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1. 发明专利

SA113340925B1 أنظمة تحويل مرتفعة ومنخفضة لإنتاج الضوء المنبعث 未知
公开(公告)号：SA113340925B1
公开(公告)日：2015-08-03
申请号：SA113340925
申请日：2010-03-20
申请人： LAN NICHOLAS STANTON , JOSEPH H SIMMONS , BENOIL LAULY , JENNIFER AYRES , MICHAEL J THERIEN , MOLLY K GREGAS , TUAN VO DINH , JONATHAN P SCAFFIDI , FREDERIC A BOURKE JR , YAN ZHANG , JOSHUA T STECHER , ZAK FATHI , ZHENYUAN ZHANG , VENKATA GOPAL REDDY CHADA
发明人： N/A , N/A , N/A , N/A , N/A , N/A , N/A , N/A , N/A , N/A , N/A , N/A , N/A , N/A
摘要： يتعلقالاختراعالحاليبنظاملتحويلمرتفعو/أوتحويلمنخفضللطاقةونظاملإنتاجتفاعلمحاكاةبالضوءفيوسط. هذهالنظمتشتملعلى : 1) جسيماتبحجمالنانو nanoparticle تمتتهيئتها, عندالتعرضلطولموجيأول first wavelength λ1 منالإشعاع radiation , لتوليدطولموجيثان second wavelength λ2 منالإشعاع radiation يحتويعلىطاقةأعلىمنالطولالموجيالأولλ1 و 2) هيكلمعدنييتموضعهوفقاًللجسيمبحجمالنانو nanoparticle. يتمضبطالخصائصالفيزيائيةللهيكلالمعدنيإلىقيمةحيثيرجعبلازمونرنينالسطحفيالهيكلالمعدنيالصدىعندترددوالذييوفرتراكبطيفيإمامعالطولالموجيالأولλ1 أوالطولالموجيالثانيλ2, أومعكلمنλ1 وλ2. يشتملالنظاملإنتاجتفاعلمحاكاةبالضوءفيوسطعلىمستقبلموضوعفيالوسطقريباًمنالجسيمبحجمالنانو nanoparticle والذي, عندالتنشيطبواسطةالطولالموجيالثانيλ2, يولدالتفاعلالمحاكىبالضوء. شكل 1.

2. 发明专利

SA115360501B1 أنظمة تحويل مرتفعة ومنخفضة لإنتاج الضوء المنبعث 未知
公开(公告)号：SA115360501B1
公开(公告)日：2016-05-17
申请号：SA115360501
申请日：2010-03-20
申请人： LAN NICHOLAS STANTON , BENOIL LAULY , TUAN VO DINH , JOSEPH H SIMMONS , JOSHUA T STECHER , JONATHAN P SCAFFIDI , JENNIFER AYRES , ZAK FATHI , ZHENYUAN ZHANG , FREDERIC A BOURKE JR , VENKATA GOPAL REDDY CHADA , MICHAEL J THERIEN , MOLLY K GREGAS , YAN ZHANG
发明人： LAN NICHOLAS STANTON , N/A , BENOIL LAULY , N/A , TUAN VO-DINH , N/A , JOSEPH H SIMMONS , N/A , JOSHUA T STECHER , N/A , JONATHAN P SCAFFIDI , N/A , JENNIFER AYRES , N/A , N/A , ZAK FATHI , N/A , ZHENYUAN ZHANG , N/A , FREDERIC A BOURKE JR , N/A , VENKATA GOPAL REDDY CHADA , MICHAEL J THERIEN , N/A , MOLLY K GREGAS , N/A , N/A , YAN ZHANG
摘要： يتعلقالاختراعالحاليبنظاملتحويلمرتفعو/أوتحويلمنخفضللطاقةونظاملإنتاجتفاعلمحاكاةبالضوءفيوسط. هذهالنظمتشتملعلى : 1) جسيماتبحجمالنانو nanoparticle تمتتهيئتها, عندالتعرضلطولموجيأول first wavelength λ1 منالإشعاع radiation , لتوليدطولموجيثان second wavelength λ2 منالإشعاع radiation يحتويعلىطاقةأعلىمنالطولالموجيالأولλ1 و 2) هيكلمعدنييتموضعهوفقاًللجسيمبحجمالنانو nanoparticle. يتمضبطالخصائصالفيزيائيةللهيكلالمعدنيإلىقيمةحيثيرجعبلازمونرنينالسطحفيالهيكلالمعدنيالصدىعندترددوالذييوفرتراكبطيفيإمامعالطولالموجيالأولλ1 أوالطولالموجيالثانيλ2, أومعكلمنλ1 وλ2. يشتملالنظاملإنتاجتفاعلمحاكاةبالضوءفيوسطعلىمستقبلموضوعفيالوسطقريباًمنالجسيمبحجمالنانو nanoparticle والذي, عندالتنشيطبواسطةالطولالموجيالثانيλ2, يولدالتفاعلالمحاكىبالضوء. شكل 1.

3. 发明授权

US09302116B2 Non-invasive energy upconversion methods and systems for in-situ photobiomodulation 有权
标题翻译：用于原位光生物调节的非侵入性能量上转换方法和系统
公开(公告)号：US09302116B2
公开(公告)日：2016-04-05
申请号：US12764184
申请日：2010-04-21
申请人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
发明人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号： A61N5/06 , A61K49/00 , A61L2/08 , A61N1/40 , A61N5/02
CPC分类号： A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病或胞外结构。所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生直接或通过调制剂对目标结构的影响或改变。纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

4. 发明申请

US20110021970A1 NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS FOR IN-SITU PHOTOBIOMODULATION 有权
标题翻译：非入侵能源逆转方法和系统用于现场光电转换
公开(公告)号：US20110021970A1
公开(公告)日：2011-01-27
申请号：US12764184
申请日：2010-04-21
申请人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
发明人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
IPC分类号： A61M37/00 , G02F1/01 , A61K35/12 , A61K39/00 , A61K9/16 , B82Y5/00
CPC分类号： A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病或胞外结构。所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生直接或通过调制剂对目标结构的影响或改变。纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

5. 发明申请

US20100261263A1 UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES 有权
标题翻译：用于生产来自各种能源的发光的向上和向下转换系统
公开(公告)号：US20100261263A1
公开(公告)日：2010-10-14
申请号：US12725108
申请日：2010-03-16
申请人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John Norton
发明人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John Norton
IPC分类号： B32B5/16 , B01J19/08 , B01J19/12 , G01N30/96 , B01J19/00 , C12M1/34 , C08F2/46 , F21V9/16 , A61L2/08 , G21K1/00 , G01N21/63 , A61N5/06
CPC分类号： F21K2/00 , A61L2/08 , A61L2202/22 , A61N5/062 , B82Y20/00 , B82Y30/00 , G01N21/63 , G02B5/003 , G02F2/02 , Y10T428/25 , Y10T428/256
摘要： A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.
摘要翻译：一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。

6. 发明申请

US20100003316A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) 有权
标题翻译：使用PLASMONICS增强光疗法（PEPST）和EXCITON-PLASMON增强型照相疗法（EPEP）治疗细胞增殖性疾病的方法和系统
公开(公告)号：US20100003316A1
公开(公告)日：2010-01-07
申请号：US12389946
申请日：2009-02-20
申请人： Tuan Vo Dinh , Frederic A. Bourke, JR.
发明人： Tuan Vo Dinh , Frederic A. Bourke, JR.
IPC分类号： A61K9/127 , A61K9/00 , A61K9/48 , A61K9/14 , A61K39/395 , A61K35/12 , A61K38/43 , A61K38/02 , A61K31/711 , A61K31/433 , A61K31/352 , A61K31/7105
CPC分类号： A61K41/0061 , A61K9/14 , A61K9/143 , A61K31/37 , A61K39/00 , A61K41/0028 , A61K41/0066 , A61K47/52 , A61K2039/57 , A61N5/06 , A61N5/062
摘要： The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.
摘要翻译：使用等离子体激元增强光谱疗法（PEPST）和离子等离子体增强光疗法（EPEP）治疗各种细胞增殖障碍，以及其中使用的PEPST和EPEP试剂和探针。

7. 发明申请

US20080219926A1 SERS MOLECULAR PROBE FOR DIAGNOSTICS AND THERAPY AND METHODS OF USE THEREOF 有权
标题翻译：用于诊断和治疗的SERS分子探针及其使用方法
公开(公告)号：US20080219926A1
公开(公告)日：2008-09-11
申请号：US11972110
申请日：2008-01-10
申请人： TUAN VO-DINH
发明人： TUAN VO-DINH
IPC分类号： A61K49/00 , C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2565/632 , C12Q2563/155 , C12Q2525/301
摘要： An oligonucleotide-based SERS molecular probe (SMP) includes a nanoparticle having at least a metal component, and at least one pin loop, the pin loop including a loop sequence complementary to at least one target sequence, a first stem attached to one end of the loop sequence, a second stem attached to the other end of the loop sequence, and at least one SERS active label attached to the first stem. The nanoparticle is attached to the second stem. The probe generates a stronger SERS signal upon irradiation with excitation radiation when not bound to the target sequence as compared to the SERS signal generated following hybridization of the probe with the target sequence.
摘要翻译：基于寡核苷酸的SERS分子探针（SMP）包括具有至少一种金属成分的纳米颗粒和至少一个针环，所述针环包括与至少一个靶序列互补的环序列，附接到至少一个靶序列的一端的第一茎环序列，连接到环序列的另一端的第二茎和连接到第一茎的至少一个SERS活性标签。纳米颗粒附着于第二茎。与探针与目标序列杂交后产生的SERS信号相比，当与靶序列没有结合时，探针在照射激发辐射时产生更强的SERS信号。

8. 发明申请

US20050074784A1 Integrated biochip with continuous sampling and processing (CSP) system 审中-公开
标题翻译：具有连续采样和处理（CSP）系统的集成生物芯片
公开(公告)号：US20050074784A1
公开(公告)日：2005-04-07
申请号：US10680046
申请日：2003-10-07
申请人： Tuan Vo-Dinh
发明人： Tuan Vo-Dinh
IPC分类号： C12M1/34 , C12Q1/68 , G01N21/64 , G01N33/53 , G01N33/543 , H01L20060101
CPC分类号： G01N21/6454 , G01N21/6428 , G01N33/54373
摘要： An integrated circuit based analyte detection system includes a plurality of bioprobe microarrays, each of the microarrays having a plurality of probe elements for combining with at least one target molecule. The probe elements generate an identifiable signal when combined with target molecules responsive to incident electromagnetic radiation. Structure is provided for translating the microarrays, allowing microarrays used by the system to be replaced by other microarrays. An integrated circuit microchip includes a plurality of detection channels to which the probe elements are brought into optical alignment.
摘要翻译：基于集成电路的分析物检测系统包括多个生物探针微阵列，每个微阵列具有用于与至少一个靶分子组合的多个探针元件。当与入射电磁辐射反应的目标分子结合时，探针元件产生可识别的信号。提供了用于翻译微阵列的结构，允许系统使用的微阵列被其他微阵列替代。集成电路微芯片包括多个检测通道，探针元件对其进行光学对准。

9. 发明授权

US06614730B1 SERODS optical data storage with parallel signal transfer 失效
标题翻译： SERODS光学数据存储并行信号传输
公开(公告)号：US06614730B1
公开(公告)日：2003-09-02
申请号：US09909236
申请日：2001-07-19
申请人： Tuan Vo-Dinh
发明人： Tuan Vo-Dinh
IPC分类号： G11B1100
CPC分类号： G11B7/1362 , G11B7/00453 , G11B7/12 , G11B7/127 , G11B7/128 , G11B7/1381 , G11B7/14
摘要： Surface-enhanced Raman optical data storage (SERODS) systems having increased reading and writing speeds, that is, increased data transfer rates, are disclosed. In the various SERODS read and write systems, the surface-enhanced Raman scattering (SERS) data is written and read using a two-dimensional process called parallel signal transfer (PST). The various embodiments utilize laser light beam excitation of the SERODS medium, optical filtering, beam imaging, and two-dimensional light detection. Two- and three-dimensional SERODS media are utilized. The SERODS write systems employ either a different laser or a different level of laser power.
摘要翻译：公开了具有增加的读取和写入速度的表面增强拉曼光学数据存储（SERODS）系统，即增加的数据传输速率。在各种SERODS读写系统中，使用称为并行信号传输（PST）的二维处理来写入和读取表面增强拉曼散射（SERS）数据。各种实施例利用SERODS介质的激光束激发，光学滤波，光束成像和二维光检测。使用二维和三维的SERODS介质。 SERODS写入系统采用不同的激光或不同级别的激光功率。

10. 发明授权

US5721102A Surface enhanced Raman gene probe and methods thereof 失效
标题翻译：表面增强拉曼基因探针及其方法
公开(公告)号：US5721102A
公开(公告)日：1998-02-24
申请号：US792085
申请日：1997-01-31
申请人： Tuan Vo-Dinh
发明人： Tuan Vo-Dinh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , G01N21/658
摘要： The subject invention disclosed herein is a new gene probe biosensor and methods thereof based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed thereon. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means supporting the SERS active substrate includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays.
摘要翻译：本文公开的本发明是基于表面增强拉曼散射（SERS）标签检测的新型基因探针生物传感器及其方法。 SER基因探针生物传感器包括支持装置，具有至少一个用至少一个SERS标记标记的寡核苷酸链的SER基因探针和置于支持装置上并且至少一个SER基因探针吸附在其上的SERS活性底物。通过与SER基因探针互补的寡核苷酸链的杂交，使用SER基因探针检测细菌和病毒DNA，RNA和PNA等生物靶。支持SERS活性底物的支持装置包括光纤探针，用于执行多个测定的光纤探针阵列和具有电荷耦合器件或光电二极管阵列的波导微传感器阵列。

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