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    • 3. 发明公开
    • Dlk-1 유전자 발현억제용 조성물
    • 用于抑制DLK-1基因表达的组合物
    • KR1020130051520A
    • 2013-05-21
    • KR1020110116215
    • 2011-11-09
    • 경희대학교 산학협력단
    • 김상훈김윤진이학교윤두학서강석
    • A61K48/00A61K31/7088A61P35/00
    • A61K48/00
    • PURPOSE: A composition for suppressing Dlk-1 gene expression is provided to suppress cancer cell progression induced by pref-1 expression, and to develop a cell therapeutic agent or an anticancer therapeutic agent using stem cells. CONSTITUTION: A composition for preventing or treating cancer contains an miR-143 nucleic acid molecule as an active ingredient. The molecule contains a base sequence in sequence number 1. The molecule suppresses Dlk-1 gene expression. The composition is used for treating cancer in which pref-1 is overexpressed. The cancer is selected from the group consisting of small cell lung cancer, neuroendocrine tumor, neuroblastoma, glioma, type-1 neurofibromatosis, liver cancer, kidney cancer, ovarian cancer, and acute leukemia. The molecule contains a vector for intracellular expression.
    • 目的:提供抑制Dlk-1基因表达的组合物,以抑制由pre-1表达诱导的癌细胞进程,并开发使用干细胞的细胞治疗剂或抗癌治疗剂。 构成:用于预防或治疗癌症的组合物含有miR-143核酸分子作为活性成分。 该分子含有序列号1中的碱基序列。该分子抑制Dlk-1基因表达。 该组合物用于治疗pre-1过表达的癌症。 癌症选自小细胞肺癌,神经内分泌肿瘤,神经母细胞瘤,神经胶质瘤,1型神经纤维瘤病,肝癌,肾癌,卵巢癌和急性白血病。 该分子含有用于细胞内表达的载体。