo, alcoxicarbonilalquilo, alquilo C1-C6, alquinilo, arilo, arilalcoxicarbonilo, arilalquilo, cicloalquilo, cicloalquilalquilo, ciano, haloalcoxi, haloalquilo, halógeno, heterociclo, heterocicloalquilo, heterociclocarbonilo, heterociclocarbonilalquilo, heterociclosulfonilo, heteroarilo, heteroarilalquilo, hidroxi, hidroxialquilo, nitro, NRARB, (NRARB)alquilo, (NRARB)carbonilo, (NRARB)carbonilalquilo y (NRARB)sulfonilo; R3 se selecciona entre el grupo que consiste en arilo, cicloalquilo, heterociclo y heteroarilo; X es NR4; R4 se selecciona entre el grupo que consiste en alquilo C1-C6; y RA y RB se seleccionan independientemente entre el grupo que consiste en hidrógeno, alquilo C1-C6, arilo, arilalquilo, arilalquilcarbonilo, arilalcoxi, arilalcoxicarbonilo, cicloalquilo, cicloalquilalquilo y heterociclo; donde el arilo, cicloalquilo y heterociclo representados por R3 en solitario o como parte de otro resto, están independientemente sin sustituir o sustituidos con 1, 2 ó 3 sustituyentes seleccionados independientemente entre el grupo que consiste en alquenilo, alcoxi, alcoxialquilo, alcoxicarbonilo, alquilo C1-C6, alquilcarbonilo, alquilcarboniloxi, alquiltio, alquiltioalquilo, alquinilo, arilo, arilalquilo, arilalcoxi, arilalcoxicarbonilo, carboxi, ciano, cicloalquilo, cicloalquilalquilo, formilo, haloalcoxi, haloalquilo, halógeno, hidroxi, hidroxialquilo, mercapto, nitro, oxo, -NRARB, (NRARB)alquilo, (NRARB)carbonilo, (NRARB)carbonilalquilo, (NRARB)sulfonilo, alquilsulfonilo, heterociclo, heterocicloalquilo, heteroarilo y heteroarilalquilo, donde los restos de sustituyentes están adicionalmente sin sustituir.

10. 发明专利

CA2864142A1 PYRIDOPYRIMIDINONE INHIBITORS OF KINASES 未知
公开(公告)号：CA2864142A1
公开(公告)日：2013-08-29
申请号：CA2864142
申请日：2013-02-22
申请人： ABBVIE INC
发明人： WOODS KEITH , MASTRACCHIO ANTHONY , LAI CHUNQIU , GANDHI VIRAJKUMAR B , PENNING THOMAS
IPC分类号： C07D471/04 , A61K31/52 , A61P35/00 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.

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