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1. 发明授权

US10847666B2 Up and down conversion systems for improved solar cell performance or other energy conversion 有权
公开(公告)号：US10847666B2
公开(公告)日：2020-11-24
申请号：US12891466
申请日：2010-09-27
申请人： Frederic A. Bourke, Jr. , Zak Fathi , Ian Nicholas Stanton , Michael J. Therien
发明人： Frederic A. Bourke, Jr. , Zak Fathi , Ian Nicholas Stanton , Michael J. Therien
IPC分类号： H01L31/055
CPC分类号： H01L31/055 , Y02E10/52
摘要： A system and a conversion element for power conversion. The power conversion system includes a power conversion device which produces electric power upon illumination and includes a light conversion device which down-converts and up-converts a radiant source of energy into a specific energy spectrum for the illumination of the power conversion device. The conversion element includes a first plurality of particles which upon radiation from a first radiation source radiate at a higher energy than the first radiation source, and includes a second plurality of particles which upon radiation from the first radiation source radiate at a lower energy than the first radiation source. At least one of the first plurality of particles and the second plurality of particles can be at least partially metal coated.

2. 发明授权

US09302116B2 Non-invasive energy upconversion methods and systems for in-situ photobiomodulation 有权
标题翻译：用于原位光生物调节的非侵入性能量上转换方法和系统
公开(公告)号：US09302116B2
公开(公告)日：2016-04-05
申请号：US12764184
申请日：2010-04-21
申请人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
发明人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian N. Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
IPC分类号： A61N5/06 , A61K49/00 , A61L2/08 , A61N1/40 , A61N5/02
CPC分类号： A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病或胞外结构。所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生直接或通过调制剂对目标结构的影响或改变。纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

3. 发明申请

US20110021970A1 NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS FOR IN-SITU PHOTOBIOMODULATION 有权
标题翻译：非入侵能源逆转方法和系统用于现场光电转换
公开(公告)号：US20110021970A1
公开(公告)日：2011-01-27
申请号：US12764184
申请日：2010-04-21
申请人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
发明人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Harold WALDER , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John NORTON
IPC分类号： A61M37/00 , G02F1/01 , A61K35/12 , A61K39/00 , A61K9/16 , B82Y5/00
CPC分类号： A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.
摘要翻译：用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病或胞外结构。所述方法可以以非侵入性方式在原位进行，通过将具有金属壳的纳米颗粒放置在受试者的靶结构附近的表面的至少一部分上，并向受试者施加引发能量，从而产生直接或通过调制剂对目标结构的影响或改变。纳米颗粒在暴露于第一波长λ1时被配置为产生具有比第一波长λ1更高的能量的辐射的第二波长λ2。所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在一种或多种等离子体激活剂活性剂的存在下进行，从而产生对其的作用或改变目标结构。包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

4. 发明申请

US20100261263A1 UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES 有权
标题翻译：用于生产来自各种能源的发光的向上和向下转换系统
公开(公告)号：US20100261263A1
公开(公告)日：2010-10-14
申请号：US12725108
申请日：2010-03-16
申请人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John Norton
发明人： Tuan VO-DINH , Jonathan P. SCAFFIDI , Venkata Gopal Reddy CHADA , Benoit LAULY , Yan ZHANG , Molly K. GREGAS , Ian N. STANTON , Joshua T. STECHER , Michael J. THERIEN , Frederic A. BOURKE, JR. , Zak FATHI , Jennifer A. AYRES , Zhenyuan ZHANG , Joseph H. SIMMONS , Stephen John Norton
IPC分类号： B32B5/16 , B01J19/08 , B01J19/12 , G01N30/96 , B01J19/00 , C12M1/34 , C08F2/46 , F21V9/16 , A61L2/08 , G21K1/00 , G01N21/63 , A61N5/06
CPC分类号： F21K2/00 , A61L2/08 , A61L2202/22 , A61N5/062 , B82Y20/00 , B82Y30/00 , G01N21/63 , G02B5/003 , G02F2/02 , Y10T428/25 , Y10T428/256
摘要： A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.
摘要翻译：一种用于能量上转换和/或下转换的系统和用于在介质中产生光刺激反应的系统。这些系统包括1）在暴露于辐射的第一波长λ1时配置的纳米颗粒，以产生具有比第一波长λ1更高的能量的辐射的第二波长λ2，和2）相对于纳米颗粒设置的金属结构。金属结构的物理特性被设定为金属结构中的表面等离子体共振在以与第一波长λ1或第二波长λ2或与λ1和λ2两者提供光谱重叠的频率谐振的值。用于在培养基中产生光刺激反应的系统包括设置在接近纳米颗粒的培养基中的受体，其在第二波长λ2激活时产生光刺激反应。

5. 发明申请

US20100003316A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) 有权
标题翻译：使用PLASMONICS增强光疗法（PEPST）和EXCITON-PLASMON增强型照相疗法（EPEP）治疗细胞增殖性疾病的方法和系统
公开(公告)号：US20100003316A1
公开(公告)日：2010-01-07
申请号：US12389946
申请日：2009-02-20
申请人： Tuan Vo Dinh , Frederic A. Bourke, JR.
发明人： Tuan Vo Dinh , Frederic A. Bourke, JR.
IPC分类号： A61K9/127 , A61K9/00 , A61K9/48 , A61K9/14 , A61K39/395 , A61K35/12 , A61K38/43 , A61K38/02 , A61K31/711 , A61K31/433 , A61K31/352 , A61K31/7105
CPC分类号： A61K41/0061 , A61K9/14 , A61K9/143 , A61K31/37 , A61K39/00 , A61K41/0028 , A61K41/0066 , A61K47/52 , A61K2039/57 , A61N5/06 , A61N5/062
摘要： The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.
摘要翻译：使用等离子体激元增强光谱疗法（PEPST）和离子等离子体增强光疗法（EPEP）治疗各种细胞增殖障碍，以及其中使用的PEPST和EPEP试剂和探针。

6. 发明授权

US09023249B2 Adhesive bonding composition and method of use 有权
标题翻译：粘合剂组合物及其使用方法
公开(公告)号：US09023249B2
公开(公告)日：2015-05-05
申请号：US13102277
申请日：2011-05-06
申请人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, Jr. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
发明人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, Jr. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
IPC分类号： C09J4/00 , B41J2/175
CPC分类号： H01L24/83 , A61B17/0057 , A61L24/06 , B32B3/266 , B32B7/14 , B32B9/04 , B32B37/1284 , B32B37/18 , B32B38/0008 , B32B2037/1253 , B32B2457/00 , B32B2457/08 , B32B2457/14 , B41J2/17559 , C08K3/00 , C09J4/00 , C09J9/02 , C09J11/04 , C09J11/06 , C09J133/08 , C09K11/02 , C09K11/7769 , C09K11/777 , H01L23/5226 , H01L24/32 , H01L25/0657 , H01L25/50 , H01L2224/16225 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2224/83192 , H01L2224/83855 , H01L2224/92125 , H01L2225/06524 , H01L2225/06589 , H01L2924/07811 , H01L2924/1461 , H01L2924/15311 , Y10T428/2852 , H01L2924/00014 , H01L2924/00
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
摘要翻译：可聚合组合物包括至少一种单体，当暴露于光时能够引发单体聚合的光引发剂和当暴露于辐射（通常为X射线）时能产生光的荧光体）。该材料特别适用于在外部光源不能接合接合点的情况下在环境温度下结合部件。相关方法包括：将可聚合粘合剂组合物，包括光引发剂和能量转换材料（例如下变换磷光体）与要结合的至少两种组分接触以形成组件; 并且能够将第一波长的辐射照射到组件上，该辐射能够转换（由荧光体进行下变频）到能够激活光引发剂的第二波长，以制备诸如喷墨墨盒，晶片到晶片组件，半导体，集成电路等。

7. 发明申请

US20120089180A1 ADHESIVE BONDING COMPOSITION AND METHOD OF USE 有权
标题翻译：胶粘剂组合物及其使用方法
公开(公告)号：US20120089180A1
公开(公告)日：2012-04-12
申请号：US13102277
申请日：2011-05-06
申请人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, JR. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
发明人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, JR. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
IPC分类号： A61B17/03 , G03F7/038 , C09D163/10 , H01B1/12 , C09D167/07 , G21K5/00 , B41J2/175 , H01L23/28 , B32B37/12 , B32B38/14 , B32B7/12 , C09D7/12 , C09D4/02 , B82Y30/00
CPC分类号： H01L24/83 , A61B17/0057 , A61L24/06 , B32B3/266 , B32B7/14 , B32B9/04 , B32B37/1284 , B32B37/18 , B32B38/0008 , B32B2037/1253 , B32B2457/00 , B32B2457/08 , B32B2457/14 , B41J2/17559 , C08K3/00 , C09J4/00 , C09J9/02 , C09J11/04 , C09J11/06 , C09J133/08 , C09K11/02 , C09K11/7769 , C09K11/777 , H01L23/5226 , H01L24/32 , H01L25/0657 , H01L25/50 , H01L2224/16225 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2224/83192 , H01L2224/83855 , H01L2224/92125 , H01L2225/06524 , H01L2225/06589 , H01L2924/07811 , H01L2924/1461 , H01L2924/15311 , Y10T428/2852 , H01L2924/00014 , H01L2924/00
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
摘要翻译：可聚合组合物包括至少一种单体，当暴露于光时能够引发单体聚合的光引发剂和当暴露于辐射（通常为X射线）时能产生光的荧光体）。该材料特别适用于在外部光源不能接合接合点的情况下在环境温度下结合部件。相关方法包括：将可聚合粘合剂组合物，包括光引发剂和能量转换材料（例如下变换磷光体）与要结合的至少两种组分接触以形成组件; 并且能够将第一波长的辐射照射到组件上，该辐射能够转换（由荧光体进行下变频）到能够激活光引发剂的第二波长，以制备诸如喷墨墨盒，晶片到晶片组件，半导体，集成电路等。

8. 发明申请

US20110117202A1 UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES INCLUDING RADIO FREQUENCY, MICROWAVE ENERGY AND MAGNETIC INDUCTION SOURCES FOR UPCONVERSION 有权
标题翻译：用于生产来自各种能量源的发射光的UP和DOWN转换系统，包括无线电频率，微波能量和用于上变换的磁感应源
公开(公告)号：US20110117202A1
公开(公告)日：2011-05-19
申请号：US12943787
申请日：2010-11-10
申请人： Frederic A. Bourke, JR. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo MacCarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt , Mark Wesley Dewhirst
发明人： Frederic A. Bourke, JR. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo MacCarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt , Mark Wesley Dewhirst
IPC分类号： A61N5/00 , H01J61/00 , H01J61/20 , B01J8/18 , B01J19/08 , A61K9/14 , A61K38/20 , A61K39/395 , A61K38/44 , A61K33/00 , A61K33/38 , A61K33/24 , A61K38/28 , A61K38/22 , A61K38/14 , A61K31/7052 , A61K31/7084 , A61K31/655 , A61K31/5415 , A61K31/525 , A61K31/473 , A61K31/47 , A61K31/40 , A61K31/405 , A61K31/352 , A61K31/122 , A61K31/015 , C08G77/00 , A61L2/10 , G21G5/00 , A61M37/00 , B01J19/12 , C23C14/28 , B32B37/00 , B29C65/14 , B82Y15/00 , B82Y25/00 , B82Y99/00
CPC分类号： H05B41/2806 , A61L2/10 , A61N1/40 , A61N1/44 , A61N2/00 , A61N5/10 , C02F1/32 , H01J65/042 , Y02B20/22 , Y02W10/37
摘要： Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λ1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
摘要翻译：用于产生介质变化的方法和系统。第一种方法和系统（1）在介质附近放置至少一个包括用于等离子体点火的气体的上变频器，其中上变频器被配置为在暴露于引发能量时产生用于发射到介质中的光，和（2 ）将包括第一波长λ1的能量源的引发能量施加到介质，其中发射的光直接或间接地产生介质中的变化。第二种方法和系统（1）在介质附近放置接收微波辐射或射频辐射的试剂，以及（2）作为引发能量施加微波辐射或射频辐射，其中所述试剂直接或间接产生发射光在红外线，可见光或紫外线范围内产生介质中物理和生物变化中的至少一种。

9. 发明申请

US20100266621A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES 有权
标题翻译：用PSORALEN衍生物治疗细胞增殖障碍的方法和系统
公开(公告)号：US20100266621A1
公开(公告)日：2010-10-21
申请号：US12763404
申请日：2010-04-20
申请人： Eric Toone , David Gooden , Tuan Vo-Dinh , Frederic A. Bourke, JR.
发明人： Eric Toone , David Gooden , Tuan Vo-Dinh , Frederic A. Bourke, JR.
IPC分类号： A61K39/00 , C07D405/14 , A61K31/4433 , A61K31/453 , C07D211/22 , C07D215/38 , A61K31/4709 , A61P35/00
CPC分类号： C07D493/04 , A61K31/4433 , A61K31/453 , A61K31/4709 , A61K41/0066 , A61K45/06 , A61N5/062 , A61N5/10
摘要： Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.
摘要翻译：式（I）的补骨脂素化合物：其中（N +芳基）是选自式（i） - （iii）的含氮芳族杂环的成员：其中Z是下式的基团：其中R是C1-C30 烃基，其可以是直链，支链或环状的并且含有1至15个碳 - 碳双键，其可以彼此共轭或非共轭或可以包括芳环，并且可以含有一个或多个取代基; R 1是氢，芳基，杂芳基，烷基，环烷基，杂环基，烯基，炔基，烯 - 芳基，烯 - 杂芳基，烯烃 - 杂环基，烯 - 环烷基，稠合环烷基芳基，稠合环烷基杂芳基，稠合杂环基芳基，稠合杂环杂芳基，亚烷基稠合环烷基芳基亚烷基稠合的环烷基杂芳基，亚烷基稠合的杂环基芳基，亚烷基稠合的杂环杂芳基; n为1〜8的整数，X为药学上可接受的抗衡离子; 及其在治疗受试者的细胞增殖障碍的方法中的用途，含有补骨脂素衍生物的药物组合物，用于进行该方法的试剂盒以及使用该方法在受试者中引起自身疫苗效应的方法。

10. 发明授权

US08951561B2 Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP) 有权
标题翻译：使用等离子体激元增强光谱疗法（PEPST）和激子等离子体增强光疗法（EPEP）治疗细胞增殖障碍的方法和系统
公开(公告)号：US08951561B2
公开(公告)日：2015-02-10
申请号：US12389946
申请日：2009-02-20
申请人： Tuan Vo-Dinh , Frederic A. Bourke, Jr.
发明人： Tuan Vo-Dinh , Frederic A. Bourke, Jr.
IPC分类号： A61K41/00 , A61K9/14 , A61K31/34 , A61K31/35 , A61K31/365 , C07D493/00 , A61N5/06 , A61K39/00
CPC分类号： A61K41/0061 , A61K9/14 , A61K9/143 , A61K31/37 , A61K39/00 , A61K41/0028 , A61K41/0066 , A61K47/52 , A61K2039/57 , A61N5/06 , A61N5/062
摘要： The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.
摘要翻译：使用等离子体激元增强光谱疗法（PEPST）和离子等离子体增强光疗法（EPEP）治疗各种细胞增殖障碍，以及其中使用的PEPST和EPEP试剂和探针。

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