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    • 2. 发明授权
    • 한우 고급육 선발을 위한 배최장근단면적 관련 바이오 마커단백질
    • 与EMA相关的蛋白质标记,用于提高汉族肉质量
    • KR100832348B1
    • 2008-05-26
    • KR1020060116602
    • 2006-11-23
    • 경희대학교 산학협력단
    • 김상훈신연남이홍구서강석윤두학신연남
    • C07K14/47C07K16/00
    • A bio-marker relating to economic traits including longissimus muscle area of Korean native cattle in a protein level is provided to be selected by using a proteome analysis technique and be used for producing meat with high quality. A bio-marker for selecting Korean native cattle with high quality comprises adenylate kinase 1 which shows relatively increased expression in longissimus dorsi having higher estimated breeding value relating to longissimus muscle area than in longissimus dorsi having lower estimated breeding value, includes trypsin decomposed peptide sequences of SEQ ID : NOs. 5, 6, and 7, and has a molecular weight of 21-23kDa and pI of 8.2-8.6. A diagnostic agent or a diagnostic kit for selecting the Korean native cattle with high quality comprises the bio-marker protein or an antibody specifically coupled to an immunogenic fragment thereof as an effective ingredient.
    • 通过使用蛋白质组分析技术选择与蛋白质水平上的韩国本地牛的长肌肌肉面积的经济性状相关的生物标记物,并用于生产高质量的肉类。 用于选择具有高质量的韩国本地牛的生物标记物包括腺苷酸激酶1,其在具有较高估计育种值的较长假背景中具有较高估计育种值的长背景背景中显示相对增加的表达,包括胰蛋白酶分解的肽序列 SEQ ID:NO。 5,6和7,分子量21-23kDa,pI为8.2-8.6。 用于选择高质量的韩国本地牛的诊断试剂或诊断试剂盒包括生物标记蛋白或与其免疫原性片段特异性结合的抗体作为有效成分。
    • 3. 发明公开
    • Dlk-1 유전자 발현억제용 조성물
    • 用于抑制DLK-1基因表达的组合物
    • KR1020130051520A
    • 2013-05-21
    • KR1020110116215
    • 2011-11-09
    • 경희대학교 산학협력단
    • 김상훈김윤진이학교윤두학서강석
    • A61K48/00A61K31/7088A61P35/00
    • A61K48/00
    • PURPOSE: A composition for suppressing Dlk-1 gene expression is provided to suppress cancer cell progression induced by pref-1 expression, and to develop a cell therapeutic agent or an anticancer therapeutic agent using stem cells. CONSTITUTION: A composition for preventing or treating cancer contains an miR-143 nucleic acid molecule as an active ingredient. The molecule contains a base sequence in sequence number 1. The molecule suppresses Dlk-1 gene expression. The composition is used for treating cancer in which pref-1 is overexpressed. The cancer is selected from the group consisting of small cell lung cancer, neuroendocrine tumor, neuroblastoma, glioma, type-1 neurofibromatosis, liver cancer, kidney cancer, ovarian cancer, and acute leukemia. The molecule contains a vector for intracellular expression.
    • 目的:提供抑制Dlk-1基因表达的组合物,以抑制由pre-1表达诱导的癌细胞进程,并开发使用干细胞的细胞治疗剂或抗癌治疗剂。 构成:用于预防或治疗癌症的组合物含有miR-143核酸分子作为活性成分。 该分子含有序列号1中的碱基序列。该分子抑制Dlk-1基因表达。 该组合物用于治疗pre-1过表达的癌症。 癌症选自小细胞肺癌,神经内分泌肿瘤,神经母细胞瘤,神经胶质瘤,1型神经纤维瘤病,肝癌,肾癌,卵巢癌和急性白血病。 该分子含有用于细胞内表达的载体。